HIV-1 envelope-dependent restriction of CXCR4-using viruses in child but not adult untransformed CD4+ T-lymphocyte lines

Blood

Volumn 119, Issue 9, 2012, Pages 2013-2023

  Mariani, Samanta A ^a   Brigida, Immacolata ^b,c   Kajaste Rudnitski, Anna ^a   Ghezzi, Silvia ^a   Rocchi, Alessia ^d   Plebani, Anna ^d   Vicenzi, Elisa ^a   Aiuti, Alessandro ^b,c   Poli, Guido ^a,e  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CD4 ANTIGEN; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; PHYTOHEMAGGLUTININ; VIRUS DNA;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL ASSAY; CELL EXPANSION; CHILD; CLINICAL ARTICLE; DNA SYNTHESIS; FEEDER CELL; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE DEFICIENCY; IN VITRO STUDY; INFANT; LEUKOCYTE; LYMPHOCYTE PROLIFERATION; PRESCHOOL CHILD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; VESICULAR STOMATITIS VIRUS; VIRUS REPLICATION;

EID: 84857752878     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-12-325308     Document Type: Article

References (44)

1. Berger EA, Doms RW, Fenyo EM, et al. A new classification for HIV-1. Nature. 1998;391(6664): 240.
2. Thompson DA, Cormier EG, Dragic T. CCR5 and CXCR4 usage by non-clade B human immunodeficiency virus type 1 primary isolates. J Virol. 2002;76(6):3059-3064. (Pubitemid 34184893)
3. Salvatori F, Masiero S, Giaquinto C, et al. Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to disease. J Virol. 1997;71(6):4694-4706. (Pubitemid 27204162)
4. Philpott SM. HIV-1 coreceptor usage, transmission, and disease progression. Curr HIV Res. 2003;1(2):217-227.
5. Moore JP, Kitchen SG, Pugach P, Zack JA. The CCR5 and CXCR4 coreceptors: central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 2004;20(1):111-126. (Pubitemid 38147183)
6. Quinn TC. Acute primary HIV infection. JAMA. 1997;278(1):58-62. (Pubitemid 27274518)
7. Ammann AJ. Pediatric Human Immunodeficiency Virus Infection. In: Immunologic Disorders in Infants and Children (5th Ed). Stiehm ER, Ochs HD, Winkelstein JA, eds. Philadelphia: WB Saunders; 2004.
8. De Rossi A, Masiero S, Giaquinto C, et al. Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection. J Clin Invest. 1996;97(2):323-330. (Pubitemid 26039394)
9. Shearer WT, Quinn TC, LaRussa P, et al. Viral load and disease progression in infants infected with human immunodeficiency virus type 1: Women and Infants Transmission Study Group. N Engl J Med. 1997;336(19):1337-1342. (Pubitemid 27208616)
10. European Collaborative Study. Children born to women with HIV-1 infection: natural history and risk of transmission. Lancet. 1991;337(8736): 253-260.
11. Tovo PA, de Martino M, Gabiano C, et al. Prognostic factors and survival in children with perinatal HIV-1 infection: the Italian Register for HIV Infections in Children. Lancet. 1992;339(9):1249-1253.
12. Scott GB, Hutto C, Makuch RW, et al. Survival in children with perinatally acquired human immunodeficiency virus type 1 infection. N Engl J Med. 1989;321(26):1791-1796. (Pubitemid 20015572)
13. Auger I, Thomas P, De Gruttola V, et al. Incubation periods for paediatric AIDS patients. Nature. 1988;336(6199):575-577. (Pubitemid 19007314)
14. Casper C, Naver L, Clevestig P, et al. Coreceptor change appears after immune deficiency is established in children infected with different HIV-1 subtypes. AIDS Res Hum Retroviruses. 2002; 18(5):343-352. (Pubitemid 34253134)
15. Scarlatti G, Hodara V, Rossi P, et al. Transmission of human immunodeficiency virus type 1 (HIV-1) from mother to child correlates with viral phenotype. Virology. 1993;197(2):624-629.
16. Clevestig P, Maljkovic I, Casper C, et al. The X4 phenotype of HIV type 1 evolves from R5 in two children of mothers, carrying X4, and is not linked to transmission. AIDS Res Hum Retroviruses. 2005;21(5):371-378. (Pubitemid 40800453)
17. Salazar-Gonzalez JF, Salazar MG, Keele BF, et al. Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. J Exp Med. 2009;206(6):1273-1289.
18. Cassani B, Mirolo M, Cattaneo F, et al. Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. Blood. 2008;111(8):4209-4219.
19. Bacchetta R, de Waal Malefijt R, Yssel H, et al. Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4. J Immunol. 1990;144(3):902-908. (Pubitemid 20065029)
20. Ferrua F, Brigida I, Aiuti A. Update on gene therapy for adenosine deaminase-deficient severe combined immunodeficiency. Curr Opin Allergy Clin Immunol. 2010;10(6):551-556.
21. Englund G, Theodore TS, Freed EO, Engelman A, Martin MA. Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. J Virol. 1995;69(5): 3216-3219.
22. Vicenzi E, Bordignon PP, Biswas P, et al. Envelope-dependent restriction of human immunodeficiency virus type 1 spreading in CD4(+) T lymphocytes: R5 but not X4 viruses replicate in the absence of T-cell receptor restimulation. J Virol. 1999;73(9):7515-7523. (Pubitemid 29383235)
23. Neagu MR, Ziegler P, Pertel T, et al. Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. J Clin Invest. 2009;119(10):3035-3047.
24. Bjorndal A, Deng H, Jansson M, et al. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. J Virol. 1997;71(10):7478-7487. (Pubitemid 27391688)
25. Monini P, Colombini S, Stürzl, et al. Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma. Blood. 1999; 93(12):4044-4058. (Pubitemid 29279246)
26. Ometto L, Zanotto C, Maccabruni A, et al. Viral phenotype and host-cell susceptibility to HIV-1 infection as risk factors for mother-to-child HIV-1 transmission. AIDS. 1995;9(5):427-434.
27. Jones KL, Roche M, Gantier MP, et al. X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells. J Biol Chem. 2010;285(24):18603-18614.
28. Goila-Gaur R, Strebel K. HIV-1 Vif, APOBEC, and intrinsic immunity. Retrovirology. 2008;5:51.
29. Towers GJ. The control of viral infection by tripartite motif proteins and cyclophilin A. Retrovirology. 2007;4:40.
30. Evans DT, Serra-Moreno R, Singh RK, Guatelli JC. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol. 2010;18(9):388-396.
31. Hrecka K, Hao C, Gierszewska M, et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature. 2011;474(7353):658-661.
32. Laguette N, Sobhian B, Casartelli N, et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature. 2011;474(7353):654-657.
33. Sundaravaradan V, Saxena SK, Ramakrishnan R, Yedavalli VR, Harris DT,Ahmad N. Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression. Proc Natl Acad Sci U S A. 2006;103(31):11701-11706. (Pubitemid 44182514)
34. Reinhardt PP, Reinhardt B, Lathey JL, Spector SA. Human cord blood mononuclear cells are preferentially infected by non-syncytium-inducing, macrophage-tropic human immunodeficiency virus type 1 isolates. J Clin Microbiol. 1995;33(2):292-297.
35. Lin YL, Mettling C, Portales P, Reant B, Clot J, Corbeau P. G-protein signaling triggered by R5 human immunodeficiency virus type 1 increases virus replication efficiency in primary T lymphocytes. J Virol. 2005;79(12):7938-7941. (Pubitemid 40756833)
36. Arthos J, Rubbert A, Rabin RL, et al. CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes. J Virol. 2000;74(14):6418-6424. (Pubitemid 30429808)
37. Kinter AL, Umscheid CA, Arthos J, et al. HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis. J Immunol. 2003;170(5):2449-2455. (Pubitemid 36245633)
38. Tuttle DL, Coberley CR, Xie X, Kou ZC, Sleasman JW, Goodenow MM. Effects of human immunodeficiency virus type 1 infection on CCR5 and CXCR4 coreceptor expression on CD4 T lymphocyte subsets in infants and adolescents. AIDS Res Hum Retroviruses. 2004;20(3):305-313. (Pubitemid 38429403)
39. van'tWout AB, Kootstra NA, Mulder-Kampinga GA, et al. Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission. J Clin Invest. 1994;94(5):2060-2067. (Pubitemid 24348247)
40. Fowler MG, Newell ML. Breast-feeding and HIV-1 transmission in resource-limited settings. J Acquir Immune Defic Syndr. 2002;30(2):230-239. (Pubitemid 34664420)
41. Blokzijl ML. Human immunodeficiency virus infection in childhood. Ann Trop Paediatr. 1988;8(1):1-17.
42. Cavarelli M, Scarlatti G. Phenotype variation in human immunodeficiency virus type 1 transmission and disease progression. Dis Markers. 2009; 27(3):121-136.
43. Correa R, Munoz-Fernandez MA. Viral phenotype affects the thymic production of new T cells in HIV-1-infected children. AIDS. 2001;15(15):1959- 1963. (Pubitemid 32980637)
44. Haase AT. Perils at mucosal front lines for HIV and SIV and their hosts. Nat Rev Immunol. 2005; 5(10):783-792. (Pubitemid 41400852)