Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy

PLoS Genetics

Volumn 5, Issue 5, 2009, Pages

  Davé, Utpal P ^a,b   Akagi, Keiko ^c   Tripathi, Rati ^a,b   Cleveland, Susan M ^a,b   Thompson, Mary A ^a   Yi, Ming ^c   Stephens, Robert ^c   Downing, James R ^d   Jenkins, Nancy A ^e   Copeland, Neal G ^e  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; IL2RG GENE; LEUKEMIA; LMO2 GENE; MALE; MEF2C GENE; MICROARRAY ANALYSIS; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRDM16 GENE; TCF12 GENE; TUMOR; VIRAL GENE THERAPY; X LINKED SEVERE COMBINED IMMUNODEFICIENCY; ANIMAL; AUTOTRANSPLANTATION; BIOLOGICAL MODEL; EXPERIMENTAL LEUKEMIA; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MOLECULAR GENETICS; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; RETROVIRUS; T CELL LEUKEMIA; VIRUS DNA CELL DNA INTERACTION;

MURINAE; MUS;

DNA; DNA BINDING PROTEIN; IL2RG PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR GAMMA; LMO2 PROTEIN, HUMAN; LMO2 PROTEIN, MOUSE; METALLOPROTEIN;

ANIMALS; BASE SEQUENCE; DNA, NEOPLASM; DNA-BINDING PROTEINS; GENE THERAPY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; LEUKEMIA, EXPERIMENTAL; LEUKEMIA-LYMPHOMA, ADULT T-CELL; METALLOPROTEINS; MICE; MICE, SCID; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; RETROVIRIDAE; TRANSPLANTATION, AUTOLOGOUS; VIRUS INTEGRATION; X-LINKED COMBINED IMMUNODEFICIENCY DISEASES;

EID: 67149105856     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000491     Document Type: Article

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