메뉴 건너뛰기




Volumn 10, Issue 3, 2012, Pages 369-380

The immune response to severe bacterial infections: Consequences for therapy

Author keywords

apoptosis; bacterial infections; cytokines; immunostimulation; macrolides; monocytes; sepsis

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN; ERITORAN; GAMMA INTERFERON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MACROLIDE; PATTERN RECOGNITION RECEPTOR; PLACEBO; POLYMYXIN B; SIMVASTATIN; TOLL LIKE RECEPTOR 4;

EID: 84858173181     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.12.2     Document Type: Review
Times cited : (44)

References (93)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29(7), 1303-1310 (2001). (Pubitemid 32641789)
    • (2001) Critical Care Medicine , vol.29 , Issue.7 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 3
    • 61849170035 scopus 로고    scopus 로고
    • TLRs and innate immunity
    • Beutler BA. TLRs and innate immunity. Blood 113(7), 1399-1407 (2009).
    • (2009) Blood , vol.113 , Issue.7 , pp. 1399-1407
    • Beutler, B.A.1
  • 4
    • 37049024099 scopus 로고    scopus 로고
    • Role of Toll-like receptor responses for sepsis pathogenesis
    • DOI 10.1016/j.imbio.2007.09.010, PII S0171298507001155, Macrophage and Dendritic Cells
    • Weighardt H, Holzmann B. Role of Toll-like receptor response for sepsis pathogenesis. Immunobiology 212(9-10), 715-722 (2008). (Pubitemid 350246264)
    • (2008) Immunobiology , vol.212 , Issue.9-10 , pp. 715-722
    • Weighardt, H.1    Holzmann, B.2
  • 5
    • 77249179630 scopus 로고    scopus 로고
    • The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection
    • Jin X, Lin Z, Xie X. The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. Eur. J. Clin. Microbiol. Infect. Dis. 29(2), 231-238 (2010).
    • (2010) Eur. J. Clin. Microbiol. Infect. Dis. , vol.29 , Issue.2 , pp. 231-238
    • Jin, X.1    Lin, Z.2    Xie, X.3
  • 6
    • 49249138761 scopus 로고    scopus 로고
    • TLR-induced IFN-gproduction increases TLR2 sensitivity and drives Gram-negative sepsis in mice
    • Spiller S, Elson G, Ferstl R et al. TLR-induced IFN-gproduction increases TLR2 sensitivity and drives Gram-negative sepsis in mice. J. Exp. Med. 205(8), 1747-1754 (2008).
    • (2008) J. Exp. Med. , vol.205 , Issue.8 , pp. 1747-1754
    • Spiller, S.1    Elson, G.2    Ferstl, R.3
  • 7
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: The sentinels of the immune system
    • Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10(7), 479-490.
    • Nat. Rev. Immunol. , vol.10 , Issue.7 , pp. 479-490
    • Cua, D.J.1    Tato, C.M.2
  • 8
    • 77955274188 scopus 로고    scopus 로고
    • IFN-genhances killing of methicillin-resistant Staphylococcus aureus by human monocytes more effectively that GM-CSF in the presence of daptomycin and other antibiotics
    • Smith RP, Baltch AL, Ritz WJ, Michelsen PB, Bopp LH. IFN-genhances killing of methicillin-resistant Staphylococcus aureus by human monocytes more effectively that GM-CSF in the presence of daptomycin and other antibiotics. Cytokine 51(3), 274-277 (2010).
    • (2010) Cytokine , vol.51 , Issue.3 , pp. 274-277
    • Smith, R.P.1    Baltch, A.L.2    Ritz, W.J.3    Michelsen, P.B.4    Bopp, L.H.5
  • 9
    • 49649092660 scopus 로고    scopus 로고
    • IL-10 helps control pathogen load during high-level bacteremia
    • Lordoo D, Marques A, Hornung RL, Cadavid D. IL-10 helps control pathogen load during high-level bacteremia. J. Immunol. 181(3), 2076-2083 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.3 , pp. 2076-2083
    • Lordoo, D.1    Marques, A.2    Hornung, R.L.3    Cadavid, D.4
  • 12
    • 77957121402 scopus 로고    scopus 로고
    • Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: An observational study
    • Porfyridis I, Plachouras D, Karagianni V et al. Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study. BMC Infect. Dis. 10, 286 (2010).
    • (2010) BMC Infect. Dis. , vol.10 , pp. 286
    • Porfyridis, I.1    Plachouras, D.2    Karagianni, V.3
  • 13
    • 64049095240 scopus 로고    scopus 로고
    • TREM and TREM-like receptors in inflammation and disease
    • Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 21(1), 38-46 (2009).
    • (2009) Curr. Opin. Immunol. , vol.21 , Issue.1 , pp. 38-46
    • Ford, J.W.1    McVicar, D.W.2
  • 15
    • 70349459734 scopus 로고    scopus 로고
    • RIG-I dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-I dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10(10), 1065-1073 (2009).
    • (2009) Nat. Immunol. , vol.10 , Issue.10 , pp. 1065-1073
    • Ablasser, A.1    Bauernfeind, F.2    Hartmann, G.3    Latz, E.4    Fitzgerald, K.A.5    Hornung, V.6
  • 16
    • 80051880722 scopus 로고    scopus 로고
    • Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
    • Sharma S, De Oliveira RB, Kalantari P et al. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity 35(2), 194-207 (2011).
    • (2011) Immunity , vol.35 , Issue.2 , pp. 194-207
    • Sharma, S.1    De Oliveira, R.B.2    Kalantari, P.3
  • 17
    • 80052966551 scopus 로고    scopus 로고
    • Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    • Kinjo Y, Illarionov P, Vela JL et al. Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat. Immunol. 12(10), 966-975 (2011).
    • (2011) Nat. Immunol. , vol.12 , Issue.10 , pp. 966-975
    • Kinjo, Y.1    Illarionov, P.2    Vela, J.L.3
  • 18
    • 78650224861 scopus 로고    scopus 로고
    • What is the pathophysiology of the septic host upon admission?
    • Giamarellos-Bourboulis EJ. What is the pathophysiology of the septic host upon admission? Int. J. Antimicrob. Agents 36(Suppl. 2), S2-S5 (2010).
    • (2010) Int. J. Antimicrob. Agents , vol.36 , Issue.SUPPL. 2
    • Giamarellos-Bourboulis, E.J.1
  • 19
    • 33747089041 scopus 로고    scopus 로고
    • Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
    • Uhlig HH, McKenzie BS, Hue S et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25(2), 309-318 (2006).
    • (2006) Immunity , vol.25 , Issue.2 , pp. 309-318
    • Uhlig, H.H.1    McKenzie, B.S.2    Hue, S.3
  • 20
    • 43349085604 scopus 로고    scopus 로고
    • The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression
    • O'Dwyer MJ, Mankan AK, White M et al. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. Intensive Care Med. 34(4), 683-691 (2008).
    • (2008) Intensive Care Med. , vol.34 , Issue.4 , pp. 683-691
    • O'Dwyer, M.J.1    Mankan, A.K.2    White, M.3
  • 21
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of Treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur. J. Immunol. 40(7), 1830-1835 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , Issue.7 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 22
    • 0037090339 scopus 로고    scopus 로고
    • Clinical trials of immunomodulatory therapies in severe sepsis and septic shock
    • Vincent JL, Sun Q, Dubois MJ. Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin. Infect. Dis. 34, 1084-1093 (2003).
    • (2003) Clin. Infect. Dis. , vol.34 , pp. 1084-1093
    • Vincent, J.L.1    Sun, Q.2    Dubois, M.J.3
  • 23
    • 46149105672 scopus 로고    scopus 로고
    • The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome
    • DOI 10.1016/j.ajem.2007.10.031, PII S0735675707007097
    • Wang H, Ma S. The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome. Am. J. Emerg. Med. 26(6), 711-715 (2008). (Pubitemid 351905818)
    • (2008) American Journal of Emergency Medicine , vol.26 , Issue.6 , pp. 711-715
    • Wang, H.1    Ma, S.2
  • 24
    • 34249318067 scopus 로고    scopus 로고
    • Cytokine profiles as markers of disease severity in sepsis: A multiplex analysis
    • Bozza FA, Salluh JI, Japiassu AM et al. Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit. Care 11(2), R49 (2007).
    • (2007) Crit. Care , vol.11 , Issue.2
    • Bozza, F.A.1    Salluh, J.I.2    Japiassu, A.M.3
  • 25
    • 39449128087 scopus 로고    scopus 로고
    • Lactate, procalcitonin, and amino-terminal pro-B-type natriuretic peptide versus cytokine measurements and clinical severity scores for prognostication in septic shock
    • DOI 10.1097/SHK.0b013e318150716b, PII 0002438220080300000004
    • Phua J, Koay ES, Lee KH. Lactate, procalcitonin, and amino-terminal pro-B-type natriuretic peptide versus cytokine measurements and clinical severity scores for prognostication in septic shock. Shock 29(3), 328-333 (2008). (Pubitemid 351271703)
    • (2008) Shock , vol.29 , Issue.3 , pp. 328-333
    • Phua, J.1    Koay, E.S.C.2    Lee, K.H.3
  • 27
    • 70349653291 scopus 로고    scopus 로고
    • Monocytic HLA-DR expression in intensive care patients: Interest for prognosis and secondary infection prediction
    • Lukaszewicz AC, Grienay M, Resche-Rigon M et al. Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction. Crit. Care Med. 37(10), 2746-2752 (2009).
    • (2009) Crit. Care Med. , vol.37 , Issue.10 , pp. 2746-2752
    • Lukaszewicz, A.C.1    Grienay, M.2    Resche-Rigon, M.3
  • 28
    • 57349140752 scopus 로고    scopus 로고
    • Downregulation of CD40 ligand response in monocytes form sepsis patients
    • Sinistro A, Almerighi C, Ciaprini C et al. Downregulation of CD40 ligand response in monocytes form sepsis patients. Clin. Vacc. Immunol. 15(12), 1851-1858 (2008).
    • (2008) Clin. Vacc. Immunol. , vol.15 , Issue.12 , pp. 1851-1858
    • Sinistro, A.1    Almerighi, C.2    Ciaprini, C.3
  • 29
    • 78651468128 scopus 로고    scopus 로고
    • Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia
    • Giamarellos-Bourboulis EJ, van de Veerdonk FL, Mouktaroudi M et al. Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia. Crit. Care 15(1), R27 (2011).
    • (2011) Crit. Care , vol.15 , Issue.1
    • Giamarellos-Bourboulis, E.J.1    Van De Veerdonk, F.L.2    Mouktaroudi, M.3
  • 30
    • 33751250175 scopus 로고    scopus 로고
    • The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression
    • DOI 10.1097/01.shk.0000235091.38174.8d, PII 0002438220061200000003
    • O'Dwyer MJ, Mankan AK, Stordeur P et al. The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression. Shock 26(6), 544-550 (2006). (Pubitemid 44789626)
    • (2006) Shock , vol.26 , Issue.6 , pp. 544-550
    • O'Dwyer, M.J.1    Mankan, A.K.2    Stordeur, P.3    O'Connell, B.4    Duggan, E.5    White, M.6    Kelleher, D.P.7    McManus, R.8    Ryan, T.9
  • 31
    • 84861198367 scopus 로고    scopus 로고
    • Early serum levels of soluble triggering receptor expressed on myeloid cells-1 in septic patients: Correlation with monocyte gene expression
    • doi:10.1016/j. jcrc.2011.06.013 Epub ahead of print
    • Dimopoulou I, Pelekanou A, Mavrou I et al. Early serum levels of soluble triggering receptor expressed on myeloid cells-1 in septic patients: Correlation with monocyte gene expression. J. Crit. Care doi:10.1016/j. jcrc.2011.06.013 (2011) (Epub ahead of print).
    • (2011) J. Crit. Care
    • Dimopoulou, I.1    Pelekanou, A.2    Mavrou, I.3
  • 32
    • 77950208700 scopus 로고    scopus 로고
    • Characterization and modulation of the immunosuppressive phase of sepsis
    • Muenzer JT, Davis CG, Chang K et al. Characterization and modulation of the immunosuppressive phase of sepsis. Infect. Immun. 78(4), 1582-1592 (2010).
    • (2010) Infect. Immun. , vol.78 , Issue.4 , pp. 1582-1592
    • Muenzer, J.T.1    Davis, C.G.2    Chang, K.3
  • 33
    • 0033969341 scopus 로고    scopus 로고
    • Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
    • DOI 10.1086/315214
    • Gogos CA, Drosou E, Bassaris HP, Skoutelis A. Pro-versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J. Infect. Dis. 181(1), 176-180 (2000). (Pubitemid 30049046)
    • (2000) Journal of Infectious Diseases , vol.181 , Issue.1 , pp. 176-180
    • Gogos, C.A.1    Drosou, E.2    Bassaris, H.P.3    Skoutelis, A.4
  • 37
    • 62949142070 scopus 로고    scopus 로고
    • Increased circulating regulatory T cells (CD4+CD25+CD127-) contribute to lymphocyte anergy in septic shock patients
    • Venet F, Chung CS, Kherouf H et al. Increased circulating regulatory T cells (CD4+CD25+CD127-) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med. 35(4), 678-686 (2009).
    • (2009) Intensive Care Med. , vol.35 , Issue.4 , pp. 678-686
    • Venet, F.1    Chung, C.S.2    Kherouf, H.3
  • 38
    • 0035338993 scopus 로고    scopus 로고
    • Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
    • Hotchkiss RS, Tinsley K W, Swanson PE et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J. Immunol. 166(11), 6952-6953 (2001).
    • (2001) J. Immunol. , vol.166 , Issue.11 , pp. 6952-6953
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3
  • 43
    • 80051572876 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor g-induced T cell apoptosis reduces survival during polymicrobial sepsis
    • Schmidt MV, Paulus P, Kuhn AM et al. Peroxisome proliferator-activated receptor g-induced T cell apoptosis reduces survival during polymicrobial sepsis. Am. J. Resp. Crit. Care Med. 184(1), 64-74 (2011).
    • (2011) Am. J. Resp. Crit. Care Med. , vol.184 , Issue.1 , pp. 64-74
    • Schmidt, M.V.1    Paulus, P.2    Kuhn, A.M.3
  • 44
    • 79952236016 scopus 로고    scopus 로고
    • An early circulating factor in severe sepsis modulates apoptosis of monocytes and lymphocytes
    • Vaki I, Kranidioti H, Karagianni V et al. An early circulating factor in severe sepsis modulates apoptosis of monocytes and lymphocytes. J. Leukoc Biol. 89(3), 343-349 (2011).
    • (2011) J. Leukoc Biol. , vol.89 , Issue.3 , pp. 343-349
    • Vaki, I.1    Kranidioti, H.2    Karagianni, V.3
  • 45
    • 49449091882 scopus 로고    scopus 로고
    • Splenic nerve is required for cholinergic anti-inflammatory pathway control of TNF in endotoxemia
    • Rosas-Ballina M, Ochani M, Parrish WR et al. Splenic nerve is required for cholinergic anti-inflammatory pathway control of TNF in endotoxemia. Proc. Natl Acad. Sci. USA 105(31), 11008-11013 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.31 , pp. 11008-11013
    • Rosas-Ballina, M.1    Ochani, M.2    Parrish, W.R.3
  • 46
    • 73949141883 scopus 로고    scopus 로고
    • Requisite role of the cholinergic a7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury
    • Su X, Matthay MA, Malik AB. Requisite role of the cholinergic a7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J. Immunol. 184(1), 401-410 (2009).
    • (2009) J. Immunol. , vol.184 , Issue.1 , pp. 401-410
    • Su, X.1    Matthay, M.A.2    Malik, A.B.3
  • 47
    • 44449143573 scopus 로고    scopus 로고
    • NK but not CD1-restricted NKT cells facilitate systemic inflammation during polymicrobial intra-abdominal sepsis
    • Etogo AO, Nunez J, Lin CY, Toliver-Kinsky TE, Sherwood ER. NK but not CD1-restricted NKT cells facilitate systemic inflammation during polymicrobial intra-abdominal sepsis. J. Immunol. 180(9), 6334-6345 (2008).
    • (2008) J. Immunol. , vol.180 , Issue.9 , pp. 6334-6345
    • Etogo, A.O.1    Nunez, J.2    Lin, C.Y.3    Toliver-Kinsky, T.E.4    Sherwood, E.R.5
  • 48
    • 61449132374 scopus 로고    scopus 로고
    • The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock
    • Hu CK, Venet F, Heffernan DS, Wang YL et al. The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock. J. Immunol. 182(4), 2467-2475 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.4 , pp. 2467-2475
    • Hu, C.K.1    Venet, F.2    Heffernan, D.S.3    Wang, Y.L.4
  • 49
    • 61449116805 scopus 로고    scopus 로고
    • Bacterial endotoxin induces the release of high mobility group box a via the IFN-b signaling pathway
    • Kim JH, Kim SJ, Lee IM et al. Bacterial endotoxin induces the release of high mobility group box a via the IFN-b signaling pathway. J. Immunol. 182(4), 2458-2466 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.4 , pp. 2458-2466
    • Kim, J.H.1    Kim, S.J.2    Lee, I.M.3
  • 52
    • 52949118458 scopus 로고    scopus 로고
    • Harmful molecular mechanisms in sepsis
    • Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat. Immunol. 8(10), 776-786 (2008).
    • (2008) Nat. Immunol. , vol.8 , Issue.10 , pp. 776-786
    • Rittirsch, D.1    Flierl, M.A.2    Ward, P.A.3
  • 53
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammation response to injury
    • Zhang Q, Raoof M, Chen Y et al. Circulating mitochondrial DAMPs cause inflammation response to injury. Nature 464(7285), 104-108 (2010).
    • (2010) Nature , vol.464 , Issue.7285 , pp. 104-108
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3
  • 54
    • 77951646419 scopus 로고    scopus 로고
    • Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: Results from an observational study
    • Pelekanou A, Tsangaris I, Kotsaki A et al. Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: results from an observational study. Crit. Care 13(6), R172 (2009).
    • (2009) Crit. Care , vol.13 , Issue.6
    • Pelekanou, A.1    Tsangaris, I.2    Kotsaki, A.3
  • 55
    • 77952630881 scopus 로고    scopus 로고
    • Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
    • Gogos C, Kotsaki A, Pelekanou A et al. Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection. Crit. Care 14(3), R96 (2010).
    • (2010) Crit. Care , vol.14 , Issue.3
    • Gogos, C.1    Kotsaki, A.2    Pelekanou, A.3
  • 57
    • 78049433417 scopus 로고    scopus 로고
    • Interleukin-7 (IL-7) treatment accelerates neutrophils recruitment through gd T-cell IL-17 production in a murine model of sepsis
    • Kasten KR, Prakash PS, Unsinger J et al. Interleukin-7 (IL-7) treatment accelerates neutrophils recruitment through gd T-cell IL-17 production in a murine model of sepsis. Infect. Immun. 78(11), 4714-4722 (2010).
    • (2010) Infect. Immun. , vol.78 , Issue.11 , pp. 4714-4722
    • Kasten, K.R.1    Prakash, P.S.2    Unsinger, J.3
  • 58
    • 44649084235 scopus 로고    scopus 로고
    • Diversity of interferon γ and granulocyte-macrophage colony-stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis
    • DOI 10.2119/2007-00120.Flohe
    • Flohé SB, Agrawal H, Flohé S, Rani M, Bangen JM, Schade FU. Diversity of interferon gand granulocyte-macrophage-colony stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis. Mol. Med. 14(5-6), 247-256 (2008). (Pubitemid 351785697)
    • (2008) Molecular Medicine , vol.14 , Issue.5-6 , pp. 247-256
    • Flohe, S.B.1    Agrawal, H.2    Flohe, S.3    Rani, M.4    Bangen, J.M.5    Schade, F.U.6
  • 59
    • 79751531129 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: A meta-analysis
    • Bo L, Wang F, Zhu J, Li J, Deng X. Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis. Crit. Care 15(1), R58 (2011).
    • (2011) Crit. Care , vol.15 , Issue.1
    • Bo, L.1    Wang, F.2    Zhu, J.3    Li, J.4    Deng, X.5
  • 60
    • 38549139528 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock
    • DOI 10.1097/01.CCM.0B013E318161E480, PII 0000324620080200000012
    • Stephens DP, Thomas JH, Dip G et al. Randomized, double-blind, placebo-controlled trials of ganulocyte colony stimulating factor in patients with septic shock. Crit. Care Med. 36(2), 448-454 (2008). (Pubitemid 351158618)
    • (2008) Critical Care Medicine , vol.36 , Issue.2 , pp. 448-454
    • Stephens, D.P.1    Thomas, J.H.2    Higgins, A.3    Bailey, M.4    Anstey, N.M.5    Currie, B.J.6    Cheng, A.C.7
  • 62
    • 21844453227 scopus 로고    scopus 로고
    • Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in non-neutropenic patients
    • Rosenbloom AJ, Linden PK, Dorrance A, Penkosky N, Cohen-Melamed MH, Rinsky MR. Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in non-neutropenic patients. Chest 127(6), 2139-2150 (2005).
    • (2005) Chest , vol.127 , Issue.6 , pp. 2139-2150
    • Rosenbloom, A.J.1    Linden, P.K.2    Dorrance, A.3    Penkosky, N.4    Cohen-Melamed, M.H.5    Rinsky, M.R.6
  • 63
    • 76649104745 scopus 로고    scopus 로고
    • Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock
    • Schefold JC, Zeden JP, Pschowski R et al. Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. Scand. J. Infect. Dis. 42(3), 164-171 (2010).
    • (2010) Scand. J. Infect. Dis. , vol.42 , Issue.3 , pp. 164-171
    • Schefold, J.C.1    Zeden, J.P.2    Pschowski, R.3
  • 64
    • 79953819133 scopus 로고    scopus 로고
    • Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome
    • Hall MW, Knatz NL, Vetterly C et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med. 37(3), 525-532 (2011).
    • (2011) Intensive Care Med. , vol.37 , Issue.3 , pp. 525-532
    • Hall, M.W.1    Knatz, N.L.2    Vetterly, C.3
  • 66
    • 34249296716 scopus 로고    scopus 로고
    • Effectiveness of polymyxin B-immobilized fiber column in sepsis: A systematic review
    • Cruz DN, Perazella MA, Bellomo R et al. Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit. Care 11(2), R47 (2007).
    • (2007) Crit. Care , vol.11 , Issue.2
    • Cruz, D.N.1    Perazella, M.A.2    Bellomo, R.3
  • 67
    • 59449106666 scopus 로고    scopus 로고
    • Direct hemoperfusion with polymyxin-B-immobilized fiber columns improves septic hypotension and reduces inflammatory mediators in septic patients with colorectal perforation
    • Shimizu T, Hanasawa K, Sato K et al. Direct hemoperfusion with polymyxin-B-immobilized fiber columns improves septic hypotension and reduces inflammatory mediators in septic patients with colorectal perforation. Langenbecks Arch. Surg. 394(2), 303-311 (2009).
    • (2009) Langenbecks Arch. Surg. , vol.394 , Issue.2 , pp. 303-311
    • Shimizu, T.1    Hanasawa, K.2    Sato, K.3
  • 68
    • 31744448362 scopus 로고    scopus 로고
    • Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation
    • Kushi H, Miki T, Okamaoto K, Nakahara J, Saito T, Tanjoh K. Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation. Crit. Care 9(6), R653-R661 (2005).
    • (2005) Crit. Care , vol.9 , Issue.6
    • Kushi, H.1    Miki, T.2    Okamaoto, K.3    Nakahara, J.4    Saito, T.5    Tanjoh, K.6
  • 69
    • 3142658013 scopus 로고    scopus 로고
    • Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber
    • DOI 10.1016/j.amjsurg.2003.12.067, PII S0002961004001369
    • Ono S, Tsujimoto H, Matsumoto A, Ikuta S, Kinoshita M, Mochizuki H. Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber. Am. J. Surg. 188(2), 150-156 (2004). (Pubitemid 38916733)
    • (2004) American Journal of Surgery , vol.188 , Issue.2 , pp. 150-156
    • Ono, S.1    Tsujimoto, H.2    Matsumoto, A.3    Ikuta, S.-I.4    Kinoshita, M.5    Mochizuki, H.6
  • 71
    • 67649219652 scopus 로고    scopus 로고
    • Early use of polymyxin B hemoperfusion in abdominal septic shock: The EUPHAS randomized controlled trial
    • Cruz DN, Antonelli M, Fumagalli R et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 301(23), 2445-2452 (2009).
    • (2009) JAMA , vol.301 , Issue.23 , pp. 2445-2452
    • Cruz, D.N.1    Antonelli, M.2    Fumagalli, R.3
  • 72
    • 70350217935 scopus 로고    scopus 로고
    • A longer duration of polymyxin B-immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock
    • Mitaka C, Tsuchida N, Kawada K, Nakajima Y, Imai T, Sasaki S. A longer duration of polymyxin B-immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock. Shock 32(5), 478-483 (2009).
    • (2009) Shock , vol.32 , Issue.5 , pp. 478-483
    • Mitaka, C.1    Tsuchida, N.2    Kawada, K.3    Nakajima, Y.4    Imai, T.5    Sasaki, S.6
  • 74
    • 74049125175 scopus 로고    scopus 로고
    • Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis
    • Tidswell M, Tillis W, LaRosa SP et al. Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis. Crit. Care Med. 38(1), 72-83 (2010).
    • (2010) Crit. Care Med. , vol.38 , Issue.1 , pp. 72-83
    • Tidswell, M.1    Tillis, W.2    Larosa, S.P.3
  • 75
    • 80052968260 scopus 로고    scopus 로고
    • Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis
    • Kalil AC, Larosa SP, Gogate J, Lynn M, Opal SM. Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis. Shock 36(4), 327-331 (2011).
    • (2011) Shock , vol.36 , Issue.4 , pp. 327-331
    • Kalil, A.C.1    Larosa, S.P.2    Gogate, J.3    Lynn, M.4    Opal, S.M.5
  • 76
    • 36849073243 scopus 로고    scopus 로고
    • Macrolides beyond the conventional antimicrobials: A class of potent immunomodulators
    • DOI 10.1016/j.ijantimicag.2007.08.001, PII S0924857907003822
    • Giamarellos-Bourboulis EJ. Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. Int. J. Antimicrob. Agents 31(1), 12-20 (2008). (Pubitemid 350236720)
    • (2008) International Journal of Antimicrobial Agents , vol.31 , Issue.1 , pp. 12-20
    • Giamarellos-Bourboulis, E.J.1
  • 78
    • 0037442372 scopus 로고    scopus 로고
    • Addition of a macrolide to a β-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia
    • DOI 10.1086/367541
    • Martínez, JA, Horcajada JP, Almela M et al. Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia. Clin. Infect. Dis. 36, 389-395 (2003). (Pubitemid 36241302)
    • (2003) Clinical Infectious Diseases , vol.36 , Issue.4 , pp. 389-395
    • Martinez, J.A.1    Horcajada, J.P.2    Almela, M.3    Marco, F.4    Soriano, A.5    Garcia, E.6    Marco, M.A.7    Torres, A.8    Mensa, J.9
  • 83
    • 79957635355 scopus 로고    scopus 로고
    • Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acure respiratory distress syndrome
    • O' Neal HR Jr, Koyama T, Koehler EAS et al. Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acure respiratory distress syndrome. Crti. Care Med. 39(6), 1343-1350 (2011).
    • (2011) Crti. Care Med. , vol.39 , Issue.6 , pp. 1343-1350
    • O'Neal, Jr.H.R.1    Koyama, T.2    Koehler, E.A.S.3
  • 84
    • 67649364708 scopus 로고    scopus 로고
    • The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: A randomized double-blind placebo controlled clinical trial
    • Novack V, Eisinger M, Frenkel A et al. The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Intensive Care Med. 35(7), 1255-1260 (2009).
    • (2009) Intensive Care Med. , vol.35 , Issue.7 , pp. 1255-1260
    • Novack, V.1    Eisinger, M.2    Frenkel, A.3
  • 85
    • 34247632571 scopus 로고    scopus 로고
    • The apoptotic pathway as a therapeutic target in sepsis
    • DOI 10.2174/138945007780362764
    • Wesche-Soldato DE, Swan RZ, Chung CS, Ayala A. The apoptotic pathway as a therapeutic target in sepsis. Curr. Drug Targets 8(4), 493-500 (2007). (Pubitemid 46672616)
    • (2007) Current Drug Targets , vol.8 , Issue.4 , pp. 493-500
    • Wesche-Soldato, D.E.1    Swan, R.Z.2    Chung, C.-S.3    Ayala, A.4
  • 86
    • 74449089862 scopus 로고    scopus 로고
    • Targeting HMGB1 in inflammation
    • Yang H, Tracey KJ. Targeting HMGB1 in inflammation. Biochim. Biophys. Acta 1799(1-2), 149-156 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1799 , Issue.1-2 , pp. 149-156
    • Yang, H.1    Tracey, K.J.2
  • 87
    • 37549020378 scopus 로고    scopus 로고
    • Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger RP, Levy MM, Carlet JM et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit. Care Med. 36(1), 296-327 (2008).
    • (2008) Crit. Care Med. , vol.36 , Issue.1 , pp. 296-327
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3
  • 88
    • 84858252492 scopus 로고    scopus 로고
    • Hellenic Sepsis Study Group
    • Hellenic Sepsis Study Group. www.sepsis.gr


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.