Engineering a potent and specific blocker of voltage-gated potassium channel Kv1.3, a target for autoimmune diseases

Biochemistry

Volumn 51, Issue 9, 2012, Pages 1976-1982

  Chen, Rong ^a   Chung, Shin Ho ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; IMMUNOSUPPRESSIVE THERAPY; INHIBITORY CONCENTRATION; LYSINE RESIDUES; POTENTIALS OF MEAN FORCES; SCORPION VENOM; SELECTIVITY FILTER; THREE CHANNEL; VOLTAGE-GATED POTASSIUM CHANNELS; WILD TYPES;

AMINO ACIDS; DISEASE CONTROL; MOLECULAR DYNAMICS; POTASSIUM;

TOXIC MATERIALS;

IMMUNOSUPPRESSIVE AGENT; LYSINE; OSK1 POLYPEPTIDE TOXIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.3; SCORPION VENOM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOIMMUNE DISEASE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; IC 50; MOLECULAR DYNAMICS; MUTANT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STATIC ELECTRICITY; WILD TYPE;

AUTOIMMUNE DISEASES; BINDING SITES; KV1.3 POTASSIUM CHANNEL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN ENGINEERING; SCORPION VENOMS; TOXINS, BIOLOGICAL;

SCORPIONES;

EID: 84857892330     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201811j     Document Type: Article

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