Immune system inflammation in cocaine dependent individuals: Implications for medications development

Human Psychopharmacology

Volumn 27, Issue 2, 2012, Pages 156-166

  Fox, Helen C ^a   D'Sa, Carrol ^a   Kimmerling, Anne ^a   Siedlarz, Kristen M ^a   Tuit, Keri L ^a   Stowe, Raymond ^b   Sinha, Rajita ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Microgen Laboratories   (United States)

Author keywords

cocaine dependence; cytokines; HPA axis; IL 11; IL 1ra; TNF

Indexed keywords

COCAINE; CYTOKINE; HYDROCORTISONE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALCOHOL CONSUMPTION; ANXIETY; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; CHRONIC STRESS; CIGARETTE SMOKING; CLINICAL ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRINKING BEHAVIOR; DRUG DEPENDENCE; DRUG EFFECT; EMOTION; FEMALE; HEART RATE; HUMAN; IMAGERY; IMMUNE SYSTEM; INFLAMMATION; MALE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; SALIVA LEVEL; SELF REPORT; STRESS; SUBSTANCE ABUSE; WITHDRAWAL SYNDROME;

ADULT; ALCOHOL DRINKING; BIOLOGICAL MARKERS; COCAINE-RELATED DISORDERS; CUES; FEMALE; HUMANS; IMAGERY (PSYCHOTHERAPY); INFLAMMATION; INFLAMMATION MEDIATORS; MALE; REINFORCEMENT (PSYCHOLOGY); SALIVA; STRESS, PSYCHOLOGICAL; TIME FACTORS; YOUNG ADULT;

EID: 84858066123     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.1251     Document Type: Article

References (100)

1. Anisman H, Merali Z,. 1999. Anhedonic and anxiogenic effects of cytokine exposure. Adv Exp Med Biol 461: 199-233. Review.
2. Anisman H, Poulter MO, Gandhi R, Merali Z, Hayley S,. 2007. Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations. J Neuroimmunol 186: 45-53. (Pubitemid 46770860)
3. Asadullah K, Sterry W, Volk HD,. 2003. Interleukin 10 therapy. Review of a new approach. Pharmacol Rev 55 (2): 241-269. Review. (Pubitemid 36666048)
4. Badrick E, Bobak M, Britton A, Kirschbaum C, Marmot M, Kumari M,. 2007. The relationship between smoking status and cortisol secretion. J Clin Endocrinol Metab 92: 819-824. (Pubitemid 46465649)
5. Bergquist KL, Fox HC, Sinha R,. 2010. Self-reports of interoceptive responses during stress and drug cue related experiences in cocaine and alcohol dependent individuals. Exp Clin Psychopharmacol 18 (3): 229-237
6. Blotta MH, DeKruyff RH, Umetsu DT,. 1997. Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. J Immunol 158: 5589-5595. (Pubitemid 127483960)
7. Bonaccorso S, Maier SF, Meltzer HY, Maes M,. 2003. Behavioral changes in rats after acute, chronic and repeated administration of interleukin-1beta: relevance for affective disorders. J Affect Disord 77: 143-148. (Pubitemid 37363342)
8. Brebner K, Hayley S, Zacharko R, Merali Z, Anisman H,. 2000. Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology 22: 566-580. (Pubitemid 30219401)
9. Breese GR, Chu K, Dayas CV, et al,. 2005. Stress enhancement of craving during sobriety: a risk for relapse. Alcohol Clin Exp Res 29 (2): 185-195. (Pubitemid 40250507)
10. Breese GR, Sinha R, Heilig M,. 2011. Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. Pharmacol Ther 129 (2): 149-171.
11. Butts CL, Sternberg EM,. 2008. Neuroendocrine factors alter host defense by modulating immune function. Cell Immunol 252: 7-15.
12. Bresnihan B,. 2001. The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin Arthritis Rheum 30 (5 Suppl 2): 17-20. (Pubitemid 32467131)
13. Cahalan D, Cisin IH, Crossley HM,. 1969. American drinking practices. A national study of drinking behaviors and attitudes. Monographs of the Rutgers Center of Alcohol Studies 6: 260.
14. Calcagni E, Elenkov I,. 2006. Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann N Y Acad Sci 1069: 62-76. (Pubitemid 43989851)
15. Chaplin T, Hong K-I, Bergquist K, Sinha R,. 2008. Sex differences in stress and alcohol cue-induced craving and emotion in social drinkers. Alcohol Clin Exp Res 31 (6): 603.
16. Chaplin TM, Hong K, Fox HC, Siedlarz KM, Bergquist K, Sinha R,. 2010. Behavioral arousal in response to stress and drug cue in alcohol and cocaine addicted individuals versus healthy controls. Hum Psychopharmacol Clin Exp 25 (5): 368-376.
17. Cook RT,. 1998. Alcohol abuse, alcoholism, and damage to the immune system - a review Alcohol Clin Exp Res 22: 1927-1942. Review. (Pubitemid 29031009)
18. Dantzer R, Kelley KW,. 1989. Stress and immunity: an integrated view of relationships between the brain and the immune system. Life Sci 44 (26): 1995-2008. Review. (Pubitemid 19156085)
19. Dantzer R, Kelley KW,. 2007. Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun 21: 153-160. (Pubitemid 46038917)
20. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW,. 2008. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9: 46-56. Review. (Pubitemid 350295688)
21. de Jong IE, de Kloet ER,. 2004. Glucocorticoids and vulnerability to psychostimulant drugs: toward substrate and mechanism. Ann N Y Acad Sci 1018: 192-198. (Pubitemid 38951406)
22. Delgado M,. 2003. Inhibition of interferon (IFN) gamma-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-10, and inducible nitric-oxide synthase expression. J Biol Chem 278: 27620-27629. (Pubitemid 36899948)
23. Deviere J, Content J, Denys C, et al,. 1989. High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. Clin Exp Immunol 77 (2): 221-225. (Pubitemid 19206491)
24. Dhillon NK, Williams R, Peng F, et al,. 2007. Cocaine-mediated enhancement of virus replication in macrophages: implications for human immunodeficiency virus-associated dementia. J Neurovirol 13 (6): 483-495.
25. Dinarello CA,. 2000. The role of the interleukin-1 receptor antagonist in blocking inflammation mediated by interleukin-1. N Engl J Med 343: 721-734.
26. Dunn AJ, Swiergiel AH, de Beaurepaire R,. 2005. Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev 29: 891-909. (Pubitemid 40755469)
27. Elenkov IJ,. 2008. Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being. Neurochem Int 52: 40-51 (Pubitemid 350235704)
28. Elenkov IJ, Chrousos, GP,. 1999. Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends Endocrinol Metab 10: 359-368. (Pubitemid 29496010)
29. Elenkov IJ, Chrousos GP,. 2006. Stress system - organization, physiology and immunoregulation. Neuroimmunomodulation 13: 257-267. (Pubitemid 47289508)
30. Emanuele N, LaPaglia N, Kovacs EJ, Emanuele MA,. 2005. Effects of chronic ethanol (EtOH) administration on pro-inflammatory cytokines of the hypothalamic-pituitary-gonadal (HPG) axis in female rats. Endocr Res 31: 9-16. (Pubitemid 41419980)
31. Falchetti R, Di Francesco P, Lanzilli G, Gaziano R, Casalinuovo IA, Ravagnan G, Garaci E,. 1995. In vitro effects of cocaine on cytokine secretion induced in murine splenic CD4+ T cells by antigen-specific stimulation. Cell Immunol 164 (1): 57-64
32. Falck RS, Wang J, Carlson RG, Eddy M, Siegal HA,. 2002. The prevalence and correlates of depressive symptomatology among a community sample of crack-cocaine smokers. J Psychoactive Drugs 34 (3): 281-8. (Pubitemid 35204597)
33. Fernandez-Botran R, Crespo FA, Sun X,. 2002. Soluble cytokine receptors in biological therapy. Expert Opin Biol Ther 2: 585-605. Review.
34. Fiocco U, Vezzù M, Cozzi L, Todesco S,. 2004. [IL-1Ra (recombinant human IL-1 receptor antagonist) in the treatment of rheumatoid arthritis: the efficacy]. Reumatismo 56 (1 Suppl 1): 62-73. Review. (Pubitemid 38596238)
35. First MB, Spitzer RL, Gibbon M, et al,. 1997. Structured Clinical Interview for the DSM-IV Axis I Disorders - Patient Edition (SCID-I/P, Version 2.0, 4/97 revision). New York State Psychiatric Institute: New York.
36. Fox HC, Berquist KL, Hong KI, Sinha R,. 2007. Stress-induced and alcohol cue-induced craving in recently abstinent alcohol dependent individuals. Alcohol Clin Exp Res 31 (3): 395-403. (Pubitemid 46239271)
37. Fox HC, Garcia M, Kemp K, Milivojevic V, Kreek MJ, Sinha R,. 2006. Gender differences in cardiovascular and corticoadrenal response to stress and drug-cue in cocaine dependent individuals. Psychopharmacology 185 (3): 348-357
38. Fox HC, Hong KI, Siedlarz KM, Bergquist KL, Anderson GM, Kreek MJ, Sinha R,. 2009. Gender dissociations in autonomic and HPA responses to stress and cues in alcohol dependent patients with cocaine abuse. Alcohol Alcohol 44 (6): 575-85.
39. Fox HC, Hong KI, Siedlarz KM, Sinha R,. 2008. Enhanced sensitivity to stress and drug/alcohol craving in abstinent cocaine dependent individuals compared to social drinkers. Neuropsychopharmacology 33 (4): 796-805. (Pubitemid 351252705)
40. Fox HC, Sinha R,. 2009. Sex differences in drug-related stress system changes: implications for treatment in substance-abusing women. Harv Rev Psychiatry 17 (2): 103-19.
41. Fox HC, Talih M, Malison R, Anderson GM, Kreek MJ, Sinha R,. 2005. Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and to drug-related cues. Psychoneuroendocrinology 30: 880-891. (Pubitemid 40977910)
42. Gaab J, Rohleder N, Heitz V, et al,. 2005. Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome. Psychoneuroendocrinology 30 (2): 188-198 (Pubitemid 39313115)
43. Gardner B, Zhu LX, Roth MD, Tashkin DP, Dubinett SM, Sharma S,. 2004. Cocaine modulates cytokine and enhances tumor growth through sigma receptors. J Neuroimmunol 147 (1-2): 95-98. (Pubitemid 38114955)
44. Gibb J, Hayley S, Gandhi R, Poulter MO, Anisman H,. 2008. Synergistic and additive actions of a psychosocial stressor and endotoxin challenge: circulating and brain cytokines, plasma corticosterone and behavioral changes in mice. Brain Behav Immun 22: 573-589.
45. Glaser R, Robles TF, Sheriden J, Malarkey WB, Kiecolt-Glaser JK,. 2003. Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults. Arch Gen Psychiatry 60: 1009-1014. (Pubitemid 37222084)
46. Gohier B, Goeb JL, Rannou-Dubas K, Fouchard I, CalAs P, Garré JB,. 2003. Hepatitis C, alpha interferon, anxiety and depression disorders: a prospective study of 71 patients. World J Biol Psychiatry 4: 115-118.
47. Gomez M, Raju SV, Viswanathan A, et al,. 2010. Ethanol upregulates glucocorticoid-induced leucine zipper expression and modulates cellular inflammatory responses in lung epithelial cells. J Immunol 184 (10): 5715-5722.
48. González-Quintela A, Dominguez-Santalla MJ, Pérez LF, Vidal C, Lojo S, Barrio E,. 2000. Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12. Cytokine 12 (9): 1437-1440
49. Grippo AJ, Johnson AK,. 2009. Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress 12 (1): 1-21.
50. Howren MB, Lamkin DM, Suls J,. 2009. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 71: 171-186. Review.
51. Hyman SM, Fox H, Hong KI, Doebrick C, Sinha R,. 2007. Stress and drug cue-induced craving in opioid dependent individuals in naltrexone treatment. Exp Clin Psychopharmacol 15 (2): 134-143. (Pubitemid 47445242)
52. Junghanns K, Backhaus J, Tietz U, et al,. 2003. Impaired serum cortisol stress response is a predictor of early relapse. Alcohol Alcohol 38: 189-193. (Pubitemid 36372411)
53. Junghanns K, Tietz U, Dibbelt L, et al,. 2005. Attenuated salivary cortisol secretion under cue exposure is associated with early relapse. Alcohol Alcohol 40 (1): 80-85.
54. Kent S, Bluthe R-M, Kelley KW, Dantzer R,. 1992. Sickness behavior as a new target for drug development. Trends Pharmacol Sci 13: 24-28.
55. Koob GF,. 2009. Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry 42 (Suppl 1): S32-S41.
56. Kronfol Z, Remick DG,. 2000. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry 157: 683-694. (Pubitemid 30249643)
57. Kubera M, Filip M, Basta-Kaim A, et al,. 2004. The effect of cocaine sensitization on mouse immunoreactivity. Eur J Pharmacol 483 (2-3): 309-315. (Pubitemid 38068415)
58. Kubera M, Filip M, Budziszewska B, et al,. 2008. Immunosuppression induced by a conditioned stimulus associated with cocaine self-administration. J Pharmacol Sci 107 (4): 361-369.
59. Kubera M, Kenis G, Bosmans E, et al,. 2000. Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission. Pol J Pharmacol 52 (3): 237-241. (Pubitemid 30479574)
60. Laird NM, Ware JH,. 1982. Random effects models for longitudinal data. Biometrics 38: 963-974. (Pubitemid 14272804)
61. Laso FJ, Lapeña P, Madruga JI, et al,. 1997. Alterations in tumor necrosis factor-alpha, interferon-gamma, and interleukin-6 production by natural killer cell-enriched peripheral blood mononuclear cells in chronic alcoholism: relationship with liver disease and ethanol intake. Alcohol Clin Exp Res 21 (7): 1226-1231. (Pubitemid 27446890)
62. Laso FJ, Madruga JI, San Miguel JF, et al,. 1996. Long lasting immunological effects of ethanol after withdrawal. Cytometry 26 (4): 275-280. (Pubitemid 27050664)
63. Lehto SM, Niskanen L, Miettola J, Tolmunen T, Viinamäki H, Mäntyselkä P,. 2010. Serum anti-inflammatory markers in general population subjects with elevated depressive symptoms. Neurosci Lett 484 (3): 201-205.
64. Leon LR, Kozak W, Rudolph K, Kluger MJ,. 1999. An antipyretic role for interleukin-10 in LPS fever in mice. Am J Physiol 276: R81-R89. (Pubitemid 29061692)
65. Liu L, Jia F, Yuan G, et al,. 2010. Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis. Psychiatry Res 176 (1): 1-7.
66. Maes M,. 1995. Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 19: 11-38. Review.
67. Maes M, Lin AH, Ombelet W, et al,. 2000. Immune activation in the early puerperium is related to postpartum anxiety and depressive symptoms. Psychoneuroendocrinology 25 (2): 121-137. (Pubitemid 29525386)
68. Maes M, Song C, Lin A, et al,. 1998. The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 10 (4): 313-318. (Pubitemid 28227076)
69. Maes M, Yirmyia R, Noraberg J, et al,. 2009. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis 24: 27-53.
70. Masumoto T, Onji M, Horiike N, Ohta Y,. 1993. Assay of serum interleukin 8 levels in patients with alcoholic hepatitis. Alcohol Alcohol Suppl 1A: 99-102. (Pubitemid 24010462)
71. McAfoose J, Baune BT,. 2009. Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33: 355-366.
72. McCance-Katz EF, Carroll KM, Rounsaville BJ,. 1999. Gender differences in treatment-seeking cocaine abusers - implications for treatment and prognosis. Am J Addict 8 (4): 300-311.
73. McCance-Katz EF, Hart CL, Boyarsky B, Kosten T, Jatlow P,. 2005. Gender effects following repeated administration of cocaine and alcohol in humans. Subst Use Misuse 40 (4): 511-528. (Pubitemid 40464354)
74. McNally L, Bhagwagar Z, Hannestad J,. 2008. Inflammation, glutamate, and glia in depression: a literature review. CNS Spectr 13: 501-510. Review. (Pubitemid 351965454)
75. Mello NK, Newman JL,. 2011. Discriminative and reinforcing stimulus effects of nicotine, cocaine, and cocaine+nicotine combinations in Rhesus monkeys. Exp Clin Psychopharmacol 19 (3): 203-14.
76. Mercer D, Woody G,. 1992. Addiction Counseling. Unpublished manuscript. University of Pennsylvania/ VAMC Center for Studies of Addiction.
77. Mesquita AR, Correia-Neves M, Roque S, et al,. 2008. IL-10 modulates depressive-like behavior. J Psychiatr Res 43: 89-97.
78. Moreland LW,. 2009. Cytokines as targets for anti-inflammatory agents. Ann N Y Acad Sci 1182: 88-96.
79. Patkar AA, Mannelli P, Peindl K, Murray HW, Meier B, Leone FT,. 2006. Changes in tobacco smoking following treatment for cocaine dependence. Am J Drug Alcohol Abuse 32 (2): 135-148. (Pubitemid 44341316)
80. Preston KL, Epstein DH,. 2011. Stress in the daily lives of cocaine and heroin users: relationship to mood, craving, relapse triggers, and cocaine use. Psychopharmacology (Berl) 218 (1): 29-37.
81. Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT,. 2008. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation 5: 10.
82. Ramierz F, Fowell DJ, Puklavec M,. 1996. Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol 156: 2406-2412. (Pubitemid 26091564)
83. Salome N, Tasiemski A, Dutriez I, Wigger A, Landgraf R, Viltart O,. 2008. Immune challenge induces differential corticosterone and interleukin-6 responsiveness in rats bred for extremes in anxiety-related behavior. Neuroscience 151: 1112-1118.
84. Shen HM, Kennedy JL, Ou DW,. 1994. Inhibition of cytokine release by cocaine. Int J Immunopharmacol 16 (4): 295-300. (Pubitemid 24128111)
85. Silverman MN, Macdougall MG, Hu F, Pace TW, Raison CL, Miller AH,. 2007. Endogenous glucocorticoids protect against TNF-alpha-induced increases in anxiety-like behavior in virally infected mice. Mol Psychiatry 12: 408-417. (Pubitemid 46496832)
86. Sinha R,. 2001. How does stress increase risk of drug abuse and relapse? Psychopharmacology (Berl) 158: 343-359. (Pubitemid 33141310)
87. Sinha R, Fox HC, Hong KA, Bergquist KL, Bhagwagar Z, Siedlatz K,. 2009. Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 34 (5): 1198-1208.
88. Sinha R, Fox HC, Hong KA, Siedlarz KA, Bergquist KT, Kreek MJ,. 2011. Stress and cue-induced alcohol craving, anxiety and adrenal sensitivity are predictive of alcohol relapse outcomes. Arch Gen Psychiatry 68 (9): 942-52
89. Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ,. 2006. Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychiatry 63 (3): 324-331. (Pubitemid 43345357)
90. Sinha R, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ,. 2003. Hypothalamic-pituitary-ACDrenal axis and sympatho-ACDreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology (Berl) 170: 62-72. (Pubitemid 37372479)
91. Sorocco KH, Lovallo WR, Vincent AS, Collins FL,. 2006. Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholism. Int J Psychophysiol 59: 210-217.
92. Stanulis ED, Jordan SD, Rosecrans JA, Holsapple MP,. 1997. Disruption of Th1/Th2 cytokine balance by cocaine is mediated by corticosterone. Immunopharmacology 37 (1): 25-33. (Pubitemid 27339017)
93. Stewart J,. 2003. Stress and relapse to drug seeking: studies in laboratory animals shed light on mechanisms and sources of long-term vulnerability. Am J Addict 12 (1): 1-17. Review. (Pubitemid 36307425)
94. Tilders FJ, Schmidt ED, de Goeij DC,. 1993. Phenotypic plasticity of CRF neurons during stress. Ann N Y Acad Sci 697: 39-52. (Pubitemid 24028953)
95. Turnbull AV, Rivier CL,. 1999. Regulation of the hypothalamic-pituitary- adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 79: 1-71. (Pubitemid 29056948)
96. Valentine AD, Meyers CA, Kling MA, Richelson E, Hauser P,. 1998. Mood and cognitive side effects of interferon-alpha therapy. Semin Oncol 25 (1 Suppl 1): 39-47. (Pubitemid 28093154)
97. Wang Y, Dennis SH, Watson RR,. 1994. In vivo and in vitro cocaine modulation of production of cytokines in C57BL/6 mice. Life Sci 54: 401-411. (Pubitemid 24052768)
98. Weinstein AA, Deuster PA, Francis JL, Bonsall RW, Tracy RP, Kop WJ,. 2010. Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression. Biol Psychol 84 (2): 228-234.
99. Yamada K,. 2008. Endogenous modulators for drug dependence. Biol Pharm Bull 31 (9): 1635-1638.
100. Yamagata T, Ichinose M,. 2006. Agents against cytokine synthesis or receptors. Eur J Pharmacol 533 (1-3): 289-301. (Pubitemid 43340020)