-
1
-
-
0029924265
-
The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling
-
Leonard, W. J. 1996. The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu. Rev. Med. 47:229.
-
(1996)
Annu. Rev. Med.
, vol.47
, pp. 229
-
-
Leonard, W.J.1
-
2
-
-
0034501027
-
Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency Defects of the gamma(c)-JAK3 signaling pathway as a model
-
Notarangelo, L. D., Giliani, S., Mazza, C. et al. 2000. Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model. Immunol. Rev. 178:39.
-
(2000)
Immunol. Rev.
, vol.178
, pp. 39
-
-
Notarangelo, L.D.1
Giliani, S.2
Mazza, C.3
-
4
-
-
32244444750
-
Stat5a/b are essential for normal lymphoid development and differentiation
-
Yao, Z., Cui, Y., Watford, W. T. et al. 2006. Stat5a/b are essential for normal lymphoid development and differentiation. Proc. Natl Acad. Sci. USA 103:1000.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 1000
-
-
Yao, Z.1
Cui, Y.2
Watford, W.T.3
-
5
-
-
0033082138
-
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
-
Moriggl, R., Topham, D. J., Teglund, S. et al. 1999. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249.
-
(1999)
Immunity
, vol.10
, pp. 249
-
-
Moriggl, R.1
Topham, D.J.2
Teglund, S.3
-
6
-
-
0034163579
-
The IL-2 receptor promotes lymphocyte proliferation and induction of the cmyc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5
-
Lord, J. D., McIntosh, B. C., Greenberg, P. D. et al. 2000. The IL-2 receptor promotes lymphocyte proliferation and induction of the cmyc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5. J. Immunol. 164:2533.
-
(2000)
J. Immunol.
, vol.164
, pp. 2533
-
-
Lord, J.D.1
McIntosh, B.C.2
Greenberg, P.D.3
-
7
-
-
38149004467
-
STAT5 is essential for Akt/p 70S6 kinase activity during IL-2-induced lymphocyte proliferation
-
Lockyer, H. M., Tran, E. and Nelson, B. H. 2007. STAT5 is essential for Akt/p.70S6 kinase activity during IL-2-induced lymphocyte proliferation. J. Immunol. 179:5301.
-
(2007)
J. Immunol.
, vol.179
, pp. 5301
-
-
Lockyer, H.M.1
Tran, E.2
Nelson, B.H.3
-
8
-
-
10444276464
-
Common c chainsignaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia
-
Barata, J. T., Keenan, T. D., Silva, A. et al. 2004. Common c chainsignaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia. Haematologica 89:1459.
-
(2004)
Haematologica
, vol.89
, pp. 1459
-
-
Barata, J.T.1
Keenan, T.D.2
Silva, A.3
-
9
-
-
51349090473
-
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
-
Hacein-Bey-Abina, S., Garrigue, A., Wang, G. P. et al. 2008. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J. Clin. Invest. 118:3132.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3132
-
-
Hacein-Bey-Abina, S.1
Garrigue, A.2
Wang, G.P.3
-
10
-
-
51349158298
-
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
-
Howe, S. J., Mansour, M. R., Schwarzwaelder, K. et al. 2008. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J. Clin. Invest. 118:3143.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3143
-
-
Howe, S.J.1
Mansour, M.R.2
Schwarzwaelder, K.3
-
11
-
-
64849093182
-
The cellular amount of the common c-chain influences spontaneous or induced cell proliferation
-
Amorosi, S., Russo, I., Amodio, G. et al. 2009. The cellular amount of the common c-chain influences spontaneous or induced cell proliferation. J. Immunol. 182:3304.
-
(2009)
J. Immunol.
, vol.182
, pp. 3304
-
-
Amorosi, S.1
Russo, I.2
Amodio, G.3
-
12
-
-
34247371033
-
Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy
-
Maddika, S., Ande, S. R., Panigrahi, S. et al. 2007. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist. Updat. 10:13.
-
(2007)
Drug Resist. Updat.
, vol.10
, pp. 13
-
-
Maddika, S.1
Ande, S.R.2
Panigrahi, S.3
-
13
-
-
8644219655
-
Living with or without cyclins and cyclin-dependent kinases
-
Sherr, C. J. and Roberts, J. M. 2004. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18:2699.
-
(2004)
Genes Dev
, vol.18
, pp. 2699
-
-
Sherr, C.J.1
Roberts, J.M.2
-
14
-
-
0037855829
-
Antiapoptotic signalling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit
-
Lindemann, M. J., Benczik, M. and Gaffen, S. L. 2003. Antiapoptotic signalling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit. J. Biol. Chem. 278:10239.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10239
-
-
Lindemann, M.J.1
Benczik, M.2
Gaffen, S.L.3
-
15
-
-
0035253352
-
Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-21
-
Martino, A., Holmes, J. H. IV, Lord, J. D. et al. 2001. Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-21. J. Immunol. 166:1723.
-
(2001)
J. Immunol.
, vol.166
, pp. 1723
-
-
Martino, A.1
Holmes, J.H.2
Lord, J.D.3
-
16
-
-
1242272047
-
A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor
-
Moon, J. J., Rubio, E. D., Martino, A. et al. 2004. A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor. J. Biol. Chem. 279:5520.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5520
-
-
Moon, J.J.1
Rubio, E.D.2
Martino, A.3
-
17
-
-
33747763667
-
All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3
-
Engedal, N., Gjevik, T., Blomhoff, R. et al. 2006. All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3. J. Immunol. 177:2851.
-
(2006)
J. Immunol.
, vol.177
, pp. 2851
-
-
Engedal, N.1
Gjevik, T.2
Blomhoff, R.3
-
18
-
-
33745954330
-
BCL2 family in DNA damage and cell cycle control
-
Zinkel, S., Gross, A. and Yang, E. 2006. BCL2 family in DNA damage and cell cycle control. Cell Death Differ. 13:1351.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1351
-
-
Zinkel, S.1
Gross, A.2
Yang, E.3
-
19
-
-
33645964321
-
A unique function for cyclin D3 in early B cell development
-
Cooper, A. B., Sawai, C. M., Sicinska, E. et al. 2006. A unique function for cyclin D3 in early B cell development. Nat. Immunol. 7:489.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 489
-
-
Cooper, A.B.1
Sawai, C.M.2
Sicinska, E.3
-
20
-
-
0021824427
-
Impaired suppressor activity in children affected by coeliac disease
-
Pignata, C., Troncone, R., Monaco, G. et al. 1985. Impaired suppressor activity in children affected by coeliac disease. Gut 26:285.
-
(1985)
Gut
, vol.26
, pp. 285
-
-
Pignata, C.1
Troncone, R.2
Monaco, G.3
-
22
-
-
0035123704
-
Defective function of Fas in patients with type 1 diabetes associated with other autoimmune diseases
-
DeFranco, S., Bonissoni, S., Cerutti, F. et al. 2001. Defective function of Fas in patients with type 1 diabetes associated with other autoimmune diseases. Diabetes 50:483.
-
(2001)
Diabetes
, vol.50
, pp. 483
-
-
DeFranco, S.1
Bonissoni, S.2
Cerutti, F.3
-
23
-
-
33845483887
-
Caspases in cell survival, proliferation and differentiation
-
Lamkanfi, M., Festjens, N., Declercq, W. et al. 2007. Caspases in cell survival, proliferation and differentiation. Cell Death Differ. 14:44.
-
(2007)
Cell Death Differ
, vol.14
, pp. 44
-
-
Lamkanfi, M.1
Festjens, N.2
Declercq, W.3
-
24
-
-
54949152716
-
Caspase independent cell death: leaving the set without the final cut
-
Tait, S. W. G. and Green, D. R. 2008. Caspase independent cell death: leaving the set without the final cut. Oncogene 27:6452.
-
(2008)
Oncogene
, vol.27
, pp. 6452
-
-
Tait, S.W.G.1
Green, D.R.2
-
25
-
-
0034658350
-
Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2
-
Haraguchi, B. M., Torii, S., Matsuzawa, S. et al. 2000. Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. J. Exp. Med. 191:1709.
-
(2000)
J. Exp. Med.
, vol.191
, pp. 1709
-
-
Haraguchi, B.M.1
Torii, S.2
Matsuzawa, S.3
-
26
-
-
23244462491
-
Effects of Bcl-2 levels on Fas signaling-induced Caspase-3 activation: molecular genetic tests of computational model predictions
-
Hua, F., Cornejo, M. G., Cardone, M. H. et al. 2005. Effects of Bcl-2 levels on Fas signaling-induced Caspase-3 activation: molecular genetic tests of computational model predictions. J. Immunol. 175:985.
-
(2005)
J. Immunol.
, vol.175
, pp. 985
-
-
Hua, F.1
Cornejo, M.G.2
Cardone, M.H.3
-
27
-
-
78751655392
-
Bcl-2 and Bcl-xL play important role in the crosstalk between autophagy and apoptosis
-
Zhou, F., Yang, Y. and Xing, D. 2011. Bcl-2 and Bcl-xL play important role in the crosstalk between autophagy and apoptosis. FEBS J. 278:403.
-
(2011)
FEBS J
, vol.278
, pp. 403
-
-
Zhou, F.1
Yang, Y.2
Xing, D.3
-
28
-
-
0030874326
-
The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression
-
von Freeden-Jeffry, U., Solvason, N., Howard, M. et al. 1997. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7:147.
-
(1997)
Immunity
, vol.7
, pp. 147
-
-
von Freeden-Jeffry, U.1
Solvason, N.2
Howard, M.3
-
29
-
-
0030067103
-
Interleukin-2 receptor common c-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression
-
Akbar, A., Borthwick, N. J., Wickremasinghe, R. G. et al. 1996. Interleukin-2 receptor common c-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur. J. Immunol. 26:294.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 294
-
-
Akbar, A.1
Borthwick, N.J.2
Wickremasinghe, R.G.3
-
30
-
-
69049109894
-
Coupling the cell cycle to development
-
Budirahardja, Y. and Gonczy, P. 2009. Coupling the cell cycle to development. Development 136:2861.
-
(2009)
Development
, vol.136
, pp. 2861
-
-
Budirahardja, Y.1
Gonczy, P.2
-
31
-
-
22444432945
-
Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome
-
Ekberg, J., Holm, C., Jalili, S. et al. 2005. Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome. Eur. J. Haematol. 75:106.
-
(2005)
Eur. J. Haematol.
, vol.75
, pp. 106
-
-
Ekberg, J.1
Holm, C.2
Jalili, S.3
-
32
-
-
67149105856
-
Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy
-
Davè, U. P., Akagi, K., Tripathi, R. et al. 2009. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. PLoS Genet. 5:e1000491.
-
(2009)
PLoS Genet
, vol.5
-
-
Davè, U.P.1
Akagi, K.2
Tripathi, R.3
-
33
-
-
34547686397
-
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy
-
Aiuti, A., Cassani, B., Andolfi, G. et al. 2007. Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy. J. Clin. Invest. 117:2233.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2233
-
-
Aiuti, A.1
Cassani, B.2
Andolfi, G.3
-
34
-
-
34249906359
-
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
-
Deichmann, A., Hacein-Bey-Abina, S., Schmidt, M. et al. 2007. Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J. Clin. Invest. 117:2225.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2225
-
-
Deichmann, A.1
Hacein-Bey-Abina, S.2
Schmidt, M.3
-
36
-
-
27144554190
-
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis
-
Du, Y., Spence, S. E., Jenkins, N. A. et al. 2005. Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis. Blood 106:2498.
-
(2005)
Blood
, vol.106
, pp. 2498
-
-
Du, Y.1
Spence, S.E.2
Jenkins, N.A.3
-
37
-
-
63849275092
-
Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models
-
Cornejo, M. G., Kharas, M. G., Werneck, M. B. et al. 2009. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood 113:2746.
-
(2009)
Blood
, vol.113
, pp. 2746
-
-
Cornejo, M.G.1
Kharas, M.G.2
Werneck, M.B.3
-
38
-
-
40449129817
-
JAK kinases overexpression promotes in vitro cell transformation
-
Knoops, L., Hornakova, T., Royer, Y. et al. 2008. JAK kinases overexpression promotes in vitro cell transformation. Oncogene 27:1511.
-
(2008)
Oncogene
, vol.27
, pp. 1511
-
-
Knoops, L.1
Hornakova, T.2
Royer, Y.3
-
39
-
-
0037138374
-
The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter
-
Ambrosio, R., Fimiani, G., Monfregola, J. et al. 2002. The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter. Gene 285:311.
-
(2002)
Gene
, vol.285
, pp. 311
-
-
Ambrosio, R.1
Fimiani, G.2
Monfregola, J.3
-
40
-
-
33846927933
-
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
-
Harir, N., Pecquet, C., Kerenyi, M. et al. 2007. Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood 109:1678.
-
(2007)
Blood
, vol.109
, pp. 1678
-
-
Harir, N.1
Pecquet, C.2
Kerenyi, M.3
-
42
-
-
4143080409
-
Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells
-
Yuan, J., Yan, R., Kramer, A. et al. 2004. Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells. Oncogene 23:5843.
-
(2004)
Oncogene
, vol.23
, pp. 5843
-
-
Yuan, J.1
Yan, R.2
Kramer, A.3
-
43
-
-
54549101258
-
Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
-
Hochegger, H., Takeda, S. and Hunt, T. 2008. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nature 9:910.
-
(2008)
Nature
, vol.9
, pp. 910
-
-
Hochegger, H.1
Takeda, S.2
Hunt, T.3
-
44
-
-
67650638697
-
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells
-
Kalaszczynska, I., Geng, Y., Lino, T. et al. 2009. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138:352.
-
(2009)
Cell
, vol.138
, pp. 352
-
-
Kalaszczynska, I.1
Geng, Y.2
Lino, T.3
-
45
-
-
30344479175
-
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
-
Landis, M. W., Pawlyk, B. S., Li, T. et al. 2006. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9:13.
-
(2006)
Cancer Cell
, vol.9
, pp. 13
-
-
Landis, M.W.1
Pawlyk, B.S.2
Li, T.3
-
46
-
-
0036124281
-
Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p 27
-
Decker, T., Schneller, F., Hipp, S. et al. 2002. Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p.27. Leukemia 16:327.
-
(2002)
Leukemia
, vol.16
, pp. 327
-
-
Decker, T.1
Schneller, F.2
Hipp, S.3
-
47
-
-
9144229104
-
Requirement for cyclin D3 in lymphocyte development and T cell leukemias
-
Sicinska, E., Aifantis, I., Le Cam, L. et al. 2003. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4:451.
-
(2003)
Cancer Cell
, vol.4
, pp. 451
-
-
Sicinska, E.1
Aifantis, I.2
Le Cam, L.3
-
48
-
-
4444307411
-
Mouse development and cell proliferation in the absence of D-cyclins
-
Kozar, K., Ciemerych, M. A., Rebel, V. I. et al. 2004. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118:477.
-
(2004)
Cell
, vol.118
, pp. 477
-
-
Kozar, K.1
Ciemerych, M.A.2
Rebel, V.I.3
|