One-pot efficient green synthesis of spirooxindole-annulated thiopyran derivatives via Knoevenagel condensation followed by Michael addition

Tetrahedron Letters

Volumn 53, Issue 14, 2012, Pages 1732-1737

  Majumdar, K C ^a,b   Ponra, Sudipta ^a   Nandi, Raj Kumar ^a  

^a UNIVERSITY OF KALYANI   (India)

^b TEZPUR UNIVERSITY   (India)

Author keywords

Domino reaction; Ethyl cyanoacetate; Indoline 2 thione; Isatin; Knoevenagel condensation; Malononitrile; Michael addition; Multi component reaction

Indexed keywords

2 AMINO 1,9' DIETHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBONITRILE; 2' AMINO 1 ETHYL 9' METHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBONITRILE; 2' AMINO 1,9' DIMETHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBONITRILE; 2' AMINO 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBONITRILE; 2' AMINO 9' ETHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBONITRILE; 2' AMINO 9' ETHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBOXYLATE; 2' AMINO 9' METHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBONITRILE; ACETIC ACID DERIVATIVE; ALCOHOL; ETHYL 2' AMINO 1 METHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBOXYLATE; ETHYL 2' AMINO 1,9' DIETHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBOXYLATE; ETHYL 2' AMINO 1,9' DIMETHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBOXYLATE; ETHYL 2' AMINO 9' ETHYL 1 METHYL 2 OXO 9'H SPIRO(INDOLINE 3,40 THIOPYRAN[2,3 B]INDOLE) 3' CARBOXYLATE; ETHYL 2' AMINO 9' METHYL 2 OXO 9'H SPIRO(INDOLINE 3,4' THIOPYRAN[2,3 B]INDOLE) 3' CARBOXYLATE; INDOLE DERIVATIVE; ISATIN; MALONONITRILE; THIOPYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; DRUG STRUCTURE; DRUG SYNTHESIS; KNOEVENAGEL CONDENSATION; MICHAEL ADDITION; ONE POT SYNTHESIS; REACTION TIME; TEMPERATURE;

EID: 84857789905     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2012.01.099     Document Type: Article

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