C-Jun regulates the stability of anti-apoptotic ΔNp63 in amyloid-β-induced apoptosis

Journal of Alzheimer's Disease

Volumn 28, Issue 3, 2012, Pages 685-694

  Fonseca, Maria B ^a   Nunes, Ana F ^a   Rodrigues, Cecília M P ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Amyloid peptide; apoptosis; c Jun; tauroursodeoxycholic acid; Np63

Indexed keywords

DELTA NP63 PROTEIN; ISOPROTEIN; PROTEASOME; PROTEIN C JUN; PROTEIN P63; SMALL INTERFERING RNA; TAUROURSODEOXYCHOLIC ACID; TRANSACTIVATION DOMAIN P63 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRESS; CONTROLLED STUDY; DOWN REGULATION; GENOTOXICITY; MOLECULAR MECHANICS; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; UPREGULATION;

EID: 84858016001     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-111547     Document Type: Article

References (42)

1. Selkoe DJ (2001) Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81, 741-766.
2. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW (1993) Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci U S A 90, 7951-7955. (Pubitemid 23260832)
3. Anderson AJ, Su JH, Cotman CW (1996) DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci 16, 1710-1719.
4. Estus S, Tucker HM, van Rooyen C, Wright S, Brigham EF, Wogulis M, Rydel RE (1997) Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction. J Neurosci 17, 7736- 7745.
5. Ramalho RM, Ribeiro PS, Solá S, Castro RE, Steer CJ, Rodrigues CM (2004) Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide- induced apoptosis of PC12 cells. J Neurochem 90, 567-575. (Pubitemid 38989387)
6. Solá S, Castro RE, Laires PA, Steer CJ, Rodrigues CM (2003) Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. Mol Med 9, 226-234. (Pubitemid 38858177)
7. Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira J, Tabira T (2005) Intracellular Abeta42 activates p53 promoter: A pathway to neurodegeneration in Alzheimer's disease. FASEB J 19, 255- 257.
8. Ramalho RM, Viana RJ, Low WC, Steer CJ, Rodrigues CM (2008) Bile acids and apoptosis modulation: An emerging role in experimental Alzheimer's disease. Trends Mol Med 14, 54-62.
9. Ramalho RM, Borralho PM, Castro RE, Solá S, Steer CJ, Rodrigues CM (2006) Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. J Neurochem 98, 1610-1618. (Pubitemid 44200450)
10. Solá S, Amaral JD, Borralho PM, Ramalho RM, Castro RE, Aranha MM, Steer CJ, Rodrigues CM (2006) Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis. Mol Endocrinol 20, 2292-2303. (Pubitemid 44496402)
11. Rodrigues CM, Solá S, Brito MA, Brondino CD, Brites D, Moura JJ (2001) Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: Protective role of tauroursodeoxycholate. Biochem Biophys Res Commun 281, 468-474. (Pubitemid 32928179)
12. Viana RJ, Steer CJ, Rodrigues CM (2011) Amyloid-beta peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94. J Alzheimers Dis 27, 61-73.
13. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with trans-activating, death-inducing, and dominant-negative activities. Mol Cell 2, 305-316. (Pubitemid 128379271)
14. Yang A, Kaghad M, Caput D, McKeon F (2002) On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet 18, 90-95. (Pubitemid 34127808)
15. Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR (2005) p63 is an essential proapoptotic protein during neural development. Neuron 48, 743-756. (Pubitemid 41759426)
16. Galli F, Rossi M, D'Alessandra Y, De Simone M, Lopardo T, Haupt Y, Alsheich-Bartok O, Anzi S, Shaulian E, Calabrò V, La Mantia G, Guerrini L (2010) MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation. J Cell Sci 123, 2423-2433.
17. Liefer KM, Koster MI, Wang XJ, Yang A, McKeon F, Roop DR (2000) Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res 60, 4016-4020. (Pubitemid 30636575)
18. Chatterjee A, Upadhyay S, Chang X, Nagpal JK, Trink B, Sidransky D (2008) U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha. Cell Cycle 7, 1231-1237. (Pubitemid 351749277)
19. Westfall MD, Joyner AS, Barbieri CE, Livingstone M, Pietenpol JA (2005) Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha. Cell Cycle 4, 710-716. (Pubitemid 41353857)
20. Lazzari C, Prodosmo A, Siepi F, Rinaldo C, Galli F, Gentileschi M, Bartolazzi A, Costanzo A, Sacchi A, Guerrini L, Soddu S (2011) HIPK2 phosphorylates DeltaNp63alpha and promotes its degradation in response to DNA damage. Oncogene, doi: 10.1038/onc.2011.182.
21. Papoutsaki M, Moretti F, Lanza M, Marinari B, Sartorelli V, Guerrini L, Chimenti S, Levrero M, Costanzo A (2005) A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes. Oncogene 24, 6970-6975. (Pubitemid 41509419)
22. Iwasaki K, Sunderland T, Kusiak JW, Wolozin B (1996) Changes in gene transcription during a beta-mediated cell death. Mol Psychiatry 1, 65-71. (Pubitemid 126442397)
23. Viana RJ, Ramalho RM, Nunes AF, Steer CJ, Rodrigues CM (2010) Modulation of amyloid-beta peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation. J Alzheimers Dis 22, 557-568.
24. Anderson AJ, Cummings BJ, Cotman CW (1994) Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: Association with pathology. Exp Neurol 125, 286-295. (Pubitemid 24076106)
25. Kihiko ME, Tucker HM, Rydel RE, Estus S (1999) c-Jun contributes to amyloid beta-induced neuronal apoptosis but is not necessary for amyloid beta-induced c-jun induction. J Neurochem 73, 2609-2612.
26. Yao JY, Pao CC, Chen JK (2010) Transcriptional activity of TAp63 promoter is regulated by c-jun. J Cell Physiol 225, 898-904.
27. Stine WBJ, Dahlgren KN, Krafft GA, LaDu MJ (2003) In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis. J Biol Chem 278, 11612- 11622.
28. Bjerke M, Portelius E, Minthon L, Wallin A, Anckarsäter H, Anckarsäter R, Andreasen N, Zetterberg H, Andreasson U, Blennow K (2010) Confounding factors influencing amyloid beta concentration in cerebrospinal fuid. Int J Alzheimers Dis 2010, pii: 986310.
29. Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, kurth JH, Rydel RE, Rogers J (1999) Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155, 853-862. (Pubitemid 29426831)
30. Kirschner RD, Sänger K, Müller GA, Engeland K (2008) Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site. Nucleic Acids Res 36, 2969-2980. (Pubitemid 351737189)
31. Sayan BS, Sayan AE, Yang AL, Aqeilan RI, Candi E, Cohen GM, Knight RA, Croce CM, Melino G (2007) Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis. Proc Natl Acad Sci U S A 104, 10871- 10876.
32. Hershkovitz Rokah O, Shpilberg O, Granot G (2010) NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gammadependent growth arrest. PLoS One 5, e11401.
33. Gressner O, Schilling T, Lorenz K, Schulze Schleithoff E, Koch A, Schulze-Bergkamen H, Lena AM, Candi E, Terrinoni A, Catani MV, Oren M, Melino G, Krammer PH, Stremmel W, Müller M (2005) TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J 24, 2458-2471. (Pubitemid 41032596)
34. Vanbokhoven H, Melino G, Candi E, Declercq W (2011) p63, a story of mice and men. J Invest Dermatol 131, 1196-1207.
35. Hess J, Angel P, Schorpp-Kistner M (2004) AP-1 subunits: Quarrel and harmony among siblings. J Cell Sci 117, 5965- 5973.
36. Behrens A, Sibilia M, Wagner EF (1999) Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 21, 326-329. (Pubitemid 29124945)
37. Suganuma T, Mushegian A, Swanson SK, Abmayr SM, Florens L, Washburn MP, Workman JL (2010) The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. Cell 142, 726-736.
38. Bakkers J, Camacho-Carvajal M, Nowak M, Kramer C, Danger B, Hammerschmidt M (2005) Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo. Cell Cycle 4, 790-800. (Pubitemid 41353831)
39. Gregori L, Fuchs C, Figueirado-Pereira ME, Nostrand WEV, Goldgaber D (1995) Amyloid β-protein inhibits ubiquitin-dependent protein degradation in vitro. J Biol Chem 270, 19702-19708.
40. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM (2008) Aβ inhibits the proteosome and enhances amyloid and accumulation. Neurobiol Aging 29, 1607-1161.
41. Lanni C, Nardinocchi L, Puca R, Stanga S, Uberti D, Memo M, Govoni S, D'Orazi G, Racchi M (2010) Homeodomain interacting protein kinase 2: A target of alzheimer's beta amyloid leading to misfolded p53 and inappropriated cell survival. PLoS One 5, e10171.
42. 1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses. Neurobiol Dis 25, 11061-11070.