Radiosensitizing effect of epothilone B on human epithelial cancer cells

Strahlentherapie und Onkologie

Volumn 188, Issue 2, 2012, Pages 177-184

  Baumgart, T ^a   Klautke, G ^b   Kriesen, S ^a   Kuznetsov, S A ^a   Weiss, D G ^a   Fietkau, R ^b   Hildebrandt, G ^a   Manda, K ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Cancer cells; DNA breaks; Epothilone B; Irradiation; Microtubules

Indexed keywords

EPOTHILONE B; HISTONE H2AX; PACLITAXEL; TUBULIN; ANTINEOPLASTIC AGENT; EPOTHILONE DERIVATIVE; RADIOSENSITIZING AGENT;

ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; IONIZING RADIATION; MICROTUBULE ASSEMBLY; RADIOSENSITIZATION; CHEMORADIOTHERAPY; DOSE RESPONSE; DRUG EFFECT; METHODOLOGY; MULTIMODALITY CANCER THERAPY; NEOPLASM; PATHOLOGY; PHYSIOLOGY; RADIATION DOSE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMORADIOTHERAPY; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOTHILONES; HUMANS; NEOPLASMS, GLANDULAR AND EPITHELIAL; RADIATION DOSAGE; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS;

EID: 84858067591     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-011-0029-4     Document Type: Article

References (48)

1. Agrawal NR, Ganapathi R, Mekhail T (2003) Tubulin interacting agents: novel taxanes and epothilones. Curr Oncol Rep 5:89-98
2. Al-Haddad A, Shonn MA, Redlich B et al (2001) Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motility. Mol Biol Cell 12:2742-27755
3. Altmann KH, Wartmann M, O'Reilly T (2000) Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim Biophys Acta 1470:M79-91
4. Bocci G, Nicolaou KC, Kerbel RS (2002) Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res 62:6938-6943
5. Bollag DM, McQueney PA, Zhu J et al (1995) Epothilones, a new class of microtubule-stabilzing agents with a taxol-like mechanism of action. Cancer Res 55:2325-2333
6. Bystricky B, Chau I (2011) Patupilone in cancer treatment. Expert Opin Investig Drugs 20:107-117
7. Chalmers AJ, Ruff EM, Martindale C et al (2009) Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent. Int J Radiat Oncol Biol Phys 75:1511-1519
8. Chen JG, Horwitz SB (2002) Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer Res 62:1935-1938
9. Chen JG, Yang CPH, Cammer M et al (2003) Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Res 63:7891-7899
10. Vos FY de, Bos AM, Gietema JA et al (2004) Paclitaxel and carboplatin concurrent with radiotherapy for primary cervical cancer. Anticancer Res 24:345-348
11. Ferretti S, Allegrini PR, O'Reilly T et al (2005) Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure. Clin Cancer Res 11:7773-7784
12. Fietkau R, Semrau S (2010) Stage III: definitive chemoradiotherapy. Front Radiat Ther Oncol 42:122-134
13. Fogh S, Machtay M, Werner-Wasik M et al (2010) Phase I trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys 77:1009-1016
14. Fumoleau P, Coudert B, Isambert N et al (2007) Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. Ann Oncol 18(Suppl 5):v9-15
15. Gerth K, Bedorf N, Höfle G et al (1996) Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological proberties. J Antibiot (Tokyo) 49:560-563
16. Hait WN, Rubin E, Alli E et al (2007) Tubulin targeting agents. Update Cancer Ther 2:1-18
17. Hei TK, Piao CQ, Geard CR et al (1994) Taxol and ionizing radiation: interaction and mechanisms. Int J Radiat Oncol Biol Phys 29:267-271
18. Hofstetter B, Voung V, Broggini-Tenzer A et al (2005) Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo. Clin Cancer Res 11:1588-1596
19. Kim JC, Kim JS, Saha D et al (2003) Potential radiation-sensitizing effect of semisynthetic epothilone B in human lung cancer cells. Radiother Oncol 68:305-313
20. Kingston DG (2009) Tubulin-interactive natural products as anticancer agents. J Nat Prod 72:507-515
21. Kiselyov AS, Semenova MN, Chernyshova NB et al (2010) Novel derivates of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. Eur J Med Chem 45:1683-1697
22. Klautke G, Foitzik T, Ludwig K et al (2004) Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma. Strahlenther Onkol 180:695-700
23. Kowalski RJ, Giannakakou P, Hamel E (1997) Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistent to paclitaxel (Taxol). J Biol Chem 272:2534-2541
24. Kuznetsov SA, Rodionov VI, Bershadsky AD et al (1980) High molecular weight protein MAP 2 promoting microtubule assembly in vitro is associated with microtubules in cells. Cell Biol Int Rep 4:1017-1024
25. Lee FY, Borzilleri R, Fairchild CR et al (2001) BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 7:1429-1437
26. Leibl BJ, Vitz S, Schäfer W et al (2011) Adenocarcinoma of the esophagogastric junction: Neoadjuvant radiochemotherapy and radical surgery: early results and toxicity. Strahlenther Onkol 187:231-237
27. Lichtner RB, Rotgeri A, Bunte T et al (2001) Subcellular distribution of epothilones in human tumor cells. Proc Natl Acad Sci U S A 98:11743-11748
28. Liebmann J, Cook JA, Fisher J et al (1994) In vitro studies of taxol as a radiation sensitizer in human tumor cells. J Natl Cancer Inst 86(6):441-446
29. Manda K, Kriesen S, Hildebrandt G et al (2011) Omega-3 fatty acid supplementation in cancer therapy: does eicosapentanoic acid influence the radiosensitivity of tumor cells? Strahlenther Onkol 187:127-134
30. Nettles JH, Li H, Cornett B et al (2004) The binding mode of epothilone A on alpha, beta-tubulin by electron crystallography. Science 305:866-869
31. Niero A, Emiliani E, Monti G et al (1999) Paclitaxel and radiotherapy: sequence-dependent efficacy - a preclinical model. Clin Cancer Res 5:2213-2222
32. Oehler C, Bueren AO von, Furmanova P et al (2011) The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol 13(9):1000-1010
33. Pentenero M, Donadini A, Di Nallo E et al (2011) Distinctive chromosomal instability patterns in oral verrucous and squamous cell carcinomas detected by high-resolution DNA flow cytometry. Cancer 117:5052-5057
34. Rodionov VI, Gyoeva FK, Kashina AS et al (1990) Microtubule-associated proteins and microtubule-based translocators have different binding sites on tubulin molecule. J Biol Chem 265:5702-5707
35. Rohrer Bley C, Jochum W, Orlowski K et al (2009) Role of the microenvironment for radiosensitization by patupilone. Clin Cancer Res 15:1335-1342
36. Rowinsky EK, Donehower RC (1995) Paclitaxel (taxol). N Engl J Med 332:1004-1014
37. Schiff PB, Horwitz SB (1980) Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A 77:1561-1565
38. Semrau S, Waldfahrer F, Lell M et al (2011) Feasibility, toxicity, and efficacy of short induction chemotherapy of docetaxel plus cisplatin or carboplatin (TP) followed by concurrent chemoradiotherapy for organ preservation in advanced cancer of the hypopharynx, larynx, and base of tongue. Early results. Strahlenther Onkol 187:15-22
39. Sepp-Lorenzino L, Balog A, Su DS et al (1999) The microtubule-stabilizing agents epothilones A and B and their desoxy-derivates induce mitotic arrest and apoptosis in human prostate cancer cells. Prostate Cancer Prostatic Dis 2:41-52
40. Stalder MW, Anthony CT, Woltering EA (2011) Metronomic dosing enhances the anti-angiogenic effect of epothilone B. J Surg Res 169:247-256
41. Swanton C, Nicke B, Schuett M et al (2009) Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A 106:8671-8676
42. Taneja N, Davis M, Choy JS et al (2004) Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 279:2273-2280
43. Tishler RB, Busse PM, Norris CM Jr et al (1992) An initial experience using concurrent paclitaxel and radiation in the treatment of head and neck malignancies. Cancer Res 52:3495-3497
44. Tishler RB, Geard CR, Hall EJ et al (1999) Taxol sensitizes human astrocytoma cells to radiation. Int J Radiat Oncol Biol Phys 43:1001-1008
45. Toulany M, Kasten-Pisula U, Brammer I et al (2006) Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clin Cancer Res 12:4119-4126
46. Wolff HA, Hennies S, Hermann MKA et al (2011) Comparison of the micronucleus and chromosome aberration techniques for the documentation of cytogenetic damage in radiochemotherapy-treated patients with rectal cancer. Strahlenther Onkol 187:52-58
47. Woltering EA, Lewis JM, Maxwell PJ 4th et al (2003) Development of a novel in vitro human tissue-based angiogenesis assay to evaluate the effect of antiangiogenic drugs. Ann Surg 237:790-800
48. Yeung TK, Germond C, Chen X et al (1999) The mode of action of taxol: apoptosis at low concentration and necrosis at high concentration. Biochem Biophys Res Commun 263:398-404