Antischistosomal activity of trioxaquines: In vivo efficacy and mechanism of action on schistosoma mansoni

PLoS Neglected Tropical Diseases

Volumn 6, Issue 2, 2012, Pages

  Portela, Julien ^a,b   Boissier, Jérôme ^a,b   Gourbal, Benjamin ^a,b   Pradines, Vincent ^c   Collière, Vincent ^c   Coslédan, Frédéric ^d   Meunier, Bernard ^c,d   Robert, Anne ^c  

^a UNIVERSITÉ DE PERPIGNAN   (France)

^b CNRS   (France)

^c LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

^d Palumed   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISCHISTOSOMAL AGENT; ARTEMETHER; HEME; HYDROGEN PEROXIDE; MEFLOQUINE; NITRIC OXIDE; PA 1259; PA 1647; PRAZIQUANTEL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TRIOXAQUINES; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; ANTHELMINTIC AGENT;

ALKYLATION; ANIMAL EXPERIMENT; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOMPHALARIA GLABRATA; CERCARIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MONOTHERAPY; MOUSE; NONHUMAN; PARASITE SURVIVAL; SCANNING ELECTRON MICROSCOPY; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SCHISTOSOMULUM; STRUCTURE ACTIVITY RELATION; TRANSMISSION ELECTRON MICROSCOPY; WORM INFECTION; X RAY ANALYSIS; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; HUMAN; LARVA; TREATMENT OUTCOME;

AMINOQUINOLINES; ANIMALS; ANTHELMINTICS; DRUG SYNERGISM; FEMALE; HUMANS; LARVA; MALE; MICE; PRAZIQUANTEL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; TREATMENT OUTCOME;

EID: 84857866346     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001474     Document Type: Article

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