Gene expression suggests spontaneously hypertensive rats may have altered metabolism and reduced hypoxic tolerance

Current Neurovascular Research

Volumn 9, Issue 1, 2012, Pages 10-19

  Ritz, Marie Françoise ^a   Grond Ginsbach, Caspar ^b   Engelter, Stefan ^c   Lyrer, Philippe ^c  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Neurologische Universitatsklinik Basel   (Switzerland)

Author keywords

cDNA microarrays; Energy metabolism; Hypoxia; SHR; Small vessel disease; WKY

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; ADDUCIN; ARGONAUTE 2 PROTEIN; BECLIN 1; BETA 2 MICROGLOBULIN; CALPAIN 3; CARNITINE PALMITOYLTRANSFERASE; CD151 ANTIGEN; COLONY STIMULATING FACTOR RECEPTOR; CYSTATHIONINE BETA SYNTHASE; CYTOCHROME C OXIDASE; GLUTAMATE RECEPTOR; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; GLYCOGEN PHOSPHORYLASE; HEAT SHOCK PROTEIN 40; KV CHANNEL INTERACTING PROTEIN; LECTIN; MACROPHAGE MIGRATION INHIBITION FACTOR; NEUROPILIN; NITRILASE; P21 ACTIVATED KINASE 2; PENTRAXIN; RIBOSOME PROTEIN; SOMATOSTATIN; SUCCINATE DEHYDROGENASE; SYNTAXIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DOWN REGULATION; ENERGY METABOLISM; ESSENTIAL HYPERTENSION; FEMALE; FRONTAL CORTEX; GENE EXPRESSION; HYPOXIA; ISCHEMIA; LIPID METABOLISM; MALE; MICROARRAY ANALYSIS; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION; WISTAR KYOTO RAT;

EID: 84858263192     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/156720212799297074     Document Type: Article

References (38)

1. Lammie GA. Hypertensive cerebral small vessel disease and stroke. Brain Pathol. 2002; 12(3):358-70. (Pubitemid 34743218)
2. Nishimura Y, Ito T, Saavedra JM. Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke. 2000; 31(10):2478-86.
3. Yamakawa H, Phillips MI, Saavedra JM. Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive rats. Regul Pept. 2003; 111(1-3):117-22. (Pubitemid 36254758)
4. Grabowski M, Nordborg C, Brundin P, et al. Middle cerebral artery occlusion in the hypertensive and normotensive rat: a study of histopathology and behaviour. J Hypertens. 1988; 6(5):405-11.
5. Amenta F, Di Tullio MA, Tomassoni D. Arterial hypertension and brain damage-evidence from animal models (review). Clin Exp Hypertens. 2003; 25(6):359-80. (Pubitemid 36993241)
6. Sabbatini M, Strocchi P, Vitaioli L, et al. Microanatomical changes of intracerebral arteries in spontaneously hypertensive rats: a model of cerebrovascular disease of the elderly. Mech Ageing Dev. 2001; 122(12):1257-68. (Pubitemid 32579200)
7. Ritz MF, Fluri F, Engelter ST, et al. Cortical and putamen age related changes in the microvessel density and astrocyte deficiency in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats. Curr Neurovasc Res. 2009; 6(4):279-87.
8. Allan S. The neurovascular unit and the key role of astrocytes in the regulation of cerebral blood flow. Cerebrovasc Dis. 2006; 21(1- 2):137-8.
9. Bergeron M, Yu AY, Solway KE, et al. Induction of hypoxiainducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci. 1999; 11(12):4159-70. (Pubitemid 30009246)
10. Rettig R, Stauss H, Folberth C, et al. Hypertension transmitted by kidneys from stroke-prone spontaneously hypertensive rats. Am J Physiol. 1989; 257(2 Pt 2):F197-203.
11. Kitagawa K, Yagita Y, Sasaki T, et al. Chronic mild reduction of cerebral perfusion pressure induces ischemic tolerance in focal cerebral ischemia. Stroke. 2005; 36(10):2270-4. (Pubitemid 41429258)
12. Yeh HJ, He YY, Xu J, et al. Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injury. J Neurosci. 1998; 18(10):3699-707. (Pubitemid 28225677)
13. Li F, Tian F, Wang L, et al. Pleiotrophin (PTN) is expressed in vascularized human atherosclerotic plaques: IFN-{gamma}/ JAK/STAT1 signaling is critical for the expression of PTN in macrophages. FASEB J. 2010; 24(3):810-22.
14. Costain WJ, Haqqani AS, Rasquinha I, et al. Proteomic analysis of synaptosomal protein expression reveals that cerebral ischemia alters lysosomal Psap processing. Proteomics. 2010; 10(18):3272-91.
15. Carmichael ST, Archibeque I, Luke L, et al. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Exp Neurol. 2005; 193(2):291-311. (Pubitemid 40616180)
16. Corbett D, Giles T, Evans S, et al. Dynamic changes in CA1 dendritic spines associated with ischemic tolerance. Exp Neurol. 2006; 202(1):133-8. (Pubitemid 44376593)
17. Anderton BH, Callahan L, Coleman P, et al. Dendritic changes in Alzheimer's disease and factors that may underlie these changes. Prog Neurobiol. 1998; 55(6):595-609. (Pubitemid 28293583)
18. Buki A, Okonkwo DO, Wang KK, et al. Cytochrome c release and caspase activation in traumatic axonal injury. J Neurosci. 2000; 20(8):2825-34. (Pubitemid 30220307)
19. Ignacio PC, Baldwin BA, Vijayan VK, et al. Brain isozyme of glycogen phosphorylase: immunohistological localization within the central nervous system. Brain Res. 1990; 529(1-2):42-9. (Pubitemid 20326838)
20. Seccia TM, Atlante A, Vulpis V, et al. Mitochondrial energy metabolism in the left ventricular tissue of spontaneously hypertensive rats: abnormalities in both adeninenucleotide and phosphate translocators and enzyme adenylate-kinase and creatinephosphokinase activities. Clin Exp Hypertens. 1998; 20(3):345-58. (Pubitemid 28213253)
21. Kravtsov GM, Orlov SN, Pokudin NI, et al. Calcium transport in synaptosomes and subcellular membrane fractions of brain tissue in spontaneously hypertensive rats. Clin Sci (Lond). 1983; 65(2):127-35. (Pubitemid 13054476)
22. Sumbalova Z, Kucharska J, Kristek F. Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats. Cell Mol Neurobiol. 2010; 30(5):751-8.
23. Lopez-Campistrous A, Hao L, Xiang W, et al. Mitochondrial dysfunction in the hypertensive rat brain: respiratory complexes exhibit assembly defects in hypertension. Hypertension. 2008; 51(2):412-9. (Pubitemid 351159958)
24. Postnov YV, Orlov SN, Budnikov YY, et al. Mitochondrial energy conversion disturbance with decrease in ATP production as a source of systemic arterial hypertension. Pathophysiology. 2007; 14(3-4):195-204. (Pubitemid 350166885)
25. Ghezzi D, Goffrini P, Uziel G, et al. SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Nat Genet. 2009; 41(6):654-6.
26. Brockmann K, Bjornstad A, Dechent P, et al. Succinate in dystrophic white matter: a proton magnetic resonance spectroscopy finding characteristic for complex II deficiency. Ann Neurol. 2002; 52(1):38-46. (Pubitemid 34693741)
27. Pravenec M, Kurtz TW. Molecular genetics of experimental hypertension and the metabolic syndrome: from gene pathways to new therapies. Hypertension. 2007; 49(5):941-52. (Pubitemid 351688338)
28. Kim JH, Youn HD. C-terminal binding protein maintains mitochondrial activities. Cell Death Differ. 2009; 16(4):584-92.
29. Raghavendra Rao VL, Bowen KK, Dhodda VK, et al. Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. J Neurochem. 2002; 83(5):1072-86. (Pubitemid 35397117)
30. Wang YQ, Berezovska O, Fedoroff S. Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in mice. J Neurosci Res. 1999; 57(5):616-32. (Pubitemid 29411476)
31. Berezovskaya O, Maysinger D, Fedoroff S. The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int J Dev Neurosci. 1995; 13(3-4):285-99.
32. Inacio AR, Ruscher K, Leng L, et al. Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke. J Cereb Blood Flow Metab. 2011; 31(4):1093-106.
33. Hammack SE, Cheung J, Rhodes KM, et al. Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior. Psychoneuroendocrinology. 2009; 34(6):833-43.
34. Okuda T, Sumiya T, Mizutani K, et al. Analyses of differential gene expression in genetic hypertensive rats by microarray. Hypertens Res. 2002; 25(2):249-55. (Pubitemid 34464455)
35. Hinojos CA, Boerwinkle E, Fornage M, et al. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hypertension. 2005; 45(4):698-704. (Pubitemid 40418368)
36. Pravenec M, Churchill PC, Churchill MC, et al. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet. 2008; 40(8):952-4.
37. Marro ML, Scremin OU, Jordan MC, et al. Hypertension in betaadducin- deficient mice. Hypertension. 2000; 36(3):449-53.
38. Brown WR, Moody DM, Challa VR, et al. Apoptosis in leukoaraiosis lesions. J Neurol Sci. 2002; 203-204:169-71. (Pubitemid 35287395)