Road to fulfilment: Taming the immune response to restore vision

Ophthalmic Research

Volumn 48, Issue 1, 2012, Pages 43-49

  Dick, Andrew D ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

Angiogenesis; Auto immune response; Auto immunity; Experimental auto immune uveoretinitis; Inflammation; Macrophage

Indexed keywords

CD200 ANTIGEN; CHEMOKINE RECEPTOR CCR2; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5A RECEPTOR; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADAPTIVE IMMUNITY; ANGIOGENESIS; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; BLOOD RETINA BARRIER; BONE MARROW CELL; COMPLEMENT ACTIVATION; CYTOKINE PRODUCTION; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; INFLAMMATION; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MACROPHAGE ACTIVATION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; RETINA; RETINA DEGENERATION; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TISSUE INJURY; UVEITIS; VISION; WELLBEING;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; HUMANS; MACROPHAGES; RETINITIS; UVEITIS; VISION DISORDERS;

EID: 84857695444     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000335982     Document Type: Review

References (60)

1. Forrester JV: Privilege revisited: an evaluation of the eye's defence mechanisms. Eye (Lond) 2009; 23: 756-766.
2. Forrester JV, Xu H, Lambe T, Cornall R: Immune privilege or privileged immunity? Mucosal Immunol 2008; 1: 372-381.
3. Imrie FR, Dick AD: Biologics in the treatment of uveitis. Curr Opin Ophthalmol 2007; 18: 481-486.
4. Sharma SM, Nestel AR, Lee RW, Dick AD: Clinical review: anti-TNF-α therapies in uveitis: perspective on 5 years of clinical experience. Ocul Immunol Inflamm 2009; 17: 403-414.
5. Chi W, Zhu X, Yang P, Liu X, Lin X, Zhou H, et al: Upregulated IL-23 and IL-17 in Behçet patients with active uveitis. Invest Ophthalmol Vis Sci 2008; 49: 3058-3064.
6. Ke Y, Liu K, Huang GQ, Cui Y, Kaplan HJ, Shao H, et al: Anti-inflammatory role of IL- 17 in experimental autoimmune uveitis. J Immunol 2009; 182: 3183-3190.
7. Atan D, Fraser-Bell S, Plskova J, Kuffova L, Hogan A, Tufail A, et al: Cytokine polymorphism in noninfectious uveitis. Invest Ophthalmol Vis Sci 2010; 51: 4133-4142.
8. Atan D, Fraser-Bell S, Plskova J, Kuffova L, Hogan A, Tufail A, et al: Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. Invest Ophthalmol Vis Sci 2011; 52: 3573-3581.
9. Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, et al: Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nat Genet 2010; 42: 703-706.
10. Burn GL, Svensson L, Sanchez-Blanco C, Saini M, Cope AP: Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? FEBS Lett 2011: 585: 3689-3698.
11. McDermott MF: Genetic clues to understanding periodic fevers, and possible therapies. Trends Mol Med 2002; 8: 550-554.
12. Scher JU, Abramson SB: The microbiome and rheumatoid arthritis. Nat Rev Rheumatol 2011; 7: 569-578.
13. Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, et al: Control of TH17 cells occurs in the small intestine. Nature 2011; 475: 514-518.
14. Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D: Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci USA 2011; 108: 11548-11553.
15. Lathrop SK, Bloom SM, Rao SM, Nutsch K, Lio CW, Santacruz N, et al: Peripheral education of the immune system by colonic commensal microbiota. Nature 2011; 478: 250-254.
16. Matzinger P: The danger model: a renewed sense of self. Science 2002; 296: 301-305.
17. Medzhitov R, Janeway CA Jr: Decoding the patterns of self and nonself by the innate immune system. Science 2002; 296: 298-300.
18. Nathan C: Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006; 6: 173-182.
19. Medzhitov R: Origin and physiological roles of inflammation. Nature 2008; 454: 428-435.
20. Chen M, Forrester JV, Xu H: Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One 2011; 6:e22818.
21. Xu H, Chen M, Forrester JV: Para-inflammation in the aging retina. Prog Retin Eye Res 2009; 28: 348-368.
22. Lee RW, Schewitz LP, Nicholson LB, Dayan CM, Dick AD: Steroid refractory CD4+ T cells in patients with sight-threatening uveitis. Invest Ophthalmol Vis Sci 2009; 50: 4273-4278.
23. McKinney EF, Lyons PA, Carr EJ, Hollis JL, Jayne DR, Willcocks LC, et al: A CD8+ T cell transcription signature predicts prognosis in autoimmune disease. Nat Med 2010; 16: 586-591, 1 p following 591.
24. Forrester JV, Xu H, Kuffova L, Dick AD, Mc- Menamin PG: Dendritic cell physiology and function in the eye. Immunol Rev 2010; 234: 282-304.
25. Kezic J, Xu H, Chinnery HR, Murphy CC, McMenamin PG: Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye. Invest Ophthalmol Vis Sci 2008; 49: 1599-1608.
26. Xu H, Chen M, Mayer EJ, Forrester JV, Dick AD: Turnover of resident retinal microglia in the normal adult mouse. Glia 2007; 55: 1189-1198.
27. Balasubramaniam B, Carter DA, Mayer EJ, Dick AD: Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions. Exp Eye Res 2009; 89: 757-766.
28. Dick AD: Influence of microglia on retinal progenitor cell turnover and cell replacement. Eye (Lond) 2009; 23: 1939-1945.
29. Dick AD, Carter D, Robertson M, Broderick C, Hughes E, Forrester JV, et al: Control of myeloid activity during retinal inflammation. J Leukoc Biol 2003; 74: 161-166.
30. Ransohoff RM, Cardona AE: The myeloid cells of the central nervous system parenchyma. Nature 2010; 468: 253-262.
31. Broderick C, Duncan L, Taylor N, Dick AD: IFN-gamma and LPS-mediated IL-10-dependent suppression of retinal microglial activation. Invest Ophthalmol Vis Sci 2000; 41: 2613-2622.
32. Carter DA, Dick AD: Lipopolysaccharide/ interferon-γ and not transforming growth factor- β inhibits retinal microglial migration from retinal explant. Br J Ophthalmol 2003; 87: 481-487.
33. Carter DA, Dick AD: CD200 maintains microglial potential to migrate in adult human retinal explant model. Curr Eye Res 2004; 28: 427-436.
34. Rao NA, Kimoto T, Zamir E, Giri R, Wang R, Ito S, et al: Pathogenic role of retinal microglia in experimental uveoretinitis. Invest Ophthalmol Vis Sci 2003; 44: 22-31.
35. Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM: Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 2011; 14: 1142-1149.
36. Gordon S: Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23-35.
37. Gordon S, Taylor PR: Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005; 5: 953-964.
38. Murray PJ, Wynn TA: Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011.
39. Copland DA, Wertheim MS, Armitage WJ, Nicholson LB, Raveney BJ, Dick AD: The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. Invest Ophthalmol Vis Sci 2008; 49: 5458-5465.
40. Kerr EC, Raveney BJ, Copland DA, Dick AD, Nicholson LB: Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. J Autoimmun 2008; 31: 354-361.
41. Robertson MJ, Erwig LP, Liversidge J, Forrester JV, Rees AJ, Dick AD: Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis. Invest Ophthalmol Vis Sci 2002; 43: 2250-2257.
42. Dick AD, Broderick C, Forrester JV, Wright GJ: Distribution of OX2 antigen and OX2 receptor within retina. Invest Ophthalmol Vis Sci. 2001; 42: 170-176.
43. Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, et al: Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 2000; 290: 1768-1771.
44. Banerjee D, Dick AD: Blocking CD200- CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats. Ocul Immunol Inflamm 2004; 12: 115-125.
45. Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD: Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 2002; 161: 1669-1677.
46. Jenmalm MC, Cherwinski H, Bowman EP, Phillips JH, Sedgwick JD: Regulation of myeloid cell function through the CD200 receptor. J Immunol 2006; 176: 191-199.
47. Copland DA, Calder CJ, Raveney BJ, Nicholson LB, Phillips J, Cherwinski H, et al: Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. Am J Pathol 2007; 171: 580-588.
48. Broderick CA, Smith AJ, Balaggan KS, Georgiadis A, Buch PK, Trittibach PC, et al: Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis. Mol Ther 2005; 12: 369-373.
49. Ferrara DC, Merriam JE, Freund KB, Spaide RF, Takahashi BS, Zhitomirsky I, et al: Analysis of major alleles associated with age-related macular degeneration in patients with multifocal choroiditis: strong association with complement factor H. Arch Ophthalmol 2008; 126: 1562-1566.
50. Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, et al: A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 2005; 102: 7227-7232.
51. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, et al: Complement factor H polymorphism in age-related macular degeneration. Science 2005; 308: 385-389.
52. Chen M, Muckersie E, Luo C, Forrester JV, Xu H: Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis. Eur J Immunol 2010; 40: 2870-2881.
53. Chen M, Muckersie E, Robertson M, Forrester JV, Xu H: Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina. Exp Eye Res 2008; 87: 543-550.
54. Copland DA, Hussain K, Baalasubramanian S, Hughes TR, Morgan BP, Xu H, et al: Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis. Clin Exp Immunol 2010; 159: 303-314.
55. Chen M, Copland DA, Zhao J, Liu J, Forrester JV, Dick AD, et al: Persistent inflammation subverts thrombospondin-1-induced regulation of retinal angiogenesis and is driven by CCR2 ligation. Am J Pathol 2011.
56. Kerr EC, Copland DA, Dick AD, Nicholson LB: The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis. Prog Retin Eye Res 2008; 27: 527-535.
57. Apte RS, Richter J, Herndon J, Ferguson TA: Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 2006; 3:e310.
58. Kelly J, Ali Khan A, Yin J, Ferguson TA, Apte RS: Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest 2007; 117: 3421-3426.
59. Wu WK, Llewellyn OP, Bates DO, Nicholson LB, Dick AD: IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia. Immunobiology 2010; 215: 796-803.
60. Raveney BJ, Copland DA, Nicholson LB, Dick AD: Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease. Arch Ophthalmol 2008; 126: 1390-1395.