Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Guthridge, Joel M ^a   Clark, Daniel N ^b   Templeton, Amanda ^a   Dominguez, Nicolas ^a   Lu, Rufei ^a   Vidal, Gabriel S ^a   Kelly, Jennifer A ^a   Kauffman, Kenneth M ^c   Harley, John B ^c   Gaffney, Patrick M ^a   James, Judith A ^a,d   Poole, Brian D ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b BRIGHAM YOUNG UNIVERSITY   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; INTERFERON; INTERFERON REGULATORY FACTOR 5; TOLL LIKE RECEPTOR; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, HUMAN;

ARTICLE; B LYMPHOCYTE; GENE EXPRESSION; GENOTYPE; HAPLOTYPE; HEREDITY; HUMAN; INFLAMMATION; MICROARRAY ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; CASE CONTROL STUDY; CELL CULTURE; FEMALE; GENE EXPRESSION PROFILING; GENETIC DATABASE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; SIGNAL TRANSDUCTION;

B-LYMPHOCYTES; CASE-CONTROL STUDIES; CELLS, CULTURED; DATABASES, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INTERFERON REGULATORY FACTORS; INTERFERONS; LUPUS ERYTHEMATOSUS, SYSTEMIC; SIGNAL TRANSDUCTION;

EID: 84858141577     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/594056     Document Type: Article

References (73)

1. Deapen D., Escalante A., Weinrib L., Horwitz D., Bachman B., Roy-Burman P., Walker A., Mack T. M., A revised estimate of twin concordance in systemic lupus erythematosus Arthritis Rheumatism 1992 35 3 311 318
2. Block S. R., A brief history of twins Lupus 2006 15 2 61 64 (Pubitemid 43345328)
3. Guo L., Deshmukh H., Lu R., Vidal G. S., Kelly J. A., Kaufman K. M., Dominguez N., Klein W., Kim-Howard X., Bruner G. R., Scofield R. H., Moser K. L., Gaffney P. M., Dozmorov I. M., Gilkeson G. S., Wakeland E. K., Li Q. Z., Langefeld C. D., Marion M. C., Williams A. H., Divers J., Alarcn G. S., Brown E. E., Kimberly R. P., Edberg J. C., Ramsey-Goldman R., Reveille J. D., McGwin G., Vil L. M., Petri M. A., Vyse T. J., Merrill J. T., James J. A., Nath S. K., Harley J. B., Guthridge J. M., Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population Genes Immunity 2009 10 5 531 538
4. Han S., Kim-Howard X., Deshmukh H., Kamatani Y., Viswanathan P., Guthridge J. M., Thomas K., Kaufman K. M., Ojwang J., Rojas-Villarraga A., Baca V., Orozco L., Rhodes B., Choi C. B., Gregersen P. K., Merrill J. T., James J. A., Gaffney P. M., Moser K. L., Jacob C. O., Kimberly R. P., Harley J. B., Bae S. C., Anaya J. M., Alarc-Riquelme M. E., Matsuda K., Vyse T. J., Nath S. K., Evaluation of imputation-based association in and around the integrin- -M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE) Human Molecular Genetics 2009 18 6 1171 1180
5. Liu K., Li Q. Z., Delgado-Vega A. M., Abelson A. K., Snchez E., Kelly J. A., Li L., Liu Y., Zhou J., Yan M., Ye Q., Liu S., Xie C., Zhou X. J., Chung S. A., Pons-Estel B., Witte T., De Ramn E., Bae S. C., Barizzone N., Sebastiani G. D., Merrill J. T., Gregersen P. K., Gilkeson G. G., Kimberly R. P., Vyse T. J., Kim I., D'Alfonso S., Martin J., Harley J. B., Criswell L. A., Wakeland E. K., Alarcn-Riquelme M. E., Mohan C., Danieli M. G., Galeazzi M., Querini P. R., Migliaresi S., Scherbarth H. R., Lopez J. A., Motta E. L., Gamron S., Drenkard C., Menso E., Allievi A., Tate G. A., Presas J. L., Palatnik S. A., Abdala M., Bearzotti M., Alvarellos A., Caeiro F., Bertoli A., Paira S., Roverano S., Graf C. E., Bertero E., Caprarulo C., Buchanan G., Guillern C., Grimaudo S., Manni J., Catoggio L. J., Soriano E. R., Santos C. D., Prigione C., Ramos F. A., Navarro S. M., Berbotto G. A., Jorfen M., Romero E. J., Garcia M. A., Marcos J. C., Marcos A. I., Perandones C. E., Eimon A., Battagliotti C. G., Armadi-Simab K., Gross W. L., Gromnica-Ihle E., Peter H. H., Manger K., Schnarr S., Zeidler H., Schmidt R. E., Ortego N., Callejas J. L., Jiménez-Alonso J., Sabio M., Snchez-Romn J., Garcia-Hernandez F. J., Camps M., Lpez-Nevot M. A., Gonzlez-Escribano M. F., Langefeld C., Tsao B., Jacob C., Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans The Journal of Clinical Investigation 2009 119 4 911 923
6. Lu R., Vidal G. S., Kelly J. A., Delgado-Vega A. M., Howard X. K., Macwana S. R., Dominguez N., Klein W., Burrell C., Harley I. T., Kaufman K. M., Bruner G. R., Moser K. L., Gaffney P. M., Gilkeson G. S., Wakeland E. K., Li Q. Z., Langefeld C. D., Marion M. C., Divers J., Alarcn G. S., Brown E. E., Kimberly R. P., Edberg J. C., Ramsey-Goldman R., Reveille J. D., McGwin G., Vil L. M., Petri M. A., Bae S. C., Cho S. K., Bang S. Y., Kim I., Choi C. B., Martin J., Vyse T. J., Merrill J. T., Harley J. B., Alarcn-Riquelme M. E., Nath S. K., James J. A., Guthridge J. M., Genetic associations of LYN with systemic lupus erythematosus Genes Immunity 2009 10 5 397 403
7. Namjou B., Sestak A. L., Armstrong D. L., Zidovetzki R., Kelly J. A., Ciobanu N. J. V., Kaufman K. M., Ojwang J. O., Ziegler J., Quismorio F. P., Reiff A., Myones B. L., Guthridge J. M., Nath S. K., Bruner G. R., Mehrian-Shai R., Silverman E., Klein-Gitelman M., Mccurdy D., Wagner-Weiner L., Nocton J. J., Putterman C., Bae S. C., Kim Y. J., Petri M., Reveille J. D., Vyse T. J., Gilkeson G. S., Kamen D. L., Alarcn-Riquelme M. E., Gaffney P. M., Moser K. L., Merrill J. T., Scofield R. H., James J. A., Langefeld C. D., Harley J. B., Jacob C. O., High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups Arthritis Rheumatism 2009 60 4 1085 1095
8. Kozyrev S. V., Abelson A. K., Wojcik J., Zaghlool A., Linga Reddy M. V. P., Sanchez E., Gunnarsson I., Svenungsson E., Sturfelt G., Jnsen A., Truedsson L., Pons-Estel B. A., Witte T., D'Alfonso S., Barrizzone N., Danieli M. G., Gutierrez C., Suarez A., Junker P., Laustrup H., Gonzlez-Escribano M. F., Martin J., Abderrahim H., Alarcn-Riquelme M. E., Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus Nature Genetics 2008 40 2 211 216 (Pubitemid 351171404)
9. Demirci F. Y., Manzi S., Ramsey-Goldman R., Minster R. L., Kenney M., Shaw P. S., Dunlop-Thomas C. M., Kao A. H., Rhew E., Bontempo F., Kammerer C., Kamboh M. I., Association of a Common Interferon Regulatory Factor 5 (IRF5) variant with increased risk of Systemic Lupus Erythematosus (SLE) Annals of Human Genetics 2007 71 part 3 308 311 (Pubitemid 46585673)
10. Graham R. R., Kyogoku C., Sigurdsson S., Vlasova I. A., Davies L. R. L., Baechler E. C., Plenge R. M., Koeuth T., Ortmann W. A., Hom G., Bauer J. W., Gillett C., Burtt N., Graham D. S. C., Onofrio R., Petri M., Gunnarsson I., Svenungsson E., Rnnblom L., Nordmark G., Gregersen P. K., Moser K., Gaffney P. M., Criswell L. A., Vyse T. J., Syvnen A. C., Bohjanen P. R., Daly M. J., Behrens T. W., Altshuler D., Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus Proceedings of the National Academy of Sciences of the United States of America 2007 104 16 6758 6763 (Pubitemid 47175574)
11. Harley J. B., Alarcn-Riquelme M. E., Criswell L. A., Jacob C. O., Kimberly R. P., Moser K. L., Tsao B. P., Vyse T. J., Langefeld C. D., Nath S. K., Guthridge J. M., Cobb B. L., Mirel D. B., Marion M. C., Williams A. H., Divers J., Wang W., Frank S. G., Namjou B., Gabriel S. B., Lee A. T., Gregersen P. K., Behrens T. W., Taylor K. E., Fernando M., Zidovetzki R., Gaffney P. M., Edberg J. C., Rioux J. D., Ojwang J. O., James J. A., Merrill J. T., Gilkeson G. S., Seldin M. F., Yin H., Baechler E. C., Li Q. Z., Wakeland E. K., Bruner G. R., Kaufman K. M., Kelly J. A., Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nature Genetics 2008 40 2 204 210 (Pubitemid 351171405)
12. Kaufman K. M., Kelly J. A., Herring B. J., Adler A. J., Glenn S. B., Namjou B., Frank S. G., Dawson S. L., Bruner G. R., James J. A., Harley J. B., Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus Arthritis Rheumatism 2006 54 8 2533 2540 (Pubitemid 44205014)
13. Kawasaki A., Kyogoku C., Ohashi J., Miyashita R., Hikami K., Kusaoi M., Tokunaga K., Takasaki Y., Hashimoto H., Behrens T. W., Tsuchiya N., Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms Arthritis Rheumatism 2008 58 3 826 834 (Pubitemid 351364880)
14. Kelly J. A., Kelley J. M., Kaufman K. M., Kilpatrick J., Bruner G. R., Merrill J. T., James J. A., Frank S. G., Reams E., Brown E. E., Gibson A. W., Marion M. C., Langefeld C. D., Li Q. Z., Karp D. R., Wakeland E. K., Petri M., Ramsey-Goldman R., Reveille J. D., Vil L. M., Alarcn G. S., Kimberly R. P., Harley J. B., Edberg J. C., Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans Genes Immunity 2008 9 3 187 194 (Pubitemid 351584185)
15. Kozyrev S. V., Alarcon-Riquelme M. E., The genetics and biology of Irf5-mediated signaling in lupus Autoimmunity 2007 40 8 591 601 (Pubitemid 350302184)
16. Moser K. L., Neas B. R., Salmon J. E., Yu H., Gray-Mcguire C., Asundi N., Bruner G. R., Fox J., Kelly J., Henshall S., Bacino D., Dietz M., Hogue R., Koelsch G., Nightingale L., Shaver T., Abdou N. I., Albert D. A., Carson C., Petri M., Treadwell E. L., James J. A., Harley J. B., Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees Proceedings of the National Academy of Sciences of the United States of America 1998 95 25 14869 14874 (Pubitemid 29003723)
17. Moser K. L., Kelly J. A., Lessard C. J., Harley J. B., Recent insights into the genetic basis of systemic lupus erythematosus Genes Immunity 2009 10 5 373 379
18. Harley I. T. W., Kaufman K. M., Langefeld C. D., Harley J. B., Kelly J. A., Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies Nature Reviews Genetics 2009 10 5 285 290
19. Niewold T. B., Kelly J. A., Flesch M. H., Espinoza L. R., Harley J. B., Crow M. K., Association of the IRF5 risk haplotype with high serum interferon- activity in systemic lupus erythematosus patients Arthritis Rheumatism 2008 58 8 2481 2487
20. Reddy M. V., Velzquez-Cruz R., Baca V., Lima G., Granados J., Orozco L., Alarcn-Riquelme M. E., Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans Human Genetics 2007 121 6 721 727 (Pubitemid 46916971)
21. Graham R. R., Kozyrev S. V., Baechler E. C., Reddy M. V. P. L., Plenge R. M., Bauer J. W., Ortmann W. A., Koeuth T., Escribano M. F. G., Pons-Estel B., Petri M., Daly M., Gregersen P. K., Martn J., Altshuler D., Behrens T. W., Alarcn-Riquelme M. E., A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus Nature Genetics 2006 38 5 550 555
22. Sigurdsson S., Nordmark G., Garnier S., Grundberg E., Kwan T., Nilsson O., Eloranta M. L., Gunnarsson I., Svenungsson E., Sturfelt G., Bengtsson A. A., Jnsen A., Truedsson L., Rantap-Dahlqvist S., Eriksson C., Alm G., Gring H. H. H., Pastinen T., Syvnen A. C., Rnnblom L., A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5 Human Molecular Genetics 2008 17 18 2868 2876
23. Martin H. J., Jae J. M., Walls D., Hayward S. D., Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus Journal of Virology 2007 81 18 9748 9758 (Pubitemid 350067679)
24. Barnes B. J., Richards J., Mancl M., Hanash S., Beretta L., Pitha P. M., Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection The Journal of Biological Chemistry 2004 279 43 45194 45207 (Pubitemid 39430935)
25. Yasuda K., Richez C., Maciaszek J. W., Agrawal N., Akira S., Marshak-Rothstein A., Rifkin I. R., Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes Is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production The Journal of Immunology 2007 178 11 6876 6885 (Pubitemid 46847413)
26. Niewold T. B., Hua J., Lehman T. J. A., Harley J. B., Crow M. K., High serum IFN- activity is a heritable risk factor for systemic lupus erythematosus Genes Immunity 2007 8 6 492 502 (Pubitemid 47365615)
27. Harley B. J., Harley I. T. W., Guthridge J. M., James J. A., The curiously suspicious: a role for Epstein-Barr virus in lupus Lupus 2006 15 11 768 777
28. Harley J. B., James J. A., Epstein-Barr virus infection induces lupus autoimmunity Bulletin of the NYU Hospital for Joint Diseases 2006 64 1-2 45 50 (Pubitemid 44625532)
29. James J. A., Harley J. B., Epstein-Barr virus infection may be an environmental risk factor for SLE in children and teenagers Arthritis Rheumatism 1999 42 1122 1126
30. James J. A., Harley J. B., Scofield R. H., Epstein-Barr virus and systemic lupus erythematosus Current Opinion in Rheumatology 2006 18 5 462 467 (Pubitemid 44200328)
31. James J. A., Kaufman K. M., Farris A. D., Taylor-Albert E., Lehman T. J. A., Harley J. B., An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus The Journal of Clinical Investigation 1997 100 12 3019 3026 (Pubitemid 28022839)
32. James J. A., Neas B. R., Moser K. L., Hall T., Bruner G. R., Sestak A. L., Harley J. B., Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure Arthritis Rheumatism 2001 44 5 1122 1126 (Pubitemid 32433618)
33. Lu J. J. Y., Chen D. Y., Hsieh C. W., Lan J. L., Lin F. J., Lin S. H., Association of Epstein-Barr virus infection with systemic lupus erythematosus in Taiwan Lupus 2007 16 3 168 175
34. James J. A., Scofield R. H., Harley J. B., Lupus humoral autoimmunity after short peptide immunization Annals of the New York Academy of Sciences 1997 815 124 127 (Pubitemid 27309498)
35. Poole B. D., Scofield R. H., Harley J. B., James J. A., Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus Autoimmunity 2006 39 1 63 70 (Pubitemid 43878521)
36. Sabbatini A., Bombardieri S., Migliorini P., Autoantibodies from patients with systemic lupus erythematosus bind a shared sequence of SmD and Epstein-Barr virus-encoded nuclear antigen EBNA I European Journal of Immunology 1993 23 5 1146 1152 (Pubitemid 23120179)
37. Sabbatini A., Dolcher M. P., Marchini B., Bombardieri S., Migliorini P., Mapping of epitopes on the SmD molecule: the use of multiple antigen peptides to measure autoantibodies in systemic lupus erythematosus The Journal of Rheumatology 1993 20 10 1679 1683 (Pubitemid 24017569)
38. Sundar K., Jacques S., Gottlieb P., Villars R., Benito M. E., Taylor D. K., Spatz L. A., Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies Journal of Autoimmunity 2004 23 2 127 140 (Pubitemid 39485794)
39. Poole B. D., Gross T., Maier S., Harley J. B., James J. A., Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments Journal of Autoimmunity 2008 31 4 362 371
40. McClain M. T., Poole B. D., Bruner B. F., Kaufman K. M., Harley J. B., James J. A., An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus Arthritis Rheumatism 2006 54 1 360 368 (Pubitemid 43122221)
41. Kang I., Quan T., Nolasco H., Park S. H., Hong M. S., Crouch J., Pamer E. G., Howe J. G., Craft J., Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus The Journal of Immunology 2004 172 2 1287 1294 (Pubitemid 38113792)
42. Moon U. Y., Park S. J., Oh S. T., Kim W. U., Park S. H., Lee S. H., Cho C. S., Kim H. Y., Lee W. K., Lee S. K., Patients with systemic lupus erythematosus have abnormally elevated Epstein-Barr virus load in blood Arthritis Research Therapy 2004 6 4 R295 302
43. Babcock G. J., Hochberg D., Thorley-Lawson A. D., The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell Immunity 2000 13 4 497 506
44. Knowlton N., Dozmorov I. M., Centola M., Microarray data analysis toolbox (MDAT): for normalization, adjustment and analysis of gene expression data Bioinformatics 2004 20 18 3687 3690 (Pubitemid 40136817)
45. Mootha V. K., Lindgren C. M., Eriksson K. F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstrle M., Laurila E., Houstis N., Daly M. J., Patterson N., Mesirov J. P., Golub T. R., Tamayo P., Spiegelman B., Lander E. S., Hirschhorn J. N., Altshuler D., Groop L. C., PGC-1 -responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes Nature Genetics 2003 34 3 267 273 (Pubitemid 36792858)
46. Subramanian A., Tamayo P., Mootha V. K., Mukherjee S., Ebert B. L., Gillette M. A., Paulovich A., Pomeroy S. L., Golub T. R., Lander E. S., Mesirov J. P., Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles Proceedings of the National Academy of Sciences of the United States of America 2005 102 43 15545 15550 (Pubitemid 41528093)
47. Kozyrev S. V., Lewén S., Reddy P. M. V. L., Pons-Estel B., Witte T., Junker P., Laustrup H., Gutiérrez C., Surez A., Gonzlez-Escribano M. F., Martn J., Alarcn-Riquelme M. E., Scherbarth H. R., Marino P. C., Motta E. L., Gamron S., Drenkard C., Menso E., Allievi A., Tate G. A., Presas J. L., Palatnik S. A., Abdala M., Bearzotti M., Alvarellos A., Caeiro F., Bertoli A., Paira S., Roverano S., Graf C. E., Bertero E., Caprarulo C., Buchanan G., Guillern C., Grimaudo S., Manni J., Catoggio L. J., Soriano E. R., Santos C. D., Prigione C., Ramos F. A., Navarro S. M., Berbotto G. A., Jorfen M., Romero E. J., Garcia M. A., Marcos J. C., Marcos A. I., Perandones C. E., Eimon A., Battagliotti C. G., Armadi-Simab K., Gross W. L., Gromnica-IhIe E., Peter H. H., Manger K., Schnarr S., Zeidler H., Schmidt R. E., Ortego N., De Ramn E., Jiménez-Alonso J., Snchez-Romn J., Lpez-Nevot M. A., Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus Arthritis Rheumatism 2007 56 4 1234 1241 (Pubitemid 46608648)
48. Subramanian S., Tus K., Li Q. Z., Wang A., Tian X. H., Zhou J., Liang C., Bartov G., McDaniel L. D., Zhou X. J., Schultz R. A., Wakeland E. K., A Tlr7 translocation accelerates systemic autoimmunity in murine lupus Proceedings of the National Academy of Sciences of the United States of America 2006 103 26 9970 9975 (Pubitemid 43993607)
49. Dumont C., Henderson R., Tybulewicz V. L., Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development Methods in Enzymology 2008 439 235 254
50. Bennett L., Palucka A. K., Arce E., Cantrell V., Borvak J., Banchereau J., Pascual V., Interferon and granulopoiesis signatures in systemic lupus erythematosus blood The Journal of Experimental Medicine 2003 197 6 711 723 (Pubitemid 36350866)
51. Baechler E. C., Batliwalla F. M., Karypis G., Gaffney P. M., Ortmann W. A., Espe K. J., Shark K. B., Grande W. J., Hughes K. M., Kapur V., Gregersen P. K., Behrens T. W., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2610 2615 (Pubitemid 36297546)
52. Crow M. K., Interferon- : a new target for therapy in systemic lupus erythematosus? Arthritis Rheumatism 2003 48 9 2396 2401 (Pubitemid 37129415)
53. Niewold T. B., Clark D. N., Salloum R., Poole B. D., Interferon alpha in systemic lupus erythematosus Journal of Biomedicine and Biotechnology 2010 2010 8
54. Batteux F., Palmer P., Daron M., Weill B., Lebon P., FC RII (CD32)-dependent induction of interferon-alpha by serum from patients with lupus erythematosus European Cytokine Network 1999 10 4 509 514
55. Bave U., Magnusson M., Eloranta M. L., Perers A., Alm G. V., Rnnblom L., Fc RIIa is expressed on natural IFN- -producing cells (plasmacytoid dendritic cells) and is required for the IFN- production induced by apoptotic cells combined with lupus IgG The Journal of Immunology 2003 171 6 3296 3302 (Pubitemid 37093557)
56. Lovgren T., Eloranta M.-L., Bave U., Alm G. V., Rnnblom L., Induction of interferon- production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG Arthritis Rheumatism 2004 50 6 1861 1872 (Pubitemid 38725099)
57. Lovgren T., Eloranta M.-L., Kastner B., Wahren-Herlenius M., Alm G. V., Rnnblom L., Induction of interferon- by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjgren's syndrome auto antigenassociated RNA Arthritis Rheumatism 2006 54 6 1917 1927 (Pubitemid 43877941)
58. Rnnblom L., Alm G. V., Systemic lupus erythematosus and the type I interferon system Arthritis Research Therapy 2003 5 2 68 75 (Pubitemid 36849752)
59. Rnnblom L., Pascual V., The innate immune system in SLE: type I interferons and dendritic cells Lupus 2008 17 5 394 399 (Pubitemid 351798715)
60. Tian J., Avalos A. M., Mao S. Y., Chen B., Senthil K., Wu H., Parroche P., Drabic S., Golenbock D., Sirois C., Hua J., An L. L., Audoly L., La Rosa G., Bierhaus A., Naworth P., Marshak-Rothstein A., Crow M. K., Fitzgerald K. A., Latz E., Kiener P. A., Coyle A. J., Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE Nature Immunology 2007 8 5 487 496 (Pubitemid 46605917)
61. Barnes B. J., Field A. E., Pitha-Rowe P. M., Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes The Journal of Biological Chemistry 2003 278 19 16630 16641 (Pubitemid 36799526)
62. Barnes B. J., Moore P. A., Pitha P. M., Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon genes The Journal of Biological Chemistry 2001 276 26 23382 23390
63. Savitsky D. A., Yanai H., Tamura T., Taniguchi T., Honda K., Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus Proceedings of the National Academy of Sciences of the United States of America 2010 107 22 10154 10159
64. Werner S. L., Kearns J. D., Zadorozhnaya V., Lynch C., O'Dea E., Boldin M. P., Ma A., Baltimore D., Hoffmann A., Encoding NF- B temporal control in response to TNF: distinct roles for the negative regulators I B and A20 Genes Development 2008 22 15 2093 2101
65. Graham R. R., Cotsapas C., Davies L., Hackett R., Lessard C. J., Leon J. M., Burtt N. P., Guiducci C., Parkin M., Gates C., Plenge R. M., Behrens T. W., Wither J. E., Rioux J. D., Fortin P. R., Cunninghame Graham D., Wong A. K., Vyse T. J., Daly M. J., Altshuler D., Moser K. L., Gaffney P. M., Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus Nature Genetics 2008 40 9 1059 1061
66. Kang N. I., Yoon H. Y., Lee Y. R., Won M., Chung M. J., Park J. W., Hur G. M., Lee H. K., Park B. H., A20 attenuates allergic airway inflammation in mice The Journal of Immunology 2009 183 2 1488 1495
67. Trynka G., Zhernakova A., Romanos J., Franke L., Hunt K. A., Turner G., Bruinenberg M., Heap G. A., Platteel M., Ryan A. W., De Kovel C., Holmes G. K. T., Howdle P. D., Walters J. R. F., Sanders D. S., Mulder C. J. J., Mearin M. L., Verbeek W. H. M., Trimble V., Stevens F. M., Kelleher D., Barisani D., Bardella M. T., McManus R., Van Heel D. A., Wijmenga C., Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF- B signalling Gut 2009 58 8 1078 1083
68. Bates J. S., Lessard C. J., Leon J. M., Nguyen T., Battiest L. J., Rodgers J., Kaufman K. M., James J. A., Gilkeson G. S., Kelly J. A., Humphrey M. B., Harley J. B., Gray-McGuire C., Moser K. L., Gaffney P. M., Meta-analysis and imputation identifies a 109kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations Genes Immunity 2009 10 5 470 477
69. Gateva V., Sandling J. K., Hom G., Taylor K. E., Chung S. A., Sun X., Ortmann W., Kosoy R., Ferreira R. C., Nordmark G., Gunnarsson I., Svenungsson E., Padyukov L., Sturfelt G., Jnsen A., Bengtsson A. A., Rantap-Dahlqvist S., Baechler E. C., Brown E. E., Alarcn G. S., Edberg J. C., Ramsey-Goldman R., McGwin G., Reveille J. D., Vil L. M., Kimberly R. P., Manzi S., Petri M. A., Lee A., Gregersen P. K., Seldin M. F., Rnnblom L., Criswell L. A., Syvnen A. C., Behrens T. W., Graham R. R., A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus Nature Genetics 2009 41 11 1228 1233
70. Han J. W., Zheng H. F., Cui Y., Sun L. D., Ye D. Q., Hu Z., Xu J. H., Cai Z. M., Huang W., Zhao G. P., Xie H. F., Fang H., Lu Q. J., Xu J. H., Li X. P., Pan Y. F., Deng D. Q., Zeng F. Q., Ye Z. Z., Zhang X. Y., Wang Q. W., Hao F., Ma L., Zuo X. B., Zhou F. S., Du W. H., Cheng Y. L., Yang J. Q., Shen S. K., Li J., Sheng Y. J., Zuo X. X., Zhu W. F., Gao F., Zhang P. L., Guo Q., Li B., Gao M., Xiao F. L., Quan C., Zhang C., Zhang Z., Zhu K. J., Li Y., Hu D. Y., Lu W. S., Huang J. L., Liu S. X., Li H., Ren Y. Q., Wang Z. X., Yang C. J., Wang P. G., Zhou W. M., Lv Y. M., Zhang A. P., Zhang S. Q., Lin D., Li Y., Low H. Q., Shen M., Zhai Z. F., Wang Y., Zhang F. Y., Yang S., Liu J. J., Zhang X. J., Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus Nature Genetics 2009 41 11 1234 1237
71. Musone S. L., Taylor K. E., Lu T. T., Nititham J., Ferreira R. C., Ortmann W., Shifrin N., Petri M. A., Ilyas Kamboh M., Manzi S., Seldin M. F., Gregersen P. K., Behrens T. W., Ma A., Kwok P. Y., Criswell L. A., Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus Nature Genetics 2008 40 9 1062 1064
72. Honma K., Tsuzuki S., Nakagawa M., Tagawa H., Nakamura S., Morishima Y., Seto M., TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas Blood 2009 114 12 2467 2475
73. Kato M., Sanada M., Kato I., Sato Y., Takita J., Takeuchi K., Niwa A., Chen Y., Nakazaki K., Nomoto J., Asakura Y., Muto S., Tamura A., Iio M., Akatsuka Y., Hayashi Y., Mori H., Igarashi T., Kurokawa M., Chiba S., Mori S., Ishikawa Y., Okamoto K., Tobinai K., Nakagama H., Nakahata T., Yoshino T., Kobayashi Y., Ogawa S., Frequent inactivation of A20 in B-cell lymphomas Nature 2009 459 7247 712 716