메뉴 건너뛰기




Volumn 142, Issue 3, 2012, Pages 411-418

Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators: PPARα, Interferon-γ, and interleukin-10

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); APOLIPOPROTEIN A1; GAMMA INTERFERON; INTERLEUKIN 10; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

EID: 84858215555     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.151753     Document Type: Article
Times cited : (19)

References (60)
  • 1
    • 77950505848 scopus 로고    scopus 로고
    • Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice
    • Chan J, Deng L, Mikael LG, Yan J, Pickell L, Wu Q, Caudill MA, Rozen R. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr. 2010;91:1035-43.
    • (2010) Am J Clin Nutr , vol.91 , pp. 1035-1043
    • Chan, J.1    Deng, L.2    Mikael, L.G.3    Yan, J.4    Pickell, L.5    Wu, Q.6    Caudill, M.A.7    Rozen, R.8
  • 2
    • 0033548534 scopus 로고    scopus 로고
    • Choline availability alters embryonic development of the hippocampus and septum in the rat
    • Albright CD, Tsai A, Friedrich C, Mar M, Zeisel S. Choline availability alters embryonic development of the hippocampus and septum in the rat. Brain Res Dev Brain Res. 1999;113:13-20.
    • (1999) Brain Res Dev Brain Res , vol.113 , pp. 13-20
    • Albright, C.D.1    Tsai, A.2    Friedrich, C.3    Mar, M.4    Zeisel, S.5
  • 3
    • 0034893463 scopus 로고    scopus 로고
    • Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos
    • Fisher MC, Zeisel S, Mar M, Sadler T. Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology. 2001;64:114-22.
    • (2001) Teratology , vol.64 , pp. 114-122
    • Fisher, M.C.1    Zeisel, S.2    Mar, M.3    Sadler, T.4
  • 5
    • 23444448459 scopus 로고    scopus 로고
    • Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice
    • Li D, Pickell L, Liu Y, Wu Q, Cohn JS, Rozen R. Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice. Am J Clin Nutr. 2005;82:188-95.
    • (2005) Am J Clin Nutr , vol.82 , pp. 188-195
    • Li, D.1    Pickell, L.2    Liu, Y.3    Wu, Q.4    Cohn, J.S.5    Rozen, R.6
  • 7
    • 0000795715 scopus 로고
    • Introduction: structure and metabolism of plasma lipoproteins
    • Scriver CR, Beaudet AL, Sly WS, Valle D, editors. 7th ed., New York: McGraw-Hill
    • Havel RJ. Introduction: structure and metabolism of plasma lipoproteins. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease. 7th ed. New York: McGraw-Hill; 1995. p. 1841-51.
    • (1995) The metabolic and molecular bases of inherited disease , pp. 1841-1851
    • Havel, R.J.1
  • 8
    • 0035818556 scopus 로고    scopus 로고
    • Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming
    • Shah PK, Kaul S, Nilsson J, Cercek B. Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming. Circulation. 2001;104:2376-83.
    • (2001) Circulation , vol.104 , pp. 2376-2383
    • Shah, P.K.1    Kaul, S.2    Nilsson, J.3    Cercek, B.4
  • 9
    • 0034068935 scopus 로고    scopus 로고
    • Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse
    • McConihay JA, Honkomp AM, Granholm NA, Woollett LA. Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse. J Lipid Res. 2000;41:424-32.
    • (2000) J Lipid Res , vol.41 , pp. 424-432
    • McConihay, J.A.1    Honkomp, A.M.2    Granholm, N.A.3    Woollett, L.A.4
  • 11
    • 33645282568 scopus 로고    scopus 로고
    • Elevated homocysteine reduces Apolipoprotein A-I expression in Hyperhomocysteinemic mice and in males with coronary artery disease
    • Mikael LG, Genest J Jr, Rozen R. Elevated homocysteine reduces Apolipoprotein A-I expression in Hyperhomocysteinemic mice and in males with coronary artery disease. Circ Res. 2006;98:564-71.
    • (2006) Circ Res , vol.98 , pp. 564-571
    • Mikael, L.G.1    Genest Jr., J.2    Rozen, R.3
  • 12
    • 51749113619 scopus 로고    scopus 로고
    • Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kB/ iNOS
    • Mikael LG, Rozen R. Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kB/ iNOS. Cardiovasc Res. 2008; 80:151-8.
    • (2008) Cardiovasc Res , vol.80 , pp. 151-158
    • Mikael, L.G.1    Rozen, R.2
  • 13
    • 0033533527 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: a critical review of the epidemiologic evidence
    • Eikelboom JW, Lonn E, Genest J Jr, Hankey G, Yusuf S. Homocysteine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med. 1999;131:363-75.
    • (1999) Ann Intern Med , vol.131 , pp. 363-375
    • Eikelboom, J.W.1    Lonn, E.2    Genest Jr., J.3    Hankey, G.4    Yusuf, S.5
  • 14
    • 39749185354 scopus 로고    scopus 로고
    • Effect of homocysteine concentration in early pregnancy on gestational hypertensive disorders and other pregnancy outcomes
    • Dodds L, Fell DB, Dooley KC, Armson BA, Allen AC, Nassar BA, Perkins S, Joseph KS. Effect of homocysteine concentration in early pregnancy on gestational hypertensive disorders and other pregnancy outcomes. Clin Chem. 2008;54:326-34.
    • (2008) Clin Chem , vol.54 , pp. 326-334
    • Dodds, L.1    Fell, D.B.2    Dooley, K.C.3    Armson, B.A.4    Allen, A.C.5    Nassar, B.A.6    Perkins, S.7    Joseph, K.S.8
  • 17
    • 0035282903 scopus 로고    scopus 로고
    • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
    • Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, Smith RS, et al. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet. 2001;10:433-43.
    • (2001) Hum Mol Genet , vol.10 , pp. 433-443
    • Chen, Z.1    Karaplis, A.C.2    Ackerman, S.L.3    Pogribny, I.P.4    Melnyk, S.5    Lussier-Cacan, S.6    Chen, M.F.7    Pai, A.8    John, S.W.9    Smith, R.S.10
  • 18
    • 67651225118 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency
    • Mikael LG, Wang XL, Wu Q, Jiang H, Maclean KN, Rozen R. Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. Mol Genet Metab. 2009;98:187-94.
    • (2009) Mol Genet Metab , vol.98 , pp. 187-194
    • Mikael, L.G.1    Wang, X.L.2    Wu, Q.3    Jiang, H.4    Maclean, K.N.5    Rozen, R.6
  • 20
    • 78549249738 scopus 로고    scopus 로고
    • High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide
    • Suzuki M, Pritchard DK, Becker L, Hoofnagle AN, Tanimura N, Bammler TK, Beyer RP, Bumgarner R, Vaisar T, de Beer MC, et al. High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide. Circulation. 2010;122:1919-27.
    • (2010) Circulation , vol.122 , pp. 1919-1927
    • Suzuki, M.1    Pritchard, D.K.2    Becker, L.3    Hoofnagle, A.N.4    Tanimura, N.5    Bammler, T.K.6    Beyer, R.P.7    Bumgarner, R.8    Vaisar, T.9    de Beer, M.C.10
  • 21
    • 22844452941 scopus 로고    scopus 로고
    • Placental imbalance of Th1-and Th2-type cytokines in preeclampsia
    • Dong M, He J, Wang Z, Xie X, Wang H. Placental imbalance of Th1-and Th2-type cytokines in preeclampsia. Acta Obstet Gynecol Scand. 2005;84:788-93.
    • (2005) Acta Obstet Gynecol Scand , vol.84 , pp. 788-793
    • Dong, M.1    He, J.2    Wang, Z.3    Xie, X.4    Wang, H.5
  • 22
    • 33747598715 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor a deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: modulation of T cell differentiation
    • Yessoufou A, Hichami A, Besnard P, Moutairou K, Khan NA. Peroxisome proliferator-activated receptor a deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: modulation of T cell differentiation. Endocrinology. 2006;147:4410-8.
    • (2006) Endocrinology , vol.147 , pp. 4410-4418
    • Yessoufou, A.1    Hichami, A.2    Besnard, P.3    Moutairou, K.4    Khan, N.A.5
  • 23
    • 30344471866 scopus 로고    scopus 로고
    • Placental expression of peroxisome proliferator-activated receptors in rat pregnancy and the effect of increased glucocorticoid exposure
    • Hewitt DP, Mark PJ, Waddell BJ. Placental expression of peroxisome proliferator-activated receptors in rat pregnancy and the effect of increased glucocorticoid exposure. Biol Reprod. 2006;74:23-8.
    • (2006) Biol Reprod , vol.74 , pp. 23-28
    • Hewitt, D.P.1    Mark, P.J.2    Waddell, B.J.3
  • 24
    • 14044262361 scopus 로고    scopus 로고
    • Placental expression of interferon-g (IFN-γ) and its receptor IFN-γR2 fail to switch from early hypoxic to late normotensive development in preeclampsia
    • Banerjee S, Smallwood A, Moorhead J, Chambers AE, Papageorghiou A, Campbell S, Nicolaides K. Placental expression of interferon-g (IFN-γ) and its receptor IFN-γR2 fail to switch from early hypoxic to late normotensive development in preeclampsia. J Clin Endocrinol Metab. 2005;90:944-52.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 944-952
    • Banerjee, S.1    Smallwood, A.2    Moorhead, J.3    Chambers, A.E.4    Papageorghiou, A.5    Campbell, S.6    Nicolaides, K.7
  • 25
    • 84858198378 scopus 로고    scopus 로고
    • How your mother tolerated you for nine months
    • De Lemos MA. How your mother tolerated you for nine months. BioTeach J. 2003;1:27-9.
    • (2003) BioTeach J , vol.1 , pp. 27-29
    • De Lemos, M.A.1
  • 26
    • 70450277204 scopus 로고    scopus 로고
    • Progesterone in pregnancy; receptor-ligand interaction and signaling pathways
    • Szekeres-Bartho J, Halasz M, Palkovics T. Progesterone in pregnancy; receptor-ligand interaction and signaling pathways. J Reprod Immunol. 2009;83:60-4.
    • (2009) J Reprod Immunol , vol.83 , pp. 60-64
    • Szekeres-Bartho, J.1    Halasz, M.2    Palkovics, T.3
  • 27
    • 77956494550 scopus 로고    scopus 로고
    • Understanding the molecular mechanisms of the multifaceted IL-10-mediated anti-inflammatory response: lessons from neutrophils
    • Bazzoni F, Tamassia N, Rossato M, Cassatella MA. Understanding the molecular mechanisms of the multifaceted IL-10-mediated anti-inflammatory response: lessons from neutrophils. Eur J Immunol. 2010;40: 2360-8.
    • (2010) Eur J Immunol , vol.40 , pp. 2360-2368
    • Bazzoni, F.1    Tamassia, N.2    Rossato, M.3    Cassatella, M.A.4
  • 28
    • 35348990389 scopus 로고    scopus 로고
    • Interleukin-10 is upregulated by nanomolar rosiglitazone treatment of mature dendritic cells and human CD4+ T cells
    • Thompson PW, Bayliffe AI, Warren AP, Lamb JR. Interleukin-10 is upregulated by nanomolar rosiglitazone treatment of mature dendritic cells and human CD4+ T cells. Cytokine. 2007;39:184-91.
    • (2007) Cytokine , vol.39 , pp. 184-191
    • Thompson, P.W.1    Bayliffe, A.I.2    Warren, A.P.3    Lamb, J.R.4
  • 29
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey Jr., G.C.3
  • 31
    • 50049108528 scopus 로고    scopus 로고
    • Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    • Lillycrop KA, Phillips ES, Torrens C, Hanson MA, Jackson AA, Burdge GC. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br J Nutr. 2008;100:278-82.
    • (2008) Br J Nutr , vol.100 , pp. 278-282
    • Lillycrop, K.A.1    Phillips, E.S.2    Torrens, C.3    Hanson, M.A.4    Jackson, A.A.5    Burdge, G.C.6
  • 32
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005;135:1382-6.
    • (2005) J Nutr , vol.135 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3    Hanson, M.A.4    Burdge, G.C.5
  • 33
    • 34047258298 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    • Burdge GC, Slater-Jefferies J, Torrens C, Phillips ES, Hanson MA, Lillycrop KA. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr. 2007;97: 435-9.
    • (2007) Br J Nutr , vol.97 , pp. 435-439
    • Burdge, G.C.1    Slater-Jefferies, J.2    Torrens, C.3    Phillips, E.S.4    Hanson, M.A.5    Lillycrop, K.A.6
  • 42
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol. 2001;169:453-9.
    • (2001) J Endocrinol , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 43
    • 38649119729 scopus 로고    scopus 로고
    • The roles of PPARs in the fetal origins of metabolic health and disease
    • Rees WD, McNeil CJ, Maloney CA. The roles of PPARs in the fetal origins of metabolic health and disease. PPAR Res. 2008;2008:459030.
    • (2008) PPAR Res , vol.2008 , pp. 459030
    • Rees, W.D.1    McNeil, C.J.2    Maloney, C.A.3
  • 46
    • 34548317277 scopus 로고    scopus 로고
    • Mid-pregnancy maternal plasma levels of interleukin-2, 6, and 12, tumor necrosis factor-alpha, interferon gamma, and granulocyte-macrophage colony-stimulating factor and spontaneous preterm delivery
    • Curry AE, Vogel I, Drews C, Shcendel D, Skogstrand K, Flanders WD, Hougaard D, Olsen J, Thorsen P. Mid-pregnancy maternal plasma levels of interleukin-2, 6, and 12, tumor necrosis factor-alpha, interferon gamma, and granulocyte-macrophage colony-stimulating factor and spontaneous preterm delivery. Acta Obstet Gynecol Scand. 2007;86:1103-10.
    • (2007) Acta Obstet Gynecol Scand , vol.86 , pp. 1103-1110
    • Curry, A.E.1    Vogel, I.2    Drews, C.3    Shcendel, D.4    Skogstrand, K.5    Flanders, W.D.6    Hougaard, D.7    Olsen, J.8    Thorsen, P.9
  • 47
    • 33645053785 scopus 로고    scopus 로고
    • Placental deficiency of interleukin-10 (IL-10) in preeclampsia and its relationship to an IL10 promoter polymorphism
    • Makris A, Xu B, Yu B, Thornton C, Hennessy A. Placental deficiency of interleukin-10 (IL-10) in preeclampsia and its relationship to an IL10 promoter polymorphism. Placenta. 2006;27:445-51.
    • (2006) Placenta , vol.27 , pp. 445-451
    • Makris, A.1    Xu, B.2    Yu, B.3    Thornton, C.4    Hennessy, A.5
  • 49
    • 78650976421 scopus 로고    scopus 로고
    • Epigenetic mechanisms in inflammation
    • Bayarsaihan D. Epigenetic mechanisms in inflammation. J Dent Res. 2011;90:9-17.
    • (2011) J Dent Res , vol.90 , pp. 9-17
    • Bayarsaihan, D.1
  • 50
    • 0036532202 scopus 로고    scopus 로고
    • Histone methylation in transcriptional control
    • Kouzarides T. Histone methylation in transcriptional control. Curr Opin Genet Dev. 2002;12:198-209.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 198-209
    • Kouzarides, T.1
  • 51
    • 75149164375 scopus 로고    scopus 로고
    • Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene
    • Mehedint MG, Niculescu MD, Craciunescu CN, Zeisel S. Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB J. 2010;24:184-95.
    • (2010) FASEB J , vol.24 , pp. 184-195
    • Mehedint, M.G.1    Niculescu, M.D.2    Craciunescu, C.N.3    Zeisel, S.4
  • 52
    • 59049105953 scopus 로고    scopus 로고
    • Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain
    • Davison JM, Mellott TJ, Kovacheva VP, Blusztajn J. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem. 2009;284:1982-9.
    • (2009) J Biol Chem , vol.284 , pp. 1982-1989
    • Davison, J.M.1    Mellott, T.J.2    Kovacheva, V.P.3    Blusztajn, J.4
  • 54
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor a negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kB and AP-1
    • Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B. Peroxisome proliferator-activated receptor a negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kB and AP-1. J Biol Chem. 1999;274:32048-54.
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3    Vanden Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6    Fruchart, J.C.7    Tedgui, A.8    Haegeman, G.9    Staels, B.10
  • 55
    • 33644839513 scopus 로고    scopus 로고
    • Nuclear receptors and autoimmune disease: the potential of PPAR agonists to treat multiple sclerosis
    • Racke MK, Gocke AR, Muir M, Diab A, Drew PD, Lovett-Racke AE. Nuclear receptors and autoimmune disease: the potential of PPAR agonists to treat multiple sclerosis. J Nutr. 2006;136:700-3.
    • (2006) J Nutr , vol.136 , pp. 700-703
    • Racke, M.K.1    Gocke, A.R.2    Muir, M.3    Diab, A.4    Drew, P.D.5    Lovett-Racke, A.E.6
  • 56
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gammaproduction by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea A, Aste-Amezaga M, Valiante N, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gammaproduction by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med. 1993;178:1041-8.
    • (1993) J Exp Med , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 57
    • 33747819235 scopus 로고    scopus 로고
    • Crucial role of interferon-gamma and stimulated macrophages in cardiovascular disease
    • Schroecksnadel K, Frick B, Winkler C, Fuchs D. Crucial role of interferon-gamma and stimulated macrophages in cardiovascular disease. Curr Vasc Pharmacol. 2006;4:205-13.
    • (2006) Curr Vasc Pharmacol , vol.4 , pp. 205-213
    • Schroecksnadel, K.1    Frick, B.2    Winkler, C.3    Fuchs, D.4
  • 59
    • 79955762824 scopus 로고    scopus 로고
    • Circulating homocysteine is an inflammation marker and a risk factor of life-threatening inflammatory diseases
    • Wu JT. Circulating homocysteine is an inflammation marker and a risk factor of life-threatening inflammatory diseases. J Biomed Lab Sci. 2007;19:107-11.
    • (2007) J Biomed Lab Sci , vol.19 , pp. 107-111
    • Wu, J.T.1
  • 60
    • 79956332924 scopus 로고    scopus 로고
    • Methionine- and choline-deficient diet induces hepatic changes characteristic of non-alcoholic steatohepatitis
    • Marcolin E, Forgiarini LF, Tieppo J, Dias AS, Freitas LA, Marroni N. Methionine- and choline-deficient diet induces hepatic changes characteristic of non-alcoholic steatohepatitis. Arq Gastroenterol. 2011;48: 72-9.
    • (2011) Arq Gastroenterol , vol.48 , pp. 72-79
    • Marcolin, E.1    Forgiarini, L.F.2    Tieppo, J.3    Dias, A.S.4    Freitas, L.A.5    Marroni, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.