P2 receptor signalling, proliferation of astrocytes, and expression of molecules involved in cell-cell interactions

Novartis Foundation Symposium

Volumn 276, Issue , 2006, Pages 131-143

  Neary, Joseph T ^a   Kang, Yuan ^a   Shi, You Fang ^a   Tran, Minh D ^a   Wanner, Ina B ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GLYCOGEN SYNTHASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEOTIDE; PURINE P2 RECEPTOR;

ANIMAL; ASTROCYTE; CELL COMMUNICATION; CELL PROLIFERATION; ENZYME ACTIVATION; GENERAL ASPECTS OF DISEASE; METABOLISM; NERVE CELL; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ASTROCYTES; CELL COMMUNICATION; CELL PROLIFERATION; DISEASE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; GLYCOGEN SYNTHASE KINASE 3; NEURONS; NUCLEOTIDES; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 33747393722     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (62)

1. Abbracchio MP, Saffrey MJ, Hopker V, Burnstock G 1994 Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neurosci 59:67-76
2. Adams JC, Lawler J 2004 The thrombospondins. Int J Biochem Cell Biol 36:961-968
3. Ahmed SM, Rzigalinski BA, Willoughby KA, Sitterding HA, Ellis EF 2000 Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons. J Neurochem 74:1951-1960
4. 7 ATP receptor. J Biol Chem 274:33206-33208
5. Bergfeld GR, Forrester T 1992 Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardio Res 26:40-47
6. Bodin P, Milner P, Winter R, Burnstock G 1992 Chronic hypoxia changes the ratio of endothelin to ATP release from rat aortic endothelial cells exposed to high flow. Proc Biol Sci 247:131-135
7. Bolego C, Ceruti S, Brambilla R et al 1997 Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor-induced astrogliosis. Brit J Pharmacol 121:1692-1699
8. Brambilla R, Neary JT, Cattabeni F et al 2002 Induction of COX-2 by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signaling. J Neurochem 83:1285-1296
9. Brazil DP, Yang ZZ, Hemmings BA 2004 Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29:233-242
10. Budagian V, Bulanova E, Brovko L et al 2003 Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B. J Biol Chem 278:1549-1560
11. Burnstock G 1990 Overview: Purinergic mechanisms. Ann N Y Acad Sci 603:1-18
12. Burnstock G 2002 Potential therapeutic targets in the rapidly expanding field of purinergic signalling. Clin Med 2:45-53
13. Burnstock G, Williams M 2000 P2 purinergic receptors: modulation of cell function and therapeutic potential. J Pharmacol Exp Ther 295:862-869
14. Christopherson KS, Ullian EM, Stokes CC et al 2005 Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell 120:421-433
15. Cohen P 2002 Protein kinases - the major drug targets of the twenty-first century? Nat Rev Drug Discov 1:309-315
16. Dietrich WD, Alonso O, Busto R, Finklestein SP 1996 Posttreatment with intravenous basic fibroblast growth factor reduces histopathological damage following fluid-percussion brain injury in rats. J Neurotrauma 13:309-316
17. Doble BW, Woodgett JR 2003 GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116:1175-1186
18. Druker BJ, Talpaz M, Resta DJ et al 2001 Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031-1037
19. Fairless R, Frame MC, Barnett SC 2005 N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes. Mol Cell Neurosci 28:253-263
20. Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV 2004 Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 24:2143-2155
21. Ferrari D, Chiozzi P, Falzoni S et al 1997 ATP-mediated cytotoxicity in microglial cells. Neuropharmacol 36:1295-1301
22. Finklestein SP, Apostolides PJ, Caday CG, Prosser J, Philips MF, Klagsbrun M 1988 Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds. Brain Res 460:253-259
23. Floyd CL, Rzigalinski BA, Sitterding HA, Willoughby KA, Ellis EF 2004 Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes. J Neurotrauma 21: 205-216
24. Franke H, Krügel U, Illes P 1999 P2 receptor-mediated proliferative effects on astrocytes in vivo. Glia 28:190-200
25. Franke H, Krugel U, Schmidt R, Grosche J, Reichenbach A, Illes P 2001 P2 receptor-types involved in astrogliosis in vivo. Br J Pharmacol 134:1180-1189
26. Fumagalli M, Brambilla R, D'Ambrosi N et al 2003 Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors. Glia 43:218-230
27. Gendron FP, Newbold NL, Vivas-Mejia PE et al 2003 Signal transduction pathways for P2Y2 and P2X7 nucleotide receptors that mediate neuroinflammatory responses in astrocytes and microglial cells. Biomed Res 14:47-61
28. Huang N, Wang D, Heppel LA 1989 Extracellular ATP is a mitogen for 3T3, 3T6, and A431 cells and acts synergistically with other growth factors. Proc Natl Acad Sci USA 86:7904-7908
29. Jacobson KA, Costanzi S, Joshi BV et al 2006 Agonists and antagonist for P2 receptors. In: Purinergic signalling in neuron-glia interactions. Wiley, Chichester (Novartis Found Symp 276) p 58-72
30. Jacques-Silva MC, Rodnight R, Lenz G et al 2004 P2X7 receptors stimulate Akt phosphorylation in astrocytes. Br J Pharmacol 141:1107-1118
31. Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB 2003 A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: Application to sepsis-apoptosis. Mol Cell Proteomics 2:463-473
32. Jope RS, Bijur GN 2002 Mood stabilizers, glycogen synthase kinase-3beta and cell survival. Mol Psychiatry 7 Suppl 1:S35-45
33. King BF, Liu M, Townsend-Nicholson A et al 2005 Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red. Br J Pharmacol 145:313-322
34. King BF, Neary JT, Zhu Q, Wang S, Norenberg MD, Burnstock G 1996 P2 purinoceptors in rat cortical astrocytes: expression, calcium-imaging and signalling studies. Neurosci 74:1187-1196
35. Lenz G, Gottfried C, Luo Z et al 2000 P2Y purinoceptor subtypes recruit different MEK activators in astrocytes. Brit J Pharmacol 129:927-936
36. Lenz G, Goncalves D, Luo Z, Avruch J, Rodnight R, Neary JT 2001 Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK1 activation in astrocyte cultures. J Neurochem 77:1001-1009
37. Marshall CJ 1995 Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185
38. Neary JT 1996 Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors, and underlying signal transduction mechanisms. Wiley, Chichester (Ciba Found Symp 198) p 130-141
39. Neary JT, Kang Y 2004a Mechanical strain activates glycogen synthase kinase-3beta in astrocytes. J Neurotrauma 21:1283
40. Neary JT, Kang Y 2004b P2 nucleotide receptors are coupled to glycogen synthase kinase-3beta in astrocytes. Soc Neurosci Abstr Program No. 631.7 http://chroma.med.miami.edu/neuro/events_nd2005_presenters.php
41. Neary JT, Norenberg MD 1992 Signalling by extracellular ATP: Physiological and pathological considerations in neuronal-astrocytic interactions. Prog Brain Res 94:145-151
42. Neary JT, Zhu Q 1994 Signaling by ATP receptors in astrocytes. NeuroReport 5:1617-1620
43. Neary JT, Baker L, Jorgensen SL, Norenberg MD 1994a Extracellular ATP induces stellation and increases GFAP content and DNA synthesis in primary astrocyte cultures. Acta Neuropathol 87:8-13
44. Neary JT, Whittemore SR, Zhu Q, Norenberg MD 1994b Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factor and extracellular ATP. J Neurochem 63:490-494
45. Neary JT, McCarthy M, Kang Y, Zuniga S 1998 Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocytes. Neurosci Letters 242:159-162
46. Neary JT, Kang Y, Bu Y, Yu E, Akong K, Peters CM 1999 Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C, calcium pathway. J Neurosci 19:4211-4220
47. Neary JT, Kang Y, Willoughby KA, Ellis EF 2003 Activation of ERK by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J Neurosci 23:2348-2356
48. Neary JT, Kang Y, Shi Y-F 2005a Cell cycle regulation of astrocytes by extracellular nucleotides and fibroblast growth factor-2. Purinergic Signalling Vol 1, p 329-336
49. Neary JT, Kang Y, Tran M, Feld J 2005b Traumatic injury activates protein kinase B/Akt in cultured astrocytes: Role of extracellular ATP and P2 purinergic receptors. J Neurotrauma 22:491-500
50. Noble ME, Endicott JA, Johnson LN 2004 Protein kinase inhibitors: insights into drug design from structure. Science 303:1800-1805
51. Norenberg MD 1994 Astrocyte responses to CNS injury. J Neuropath Exp Neurol 53: 213-220
52. Panenka W, Jijon H, Herx LM et al 2001 P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J Neurosci 21:7135-7142
53. Rathbone MP, Middlemiss PJ, Kim J-L et al 1992 Adenosine and its nucleotides stimulate proliferation of chick astrocytes and human astrocytoma cells. Neurosci Res 13:1-17
54. Ridet JL, Malhotra SK, Privat A, Gage FH 1997 Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 20:570-577
55. Roovers K, Assoian RK 2000 Integrating the MAP kinase signal into the G1 phase cell cycle machinery. BioEssays 22:818-826
56. Scheid MP, Woodgett JR 2003 Unraveling the activation mechanisms of protein kinase B/Akt. FEBS Lett 546:108-112
57. Seye CI, Yu N, Jain R et al 2003 The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells. J Biol Chem 278:24960-24965
58. Tombes RM, Auer KL, Mikkelsen R et al 1998 The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem J 330:1451-1460
59. Tran MD, Wanner IB, Neary JT 2005 ATP receptor signaling regulates N-cadherin expression in astrocytes. Soc Neurosci Abstr, Program No 375:18
60. Wanner IB, Torres M, Gelin M et al 2005 Axon growth inhibition in a novel in vitro model of the glial scar. Soc Neurosci Abstr Program No 223:11
61. Wanner IB, Wood PM 2002 N-cadherin mediates axon-aligned process growth and cell-cell interaction in rat Schwann cells. J Neurosci 22:4066-4079
62. Zanovello P, Bronte V, Rosato A, Pizzo P, Di Virgilio F 1990 Responses of mouse lymphocytes to extracellular ATP. II. Extracellular ATP causes cell type-dependent lysis and DNA fragmentation. J Immunol 145:1545-1550