Mitochondrial DNA mutations in cancer - From bench to bedside

Frontiers in Bioscience

Volumn 15, Issue 2, 2010, Pages 437-460

  Czarnecka, Anna Malgorzata ^a,b   Kukwa, Wojciech ^a   Krawczyk, Tomasz ^c   Scinska, Anna ^a   Kukwa, Andrzej ^a   Cappello, Francesco ^d  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

^c POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

^d UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cancer; Mitochondria; Molecular Marker; Mutation; OXPHOS; Review

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; BIOLOGICAL MODEL; CELL PROLIFERATION; CELL TRANSFORMATION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; MUTATION; NEOPLASM; PATHOLOGY; REVIEW; TRANSLATIONAL RESEARCH;

APOPTOSIS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DNA, MITOCHONDRIAL; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; REACTIVE OXYGEN SPECIES; TRANSLATIONAL RESEARCH;

EID: 77951230124     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3629     Document Type: Article

References (166)

1. C. DeHaan, B. Habibi-Nazhad, E. Yan, N. Salloum, M. Parliament and J. Allalunis-Turner: Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells. Mol Cancer, 3, 19 (2004)
2. M. Brandon, P. Baldi and D. C. Wallace: Mitochondrial mutations in cancer. Oncogene, 25(34), 4647-62 (2006) (Pubitemid 44187615)
3. D. C. Wallace: A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet, 39, 359-407 (2005) (Pubitemid 43011120)
4. J. Jonasson, S. Povey and H. Harris: The analysis of malignancy by cell fusion. VII. Cytogenetic analysis of hybrids between malignant and diploid cells and of tumours derived from them. J Cell Sci, 24, 217-54 (1977) (Pubitemid 8090248)
5. O. Warburg: On the Origin of Cancer Cells. Science, 123(1), 309-314 (1956)
6. E. Gottlieb and I. P. Tomlinson: Mitochondrial tumour suppressors: a genetic and biochemical update. Nat Rev Cancer, 5(11), 857-66 (2005) (Pubitemid 41746030)
7. R. J. Gillies and R. A. Gatenby: Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev, 26(2), 311-7 (2007) (Pubitemid 47101668)
8. H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Beroud, J. Demont, R. Bouvier, H. Schagger and C. Godinot: Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis, 23(5), 759-68 (2002) (Pubitemid 34567514)
9. J. S. Modica-Napolitano, M. Kulawiec and K. K. Singh: Mitochondria and human cancer. Curr Mol Med, 7(1), 121-31 (2007) (Pubitemid 46322283)
10. A. M. Czarnecka, A. Marino Gammazza, V. Di Felice, G. Zummo and F. Cappello: Cancer as a "Mitochondriopathy". J. Cancer Mol., 3(3), 71-79 (2007)
11. B. Linnartz, R. Anglmayer and S. Zanssen: Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodysplastic syndromes. Cancer Res, 64(6), 1966-71 (2004) (Pubitemid 38339441)
12. S. DiMauro: Mitochondrial diseases. Biochim Biophys Acta, 1658(1-2), 80-8 (2004)
13. J. S. Carew and P. Huang: Mitochondrial defects in cancer. Molecular Cancer, 1 (2002)
14. B. Baysal: Mitochondria: more than mitochondrial DNA in cancer. PLoS Med, 3(3), e156 (2006)
15. A. Czarnecka, P. Golik and E. Bartnik: Mitochondrial DNA mutations in human neoplasia. J Appl Genet, 47(1), 67-78 (2006) (Pubitemid 43232163)
16. A. S. Don and P. J. Hogg: Mitochondria as cancer drug targets. Trends Mol Med, 10(8), 372-8 (2004) (Pubitemid 39061138)
17. K. Ishikawa, K. Takenaga, M. Akimoto, N. Koshikawa, A. Yamaguchi, H. Imanishi, K. Nakada, Y. Honma and J. Hayashi: ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science, 320(5876), 661-4 (2008) (Pubitemid 351928347)
18. F. O. Aikhionbare, M. Khan, D. Carey, J. Okoli and R. Go: Is cumulative frequency of mitochondrial DNA variants a biomarker for colorectal tumor progression? Mol Cancer, 3, 30 (2004)
19. S. Datta, M. Majumder, N. K. Biswas, N. Sikdar and B. Roy: Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and Autosomal GSTP1 locus. Cancer, 110(9), 1991-9 (2007) (Pubitemid 350036858)
20. K. Darvishi, S. Sharma, A. K. Bhat, E. Rai and R. N. Bamezai: Mitochondrial DNA G10398A polymorphism imparts maternal Haplogroup N a risk for breast and esophageal cancer. Cancer Lett, 249(2), 249-55 (2007) (Pubitemid 46452933)
21. H. A. Coller, K. Khrapko, N. D. Bodyak, E. Nekhaeva, P. Herrero-Jimenez and W. G. Thilly: High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat Genet, 28, 147-150 (2001) (Pubitemid 32538059)
22. B. E. Baysal: Role of mitochondrial mutations in cancer. Endocr Pathol, 17(3), 203-12 (2006) (Pubitemid 46279668)
23. A. Salas, Y. G. Yao, V. Macaulay, A. Vega, A. Carracedo and H. J. Bandelt: A critical reassessment of the role of mitochondria in tumorigenesis. PLoS Med, 2(11), e296 (2005)
24. Y. Wang, V. W. Liu, H. Y. Ngan and P. Nagley: Frequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancers. Ann N Y Acad Sci, 1042(1), 123-9 (2005) (Pubitemid 40967629)
25. L. M. Booker, G. M. Habermacher, B. C. Jessie, Q. C. Sun, A. K. Baumann, M. Amin, S. D. Lim, C. Fernandez-Golarz, R. H. Lyles, M. D. Brown, F. F. Marshall and J. A. Petros: North American white mitochondrial haplogroups in prostate and renal cancer. J Urol, 175(2), 468-72 (2006) (Pubitemid 43067327)
26. J. A. Petros, A. K. Baumann, E. Ruiz-Pesini, M. B. Amin, C. Q. Sun, J. Hall, S. Lim, M. M. Issa, W. D. Flanders, S. H. Hosseini, F. F. Marshall and D. C. Wallace: mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci U S A, 102(3), 719-24 (2005) (Pubitemid 40282732)
27. Y. Shidara, K. Yamagata, T. Kanamori, K. Nakano, J. Q. Kwong, G. Manfredi, H. Oda and S. Ohta: Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res, 65(5), 1655-63 (2005) (Pubitemid 40478589)
28. C. Vives-Bauza, R. Gonzalo, G. Manfredi, E. Garcia-Arumi and A. L. Andreu: Enhanced ROS production and antioxidant defenses in cybrids harbouring mutations in mtDNA. Neurosci Lett, 391(3), 136-41 (2006) (Pubitemid 41736187)
29. P. Kakkar and B. K. Singh: Mitochondria: a hub of redox activities and cellular distress control. Mol Cell Biochem, 305(1-2), 235-53 (2007) (Pubitemid 47517185)
30. G. Amuthan, G. Biswas, S. Y. Zhang, A. Klein-Szanto, C. Vijayasarathy and N. G. Avadhani: Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. Embo J, 20(8), 1910-20 (2001) (Pubitemid 32397393)
31. M. Kulawiec, H. Arnouk, M. M. Desouki, L. Kazim, I. Still and K. K. Singh: Proteomic analysis of mitochondria-tonucleus retrograde response in human cancer. Cancer Biol Ther, 5(8), 967-75 (2006)
32. K. K. Singh, M. Kulawiec, I. Still, M. M. Desouki, J. Geradts and S. Matsui: Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene, 354, 140-6 (2005) (Pubitemid 41116693)
33. D. J. Smiraglia, M. Kulawiec, G. L. Bistulfi, S. Ghoshal and K. K. Singh: A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol Ther, 7(8) (2008)
34. C. Desler, B. Munch-Petersen, T. Stevnsner, S. Matsui, M. Kulawiec, K. K. Singh and L. J. Rasmussen: Mitochondria as determinant of nucleotide pools and chromosomal stability. Mutat Res, 625(1-2), 112-24 (2007) (Pubitemid 350016111)
35. D. M. Hockenbery: A mitochondrial Achilles' heel in cancer. Cancer Cell, 2, 1-2 (2002)
36. L. H. Augenlicht and B. G. Heerdt: Mitochondria: integrators in tumorigenesis? Nat Genet, 28, 104-105 (2001) (Pubitemid 32538047)
37. E. Bartnik, A. Lorenc and K. Mroczek: Human mitochondria in health, disease, ageing and cancer. J Appl Genet, 42(1), 65-71 (2001) (Pubitemid 33669657)
38. N. O. Bianchi, M. S. Bianchi and S. M. Richard: Mitochondrial genome instability in human cancer. Reviews in Mutation Research, 488, 9-23 (2001) (Pubitemid 32166780)
39. S. M. Richard, G. Bailliet, G. L. Paez, M. S. Bianchi, P. Peltomaki and N. O. Bianchi: Nuclear and Mitochondrial Genome Instability in Human Breast Cancer. Cancer Research, 60, 4231-4237 (2000) (Pubitemid 30636610)
40. J. S. Carew and P. Huang: Mitochondrial defects in cancer. Molecular Cancer, 1, 9 (2002)
41. J. W. Shay and H. Werbin: Are mitochondrial DNA mutations involved in the carcinogenic process? Mutation Research, 186, 149-160 (1987) (Pubitemid 17135760)
42. P. F. Chinnery and D. M. Turnbull: Epidemiology and Treatment of Mitochondrial Disorders. Am J Med Genet (Semin. Med. Gent.), 106, 94-101 (2001)
43. S. DiMauro and E. A. Schon: The mitochondrial respiratory chain and its disorders. In: Mitochondrial Medicine. Ed S. DiMauro, M. Hirano&E. A. Schon. Informa Healthcare, Abingdon (2006)
44. S. M. Richard, G. Bailliet, G. L. Paez, M. S. Bianchi, P. Peltomaki and N. O. Bianchi: Nuclear and mitochondrial genome instability in human breast cancer. Cancer Res, 60(15), 4231-7 (2000) (Pubitemid 30636610)
45. D. Chen, Z. Yu, Z. Zhu and C. D. Lopez: The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. Cancer Res, 66(7), 3485-94 (2006)
46. G. F. Chen, F. L. Chan, B. F. Hong, L. W. Chan and P. S. Chan: Mitochondrial DNA mutations in chemical carcinogeninduced rat bladder and human bladder cancer. Oncol Rep, 12(2), 463-72 (2004)
47. M. J. Jackson, S. Papa, J. Bolanos, R. Bruckdorfer, H. Carlsen, R. M. Elliott, J. Flier, H. R. Griffiths, S. Heales, B. Holst, M. Lorusso, E. Lund, J. Oivind Moskaug, U. Moser, M. Di Paola, M. C. Polidori, A. Signorile, W. Stahl, J. Vina-Ribes and S. B. Astley: Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Mol Aspects Med, 23(1-3), 209-85 (2002) (Pubitemid 34678688)
48. M. Nishikawa, S. Nishiguchi, K. Kioka, A. Tamori and M. Inoue: Interferon reduces somatic mutation of mitochondrial DNA in liver tissues from chronic viral hepatitis patients. J Viral Hepat, 12(5), 494-8 (2005) (Pubitemid 41224253)
49. L. C. Greaves, S. L. Preston, P. J. Tadrous, R. W. Taylor, M. J. Barron, D. Oukrif, S. J. Leedham, M. Deheragoda, P. Sasieni, M. R. Novelli, J. A. Jankowski, D. M. Turnbull, N. A. Wright and S. A. McDonald: Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proc Natl Acad Sci U S A, 103(3), 714-9 (2006) (Pubitemid 43153091)
50. J. Z. Chen, N. Gokden, G. F. Greene, B. Green and F. F. Kadlubar: Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesis. Carcinogenesis, 24(9), 1481-7 (2003) (Pubitemid 37160838)
51. R. H. Xu, H. Pelicano, Y. Zhou, J. S. Carew, L. Feng, K. N. Bhalla, M. J. Keating and P. Huang: Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res, 65(2), 613-21 (2005)
52. E. Hervouet, H. Simonnet and C. Godinot: Mitochondria and reactive oxygen species in renal cancer. Biochimie, 89(9), 1080-8 (2007) (Pubitemid 47248004)
53. W. J. Koopman, S. Verkaart, H. J. Visch, F. H. van der Westhuizen, M. P. Murphy, L. W. van den Heuvel, J. A. Smeitink and P. H. Willems: Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. Am J Physiol Cell Physiol, 288(6), C1440-50 (2005) (Pubitemid 40991081)
54. S. Srivastava, J. N. Barrett and C. T. Moraes: PGC- 1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations. Hum Mol Genet, 16(8), 993-1005 (2007) (Pubitemid 47062742)
55. M. Sanchez-Cespedes, P. Parrella, S. Nomoto, D. Cohen, Y. Xiao, M. Esteller, C. Jeronimo, R. C. Jordan, T. Nicol, W. M. Koch, M. Schoenberg, P. Mazzarelli, V. M. Fazio and D. Sidransky: Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. Cancer Res, 61(19), 7015-9 (2001) (Pubitemid 32946487)
56. J. Z. Chen, N. Gokden, G. F. Greene, P. Mukunyadzi and F. F. Kadlubar: Extensive somatic mitochondrial mutations in primary prostate cancer using laser capture microdissection. Cancer Res, 62(22), 6470-4 (2002) (Pubitemid 35364109)
57. G. Tamura, S. Nishizuka, C. Maesawa, Y. Suzuki, T. Iwaya, K. Sakata, Y. Endoh and T. Motoyama: Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients. Eur J Cancer, 35(2), 316-9 (1999) (Pubitemid 29136785)
58. D. J. Tan, J. Chang, L. L. Liu, R. K. Bai, Y. F. Wang, K. T. Yeh and L. J. Wong: Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer. BMC Cancer, 6, 93 (2006)
59. E. Kirches, G. Krause, M. Warich-Kirches, S. Weis, T. Schneider, B. Meyer-Puttlitz, C. Mawrin and K. Dietzmann: High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples. Int J Cancer, 93(4), 534-8 (2001) (Pubitemid 32701412)
60. V. W. Liu, H. H. Shi, A. N. Cheung, P. M. Chiu, T. W. Leung, P. Nagley, L. C. Wong and H. Y. Ngan: High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas. Cancer Res, 61(16), 5998-6001 (2001) (Pubitemid 32762527)
61. C. Jeronimo, S. Nomoto, O. L. Caballero, H. Usadel, R. Henrique, G. Varzim, J. Oliveira, C. Lopes, M. S. Fliss and D. Sidransky: Mitochondrial mutations in early stage prostate cancer and bodily fluids. Oncogene, 20(37), 5195-8 (2001) (Pubitemid 32844048)
62. S. Nomoto, K. Yamashita, K. Koshikawa, A. Nakao and D. Sidransky: Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma. Clin Cancer Res, 8(2), 481-7 (2002) (Pubitemid 34193968)
63. M. Deichmann, B. Kahle, A. Benner, M. Thome, B. Helmke and H. Naher: Somatic mitochondrial mutations in melanoma resection specimens. Int J Oncol, 24(1), 137-41 (2004)
64. V. W. Liu, H. J. Yang, Y. Wang, P. C. Tsang, A. N. Cheung, P. M. Chiu, T. Y. Ng, L. C. Wong, P. Nagley and H. Y. Ngan: High frequency of mitochondrial genome instability in human endometrial carcinomas. Br J Cancer, 89(4), 697-701 (2003) (Pubitemid 37076176)
65. P. M. Chiu, V. W. Liu, H. Y. Ngan, U. S. Khoo and A. N. Cheung: Detection of mitochondrial DNA mutations in gestational trophoblastic disease. Hum Mutat, 22(2), 177 (2003)
66. B. C. Tong, P. K. Ha, K. Dhir, M. Xing, W. H. Westra, D. Sidransky and J. A. Califano: Mitochondrial DNA alterations in thyroid cancer. J Surg Oncol, 82(3), 170-3 (2003) (Pubitemid 36278264)
67. D. Meierhofer, J. A. Mayr, K. Fink, N. Schmeller, B. Kofler and W. Sperl: Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism. Br J Cancer, 94(2), 268-74 (2006) (Pubitemid 43151546)
68. M. S. Fliss, H. Usadel, O. L. Caballero, L. Wu, M. R. Buta, S. M. Eleff, J. Jen and D. Sidransky: Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science, 287(5460), 2017-9 (2000) (Pubitemid 30158678)
69. Y. Wang, V. W. Liu, H. Y. Ngan and P. Nagley: Frequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancers. Ann N Y Acad Sci, 1042, 123-9 (2005) (Pubitemid 40967629)
70. G. Guleng, T. Lovig, G. I. Meling, S. N. Andersen and T. O. Rognum: Mitochondrial microsatellite instability in colorectal carcinomas-frequency and association with nuclear microsatellite instability. Cancer Lett, 219(1), 97-103 (2005) (Pubitemid 40203176)
71. T. Hiyama, S. Tanaka, H. Shima, K. Kose, H. Tuncel, M. Ito, Y. Kitadai, M. Sumii, M. Yoshihara, F. Shimamoto, K. Haruma and K. Chayama: Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer. Oncol Rep, 10(6), 1837-41 (2003)
72. M. Poetsch, A. Petersmann, E. Lignitz and B. Kleist: Relationship between mitochondrial DNA instability, mitochondrial DNA large deletions, and nuclear microsatellite instability in head and neck squamous cell carcinomas. Diagn Mol Pathol, 13(1), 26-32 (2004) (Pubitemid 38263880)
73. A. Vega, A. Salas, E. Gamborino, M. J. Sobrido, V. Macaulay and A. Carracedo: mtDNA mutations in tumors of the central nervous system reflect the neutral evolution of mtDNA in populations. Oncogene, 23(6), 1314-20 (2004) (Pubitemid 38297187)
74. V. Maximo, P. Soares, J. Lima, J. Cameselle-Teijeiro and M. Sobrinho-Simoes: Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hurthle cell tumors. Am J Pathol, 160(5), 1857-65 (2002) (Pubitemid 34525665)
75. Y. Li, S. Weibing, H. Liu, J. Hongli, L. Zhuosheng, W. Yadong, X. Bing and F. Daiming: Mitochondrial DNA from colorectal cancer cells promotes the malignant phenotype of NIH3T3 cells. Cell Biol Int (2008)
76. H. C. Lee, S. H. Li, J. C. Lin, C. C. Wu, D. C. Yeh and Y. H. Wei: Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutat Res, 547(1-2), 71-8 (2004)
77. H. C. Lee, P. H. Yin, J. C. Lin, C. C. Wu, C. Y. Chen, C. W. Wu, C. W. Chi, T. N. Tam and Y. H. Wei: Mitochondrial Genome Instability and mtDNA Depletion in Human Cancers. Ann N Y Acad Sci, 1042(1), 109-22 (2005)
78. M. Yu, Y. Zhou, Y. Shi, L. Ning, Y. Yang, X. Wei, N. Zhang, X. Hao and R. Niu: Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life, 59(7), 450-7 (2007) (Pubitemid 47124001)
79. X. W. Huang, Q. Zhao, D. Z. Chen and L. S. Zhang: [Mutations in the D-loop region of mitochondrial DNA and the ROS level in the tissue of hepatocellular carcinoma]. Yi Chuan, 27(1), 14-20 (2005)
80. A. Tamori, S. Nishiguchi, M. Nishikawa, S. Kubo, N. Koh, K. Hirohashi, S. Shiomi and M. Inoue: Correlation between clinical characteristics and mitochondrial D-loop DNA mutations in hepatocellular carcinoma. J Gastroenterol, 39(11), 1063-8 (2004) (Pubitemid 39618789)
81. P. O. Van Trappen, T. Cullup, R. Troke, D. Swann, J. H. Shepherd, I. J. Jacobs, S. A. Gayther and C. A. Mein: Somatic mitochondrial DNA mutations in primary and metastatic ovarian cancer. Gynecol Oncol, 104(1), 129-33 (2007) (Pubitemid 46075144)
82. M. Poetsch, T. Dittberner, A. Petersmann and C. Woenckhaus: Mitochondrial DNA instability in malignant melanoma of the skin is mostly restricted to nodular and metastatic stages. Melanoma Res, 14(6), 501-8 (2004) (Pubitemid 40221141)
83. F. Navaglia, D. Basso, P. Fogar, C. Sperti, E. Greco, C. F. Zambon, A. Stranges, A. Falda, S. Pizzi, A. Parenti, S. Pedrazzoli and M. Plebani: Mitochondrial DNA D-loop in pancreatic cancer: somatic mutations are epiphenomena while the germline 16519 T variant worsens metabolism and outcome. Am J Clin Pathol, 126(4), 593-601 (2006) (Pubitemid 44498510)
84. S. L. Prior, A. P. Griffiths, J. M. Baxter, P. W. Baxter, S. C. Hodder, K. C. Silvester and P. D. Lewis: Mitochondrial DNA mutations in oral squamous cell carcinoma. Carcinogenesis, 27(5), 945-50 (2006)
85. A. Lievre, H. Blons, A. M. Houllier, O. Laccourreye, D. Brasnu, P. Beaune and P. Laurent-Puig: Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinoma. Br J Cancer, 94(5), 692-7 (2006) (Pubitemid 43361901)
86. A. Lievre, C. Chapusot, A. M. Bouvier, F. Zinzindohoue, F. Piard, P. Roignot, L. Arnould, P. Beaune, J. Faivre and P. Laurent-Puig: Clinical value of mitochondrial mutations in colorectal cancer. J Clin Oncol, 23(15), 3517-25 (2005)
87. M. Yu, Y. Shi, F. Zhang, Y. Zhou, Y. Yang, X. Wei, L. Zhang and R. Niu: Sequence variations of mitochondrial DNA D-loop region are highly frequent events in familial breast cancer. J Biomed Sci, 15(4), 535-43 (2008)
88. L. M. Tseng, P. H. Yin, C. W. Chi, C. Y. Hsu, C. W. Wu, L. M. Lee, Y. H. Wei and H. C. Lee: Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer, 45(7), 629-38 (2006)
89. B. Kamalidehghan, M. Houshmand, M. S. Panahi, M. R. Abbaszadegan, P. Ismail and M. B. Shiroudi: Tumoral cell mtDNA approximately 8.9 kb deletion is more common than other deletions in gastric cancer. Arch Med Res, 37(7), 848-53 (2006) (Pubitemid 44333144)
90. S. Anderson, A. T. Bankier, B. G. Barrell, M. H. de Bruijn, A. R. Coulson, J. Drouin, I. C. Eperon, D. P. Nierlich, B. A. Roe, F. Sanger, P. H. Schreier, A. J. Smith, R. Staden and I. G. Young: Sequence and organization of the human mitochondrial genome. Nature, 290, 457-65. (1981) (Pubitemid 11159074)
91. A. Lorenc, J. Bryk, P. Golik, J. Kupryjanczyk, J. Ostrowski, M. Pronicki, A. Semczuk, M. Szolkowska and E. Bartnik: Homoplasmic MELAS A3243G mtDNA mutation in a colon cancer sample. Mitochondrion, 3(2), 119-24 (2003) (Pubitemid 37185477)
92. A. Lombes, D. Bories, E. Girodon, P. Frachon, M. M. Ngo, J. Breton-Gorius, M. Tulliez and M. Goossens: The first pathogenic mitochondrial methionine tRNA point mutation is discovered in splenic lymphoma. Hum Mutat, Suppl 1, S175-83 (1998)
93. J. P. Guallar, M. R. Vila, E. Lopez-Gallardo, A. Solano, J. C. Domingo, J. Gamez, M. Pineda, J. L. Capablo, P. Domingo, A. L. Andreu, J. Montoya, M. Giralt and F. Villarroya: Altered expression of master regulatory genes of adipogenesis in lipomas from patients bearing tRNA(Lys) point mutations in mitochondrial DNA. Mol Genet Metab, 89(3), 283-5 (2006) (Pubitemid 44442982)
94. N. G. Larsson, M. H. Tulinius, E. Holme and A. Oldfors: Pathogenetic aspects of the A8344G mutation of mitochondrial DNA associated with MERRF syndrome and multiple symmetric lipomas. Muscle Nerve, 3, S102-6 (1995)
95. J. Traff, E. Holme, K. Ekbom and B. Y. Nilsson: Ekbom's syndrome of photomyoclonus, cerebellar ataxia and cervical lipoma is associated with the tRNA(Lys) A8344G mutation in mitochondrial DNA. Acta Neurol Scand, 92(5), 394-7 (1995)
96. J. B. Jones, J. J. Song, P. M. Hempen, G. Parmigiani, R. H. Hruban and S. E. Kern: Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations. Cancer Res, 61(4), 1299-304 (2001) (Pubitemid 34292546)
97. J. A. Mayr, D. Meierhofer, F. Zimmermann, R. Feichtinger, C. Kogler, M. Ratschek, N. Schmeller, W. Sperl and B. Kofler: Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma. Clin Cancer Res, 14(8), 2270-5 (2008) (Pubitemid 351551057)
98. B. Bornstein, J. A. Mas, C. Patrono, M. A. Fernandez- Moreno, E. Gonzalez-Vioque, Y. Campos, R. Carrozzo, M. A. Martin, P. del Hoyo, F. M. Santorelli, J. Arenas and R. Garesse: Comparative analysis of the pathogenic mechanisms associated with the G8363A and A8296G mutations in the mitochondrial tRNA(Lys) gene. Biochem J, 387(Pt 3), 773-8 (2005) (Pubitemid 40685712)
99. A. Chomyn, A. Martinuzzi, M. Yoneda, A. Daga, O. Hurko, D. Johns, S. T. Lai, I. Nonaka, C. Angelini and G. Attardi: MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proc Natl Acad Sci U S A, 89(10), 4221-5 (1992)
100. Y. Kobayashi, M. Y. Momoi, K. Tominaga, T. Momoi, K. Nihei, M. Yanagisawa, Y. Kagawa and S. Ohta: A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes). Biochem Biophys Res Commun, 173(3), 816-22 (1990)
101. Y. Kobayashi, M. Y. Momoi, K. Tominaga, H. Shimoizumi, K. Nihei, M. Yanagisawa, Y. Kagawa and S. Ohta: Respiration-deficient cells are caused by a single point mutation in the mitochondrial tRNA-Leu (UUR) gene in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS). Am J Hum Genet, 49(3), 590-9 (1991) (Pubitemid 21891704)
102. C. J. Turner, C. Granycome, R. Hurst, E. Pohler, M. K. Juhola, M. I. Juhola, H. T. Jacobs, L. Sutherland and I. J. Holt: Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids. Genetics, 170(4), 1879-85 (2005) (Pubitemid 41362839)
103. A. Nagy, M. Wilhelm and G. Kovacs: Mutations of mtDNA in renal cell tumours arising in end-stage renal disease. J Pathol, 199(2), 237-42 (2003) (Pubitemid 36176030)
104. E. Ballana, E. Morales, R. Rabionet, B. Montserrat, M. Ventayol, O. Bravo, P. Gasparini and X. Estivill: Mitochondrial 12S rRNA gene mutations affect RNA secondary structure and lead to variable penetrance in hearing impairment. Biochem Biophys Res Commun, 341(4), 950-7 (2006) (Pubitemid 43221758)
105. F. O. Aikhionbare, S. Mehrabi, K. Kumaresan, M. Zavareh, M. Olatinwo, K. Odunsi and E. Partridge: Mitochondrial DNA sequence variants in epithelial ovarian tumor subtypes and stages. J Carcinog, 6(1), 1 (2007)
106. C. Y. Wang, H. W. Wang, Y. G. Yao, Q. P. Kong and Y. P. Zhang: Somatic mutations of mitochondrial genome in early stage breast cancer. Int J Cancer, 121(6), 1253-6 (2007)
107. K. Polyak, Y. Li, H. Zhu, C. Lengauer, J. K. Willson, S. D. Markowitz, M. A. Trush, K. W. Kinzler and B. Vogelstein: Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet, 20(3), 291-3 (1998) (Pubitemid 28507677)
108. C. B. Han, F. Li, Y. J. Zhao, J. M. Ma, D. Y. Wu, Y. K. Zhang and Y. Xin: Variations of mitochondrial D-loop region plus downstream gene 1 2S rRNA-tRNA(phe) and gastric carcinomas. World J Gastroenterol, 9(9), 1925-9 (2003) (Pubitemid 37168414)
109. C. B. Han, Y. Xin, X. F. Yang, X. Y. Mao, X. H. Li, F. Li and D. Y. Wu: [Mutation of mitochondrial 12S rRNA in gastric carcinomas and its significance]. Zhonghua Zhong Liu Za Zhi, 27(5), 260-4 (2005)
110. D. J. Tan, J. Chang, W. L. Chen, L. J. Agress, K. T. Yeh, B. Wang and L. J. Wong: Somatic mitochondrial DNA mutations in oral cancer of betel quid chewers. Ann N Y Acad Sci, 1011, 310-6 (2004) (Pubitemid 38608415)
111. D. J. Tan, J. Chang, W. L. Chen, L. J. Agress, K. T. Yeh, B. Wang and L. J. Wong: Novel heteroplasmic frameshift and missense somatic mitochondrial DNA mutations in oral cancer of betel quid chewers. Genes Chromosomes Cancer, 37(2), 186-94 (2003) (Pubitemid 36529786)
112. E. Bonora, A. M. Porcelli, G. Gasparre, A. Biondi, A. Ghelli, V. Carelli, A. Baracca, G. Tallini, A. Martinuzzi, G. Lenaz, M. Rugolo and G. Romeo: Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III. Cancer Res, 66(12), 6087-96 (2006)
113. J. J. Yeh, K. L. Lunetta, N. J. van Orsouw, F. D. Moore, Jr., G. L. Mutter, J. Vijg, P. L. Dahia and C. Eng: Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours. Oncogene, 19(16), 2060-6 (2000) (Pubitemid 30229419)
114. K. K. Abu-Amero, A. S. Alzahrani, M. Zou and Y. Shi: High frequency of somatic mitochondrial DNA mutations in human thyroid carcinomas and complex I respiratory defect in thyroid cancer cell lines. Oncogene, 24(8), 1455-60 (2005) (Pubitemid 40343125)
115. H. Simonnet, J. Demont, K. Pfeiffer, L. Guenaneche, R. Bouvier, U. Brandt, H. Schagger and C. Godinot: Mitochondrial complex I is deficient in renal oncocytomas. Carcinogenesis, 24(9), 1461-6 (2003) (Pubitemid 37160836)
116. T. M. Horton, J. A. Petros, A. Heddi, J. Shoffner, A. E. Kaufman, S. D. Graham, Jr., T. Gramlich and D. C. Wallace: Novel mitochondrial DNA deletion found in a renal cell carcinoma. Genes Chromosomes Cancer, 15(2), 95-101 (1996) (Pubitemid 26048409)
117. P. Parrella, Y. Xiao, M. Fliss, M. Sanchez-Cespedes, P. Mazzarelli, M. Rinaldi, T. Nicol, E. Gabrielson, C. Cuomo, D. Cohen, S. Pandit, M. Spencer, C. Rabitti, V. M. Fazio and D. Sidransky: Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. Cancer Res, 61(20), 7623-6 (2001) (Pubitemid 32995057)
118. S. Zhou, S. Kachhap, W. Sun, G. Wu, A. Chuang, L. Poeta, L. Grumbine, S. K. Mithani, A. Chatterjee, W. Koch, W. H. Westra, A. Maitra, C. Glazer, M. Carducci, D. Sidransky, T. McFate, A. Verma and J. A. Califano: Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A, 104(18), 7540-5 (2007) (Pubitemid 47185942)
119. G. Gasparre, E. Hervouet, E. de Laplanche, J. Demont, L. F. Pennisi, M. Colombel, F. Mege-Lechevallier, J. Y. Scoazec, E. Bonora, R. Smeets, J. Smeitink, V. Lazar, J. Lespinasse, S. Giraud, C. Godinot, G. Romeo and H. Simonnet: Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma. Hum Mol Genet, 17(7), 986-95 (2008) (Pubitemid 351426033)
120. G. Tallini: Oncocytic tumours. Virchows Arch, 433(1), 5-12 (1998) (Pubitemid 28356470)
121. H. Schagger, R. de Coo, M. F. Bauer, S. Hofmann, C. Godinot and U. Brandt: Significance of respirasomes for the assembly/stability of human respiratory chain complex I. J Biol Chem, 279(35), 36349-53 (2004) (Pubitemid 39128972)
122. F. Savagner, B. Franc, S. Guyetant, P. Rodien, P. Reynier and Y. Malthiery: Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. J Clin Endocrinol Metab, 86(10), 4920-5 (2001) (Pubitemid 33020542)
123. G. Gasparre, A. M. Porcelli, E. Bonora, L. F. Pennisi, M. Toller, L. Iommarini, A. Ghelli, M. Moretti, C. M. Betts, G. N. Martinelli, A. R. Ceroni, F. Curcio, V. Carelli, M. Rugolo, G. Tallini and G. Romeo: Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors. Proc Natl Acad Sci U S A, 104(21), 9001-6 (2007) (Pubitemid 47175426)
124. R. Vogel, L. Nijtmans, C. Ugalde, L. van den Heuvel and J. Smeitink: Complex I assembly: a puzzling problem. Curr Opin Neurol, 17(2), 179-86 (2004) (Pubitemid 38446461)
125. G. Huang, H. Lu, A. Hao, D. C. Ng, S. Ponniah, K. Guo, C. Lufei, Q. Zeng and X. Cao: GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. Mol Cell Biol, 24(19), 8447-56 (2004) (Pubitemid 39245067)
126. V. Maximo, T. Botelho, J. Capela, P. Soares, J. Lima, A. Taveira, T. Amaro, A. P. Barbosa, A. Preto, H. R. Harach, D. Williams and M. Sobrinho-Simoes: Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer, 92(10), 1892-8 (2005) (Pubitemid 40826138)
127. Y. Bai, P. Hu, J. S. Park, J. H. Deng, X. Song, A. Chomyn, T. Yagi and G. Attardi: Genetic and functional analysis of mitochondrial DNA-encoded complex I genes. Ann N Y Acad Sci, 1011, 272-83 (2004) (Pubitemid 38608411)
128. J. E. Ricci, C. Munoz-Pinedo, P. Fitzgerald, B. Bailly- Maitre, G. A. Perkins, N. Yadava, I. E. Scheffler, M. H. Ellisman and D. R. Green: Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell, 117(6), 773-86 (2004) (Pubitemid 38748893)
129. D. Meierhofer, J. A. Mayr, U. Foetschl, A. Berger, K. Fink, N. Schmeller, G. W. Hacker, C. Hauser-Kronberger, B. Kofler and W. Sperl: Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis, 25(6), 1005-10 (2004) (Pubitemid 38886085)
130. R. W. Taylor, M. J. Barron, G. M. Borthwick, A. Gospel, P. F. Chinnery, D. C. Samuels, G. A. Taylor, S. M. Plusa, S. J. Needham, L. C. Greaves, T. B. Kirkwood and D. M. Turnbull: Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest, 112(9), 1351-60 (2003) (Pubitemid 38057689)
131. V. Maximo and M. Sobrinho-Simoes: Hurthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Arch, 437(2), 107-15 (2000) (Pubitemid 30623568)
132. S. Dasgupta, M. O. Hoque, S. Upadhyay and D. Sidransky: Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer. Cancer Res, 68(3), 700-6 (2008) (Pubitemid 351206745)
133. S. Y. Guo, B. M. Wang and Q. R. Zhu: [Enzyme cytochemistry and morphometric study of the effects of macrophages on A549 pulmonary alveolar cell carcinoma cell line]. Zhonghua Bing Li Xue Za Zhi, 23(4), 218-20 (1994)
134. S. Matsuyama, Q. Xu, J. Velours and J. C. Reed: The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell, 1(3), 327-36 (1998) (Pubitemid 128378881)
135. P. Cortes-Hernandez, M. E. Vazquez-Memije and J. J. Garcia: ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization. J Biol Chem, 282(2), 1051-8 (2007) (Pubitemid 47076544)
136. Y. Fujita, M. Ito, Y. Nozawa, M. Yoneda, Y. Oshida and M. Tanaka: CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations. Mitochondrion, 7(1-2), 80-8 (2007) (Pubitemid 46357299)
137. J. M. Cuezva, M. Krajewska, M. L. de Heredia, S. Krajewski, G. Santamaria, H. Kim, J. M. Zapata, H. Marusawa, M. Chamorro and J. C. Reed: The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res, 62(22), 6674-81 (2002) (Pubitemid 35364137)
138. A. Isidoro, M. Martinez, P. L. Fernandez, A. D. Ortega, G. Santamaria, M. Chamorro, J. C. Reed and J. M. Cuezva: Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer. Biochem J, 378(Pt 1), 17-20 (2004) (Pubitemid 38299539)
139. J. M. Cuezva, G. Chen, A. M. Alonso, A. Isidoro, D. E. Misek, S. M. Hanash and D. G. Beer: The bioenergetic signature of lung adenocarcinomas is a molecular marker of cancer diagnosis and prognosis. Carcinogenesis, 25(7), 1157-63 (2004) (Pubitemid 38968043)
140. A. Isidoro, E. Casado, A. Redondo, P. Acebo, E. Espinosa, A. M. Alonso, P. Cejas, D. Hardisson, J. A. Fresno Vara, C. Belda-Iniesta, M. Gonzalez-Baron and J. M. Cuezva: Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis. Carcinogenesis, 26(12), 2095-104 (2005) (Pubitemid 41672197)
141. Y. Kamenisch, J. Wenz, G. Metzler, J. Bauer, H. Neubauer, C. Garbe, M. Rocken and M. Berneburg: The mitochondrial DNA common deletion is present in most basal and squamous cell carcinoma samples isolated by laser capture microdissection but generally at reduced rather than increased levels. J Invest Dermatol, 127(2), 486-90 (2007) (Pubitemid 46106929)
142. J. G. Dai, Y. B. Xiao, J. X. Min, G. Q. Zhang, K. Yao and R. J. Zhou: Mitochondrial DNA 4977 BP deletion mutations in lung carcinoma. Indian J Cancer, 43(1), 20-5 (2006) (Pubitemid 43900538)
143. A. Eshaghian, R. A. Vleugels, J. A. Canter, M. A. McDonald, T. Stasko and J. E. Sligh: Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers. J Invest Dermatol, 126(2), 336-44 (2006) (Pubitemid 43323168)
144. C. C. Abnet, K. Huppi, A. Carrera, D. Armistead, K. McKenney, N. Hu, Z. Z. Tang, P. R. Taylor and S. M. Dawsey: Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma. BMC Cancer, 4, 30 (2004)
145. J. Y. Shao, H. Y. Gao, Y. H. Li, Y. Zhang, Y. Y. Lu and Y. X. Zeng: Quantitative detection of common deletion of mitochondrial DNA in hepatocellular carcinoma and hepatocellular nodular hyperplasia. World J Gastroenterol, 10(11), 1560-4 (2004) (Pubitemid 38786931)
146. P. H. Yin, H. C. Lee, G. Y. Chau, Y. T. Wu, S. H. Li, W. Y. Lui, Y. H. Wei, T. Y. Liu and C. W. Chi: Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma. Br J Cancer, 90(12), 2390-6 (2004) (Pubitemid 38961905)
147. P. D. Lewis, S. R. Fradley, A. P. Griffiths, P. W. Baxter and J. M. Parry: Mitochondrial DNA mutations in the parotid gland of cigarette smokers and non-smokers. Mutat Res, 518(1), 47-54 (2002) (Pubitemid 34626844)
148. J. Y. Shao, Y. H. Li, H. Y. Gao, H. Q. Mai, Y. Zhang, X. Guo and Y. X. Zeng: High frequency of common deletion (4981 bp) in mitochondrial DNA in nasopharyngeal carcinoma and its correlation with patient age and clinical stages. Cancer Biol Ther, 3(12), 1270-4 (2004) (Pubitemid 41350964)
149. C. W. Wu, P. H. Yin, W. Y. Hung, A. F. Li, S. H. Li, C. W. Chi, Y. H. Wei and H. C. Lee: Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosomes Cancer, 44(1), 19-28 (2005) (Pubitemid 41060193)
150. M. J. Jou, T. I. Peng, H. Y. Wu and Y. H. Wei: Enhanced generation of mitochondrial reactive oxygen species in cybrids containing 4977-bp mitochondrial DNA deletion. Ann N Y Acad Sci, 1042, 221-8 (2005)
151. G. Amuthan, G. Biswas, H. K. Ananadatheerthavarada, C. Vijayasarathy, H. M. Shephard and N. G. Avadhani: Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene, 21(51), 7839-49 (2002) (Pubitemid 35398842)
152. G. Biswas, W. Tang, N. Sondheimer, M. Guha, S. Bansal and N. G. Avadhani: A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling. J Biol Chem, 283(18), 12586-94 (2008)
153. C. van Waveren, Y. Sun, H. S. Cheung and C. T. Moraes: Oxidative phosphorylation dysfunction modulates expression of extracellular matrix-remodeling genes and invasion. Carcinogenesis, 27(3), 409-18 (2006) (Pubitemid 43372870)
154. J. Annunen-Rasila, S. Ohlmeier, H. Tuokko, J. Veijola and K. Majamaa: Proteome and cytoskeleton responses in osteosarcoma cells with reduced OXPHOS activity. Proteomics, 7(13), 2189-200 (2007) (Pubitemid 47067205)
155. A. Torroni, G. Stepien, J. A. Hodge and D. C. Wallace: Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes. J Biol Chem, 265(33), 20589-93 (1990) (Pubitemid 120014048)
156. V. Dmitrenko, K. Shostak, O. Boyko, O. Khomenko, V. Rozumenko, T. Malisheva, M. Shamayev, Y. Zozulya and V. Kavsan: Reduction of the transcription level of the mitochondrial genome in human glioblastoma. Cancer Lett, 218(1), 99-107 (2005) (Pubitemid 40082706)
157. J. Abril, M. L. de Heredia, L. Gonzalez, R. Cleries, M. Nadal, E. Condom, F. Aguilo, M. Gomez-Zaera and V. Nunes: Altered expression of 12S/MT-RNR1, MTCO2/COX2, and MT-ATP6 mitochondrial genes in prostate cancer. Prostate, 68(10), 1086-96 (2008) (Pubitemid 351875180)
158. S. Durand, C. Dumur, A. Flury, P. Abadie, L. Patrito, O. Podhajcer and S. Genti-Raimondi: Altered mitochondrial gene expression in human gestational trophoblastic diseases. Placenta, 22(2-3), 220-6 (2001) (Pubitemid 32537040)
159. D. R. Haugen, O. Fluge, L. J. Reigstad, J. E. Varhaug and J. R. Lillehaug: Increased expression of genes encoding mitochondrial proteins in papillary thyroid carcinomas. Thyroid, 13(7), 613-20 (2003) (Pubitemid 36993555)
160. A. Yamamoto, S. Horai and Y. Yuasa: Increased level of mitochondrial gene expression in polyps of familial polyposis coli patients. Biochem Biophys Res Commun, 159(3), 1100-6 (1989) (Pubitemid 19101095)
161. J. A. Sanchez-Alcazar, E. Schneider, I. Hernandez-Munoz, J. Ruiz-Cabello, E. Siles-Rivas, P. de la Torre, B. Bornstein, G. Brea, J. Arenas, R. Garesse, J. A. Solis-Herruzo, A. J. Knox and P. Navas: Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-alpha in L929 cells. Biochem J, 370(Pt 2), 609-19 (2003) (Pubitemid 36315149)
162. H. J. Bandelt, L. Quintana-Murci, A. Salas and V. Macaulay: The fingerprint of phantom mutations in mitochondrial DNA data. Am J Hum Genet, 71(5), 1150-60 (2002) (Pubitemid 35305232)
163. H. J. Bandelt, Y. G. Yao, A. Salas, T. Kivisild and C. M. Bravi: High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patients. Biochem Biophys Res Commun, 352(2), 283-91 (2007) (Pubitemid 44838487)
164. D. H. Margineantu, C. B. Emerson, D. Diaz and D. M. Hockenbery: Hsp90 inhibition decreases mitochondrial protein turnover. PLoS ONE, 2(10), e1066 (2007)
165. S. J. Ralph, P. Low, L. Dong, A. Lawen and J. Neuzil: Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents. Recent Patents Anticancer Drug Discov, 1(3), 327-46 (2006)
166. Z. Chen, W. Lu, C. Garcia-Prieto and P. Huang: The Warburg effect and its cancer therapeutic implications. J Bioenerg Biomembr, 39(3), 267-74 (2007) (Pubitemid 47619379)