Towards an understanding of the mechanism of action of praziquantel

Molecular and Biochemical Parasitology

Volumn 164, Issue 1, 2009, Pages 57-65

  Aragon, Anthony D ^a   Imani, Reza A ^a   Blackburn, Vint R ^a   Cupit, Pauline M ^a   Melman, Sandra D ^a   Goronga, Tinopiwa ^b   Webb, Thomas ^b   Loker, Eric S ^a   Cunningham, Charles ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Calcineurin; Oxidative phosphorylation; Oxidative stress; Praziquantel; Schistosoma mansoni; Schistosomiasis

Indexed keywords

CALCINEURIN; GLUTATHIONE TRANSFERASE; PRAZIQUANTEL; SUPEROXIDE DISMUTASE; THIOREDOXIN; THIOREDOXIN PEROXIDASE;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM SIGNALING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; HEAT SHOCK; MALE; MICROARRAY ANALYSIS; MIRACIDIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; TRANSCRIPTOMICS; UPREGULATION;

ANIMALS; ANTHELMINTICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, HELMINTH; HEAT-SHOCK PROTEINS; MICE; NIH 3T3 CELLS; PARASITIC SENSITIVITY TESTS; PRAZIQUANTEL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; TIME FACTORS;

MAMMALIA; MUS; SCHISTOSOMA MANSONI;

EID: 58549087709     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2008.11.007     Document Type: Article

References (55)

1. Cioli D., and Pica-Mattoccia L. Praziquantel. Parasitol Res 90 (2003) S3-S9
2. Andrews P. Effect of praziquantel on the free living stages of Schistosoma mansoni. Z Parasitenkd 56 (1978) 99-106
3. Liang Y.S., Coles G.C., Doenhoff M.J., and Southgate V.R. In vitro responses of praziquantel-resistant and -susceptible Schistosoma mansoni to praziquantel. Int J Parasitol 31 (2001) 1227-1235
4. Mattos A.C.A., Kusel J.R., Pimenta P.F.P., and Coelho P.M.Z. Activity of praziquantel on in vitro transformed Schistosoma mansoni sporocysts. Mem Inst Oswaldo Cruz 101 Suppl 1 (2006) 283-287
5. Gönnert R., and Andrews P. Praziquantel a new board-spectrum antischistosomal agent. Z Parasitenkd 52 (1977) 129-150
6. Sabah A.A., Fletcher C., Webbe G., and Doenhoff M.J. Schistosoma mansoni: chemotherapy of infections of different ages. Exp Parasitol 61 (1986) 294-303
7. Pica-Mattoccia L., and Cioli D. Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment. Int J Parasitol 34 (2004) 527-533
8. Pax R., Bennett J.L., and Fetterer R. A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum. Naunyn-Schmiedebergs Arch Pharmacol 304 (1978) 309-315
9. Harnett W., and Kusel J.R. Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro. Parasitology 93 (1986) 401-405
10. Redman C.A., Robertson A., Fallon P.G., et al. Praziquantel: an urgent and exciting challenge. Parasitol Today 12 (1996) 14-20
11. 2+ channels targets of praziquantel action?. Int J Parasitol 35 (2005) 1-9
12. Kohn A.B., Anderson P.A.V., Roberts-Misterly J.M., and Greenberg R.M. Schistosome calcium channel β subunits-unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel. J Biol Chem 276 (2001) 36873-36876
13. Pica-Mattoccia L., Orsini T., Basso A., et al. Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death. Exp Parasitol 119 (2008) 332-335
14. Pica-Mattoccia L., Valle C., Basso A., et al. Cytochalasin D abolishes the schistosomicidal activity of praziquantel. Exp Parasitol 115 (2007) 344-351
15. Lima S.F., Vieira L.Q., Harder A., and Kusel J.R. Effects of culture and praziquantel on membrane fluidity parameters of adult Schistosoma mansoni. Parasitology 109 (1994) 57-64
16. Harder A., Goossens J., and Andrews P. Influence of praziquantel and Ca2+ on the bilayer-isotropic-hexagonal transition of model membranes. Mol Biochem Parasitol 29 (1988) 55-59
17. Ribeiro F., Coelho P.M., Vieira L.Q., Watson D.G., and Kusel J.R. The effect of praziquantel treatment on glutathione concentration in Schistosoma mansoni. Parasitology 116 (1998) 229-236
18. Tallima H., and El Ridi R. Praziquantel binds Schistosoma mansoni adult worm actin. Int J Antimicrob Agents 29 (2007) 570-575
19. Angelucci F., Basso A., Bellelli A., Brunori M., Pica-Mattoccia L., and Valle C. The anti-schistosomal drug praziquantel is an adenosine antagonist. Parasitology 134 (2007) 1215-1221
20. Aragon A.D., Imani R.A., Blackburn V.R., and Cunningham C. Microarray based analysis of temperature and oxidative stress induced messenger RNA in Schistosoma mansoni. Mol Biochem Parasitol 162 (2008) 134-141
21. -ΔΔCT method. Methods 25 (2001) 402-408
22. Gobert G.N., McInnes R., Moertel L., et al. Transcriptomics tool for the human Schistosoma blood flukes using microarray gene expression profiling. Exp Parasitol 114 (2006) 160-172
23. Vencio R.Z.N., and Koide T. HTself: self-self based statistical test for low replication microarray studies. DNA Res 12 (2005) 211-214
24. Conesa A., Gotz S., Garcia-Gomez J.M., Terol J., Talon M., and Robles M. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21 (2005) 3674-3676
25. Kim J.H., Lee Y.S., Park H., and Kim C.S. Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: an efficient synthesis of Praziquantel. Tetrahedron 54 (1998) 7395-7400
26. Andrews P., Thomas H., Pohlke R., and Seubert J. Praziquantel. Med Res Rev 3 (1983) 147-200
27. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98 (2001) 5116-5121
28. Ismail M., Botros S., Metwally A., et al. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60 (1999) 932-935
29. Nene V., Dunne D.W., Johnson K.S., Taylor D.W., and Cordingley J.S. Sequence and expression of a major egg antigen from Schistosoma mansoni-homologies to heat-shock proteins and alpha-crystallins. Mol Biochem Parasitol 21 (1986) 179-188
30. Johnson K.S., Wells K., Bock J.V., Nene V., Taylor D.W., and Cordingley J.S. The 86-Kilodalton antigen from Schistosoma mansoni is a heat-shock protein homologous to yeast HSP90. Mol Biochem Parasitol 36 (1989) 19-28
31. Neumann S., Ziv E., Lantner F., and Schechter I. Regulation of HSP70 gene-expression during the life-cycle of the parasitic helminth Schistosoma mansoni. Eur J Biochem 212 (1993) 589-596
32. Xiao S.H., Catto B.A., and Webster L.T. Effects of praziquantel on different developmental stages of Schistosoma mansoni in vitro and in vivo. J Infect Dis 151 (1985) 1130-1137
33. Andrews P. A summary of the efficacy of praziquantel against schistosomes in animal experiments and notes on its mode of action. Arzneimittel-Forschung 31 (1981) 538-541
34. Fallon P.G., Mubarak J.S., Fookes R.E., et al. Schistosoma mansoni: maturation rate and drug susceptibility of different geographic isolates. Exp Parasitol 86 (1997) 29-36
35. El-Bassiouni E.A., Helmy M.H., Saad E.I., El-Nabi Kamel M.A., Abdel-Meguid E., and Hussein H.S. Modulation of the antioxidant defence in different developmental stages of Schistosoma mansoni by praziquantel and artemether. Br J Biomed Sci 64 (2007) 168-174
36. Vermeire J.J., Taft A.S., Hoffmann K.F., Fitzpatrick J.M., and Yoshino T.P. Schistosoma mansoni: DNA microarray gene expression profiling during the miracidium-to-mother sporocyst transformation. Mol Biochem Parasitol 147 (2006) 39-47
37. Coles G.C. Oxidative phosphorylation in Schistosoma mansoni. Nature 240 (1972) 488-489
38. van Oordt B.E., van den Heuvel J.M., Tielens A.G.M., and van den Bergh S.G. The energy production of the adult Schistosoma mansoni is for a large part aerobic. Mol Biochem Parasitol 16 (1985) 117-126
39. Coles G.C. The metabolism of schistosomes: a review. Int J Biochem 4 (1973) 319-337
40. Horemans A.M.C., Tielens A.G.M., and van den Bergh S.G. The reversible effect of glucose on the energy metabolism of Schistosoma mansoni cercariae and schistosomula. Mol Biochem Parasitol 51 (1992) 73-79
41. Ross O.A., and Bueding E. Survival of Schistosoma mansoni in vitro. Proc Soc Exp Biol Med 73 (1950) 179-182
42. Waisberg M., Lobo F.P., Cerqueira G.C., et al. Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni. BMC Genomics 8 (2007) 181
43. Fitzpatrick J.M., and Hoffmann K.F. Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing. Int J Parasitol 36 (2006) 1081-1089
44. Van Oordt B.E., Tielens A.G.M., and Van den Bergh S.G. Aerobic to anaerobic transition in the carbohydrate metabolism of Schistosoma mansoni cercariae during transformation in vitro. Parasitology 98 (1989) 409-415
45. Tielens A.G.M., van de Pas F.A.M., van den Heuvel J.M., and van den Bergh S.G. The aerobic energy metabolism of Schistosoma mansoni miracidia. Mol Biochem Parasitol 46 (1991) 181-184
46. Tielens A.G.M., Horemans A.M.C., Dunnewijk R., van der Meer P., and van den Bergh S.G. The facultative anaerobic energy metabolism of Schistosoma mansoni sporocysts. Mol Biochem Parasitol 56 (1992) 49-57
47. Mecozzi B., Rossi A., Lazzaretti P., et al. Molecular cloning of Schistosoma mansoni calcineurin subunits and immunolocalization to the excretory system. Mol Biochem Parasitol 110 (2000) 333-343
48. Rossi A., Wippersteg V., Klinkert M.Q., and Grevelding C.G. Cloning of 5′ and 3′ flanking regions of the Schistosoma mansoni calcineurin A gene and their characterization in transiently transformed parasites. Mol Biochem Parasitol 130 (2003) 133-138
49. Klee C.B., Ren H., and Wang X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 273 (1998) 13367-13370
50. 2+ tolerance. J Biol Chem 273 (1998) 27831-27840
51. Rossi A., Ghislain M., and Klinkert M.Q. Regulatory pathways in ion homeostasis involving calcineurin and a calcium transporting ATPase are different between yeast and schistosomes. Mol Biochem Parasitol 135 (2004) 165-169
52. Valle C., Troiani A.R., Festucci A., et al. Sequence and level of endogenous expression of calcium channel beta subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel. Mol Biochem Parasitol 130 (2003) 111-115
53. Silacci P., Mazzolai L., Gauci C., Stergiopulos N., Yin H.L., and Hayoz D. Gelsolin superfamily proteins: key regulators of cellular functions. Cell Mol Life Sci 61 (2004) 2614-2623
54. Chen Y., Takizawa N., Crowley J.L., et al. F-actin and myosin II binding domains in supervillin. J Biol Chem 278 (2003) 46094-46106
55. Clark K.A., Bland J.M., and Beckerle M.C. The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci 120 (2007) 2066-2077