A simple and clean procedure for three-component synthesis of spirooxindoles in aqueous medium

Tetrahedron

Volumn 63, Issue 38, 2007, Pages 9365-9372

  Zhu, Song Lei ^a,b   Ji, Shun Jun ^a   Zhang, Yong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Aqueous medium; Spirooxindole; Three component synthesis

Indexed keywords

2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMEN 4,3'(3'H) INDOL] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 1' BENZYLINDOL] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 1' METHYLINDOL] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 4' BROMOINDOL] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 5' METHYLINDOL] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 6' BROMOINDOL] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 7' CHLOROINDOL] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXOSPIRO[(3'H) 4' BROMOINDOL 3',4(4H) PYRANO[3,2 C]CHROMEN] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXOSPIRO[(3'H) 6' BROMOINDOL 3',4(4H) PYRANO[3,2 C]CHROMEN] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXOSPIRO[(3'H) INDOL 3',4(4H) PYRANO[3,2 C]CHROMEN] (1'H) 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXOSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMEN 4,3'(3'H) INDOL] 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXOSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 4' BROMOINDOL] 2' ONE 3 CARBONITRILE; 2 AMINO 5 OXOSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 6' BROMOINDOL] 2' ONE 3 CARBONITRILE; 5,5 DIMETHYL 1,3 CYCLOHEXANEDIONE; CARBENE; CARBONYL DERIVATIVE; COUMARIN; INDOLE DERIVATIVE; ISATIN; METHYL 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMEN 4,3'(3'H) INDOL] (1'H) 2' ONE 3 CARBOXYLIC ACID; METHYL 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 6' BROMOINDOL] (1'H) 2' ONE 3 CARBOXYLIC ACID; METHYL 2 AMINO 5 OXO 7,7 DIMETHYLSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 7' CHLOROINDOL] (1'H) 2' ONE 3 CARBOXYLIC ACID; METHYL 2 AMINO 5 OXOSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMEN 4,3'(3'H) INDOL] (1'H) 2' ONE 3 CARBOXYLIC ACID; METHYL 2 AMINO 5 OXOSPIRO[(4H) 5,6,7,8 TETRAHYDROCHROMENE 4,3'(3'H) 6' BROMOINDOL] (1'H) 2' ONE 3 CARBOXYLIC ACID; OXINDOLE; PTEROPODINE; SPIRO COMPOUND; SPIROTRYPROSTATIN B; THIOBARBITURIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AQUEOUS SOLUTION; ARTICLE; CONFORMATION; DERIVATIZATION; DRUG SYNTHESIS; MOLECULAR INTERACTION; ONE POT SYNTHESIS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTUM YIELD; REACTION ANALYSIS;

EID: 34547586034     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.06.113     Document Type: Article

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