Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)

Biochemical Journal

Volumn 374, Issue 3, 2003, Pages 639-646

  Sarno, Stefania ^a,b   De Moliner, Erika ^a,b   Ruzzene, Maria ^a,b   Pagano, Mario A ^b   Battistutta, Roberto ^a,b   Bain, Jenny ^c   Fabbro, Doriano ^d   Schoepfer, Joseph ^d   Elliott, Matthew ^c   Furet, Pascal ^d   Meggio, Flavio ^b   Zanotti, Giuseppe ^a,b   Pinna, Lorenzo A ^a,b  

^a VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

4,5,6, 7 tetrabromobenzotriazole (TBB); Dual specificity tyrosine phosphorylated and regulated kinase 1a (DYRK1a); Protein kinase inhibitor; Protein phosphorylation

Indexed keywords

ACETIC ACID; ADENOSINETRIPHOSPHATE; CELLS; CRYSTALLIZATION; ENZYME INHIBITION; HYDROPHOBICITY;

NON-POLAR INTERACTIONS;

PROTEINS;

5 OXO 5,6 DIHYDROINDOLO[1,2 A]QUINAZOLIN 7 YLACETIC ACID; ADENOSINE TRIPHOSPHATE; AROMATIC COMPOUND; CASEIN KINASE II; CG 44171A; CGP 029482; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PURINE; UNCLASSIFIED DRUG; (5 OXO 5,6 DIHYDROINDOLO(1,2 A)QUINAZOLIN 7 YL)ACETIC ACID; (5-OXO-5,6-DIHYDROINDOLO(1,2-A)QUINAZOLIN-7-YL)ACETIC ACID; ACETIC ACID DERIVATIVE; PROTEIN SERINE THREONINE KINASE; QUINAZOLINE DERIVATIVE; VEGETABLE PROTEIN;

ARTICLE; BIOCHEMISTRY; CELL TRANSFORMATION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTALLIZATION; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; WILD TYPE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; MAIZE; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ZEA MAYS;

ACETIC ACIDS; ANIMALS; CASEIN KINASE II; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; MOLECULAR STRUCTURE; PLANT PROTEINS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; RATS; ZEA MAYS;

EID: 0141791013     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030674     Document Type: Article

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