-
1
-
-
0035416117
-
Microtubule-stabilizing agents: A growing class of important anticancer drugs
-
Altmann K.H. Microtubule-stabilizing agents: a growing class of important anticancer drugs. Curr Opin Chem Biol. 5:2001;424-431.
-
(2001)
Curr Opin Chem Biol
, vol.5
, pp. 424-431
-
-
Altmann, K.H.1
-
2
-
-
4243391690
-
Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients with advanced solid tumors [abstract]
-
Awada A., Bleiberg H., de Valeriola D., et al. Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients with advanced solid tumors [abstract]. Proc Am Soc Clin Oncol. 20:2001;A268.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 268
-
-
Awada, A.1
Bleiberg, H.2
De Valeriola, D.3
-
3
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
Bollag D.M., McQueney P.A., Zhu J., et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 55:1995;2325-2333.
-
(1995)
Cancer Res
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
-
4
-
-
0027160447
-
Investigation of taxol as a potential radiation sensitizer
-
Choy H., Rodriguez F.F., Koester S., Hilsenbeck S., Von Hoff D.D. Investigation of taxol as a potential radiation sensitizer. Cancer. 71:1993;3774-3778.
-
(1993)
Cancer
, vol.71
, pp. 3774-3778
-
-
Choy, H.1
Rodriguez, F.F.2
Koester, S.3
Hilsenbeck, S.4
Von Hoff, D.D.5
-
5
-
-
0035462851
-
Clinical trials referral resource. Current clinical trials of epothilone B analog (BMS-247550)
-
Colevas A.D., West P.J., Cheson B.D. Clinical trials referral resource. Current clinical trials of epothilone B analog (BMS-247550). Oncology (Huntingt). 15:(1168-1169):2001;1172-1175.
-
(2001)
Oncology (Huntingt)
, vol.15
, Issue.1168-1169
, pp. 1172-1175
-
-
Colevas, A.D.1
West, P.J.2
Cheson, B.D.3
-
6
-
-
0031569923
-
Synthetic chemistry. Cancer drugs better than taxol?
-
Cowden C.J., Paterson I. Synthetic chemistry. Cancer drugs better than taxol? Nature. 387:1997;238-239.
-
(1997)
Nature
, vol.387
, pp. 238-239
-
-
Cowden, C.J.1
Paterson, I.2
-
7
-
-
1642290335
-
Pharmacokinetics (PK) and pharmacodynamics (PD) kineticsof BMS-247550, an epothilone analog, in patients with advanced solid tumors(abstract)
-
Damle B.D., Letrent S., Duncan G., et al. Pharmacokinetics (PK) and pharmacodynamics (PD) kineticsof BMS-247550, an epothilone analog, in patients with advanced solid tumors(abstract). Proc Am Soc Clin Oncol. 20:2001;A268.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 268
-
-
Damle, B.D.1
Letrent, S.2
Duncan, G.3
-
8
-
-
0034518173
-
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics
-
Downing K.H. Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu Rev Cell Dev Biol. 16:2000;89-111.
-
(2000)
Annu Rev Cell Dev Biol
, vol.16
, pp. 89-111
-
-
Downing, K.H.1
-
9
-
-
12944277104
-
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
-
Giannakakou P., Gussio R., Nogales E., et al. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc Natl Acad Sci USA. 97:2000;2904-2909.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2904-2909
-
-
Giannakakou, P.1
Gussio, R.2
Nogales, E.3
-
10
-
-
0029965897
-
Antimitotic natural products and their interactions with tubulin
-
Hamel E. Antimitotic natural products and their interactions with tubulin. Med Res Rev. 16:1996;207-231.
-
(1996)
Med Res Rev
, vol.16
, pp. 207-231
-
-
Hamel, E.1
-
11
-
-
0029776766
-
Epothilone a and B - Novel 16-membered macrolides with cytotoxic activity: Isolation, crystal structure, and conformation in solution
-
Höfle G., Bedorf N., Steinmetz H., Schemburg D., Gerth K., Reichenbach H. Epothilone A and B - novel 16-membered macrolides with cytotoxic activity: isolation, crystal structure, and conformation in solution. Angew Chem Int Ed Engl. 35:1996;1567-1569.
-
(1996)
Angew Chem Int Ed Engl
, vol.35
, pp. 1567-1569
-
-
Höfle, G.1
Bedorf, N.2
Steinmetz, H.3
Schemburg, D.4
Gerth, K.5
Reichenbach, H.6
-
12
-
-
0035479085
-
The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells
-
Kim J.S., Amorino G.P., Pyo H., Cao Q., Price J.O., Choy H. The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells. Int J Radiat Oncol Biol Phys. 51:2001;525-534.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, pp. 525-534
-
-
Kim, J.S.1
Amorino, G.P.2
Pyo, H.3
Cao, Q.4
Price, J.O.5
Choy, H.6
-
13
-
-
0031027531
-
Activities of the microtubule-stabilizing agents epothilones a and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R))
-
Kowalski R.J., Giannakakou P., Hamel E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 272:1997;2534-2541.
-
(1997)
J Biol Chem
, vol.272
, pp. 2534-2541
-
-
Kowalski, R.J.1
Giannakakou, P.2
Hamel, E.3
-
14
-
-
0016738010
-
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining
-
Krishan A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol. 66:1975;188-193.
-
(1975)
J Cell Biol
, vol.66
, pp. 188-193
-
-
Krishan, A.1
-
15
-
-
0032862087
-
Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines
-
Kurdoglu B., Cheong N., Guan J., Corn B.W., Curran W.J. Jr, Iliakis G. Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines. Clin Cancer Res. 5:1999;2580-2587.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2580-2587
-
-
Kurdoglu, B.1
Cheong, N.2
Guan, J.3
Corn, B.W.4
Curran Jr., W.J.5
Iliakis, G.6
-
16
-
-
0003334457
-
Preclinical pharmacology of the epothilone B analog BMS-247550 - An epothilone analog possessing potent activity against paclitaxel-sensitive and -resistant human tumors
-
Lee F.Y.F., Vite G., Borzilleri R., et al. Preclinical pharmacology of the epothilone B analog BMS-247550 - an epothilone analog possessing potent activity against paclitaxel-sensitive and -resistant human tumors. Clin Cancer Res. 6:(Suppl):2000;4580s.
-
(2000)
Clin Cancer Res
, vol.6
, Issue.SUPPL
-
-
Lee, F.Y.F.1
Vite, G.2
Borzilleri, R.3
-
17
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee F.Y.F., Borzilleri R., Fairchild C.R., et al. BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res. 7:2001;1429-1437.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1429-1437
-
-
Lee, F.Y.F.1
Borzilleri, R.2
Fairchild, C.R.3
-
18
-
-
0028196623
-
In vitro studies of Taxol as a radiation sensitizer in human tumor cells
-
Liebmann J., Cook J.A., Fisher J., Teague D., Mitchell J.B. In vitro studies of Taxol as a radiation sensitizer in human tumor cells. J Natl Cancer Inst. 86:1994;441-446.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 441-446
-
-
Liebmann, J.1
Cook, J.A.2
Fisher, J.3
Teague, D.4
Mitchell, J.B.5
-
19
-
-
26444616524
-
Phase I clinical trial of BMS-247550 (epothilone B analog; NSC #710428) in adult patients with advanced solid tumors [abstract]
-
LoRusso P.M., Wozniak A.J., Flaherty L.E., Shields A.F., Wright J., Lebwohl D. Phase I clinical trial of BMS-247550 (epothilone B analog; NSC #710428) in adult patients with advanced solid tumors [abstract]. Proc Am Soc Clin Oncol. 20:2001;A2125.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 2125
-
-
Lorusso, P.M.1
Wozniak, A.J.2
Flaherty, L.E.3
Shields, A.F.4
Wright, J.5
Lebwohl, D.6
-
20
-
-
0003264497
-
Phase I evaluation of an epothilone B analog (BMS-247550): Clinical findings and molecular correlates [abstract]
-
Mani S., McDaid H., Shen H.-J. Phase I evaluation of an epothilone B analog (BMS-247550): clinical findings and molecular correlates [abstract]. Proc Am Soc Clin Oncol. 20:2001;A269.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 269
-
-
Mani, S.1
McDaid, H.2
Shen, H.-J.3
-
21
-
-
0029144003
-
Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel
-
Milas L., Hunter N.R., Mason K.A., Milross C.G., Saito Y., Peters L.J. Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res. 55:1995;3564-3568.
-
(1995)
Cancer Res
, vol.55
, pp. 3564-3568
-
-
Milas, L.1
Hunter, N.R.2
Mason, K.A.3
Milross, C.G.4
Saito, Y.5
Peters, L.J.6
-
22
-
-
0030220881
-
Therapeutic potential of paclitaxel-radiation treatment of a murine ovarian carcinoma
-
Milas L., Saito Y., Hunter N., Milross C.G., Mason K.A. Therapeutic potential of paclitaxel-radiation treatment of a murine ovarian carcinoma. Radiother Oncol. 40:1996;163-170.
-
(1996)
Radiother Oncol
, vol.40
, pp. 163-170
-
-
Milas, L.1
Saito, Y.2
Hunter, N.3
Milross, C.G.4
Mason, K.A.5
-
23
-
-
0032900181
-
Combination of taxanes with radiation: Preclinical studies
-
Milas L., Milas M.M., Mason K.A. Combination of taxanes with radiation: preclinical studies. Semin Radiat Oncol. 9:1999;12-26.
-
(1999)
Semin Radiat Oncol
, vol.9
, pp. 12-26
-
-
Milas, L.1
Milas, M.M.2
Mason, K.A.3
-
24
-
-
0030748489
-
Enhanced radioresponse of paclitaxel-sensitive and -resistant tumours in vivo
-
Milross C.G., Mason K.A., Hunter N.R., et al. Enhanced radioresponse of paclitaxel-sensitive and -resistant tumours in vivo. Eur J Cancer. 33:1997;1299-1308.
-
(1997)
Eur J Cancer
, vol.33
, pp. 1299-1308
-
-
Milross, C.G.1
Mason, K.A.2
Hunter, N.R.3
-
25
-
-
0030761974
-
Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity
-
Muhlradt P.F., Sasse F. Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity. Cancer Res. 57:1997;3344-3346.
-
(1997)
Cancer Res
, vol.57
, pp. 3344-3346
-
-
Muhlradt, P.F.1
Sasse, F.2
-
26
-
-
0018387446
-
Promotion of microtubule assembly in vitro by taxol
-
Schiff P.B., Fant J., Horwitz S.B. Promotion of microtubule assembly in vitro by taxol. Nature. 277:1979;665-667.
-
(1979)
Nature
, vol.277
, pp. 665-667
-
-
Schiff, P.B.1
Fant, J.2
Horwitz, S.B.3
-
27
-
-
17344386474
-
Tumor-killer made; How does it work?
-
Service R.F. Tumor-killer made; how does it work? Science. 274:1996;2009.
-
(1996)
Science
, vol.274
, pp. 2009
-
-
Service, R.F.1
-
28
-
-
0002723564
-
X-ray and ultraviolet sensitivity of synchronized Chinese hamster cells at various stages of the cell cycle
-
Sinclair W.K., Morton R.A. X-ray and ultraviolet sensitivity of synchronized Chinese hamster cells at various stages of the cell cycle. Biophys J. 5:1965;1-25.
-
(1965)
Biophys J
, vol.5
, pp. 1-25
-
-
Sinclair, W.K.1
Morton, R.A.2
-
29
-
-
0013973616
-
X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells
-
Sinclair W.K., Morton R.A. X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat Res. 29:1966;450-474.
-
(1966)
Radiat Res
, vol.29
, pp. 450-474
-
-
Sinclair, W.K.1
Morton, R.A.2
-
30
-
-
1642397673
-
Phase I and pharmacology study of the epothilone B analog BMS-247550 in patients with advanced cancer [abstract]. Proceedings of the 11th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy
-
Spriggs D., Soignet S., Bienvenu B., Letrent S., Lebwohl D., Burris H. Phase I and pharmacology study of the epothilone B analog BMS-247550 in patients with advanced cancer [abstract]. Proceedings of the 11th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy. Clin Cancer Res. 6:(Suppl):2000;A574.
-
(2000)
Clin Cancer Res
, vol.6
, Issue.SUPPL
, pp. 574
-
-
Spriggs, D.1
Soignet, S.2
Bienvenu, B.3
Letrent, S.4
Lebwohl, D.5
Burris, H.6
-
31
-
-
0001252689
-
Phase I first-in-man study of the epothilone B analog BMS-247550 in patients with advanced cancer [abstract]
-
Spriggs D., Soignet S., Bienvenu B., et al. Phase I first-in-man study of the epothilone B analog BMS-247550 in patients with advanced cancer [abstract]. Proc Am Soc Clin Oncol. 20:2001;A428.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 428
-
-
Spriggs, D.1
Soignet, S.2
Bienvenu, B.3
-
32
-
-
0018425119
-
Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
-
Steel G.G., Peckham M.J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys. 5:1979;85-91.
-
(1979)
Int J Radiat Oncol Biol Phys
, vol.5
, pp. 85-91
-
-
Steel, G.G.1
Peckham, M.J.2
-
33
-
-
0027161151
-
Taxol as a radiation sensitizer: A flow cytometric study
-
Steren A., Sevin B.U., Perras J., et al. Taxol as a radiation sensitizer: a flow cytometric study. Gynecol Oncol. 50:1993;89-93.
-
(1993)
Gynecol Oncol
, vol.50
, pp. 89-93
-
-
Steren, A.1
Sevin, B.U.2
Perras, J.3
-
34
-
-
0027449908
-
Taxol sensitizes human ovarian cancer cells to radiation
-
Steren A., Sevin B.U., Perras J., et al. Taxol sensitizes human ovarian cancer cells to radiation. Gynecol Oncol. 48:1993;252-258.
-
(1993)
Gynecol Oncol
, vol.48
, pp. 252-258
-
-
Steren, A.1
Sevin, B.U.2
Perras, J.3
-
35
-
-
0033965785
-
Microtubule dynamics and tubulin interacting proteins
-
Walczak C.E. Microtubule dynamics and tubulin interacting proteins. Curr Opin Cell Biol. 12:2000;52-56.
-
(2000)
Curr Opin Cell Biol
, vol.12
, pp. 52-56
-
-
Walczak, C.E.1
-
36
-
-
0037081329
-
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells
-
Yamaguchi H., Paranawithana S.R., Lee M.W., Huang Z., Bhalla K.N., Wang H.G. Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells. Cancer Res. 62:2002;466-471.
-
(2002)
Cancer Res
, vol.62
, pp. 466-471
-
-
Yamaguchi, H.1
Paranawithana, S.R.2
Lee, M.W.3
Huang, Z.4
Bhalla, K.N.5
Wang, H.G.6
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