Envelope-dependent restriction of human immunodeficiency virus type 1 spreading in CD4+ T lymphocytes: R5 but not X4 viruses replicate in the absence of T-cell receptor restimulation

Journal of Virology

Volumn 73, Issue 9, 1999, Pages 7515-7523

  Vicenzi, Elisa ^a,c   Bordignon, Paola Panina ^b   Biswas, Priscilla ^a   Brambilla, Andrea ^a   Bovolenta, Chiara ^a   Cota, Manuela ^a   Sinigaglia, Francesco ^b   Poli, Guido ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b ROCHE MILANO RICERCHE   (Italy)

^c P2 P3 Laboratories   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CELL POLARITY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS REPLICATION;

EID: 0032865672     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.9.7515-7523.1999     Document Type: Article

References (56)

1. Adachi, A., H. E. Gendelman, S. Koenig, T. Folks, R. Willey, A. Rabson, and M. A. Martin. 1986. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59:284-291.
2. + cells express CXCR4 and its ligand stromal cell derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus. Blood 94:62-73.
3. + progenitors to peripheral blood. J. Exp. Med. 185:111-120.
4. Berger, E. A., R. W. Doms, E. M. Fenyo, B. T. Korber, D. R. Littman, J. P. Moore, Q. J. Sattentau, H. Schuitemaker, J. Sodroski, and R. A. Weiss. 1998. A new classification for HIV-1. Nature 391:240.
5. Biswas, P., M. Mengozzi, B. Mantelli, F. Delfanti, A. Brambilla, E. Vicenzi, and G. Poli. 1998. 1,25-Dihydroxyvitamin D3 upregulates functional CXCR4 human immunodeficiency virus type 1 coreceptors in U937 minus clones: NF-κB-independent enhancement of viral replication. J. Virol. 72:8380-8383.
6. Biswas, P., C. A. Smith, D. Goletti, E. C. Hardy, R. W. Jackson, and A. S. Fauci. 1995. Cross-linking of CD30 induces HIV expression in chronically infected T cells. Immunity 2:587-596.
7. Bleul, C., M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T. A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-833.
8. Bonecchi, R. G. Blanchi, P. P. Bordignon, D. D'Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani, and F. Sinigaglia. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187:129-134.
9. Brinkman, K., F. Huysmans, J. M. Galama, and C. A. Boucher. 1998. In vivo anti-CD3-induced HIV-1 viraemia. Lancet 352:1446.
10. + T cells. Science 276:273-276.
11. Chackerian, B., E. M. Long, P. A. Luciw, and J Overbaugh. 1997. Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection. J. Virol. 71:3932-3939.
12. + T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. USA 95:8869-8873.
13. + T cells using a combination of cytokines. J. Exp. Med. 188:83-91.
14. Chun, T. W., L. Stuyver, S. B. Mizell, L. A. Ehler, J. A. Mican, M. Baseler, A. L. Lloyd, M. A. Nowak, and A. S. Fauci. 1997. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 94:13193-13197.
15. Clerici, M., and G. M. Shearer. 1993. A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107-111.
16. Connor, R. I. K. E. Sheridan, D. Ceradini, S. Choe, and N. R. Landau. 1997. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185:621-628.
17. Doranz, B. J., J. Rucker, Y. Yi, R. J. Smyth, M. Samson, S. C. Peiper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149-1158.
18. Englund, G., T. S. Theodore, E. O. Freed, A. Engleman, and M. A. Martin. 1995. Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. J. Virol. 69:3216-3219.
19. Fakoya, A., P. M. Matear, E. Filley, G. A. Rook, J. Stanford, R. J. Gilson, N. Beecham, I. V. Weller, and A. Vyakarnam. 1997. HIV infection alters the production of both type 1 and 2 cytokines but does not induce a polarized type 1 or 2 state. AIDS 11:1445-1452.
20. Finzi, D., M. Hermankova, T. Pierson, L. M. Carruth, C. Buck, R. E. Chaisson, T. C. Quinn, K. Chadwick, J. Margolick, R. Brookmeyer, J. Gallant, M. Markowitz, D. D. Ho, D. D. Richman, and R. F. Siliciano. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278:1295-1300.
21. Freed, E. O., and M. A. Martin. 1994. HIV-1 infection of non-dividing cells. Nature 369:107-108.
22. Galli, G., F. Annunziato, C. Mavilia, P. Romagnani, L. Cosmi, R. Manetti, C. Pupilli, E. Maggi, and S. Romagnani. 1998. Enhanced HIV expression during Th2-oriented responses explained by the opposite regulatory effect of IL-4 and IFN-gamma of fusin/CXCRA Eur. J. Immunol. 28:3280-3290.
23. Gorelick, N. R. J., and L. E. Henderson. 1994. Human retroviruses and AIDS, vol. 3. Los Alamos National Laboratory, Los Alamos, N.M.
24. He, J., Y. Chen, M. Farzan, H. Choe, A. Ohagen, S. Gartner, J. Busciglio, X. Yang, W. Hofmann, W. Newman, C. R. Mackay, J. Sodroski, and D. Gabuzda. 1997. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385:645-649.
25. Hill, C. M., H. Deng, D. Unutmaz, V. N. Kewalramani, L. Bastiani, M. K. Gorny, S. Zolla-Pazner, and D. R. Littman. 1997. Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor. J. Virol. 71:6296-6304.
26. Jourdan, P., C. Abbal, N. Nora, T. Hori, T. Uchiyama, J.-P. Vendrell, J. Bousquet, N. Taylor, J. Pène, and H. Yssel, 1998. Cutting edge: IL-4 induces functional cell-surface expression of CXCR4 on human T cells. J. Immunol. 160:4153-4157.
27. Kinter, A. L., G. Poli, L. Fox, E. Hardy, and A. S. Fauci. 1995. HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines. J. Immunol. 154:2448-2459.
28. Kinter, A. L., G. Poli, W. Maury, T. M. Folks, and A. S. Fauci. 1990. Direct and cytokine-mediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells. J. Virol. 64:4306-4312.
29. + cell depletion and progression to AIDS. Ann. Intern. Med. 118:681-688.
30. Korin, Y. D., and J. A. Zack. 1998. Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells. J. Virol. 72:3161-3168.
31. Littman, D. R. 1998. Chemokine receptors-keys to AIDS pathogenesis. Cell 93:677-680.
32. Maggi, E., M. Mazzetti, A. Ravina, F. Annunziato, M. De Carli, M. P. Piccinni, R. Manetti, M. Carbonari, A. M. Pesce, G. Del Prete, and S. Romagnani. 1994. Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells. Science 265:244-248.
33. Meyaard, L., R. A. Fouchier, M. Brouwer, E. Hovenkamp, and F. Miedema. 1996. Syncytium-inducing HIV-1 variants replicate equally well in all types of T-helper cell clones. AIDS 10:1598-1600.
34. Mikovits, J. A., D. D. Taub, S. M. Turcovski-Corrales, and F. W. Ruscetti. 1998. Similar levels of human immunodeficiency virus type 1 replication in human TH1 and TH2 clones. J. Virol. 72:5231-5238.
35. Mori, K., D. J. Ringler, and R. C. Desrosiers. 1993. Restricted replication of simian immunodeficiency virus strain 239 in macrophages is determined by env but is not due to restricted entry. J. Virol. 67:2807-2814.
36. Nagasawa, T., T. Nakajima, K. Tachibana, H. Iizasa, C. C. Bleul, O. Yoshie, K. Matsushima, N. Yoshida, T. A. Springer, and T. Kishimoto. 1996. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc. Natl. Acad. Sci. USA 93:14726-14729.
37. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275-283.
38. Panina-Bordignon, P., D. Mazzeo, P. D. Lucia, D. D'Ambrosio, R. Lang, L. Fabbri, C. Self, and F. Sinigaglia. 1997. Beta2-agonists prevent Th1 development by selective inhibition of interleukin-12. J. Clin. Invest. 100:1513-1519.
39. Paxton, W. A., S. R. Martin, D. Tse, T. R. O'Brien, J. Skurnick, N. L. VanDevanter, N. Padian, J. F. Braun, D. P. Kotler, S. M. Wolinsky, and R. A. Koup. 1996. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure. Nat. Med. 2:412-417.
40. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825-831.
41. Sallusto, F., D. Lenig, C. R. Mackay, and A. Lanzavecchia. 1998. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187:875-883.
42. Sallusto, F., C. R. Mackay, and A. Lanzavecchia. 1997. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277:2005-2007.
43. Samson, M., F. Libert, B. J. Doranz, J. Rucker, C. Liesnard, C. M. Farber, S. Saragosti, C. Lapoumeroulie, J. Cognaux, C. Forceille, G. Muyldermans, C. Verhofstede, G. Burtonboy, M. Georges, T. Imai, S. Rana, Y. Yi, R. J. Smyth, R. G. Collman, R. W. Doms, G. Vassart, and M. Parmentier. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-725.
44. Scarlatti, G., E. Tresoldi, A. Bjorndal, R. Fredriksson, C. Colognesi, H. K. Deng, M. S. Malnati, A. Plebani, A. G. Siccardi, D. R. Littman, E. M. Fenyo, and P. Lusso. 1997. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nat. Med. 3:1259-1265.
45. Schmidtmayerova, H., M. Alfano, G. Nuovo, and M. Bukrinsky. 1998. Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway, replication is restricted at a postentry level. J. Virol. 72:4633-4642.
46. Schuitemaker, H., M. Groenink, L. Meyaard, N. A. Koolstra, R. A. Fouchier, R. A. Gruters, H. G. Huisman, M. Tersmette, and F. Miedema. 1993. Early replication steps but not cell type-specific signalling of the viral long terminal repeat determine HIV-1 monocytotropism. AIDS Res. Hum. Retroviruses 9:669-675.
47. Schuitemaker, H., N. A. Kootstra, R E. de Goede, F. de Wolf, F. Miedema, and M. Tersmette. 1991. Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J. Virol. 65:356-363.
48. Sher, A., R. T. Gazzinelli, I. P. Oswald, M. Clerici, M. Kullberg, E. J. Pearch, J. A. Berzofsky, T. R. Mossman, S. L. James, and H. C. Morse. 1992. Role of T cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol. Rev. 127:183-204.
49. Shimozato, O., N. Watanabe, M. Goto, and Y. Kobayashi. 1996. Cytokine production by SV40-transformed adherent synovial cells from rheumatoid arthritis patients. Cytokine 8:99-105.
50. + T-helper 1 (Th1)- and Th2-type conditions. J. Virol. 73:316-324.
51. + type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1. J. Virol. 71:465-470.
52. Valentin, A., W. Lu, M. Rosati, R. Schneider, J. Albert, A. Karlsson, and G. N. Pavlakis. 1998. Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression. Proc. Natl. Acad. Sci. USA 95:8886-8891.
53. Weissman, D., R. L. Rabin, J. Arthos, A. Rubbert, M. Dybul, R. Swofford, S. Venkatesan, J. M. Farber, and A. S. Fauci. 1997. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389:981-985.
54. Wong, J. K., M. Hezareh, H. F. Gunthard, D. V. Havlir, C. C. Ignacio, C. A. Spina, and D. D. Richman. 1997. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278:1291-1295.
55. Zack, J. A., S. J. Arrigo, S. R. Weitsman, A. S. Go, A. Haislip, and I. S. Chen. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213-222.
56. Zaitseva, M., A. Blauvelt, S. Lee, C. K. Lapham, V. Klaus-Kovtun, H. Mostowski, J. Manischewitz, and H. Golding. 1997. Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat. Med. 3:1369-1375.