What is the pathophysiology of the septic host upon admission?

International Journal of Antimicrobial Agents

Volumn 36, Issue SUPPL. 2, 2010, Pages S2-

  Giamarellos Bourboulis, Evangelos J ^a  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cytokines; Immunity; Immunoparalysis; Infection; Pathogenesis; Sepsis

Indexed keywords

HLA DR ANTIGEN; IMMUNOMODULATING AGENT;

ADAPTIVE IMMUNITY; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; COMPENSATORY ANTIINFLAMMATORY RESPONSE SYNDROME; CYTOKINE STORM; DISEASE COURSE; FATALITY; HUMAN; IMMUNOMODULATION; IMMUNOPATHOLOGY; INNATE IMMUNITY; LYMPHOCYTOPENIA; MONOCYTE; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SEPSIS; SEPTIC SHOCK; TH1 CELL; TH17 CELL; TH2 CELL;

EID: 78650224861     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.11.003     Document Type: Article

References (22)

1. B.D. Winters, M. Eberlein, J. Leung, D.M. Needham, P.J. Pronovost, and J.E. Sevransky Long-term mortality and quality of life in sepsis: a systematic review Crit Care Med 38 2010 1276 1283
2. Hellenic Sepsis Study Group. Hellenic Society of Chemotherapy. http://www.sepsis.gr/index-en.html [accessed June 25; 2010].
3. C.E. Sandrock, and T.E. Albertson Controversies in the treatment of sepsis Semin Respir Crit Care Med 31 2010 66 78
4. J.L. Vincent, Q. Sun, and M.J. Dubois Clinical trials of immunomodulatory therapies in severe sepsis and septic shock Clin Infect Dis 34 2003 1084 1093
5. D. Rittisch, M.A. Flierl, and P.A. Ward Harmful molecular mechanisms in sepsis Nat Immunol 8 2008 776 786
6. H. Tsujimoto, S. Ono, P.A. Efron, P.O. Scumpia, L.L. Moldawer, and H. Mochizuki Role of Toll-like receptors in the development of sepsis Shock 29 2008 315 321
7. H. Weighart, and B. Holzmann Role of Toll-like receptor response for sepsis pathogenesis Immunobiology 212 2008 715 722
8. H. Wang, and S. Ma The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome Am J Emerg Med 26 2008 711 715
9. J.P.H. Drenth, and J.W.M. van Der Meer The inflammasome - a linebacker of innate defense N Engl J Med 355 2006 730 732
10. F. Martinon, A. Mayor, and J. Tschopp The inflammasomes: guardians of the body Ann Rev Immunol 27 2009 229 265
11. Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal, and W. Junger Circulating mitochondrial DAMPs cause inflammation response to injury Nature 464 2010 104 108
12. M.E. Bianchi, and A.A. Manfredi High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity Immunol Rev 220 2007 35 46
13. E.J. Giamarellos-Bourboulis, M. Mouktaroudi, E. Bodar, J. van der Ven, B.J. Kullberg, and M.G. Netea Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin-1β through a caspase-1 mediated process Ann Rheum Dis 68 2009 273 278
14. F. Venet, C.S. Chung, G. Monneret, X. Huang, B. Horner, and M. Garber Regulatory T cell populations in sepsis and trauma J Leukoc Biol 83 2008 523 535
15. A. Freitas, J.C. Alves-Filho, T. Victoni, T. Secher, H.P. Lemos, and F. Sônego IL-17 receptor signaling is required to control polymicrobial sepsis J Immunol 182 2009 7846 7854
16. N.S. Ward, B. Casserly, and A. Ayala The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients Clin Chest Med 29 2008 617 625
17. R.S. Hotchkiss, S.B. Osmon, K.C. Chang, T.H. Wagner, C.M. Coopersmith, and I.E. Karl Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways J Immunol 174 2005 5110 5118
18. R.C. Reddy, and T.J. Standiford Effects of sepsis on neutrophil chemotaxis Curr Opin Hematol 17 2010 18 24
19. K.R. Kasten, J.T. Muenzer, and C.C. Caldwell Neutrophils are significant producers of IL-10 during sepsis Biochem Biophys Res Commun 393 2010 28 31
20. M. Adib-Conquy, and J.M. Cavaillon Compensatory anti-inflammatory response syndrome Thromb Haemost 101 2009 36 47
21. C. Gogos, A. Kotsaki, A. Pelekanou, G. Giannikopoulos, I. Vaki, and P. Maravitsa Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection Crit Care 14 2010 R96
22. A. Pelekanou, I. Tsangaris, A. Kotsaki, V. Karagianni, H. Giamarellou, and A. Armaganidis Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: results from an observational study Crit Care 13 2009 R172