Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection

Journal of Clinical Investigation

Volumn 97, Issue 2, 1996, Pages 323-330

  De Rossi, Anita ^a   Masiero, Sara ^a   Giaquinto, Carlo ^a   Ruga, Ezia ^a   Comar, Manola ^b   Giacca, Mauro ^b   Chieco Bianchi, Luigi ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Intl Ctr Genetic Eng and Biotech   (Italy)

Author keywords

competitive PCR; HIV 1 replication; pediatric AIDS; primary infection; vertical infection

Indexed keywords

VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INTRAUTERINE INFECTION; NEWBORN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVIRUS; RANDOMIZED CONTROLLED TRIAL; VERTICAL TRANSMISSION; VIRUS EXPRESSION; VIRUS REPLICATION; VIRUS TRANSMISSION;

EID: 0030031543     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118419     Document Type: Article

References (44)

1. Pizzo, P. A, C. M. Wilfert, and the Pediatric AIDS Siena Workshop II. 1995 Markers and determinant of disease progression in children with HIV infection. J. Acquir. Immune Defic. Syndr. 8:30-44.
2. De Rossi, A., L. Ometto, F. Mammano, C. Zanotto, C. Giaquinto, and L. Chieco-Bianchi 1992 Vertical transmission of HIV-1: lack of detectable virus in peripheral blood cells of infected children at birth AIDS. 6:1117-1120.
3. Rogers, M F, C-Y Ou, B. Kilbourne, and G Schochetman. 1991. Advances and problems in the diagnosis of human immunodeficiency virus infection in infants. Pediatr Infect. Dis. 10:523-531.
4. Krivine, A., G. Firtion, L. Cao, C Francoual, R. Henrion, and P. Lebon. 1992. HIV replication during the first weeks of life. Lancet 339 1187-1189.
5. Burgard, M. M. J Mayaux, S Blanche, A. Ferroni, M. L. Guihard-Moscato, M. C. Allemon, N Ciraru-Vigneron, G. Firtion, C. Floch, F. Guillot, E. Lachassine, M. Vial, C. Griscelli, C. Rouzioux, and the HIV infection in New-borns French Collaborative Study 1992 The use of virus culture and p24 antigen testing to diagnose human immunodeficiency virus infection in neonates. N. Engl. J Med 327:1192-1197.
6. Borkowsky, W., K. Krasinski, H. Pollack, W. Hoover, A. Kaul, and T Il-met-Moore 1992. Early diagnosis of human immunodeficiency virus infection in children 6 months of age: comparison of polymerase chain reaction. culture. and plasma antigen capture techniques J. Infect. Dis 166.616-619.
7. Luzuriaga, K., P. McQuilken, A. Alimenti, M. Somasundaran, R. A Hesselton, and J. L Sullivan. 1993 Early viremia and immune responses in vertical human immunodeficiency virus type 1 infection. J Infect. Dis 167:1008-1013.
8. De Rossi, A., L. Ometto, F. Mammano, C. Zanotto, A Del Mistro, C. Giaquinto, and L. Chieco-Bianchi. 1993. Time course of antigenaemia and seroconversion in infants with vertically acquired HIV-1 infection. AIDS. 7:528-1529
9. Simon, F , C. Rahimy, A Krivine, M. Levine, J. M. Pepin, D Lapierre, E. Denamur, L. Vernoux, A. De Crepy, P. Blot, E. Vilmer, and F. Brun-Vezinet. 1994. Antibody avidity measurement and immune complex dissociation for serological diagnosis of vertically acquired HIV-1 infection. J Acq. Immune Defic. Syndr. 6:201-207
10. Bryson, Y J., K. Luzuriaga, and D. W. Wara. 1992. Proposed definitions for in utero versus intrapartum transmission of HIV-1. N. Engl J Med 327: 1246-1247.
11. De Rossi, A., C. Giaquinto, L Ometto, F. Mammano, C. Zanotto, D. Dunn, and L Chieco-Bianchi 1993. Replication and tropism of human immunodeficiency virus type 1 as predictors of disease outcome in infants with vertically acquired infection. J. Pediatr. 123:929-936.
12. Dickover, R E , M. Dillon, S. G. Gillette, A. Deveikis, M. Keller, S. Plaeger-Marshall, I. Chen, A. Diagne, E. R. Stiehm, and Y. Bryson. 1994. Rapid increases in load of human immunodeficiency virus correlate with early disease progression and loss of CD4 cells in vertically infected infants. J Infect. Dis. 170:1279-1284.
13. Bagnarelli, P., S. Menzo, A Valenza, A. Manzin, M. Giacca, F. Ancarani, G Scalise, P. E. Varaldo, and M. Clementi. 1992. Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS. J. Virol 66:7328-7335.
14. Menzo, S, P. Bagnarelli, M. Giacca, A. Manzin, P. E. Varaldo, and M Clementi. 1992. Absolute quantitation of viremia in HIV-infected asymptomatic subjects by competitive reverse transcription and polymerase chain reaction. J. Clin Microbiol. 30:1752-1757.
15. Piatak, M., M. S. Saag, L. C. Yang, S. J Clark, J C. Kappes, K C. Luk, B H. Hahn, G. M. Shaw, and J. D. Lifson. 1993. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science (Wash. DC). 259:1749-1754.
16. Bagnarelli, P., A. Valenza, S. Menzo, A. Manzin, G. Scalise, P. E. Varaldo, and M Clementi. 1994. Dynamics of molecular parameters of human immunodeficiency virus type 1 activity in vivo. J. Virol. 68:2495-2502.
17. Wei, X , S. K. Ghosh, M E Taylor, V. A. Johnson, E. A. Emint, P. Deutsch, J D. Lifson, S. Bonhoeffer, M A Nowak, B H. Hahn, M. S. Saag, and G. M. Shaw 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature (Lond.). 373:117-122.
18. Centers for Disease Control. 1994. Revised classification system for HIV-1 infection in children less than 13 years of age. Morb. Mortal. Weekly Rep. 43:1-10.
19. Grosch-Woerner, I., G. Castelli, L. Rosado, M Debre', and D. M. Gibbs for the PENTA Steering Committee. 1994. Treatment of AIDS (PENTA) 1. Tenth International Conference on AIDS. 1:261 (Abstract No. PB0472)
20. Mammano, F., F. Salvatori, L. Ometto, M. Panozzo, L. Chieco-Bianchi, and A De Rossi. 1995 Relationship between the V3 loop and the phenotypes of human immunodeficiency virus type 1 (HIV-1) isolates from children perinatally infected with HIV-1. J. Virol. 69:82-92.
21. Semple, M. G. S Kaye, C Lovelay, and R S Tedder. 1993. HIV-1 plasma viremia quantification: a non-culture measurement needed for therapeutic trials. J. Virol. Meth 41:167-180
22. Comar, M , G Marzio, P D'Agaro, and M. Giacca, Quantitative dynamics of HIV-1 expression. AIDS Res. Hum. Retroviruses. In press.
23. Curgo, C., H. G Huo, G. Fianchini, A. Aldovini, E. Collalti, K. Farrell, F Wong-Staal, R C. Gallo, and M. S. Reitz. 1988. Envelope sequences of two new United States HIV-1 isolates. Virology. 164:531-536.
24. Grassi, G., L. Zentilin, S. Tafuro, S. Diviacco, A. Ventura, and M Giacca. 1994. A rapid procedure for the quantitation of low abundance mRNAs by competitive RT-PCR. Nucleic Acids Res 22;4547-4549.
25. Hahn, B. H , G. M. Shaw, S. K. Arya, M. Popovic, R. C. Gallo. and F. Wong-Staal. 1984. Molecular cloning and characterization of the HTLV-III virus associated with AIDS. Nature (Lond.). 312:166-169.
26. Loveday, C , S. Kaye, M Tenant-Flowers, M. Semple, U. Ayliffe, I. V. Weller, and R. S Tedder. 1995. HIV-1 RNA serum-load and resistant viral genotypes during early zidovudine therapy. Lancet 354:820-824.
27. Clark, S J., M S. Saag, W. D. Decker, J. L. Campbell-Hill, P. J. Roberson. P. J Veldkamp, J. C Kappes. B H Hahn, and G. M Shaw. 1991 High titers of cytophathic virus in plasma of patients with symptomatic primary HIV-1 infection. N. Engl. J. Med. 324:954-960.
28. Daar, E. S., T. Moudgil, R. D. Meyer, and D. D. Ho 1991. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection N Engl J Med 324:961-964.
29. Graziosi, C., G. Pantaleo, L. Butini, J F. Demarest, M. S. Saag, G M. Shaw, and A. S Fauci 1993. Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. Proc. Natl Acad. Sci. USA 90:6405-6409.
30. Tindall, B , and D A. Cooper. 1991. Primary HIV infection: host responses and intervention strategies. AIDS. 5:1-14.
31. NIU, M T., J. A. Jermano, P. Reichelderfer, and S. M. Schnittman. 1993. Summary of the National Institutes of Health Workshop on primary Human Immunodeficiency Virus Type 1 infection AIDS Res. Hum Retroviruses 9. 913-924.
32. Robert-Guroff, M., E. Roilidies, R Muldoon, D Venzon, R. Husson, D Marshall, R C. Gallo, and P A. Pizzo. 1993. Human immunodeficiency virus (HIV) type 1 strain MN neutralizing antibody in HIV-infected children: correlation with clinical status and prognostic value. J. Infect. Dis 167:538-546.
33. Zwart, G., L. vand der Hoek, M. Valk, M. T., Cornelissen, E. Baan, J. Dekker, M Koot, C L Kuiken, and J Goudsmit. 1994. Antibody responses to HIV-1 envelope and gag epitopes in HIV-1 seroconverters with rapid versus slow disease progression. Virology. 201:285-293.
34. Kroup, R. A., J. T. Safrit, Y Cao, C A. Andrews, G. McLeod, W Borkowsky, C. Farthing, and D. D. Ho. 1994 Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome J Virol 68:4650-4655.
35. Borrow, P., H. Lewicki, B. H. Hahn, G. M. Shaw, and M. B. A. Oldstone. 1994. Virus-specific CD8+ CTL activity associated with control of viremia in primary HIV-1 infection. J. Virol. 68:6103-6110.
36. Safrit, J. T., C. A Andrews, T. Zhu, D. D Ho, and R A. Koup. 1994. Characterization of HIV-1-specific CTL clones isolated during acute serum conversion recognition of autologous virus sequences within a conserved immunodominant epitope. J. Exp Med 179.463-472
37. Palumbo, P. E., S. Kowok, S. Waters, Y. Wesley, D Lewis, N. McKinney, A. Bardeguez, E. M. Connor, and J M. Oleske. 1995. Viral measurement by polymerase chain reaction-based assays in hyman immunodeficiency virusinfected infants. J Pediatr. 126:592-595.
38. Luzuriaga, K., R Koup, C. Pikora, D. Brettler, and J Sullivan. 1991. Deficient human immunodeficiency virus type-1 specific cytotoxic T cell responses in vertically infected children. J. Pediatr. 119.230-236
39. Luzuriaga, K., D. Holmes, A Hereema, J. Wong, D. L. Panicali, and J. L. Sullivan. 1995. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J. Immunol. 154:433-443.
40. Rabin, R. L., M. Roederer, Y. Maldonado, A. Petru, L. A Herzenberg and L. A. Herzenberg. 1995. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J. Clin. Invest. 95:2054-2060.
41. Koot, M., I. P. Keet, A. H Vos, R. E. Y. de Goede, M. T. Roos, R. A Couthinho, F. Miedema, P. T Schellckens, and M. Tersmette. 1993. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern. Med 118.681-688.
42. Nielsen, C., C. Pedersen, J. D Lundgren, and J. Gerstoft. 1993. Biological properties of HIV isolates in primary HIV infection: consequences for the subsequent course of infection. AIDS. 7:1035-1040.
43. Connor, R. I , and D D. Ho. 1994. Human Immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J. Virol. 68 4400-4408.
44. De Rossi, A., M. Pasti, F. Mammano, L. Ometto. C. Giaquinto, and I. Chieco-Bianchi 1991. Perinatal infection by human immunodeficiency virus type 1 (HIV-1) relationship between proviral copy number in vivo, viral properties in vitro, and clinical outcome. J Med. Virol. 35:283-289.