Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia

Critical Care

Volumn 15, Issue 1, 2011, Pages

  Giamarellos Bourboulis, Evangelos J ^a,b   van de Veerdonk, Frank L ^b   Mouktaroudi, Maria ^a,b   Raftogiannis, Maria ^a   Antonopoulou, Anastasia ^a   Joosten, Leo A B ^b   Pickkers, Peter ^b   Savva, Athina ^a   Georgitsi, Marianna ^a   van der Meer, Jos W M ^b   Netea, Mihai G ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; URATE;

ADULT; AGED; ARTICLE; CANDIDA ALBICANS; CELL ISOLATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE SEPSIS; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASEOLUS VULGARIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PSEUDOMONAS AERUGINOSA; DRUG ANTAGONISM; ENZYMOLOGY; GRAM NEGATIVE BACTERIUM; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MONOCYTE; PROSPECTIVE STUDY; SEPSIS;

ADULT; AGED; AGED, 80 AND OVER; CASPASE 1; DOWN-REGULATION; ENDOTOXEMIA; FEMALE; GRAM-NEGATIVE BACTERIA; HUMANS; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; MONOCYTES; PROSPECTIVE STUDIES; SEPSIS;

EID: 78651468128     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9974     Document Type: Article

References (26)

1. Remick DG. Pathophysiology of sepsis. Am J Pathol 2007, 170:1435-1444. 10.2353/ajpath.2007.060872, 1854939, 17456750.
2. Vincent JL, Sun Q, Dubois MJ. Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin Infect Dis 2002, 34:1084-1093. 10.1086/339549, 11914997, 11914997.
3. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol 2008, 8:776-787. 10.1038/nri2402, 18802444, 18802444.
4. Frazier WJ, Hall MW. Immunoparalysis and adverse outcomes from critical illness. Pediatr Clin North Am 2008, 55:647-668. 10.1016/j.pcl.2008.02.009, 18501759, 18501759.
5. Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B, et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis 1990, 161:79-84.
6. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996, 87:2095-2147.
7. Pétrilli V, Dostert C, Muruve DA, Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 2007, 19:615-655.
8. Drenth JPH, van der Meer JWM. The inflammasome-a linebacker of innate defense. N Engl J Med 2006, 355:730-732. 10.1056/NEJMcibr063500, 16914711.
9. Levy M, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003, 31:1250-1256. 10.1097/01.CCM.0000050454.01978.3B, 12682500.
10. Pinson AG, Philbrick JT, Lindbeck GH, Schorling JB. Fever in the clinical diagnosis of acute pyelonephritis. Am J Emerg Med 1997, 15:148-151. 10.1016/S0735-6757(97)90087-5, 9115515.
11. Calandra T, Cohen J, . International Sepsis Forum Definition of Infection in the ICU Consensus Conference The International Sepsis Forum Consensus definitions of infections in the intensive care unit. Crit Care Med 2005, 33:1538-1548. 10.1097/01.CCM.0000168253.91200.83, 16003060, 16003060, International Sepsis Forum Definition of Infection in the ICU Consensus Conference.
12. Draisma A, Bemelmans R, van der Hoeven JG, Spronk P, Pickkers P. Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans. Shock 2009, 31:581-585. 10.1097/SHK.0b013e318193e187, 19008780.
13. Giamarellos-Bourboulis EJ, Adamis T, Laoutaris G, Sabracos L, Koussoulas V, Mouktaroudi M, Perrea D, Karayannacos PE, Giamarellou H. Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother 2004, 48:93-99. 10.1128/AAC.48.1.93-99.2004, 310186, 14693524.
14. Witte W, Strommenger B, Cuny C, Heuck D, Nuebel U. Methicillin-resistant Staphylococcus aureus containing the Panton-Valentine leucocidin gene in Germany in 2005 and 2006. J Antimicrob Chemother 2007, 60:1258-1263. 10.1093/jac/dkm384, 17934203.
15. Giamarellos-Bourboulis EJ, Mouktaroudi M, Bodar E, van der Ven J, Kullberg BJ, Netea MG, van der Meer JW. Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin-1β through a caspase-1 mediated process. Ann Rheum Dis 2009, 68:273-278. 10.1136/ard.2007.082222, 18390571.
16. Schultz MJ, Olszyna DP, de Jonge E, Verbon A, van Deventer SJH, van der Poll T. Reduced ex vivo chemokine production by polymorphonuclear cells after in vitro exposure of normal humans to endotoxin. J Infect Dis 2000, 182:1264-1267. 10.1086/315840, 10979931.
17. van Deuren M, Netea MG, Hijmans A, Demacker PN, Neeleman C, Sauerwein RW, Bartelink AK, van der Meer JW. Posttranscriptional down-regulation of tumor necrosis factor-alpha and interleukin-1beta production in acute meningococcal infections. J Infect Dis 1998, 177:1401-1405. 10.1086/517824, 9593034.
18. Keuter M, Dharmana E, Gasem MH, van der Ven-Jongekrijg J, Djokomoeljanto R, Dolmans WM, Demacker P, Sauerwein R, Gallati H, van der Meer JW. Patterns of proinflammatory cytokines and inhibitors during typhoid fever. J Infect Dis 1994, 169:1306-1311.
19. Ertel W, Kremer JP, Kenney J, Steckholzer U, Jarrar D, Trentz O, Schildberg FW. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 1995, 85:1341-1347. 7858264, 7858264.
20. Monneret G, Debard AL, Venet F, Bohe J, Hequet O, Bienvenu J, Lepape A. Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 2003, 31:2068-2071. 10.1097/01.CCM.0000069345.78884.0F, 12847405.
21. Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol 2005, 174:5110-5118.
22. Unsinger J, Herdon JM, Davis CG, Muenzer JT, Hotchkiss RS, Ferguson TA. The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. J Immunol 2006, 177:7968-7673.
23. Fahy RJ, Exline MC, Gavrilin MA, Bhatt NY, Besecker BY, Sarkar A, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall M, Wewers MD. Inflammasome mRNA expression in human monocytes during early septic shock. Am J Resp Crit Care Med 2008, 177:983-988. 10.1164/rccm.200703-418OC, 2361424, 18263805.
24. Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH, van de Veerdonk FL, Ferwerda G, Heinhuis B, Devesa I, Funk CJ, Mason RJ, Kullberg BJ, Rubartelli A, van der Meer JW, Dinarello CA. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 2009, 113:2324-2335. 10.1182/blood-2008-03-146720, 2652374, 19104081.
25. Li P, Allen H, Banerjee S, Seshadri T. Characterization of mice deficient in interleukin-1 beta converting enzyme. J Cell Biochem 1997, 64:27-32. 10.1002/(SICI)1097-4644(199701)64:1<27::AID-JCB53.0.CO;2-1, 9015751.
26. Sarkar A, Hall MW, Exline M, Hart J, Knatz N, Gatson NT, Wewers MD. Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med 2006, 174:1003-1010. 10.1164/rccm.200604-546OC, 2648100, 16908867.