Genetic association of IRF5 with SLE in Mexicans: Higher frequency of the risk haplotype and its homozygozity than Europeans

Human Genetics

Volumn 121, Issue 6, 2007, Pages 721-727

  Reddy, M V Prasad Linga ^a   Velázquez Cruz, Rafael ^b   Baca, Vicente ^c   Lima, Guadalupe ^d   Granados, Julio ^d   Orozco, Lorena ^b   Alarcón Riquelme, Marta E ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

^c HOSPITAL DE PEDIATRÍA   (Mexico)

^d INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 5; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ACTIVITY; EUROPE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEXICO; PRIORITY JOURNAL; RACE DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ALLELES; CASE-CONTROL STUDIES; CHILD; ETHNIC GROUPS; EUROPE; FEMALE; GENE FREQUENCY; HAPLOTYPES; HOMOZYGOTE; HUMANS; INDIANS, NORTH AMERICAN; INTERFERON REGULATORY FACTORS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MEXICO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 34250369117     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-007-0367-6     Document Type: Article

References (26)

1. Alarcon GS, McGwin G Jr, Roseman JM et al (2004) Systemic lupus erythematosus in three ethnic groups. XIX. Natural history of the accrual of the American College of Rheumatology criteria prior to the occurrence of criteria diagnosis. Arthritis Rheum 51:609-615
2. Alarcon GS, Bastian HM, Beasley TM et al (2006) Systemic lupus erythematosus in a multi-ethnic cohort (LUMINA) XXXII: [corrected] contributions of admixture and socioeconomic status to renal involvement. Lupus 15:26-31
3. Andrade RM, McGwin G Jr, Alarcon GS et al (2006) Predictors of post-partum damage accrual in systemic lupus erythematosus: Data from LUMINA, a multiethnic US cohort (XXXVIII). Rheumatology (Oxford) 45:1380-1384
4. Baechler EC, Batliwalla FM, Karypis G et al 2003 Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 100:2610-2615
5. Barnes BJ, Moore PA, Pitha PM (2001) Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. J Biol Chem 276:23382-23390
6. Barnes BJ, Kellum MJ, Field AE et al (2002) Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol Cell Biol 22:5721-5740
7. Barnes B, Lubyova B, Pitha PM (2002) On the role of IRF in host defense. J Interferon Cytokine Res 22:59-71
8. Bennett L, Palucka AK, Arce E et al (2003) Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 197:711-723
9. Calvo-Alen J, Reveille JD, Rodriguez-Valverde V et al (2003) Clinical, immunogenetic and outcome features of Hispanic systemic lupus erythematosus patients of different ethnic ancestry. Lupus 12:377-385
10. Cunha BA (2004) Smallpox and measles: Historical aspects and clinical differentiation. Infect Dis Clin North Am 18:79-100
11. Fenner F (1980) The global eradication of smallpox. Med J Aust, vol 1, pp 455-5
12. Graham RR, Ortmann WA, Langefeld CD et al (2002) Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet 71:543-553
13. Graham DS, Manku H, Wagner S et al (2006) Association of IRF5 in UK SLE families identifies a variant involved in Polyadenylation. Hum Mol Genet
14. Graham RR, Kozyrev SV, Baechler EC et al (2006) A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 38:550-555
15. Granados J, Vargas-Alarcon G, Andrade F et al (1996) The role of HLA-DR alleles and complotypes through the ethnic barrier in systemic lupus erythematosus in Mexicans. Lupus 5:184-189
16. Klein-Gitelman M, Reiff A, Silverman ED (2002) Systemic lupus erythematosus in childhood. Rheum Dis Clin North Am 28:561-577
17. Kozyrev SV, Lewén S, Linga Reddy MVP, Pons-Estel BA, The Argentine colloborative group, Witte T, The German colloborative group, Junker P, Laustrup H, Gutiérrez C, Suárez A, González-Escribano MF, Martín J, The Spanish colloborative group and Alarcón-Riquelme ME (2007). Structural insertion/ deletion variation in IRF5 is associated with a risk haplotype and defines the precise isoforms expressed in SLE. Arthritis Rheum 56:1234-1241
18. Patterson KB, Runge T (2002) Smallpox and the Native American. Am J Med Sci 323:216-222
19. Pons-Estel BA, Catoggio LJ, Cardiel MH et al (2004) The GLADEL multinational Latin American prospective inception cohort of 1,214 patients with systemic lupus erythematosus: Ethnic and disease heterogeneity among "Hispanics". Medicine (Baltimore) 83:1-17
20. Ronnblom LE, Alm GV, Oberg KE (1990) Possible induction of systemic lupus erythematosus by interferon-alpha treatment in a patient with a malignant carcinoid tumour. J Intern Med 227:207-210
21. Schoenemeyer A, Barnes BJ, Mancl ME et al (2005) The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem 280:17005-17012
22. Sigurdsson S, Nordmark G, Goring HH et al (2005) Polymorphisms in the Tyrosine Kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 76(3):528-537
23. Takaoka A, Yanai H, Kondo S et al (2005) Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434:243-249
24. Vila LM, Alarcon GS, McGwin G Jr et al (2004) Early clinical manifestations, disease activity and damage of systemic lupus erythematosus among two distinct US Hispanic subpopulations. Rheumatology (Oxford) 43:358-363
25. Yanai H, Chen HM, Inuzuka T, Kondo S, Mak TW, Takaoka A, Honda K, Taniguchi T (2007) Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci USA 104:3402-3407
26. Yang N, Li H, Criswell LA et al (2005) Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine. Hum Genet, pp 1-11