메뉴 건너뛰기




Volumn 15, Issue 3, 2012, Pages 258-268

The bioactive potential of red raspberry (Rubus idaeus L.) leaves in exhibiting cytotoxic and cytoprotective activity on human laryngeal carcinoma and colon adenocarcinoma

Author keywords

Antioxidant activity; Cytotoxicity; Glutathione; Polyphenols; Red raspberry leaves

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; HYDROGEN PEROXIDE; PLANT EXTRACT; POLYPHENOL; REACTIVE OXYGEN METABOLITE; RUBUS IDAEUS LEAF EXTRACT; UNCLASSIFIED DRUG;

EID: 84857533171     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.0087     Document Type: Article
Times cited : (54)

References (50)
  • 1
    • 0036846569 scopus 로고    scopus 로고
    • Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro
    • DOI 10.1002/ptr.1040
    • Rojas-Vera J, Patel AV, Dacke CG: Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro. Phytother Res 2002;16:665-668. (Pubitemid 35334189)
    • (2002) Phytotherapy Research , vol.16 , Issue.7 , pp. 665-668
    • Rojas-Vera, J.1    Patel, A.V.2    Dacke, C.G.3
  • 2
    • 0034835909 scopus 로고    scopus 로고
    • Effect of processing and storage on the antioxidant ellagic acid derivatives and flavonoids of red raspberry (Rubus idaeus) jams
    • DOI 10.1021/jf010192x
    • Zafrilla P, Federico F, Tomas-Barberan FA: Effect of processing and storage on the antioxidant ellagic acid derivatives and flavonoids of red raspberry (Rubus idaeus) jams. J Agric Food Chem 2001;49:3651-3655. (Pubitemid 32822671)
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , Issue.8 , pp. 3651-3655
    • Zafrilla, P.1    Ferreres, F.2    Tomas-Barberan, F.A.3
  • 3
    • 0141459583 scopus 로고    scopus 로고
    • n
    • DOI 10.1016/S0031-9422(03)00281-4
    • Mullen W, Yokota T, Lean MEJ, Crozier A: Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC-MSn. Phytochemistry 2003;64:617-624. (Pubitemid 37168986)
    • (2003) Phytochemistry , vol.64 , Issue.2 , pp. 617-624
    • Mullen, W.1    Yokota, T.2    Lean, M.E.J.3    Crozier, A.4
  • 4
    • 77957861676 scopus 로고    scopus 로고
    • Comparison of antioxidant capacity and phytochemical properties of wild and cultivated red raspberries (Rubus idaeus L.)
    • Cxekiç CX, Özgen M: Comparison of antioxidant capacity and phytochemical properties of wild and cultivated red raspberries (Rubus idaeus L.). J Food Compos Anal 2010;23:540-544.
    • (2010) J Food Compos Anal , vol.23 , pp. 540-544
    • Cxekiç, C.X.1    Özgen, M.2
  • 5
    • 56049111902 scopus 로고    scopus 로고
    • Comparison of quercetin derivatives in ethanolic extracts of red raspberry (Rubus idaeus L.) leaves
    • Dvaranauskaite A, Venskutonis PR, Labokas J: Comparison of quercetin derivatives in ethanolic extracts of red raspberry (Rubus idaeus L.) leaves. Acta Aliment Acad Sci Hung 2008;37:449-463.
    • (2008) Acta Aliment Acad Sci Hung , vol.37 , pp. 449-463
    • Dvaranauskaite, A.1    Venskutonis, P.R.2    Labokas, J.3
  • 6
    • 16644401126 scopus 로고    scopus 로고
    • Determination of flavonoids, taninns and ellagic acid in leaves from Rubus L. species
    • Gudej J, Tomczyk M: Determination of flavonoids, taninns and ellagic acid in leaves from Rubus L. species. Arch Pharmacol Res 2004;27:1114-1119.
    • (2004) Arch Pharmacol Res , vol.27 , pp. 1114-1119
    • Gudej, J.1    Tomczyk, M.2
  • 7
    • 37949048960 scopus 로고    scopus 로고
    • Flavonoid compounds from the leaves of Rubus idaeus L
    • Gudej J, Rychlinska I: Flavonoid compounds from the leaves of Rubus idaeus L. Herba Pol 1996;42:257-261.
    • (1996) Herba Pol , vol.42 , pp. 257-261
    • Gudej, J.1    Rychlinska, I.2
  • 8
    • 0039612436 scopus 로고
    • Phenolic acids in some tannin drugs of the Rosaceae family
    • Krcazcek T: Phenolic acids in some tannin drugs of the Rosaceae family. Farmacia Pol 1984;40:475-477.
    • (1984) Farmacia Pol , vol.40 , pp. 475-477
    • Krcazcek, T.1
  • 9
    • 37949051881 scopus 로고
    • Phytochemical investigation of Rubus plicatus blackberry
    • Wójcik E: Phytochemical investigation of Rubus plicatus blackberry. Acta Pol Pharm 1989;46:386-390.
    • (1989) Acta Pol Pharm , vol.46 , pp. 386-390
    • Wójcik, E.1
  • 10
    • 0000595475 scopus 로고
    • Ellagic acid content of red raspberry juice as influenced by cultivar, processing and environmental factors
    • Rommel A, Wrolstad RE: Ellagic acid content of red raspberry juice as influenced by cultivar, processing and environmental factors. J Agric Food Chem 1993;41:1951-1960.
    • (1993) J Agric Food Chem , vol.41 , pp. 1951-1960
    • Rommel, A.1    Wrolstad, R.E.2
  • 12
    • 77956176217 scopus 로고    scopus 로고
    • Instability of, and generation of hydrogen peroxide by phenolic compounds in cell culture media
    • Long LH, Hoi A, Halliwell B: Instability of, and generation of hydrogen peroxide by phenolic compounds in cell culture media. Arch Biochem Biophys 2010;501:162-169.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 162-169
    • Long, L.H.1    Hoi, A.2    Halliwell, B.3
  • 13
    • 33747026663 scopus 로고    scopus 로고
    • The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway
    • DOI 10.1016/j.jnutbio.2005.09.004, PII S095528630500241X
    • Larrosa M, Tomás-Barberán FA, Espín JC: The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J Nutr Biochem 2006;17: 611-625. (Pubitemid 44205438)
    • (2006) Journal of Nutritional Biochemistry , vol.17 , Issue.9 , pp. 611-625
    • Larrosa, M.1    Tomas-Barberan, F.A.2    Espin, J.C.3
  • 14
    • 0141863169 scopus 로고    scopus 로고
    • Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans
    • DOI 10.1016/S0304-3835(03)00412-9
    • van der Woude H, Gliszczyńska-Świglo A, Struijs K, Smeets A, Alink GM, Rietjens IMCM: Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 2003;200:41-47. (Pubitemid 37222357)
    • (2003) Cancer Letters , vol.200 , Issue.1 , pp. 41-47
    • Van Der Woude, H.1    Gliszczynska-Swigl2    o, A.3    Struijs, K.4    Smeets, A.5    Alink, G.M.6    Rietjens, I.M.C.M.7
  • 16
    • 0346181942 scopus 로고    scopus 로고
    • Polyphenols in cereals and their positive and negative role in human and animal nutrition
    • (Vaculová K, Ehrenbergerová J, eds.). Agricultural Research Institute Kroměříž Ltd, Brno, Czech Republic
    • Lachman J, Hosnedl V, Pivec V, Orsák M: Polyphenols in cereals and their positive and negative role in human and animal nutrition. In: Proceedings of Conference Cereals for Human Health and Preventive Nutrition (Vaculová K, Ehrenbergerová J, eds.). Agricultural Research Institute Kroměříž Ltd, Brno, Czech Republic. 1998, pp. 118-125.
    • (1998) Proceedings of Conference Cereals for Human Health and Preventive Nutrition , pp. 118-125
    • Lachman, J.1    Hosnedl, V.2    Pivec, V.3    Orsák, M.4
  • 17
    • 0002233394 scopus 로고
    • An estimate of the nonflavonoid phenols in wines
    • Kramling T, Singleton VE: An estimate of the nonflavonoid phenols in wines. Am J Enol Vitic 1969;20:86-92.
    • (1969) Am J Enol Vitic , vol.20 , pp. 86-92
    • Kramling, T.1    Singleton, V.E.2
  • 19
    • 46549091814 scopus 로고
    • The conversion of procyanidins and prodelphinidins to cyanidin and delphinidin
    • Porter LJ, Hrstich L, Chan BG: The conversion of procyanidins and prodelphinidins to cyanidin and delphinidin. Phytochemistry 1986;25:223-230.
    • (1986) Phytochemistry , vol.25 , pp. 223-230
    • Porter, L.J.1    Hrstich, L.2    Chan, B.G.3
  • 20
    • 0036758020 scopus 로고    scopus 로고
    • Estimation of total flavonoid content in propolis by two complementary colometric methods
    • Chang C, Yang M, Wen H, Chern J: Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 2002;10:178-182. (Pubitemid 35355995)
    • (2002) Journal of Food and Drug Analysis , vol.10 , Issue.3 , pp. 178-182
    • Chang, C.-C.1    Yang, M.-H.2    Wen, H.-M.3    Chern, J.-C.4
  • 21
    • 0017264857 scopus 로고
    • Zur Bestimmung der Gerbstoffe mit Casein
    • Schneider G: Zur Bestimmung der Gerbstoffe mit Casein. Arch Pharm 1976;309:38-44.
    • (1976) Arch Pharm , vol.309 , pp. 38-44
    • Schneider, G.1
  • 22
    • 0004251761 scopus 로고    scopus 로고
    • Fraxini folium. DEQS, Strasbourg
    • Fraxini folium. In: European Pharmacopoeia, 4th ed. DEQS, Strasbourg, 2002, p. 1342.
    • (2002) European Pharmacopoeia, 4th Ed. , pp. 1342
  • 23
    • 58149364663 scopus 로고
    • Use of free radical method to evaluate antioxidant activity
    • Brand-Williams W, Cuvelier ME, Berset C: Use of free radical method to evaluate antioxidant activity. Food Sci Technol 1995; 28:25-30.
    • (1995) Food Sci Technol , vol.28 , pp. 25-30
    • Brand-Williams, W.1    Cuvelier, M.E.2    Berset, C.3
  • 24
    • 0032982508 scopus 로고    scopus 로고
    • Antioxidant activity applying an improved ABTS radical cation decolorization assay
    • DOI 10.1016/S0891-5849(98)00315-3, PII S0891584998003153
    • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C: Antioxidant activity applying an improved ABTS radical cation decolorisation assay. Free Radic Biol Med 1999; 26:1231-1237. (Pubitemid 29262709)
    • (1999) Free Radical Biology and Medicine , vol.26 , Issue.9-10 , pp. 1231-1237
    • Re, R.1    Pellegrini, N.2    Proteggente, A.3    Pannala, A.4    Yang, M.5    Rice-Evans, C.6
  • 25
    • 0030586361 scopus 로고    scopus 로고
    • The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': The FRAP assay
    • Benzie IF, Strain JJ: The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay. Anal Biochem 1996;239:70-76.
    • (1996) Anal Biochem , vol.239 , pp. 70-76
    • Benzie, I.F.1    Strain, J.J.2
  • 26
    • 0000721208 scopus 로고
    • Applications of the Neutral Red cytotoxicity assay to in vitro toxicology
    • Babich H, Borenfreund E: Applications of the Neutral Red cytotoxicity assay to in vitro toxicology. ATLA 1990;18: 129-144.
    • (1990) ATLA , vol.18 , pp. 129-144
    • Babich, H.1    Borenfreund, E.2
  • 27
    • 0032820452 scopus 로고    scopus 로고
    • Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
    • DOI 10.1016/S0891-5849(99)00107-0, PII S0891584999001070
    • Wang H, Jospeh JA: Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 1999;27:612-616. (Pubitemid 29408648)
    • (1999) Free Radical Biology and Medicine , vol.27 , Issue.5-6 , pp. 612-616
    • Wang, H.1    Joseph, J.A.2
  • 28
    • 0032783532 scopus 로고    scopus 로고
    • Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
    • DOI 10.1016/S0891-5849(99)00061-1, PII S0891584999000611
    • Hempel SL, Buettner GR, O'Malley YO, Wessels DA, Flaherty DM: Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′ dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic Biol Med 1999;27: 146-159. (Pubitemid 29353095)
    • (1999) Free Radical Biology and Medicine , vol.27 , Issue.1-2 , pp. 146-159
    • Hempel, S.L.1    Buettner, G.R.2    O'Malley, Y.Q.3    Wessels, D.A.4    Flaherty, D.M.5
  • 29
    • 0142075358 scopus 로고    scopus 로고
    • Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contractions
    • DOI 10.1016/S0891-5849(03)00271-5
    • Silveira LR, Pereira-Da-Silva L, Juel C, Hellsten Y: Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contractions. Free Radic Biol Med 2003;35:455-464. (Pubitemid 37289155)
    • (2003) Free Radical Biology and Medicine , vol.35 , Issue.5 , pp. 455-464
    • Silveira, L.R.1    Pereira-Da-Silva, L.2    Juel, C.3    Hellsten, Y.4
  • 30
    • 0014481378 scopus 로고
    • Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F: Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969;27: 502-522.
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 31
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 32
    • 33846591843 scopus 로고    scopus 로고
    • Radical scavenging activity and composition of raspberry (Rubus idaeus) leaves from different locations in Lithuania
    • DOI 10.1016/j.fitote.2006.10.001, PII S0367326X06002735
    • Venskutonis PR, Dvaranauskaite A, Labokas J: Radical scavenging activity and composition of raspberry (Rubus idaeus) leaves from different locations in Lithuania. Fitoterapia 2007;78: 162-165. (Pubitemid 46177429)
    • (2007) Fitoterapia , vol.78 , Issue.2 , pp. 162-165
    • Venskutonis, P.R.1    Dvaranauskaite, A.2    Labokas, J.3
  • 34
    • 24044433292 scopus 로고    scopus 로고
    • Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols
    • DOI 10.1016/j.foodchem.2004.12.004, PII S0308814605000105
    • Katalinić V, Miloš M, Kulišić T, Jukić M: Screening of medicinal plant extracts for antioxidant capacity and total phenols. Food Chem 2006;94:550-557. (Pubitemid 41219767)
    • (2006) Food Chemistry , vol.94 , Issue.4 , pp. 550-557
    • Katalinic, V.1    Milos, M.2    Kulisic, T.3    Jukic, M.4
  • 37
    • 34948835711 scopus 로고    scopus 로고
    • Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid
    • DOI 10.1002/mnfr.200700004
    • Kern M, Fridrich D, Reichert J, Skrbek S, Nussher A, Hofemm S, Vatter S, Pahlke G, Rüfer C, Marko D: Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. Nutr Food Res 2007;51:1163-1172. (Pubitemid 47522810)
    • (2007) Molecular Nutrition and Food Research , vol.51 , Issue.9 , pp. 1163-1172
    • Kern, M.1    Fridrich, D.2    Reichert, J.3    Skrbek, S.4    Nussher, A.5    Hofem, S.6    Vatter, S.7    Pahlke, G.8    Rufer, C.9    Marke, D.10
  • 38
    • 0036819234 scopus 로고    scopus 로고
    • Effects of structurally related flavonoids on hsp gene expression in human promyeloid leukaemia cells
    • Rusak G, Gutzeit HO, Mü ller JL: Effects of structurally related flavonoids on hsp gene expression in human promyeloid leukaemia cells. Food Technol Biotechnol 2002;40:267-273. (Pubitemid 36039642)
    • (2002) Food Technology and Biotechnology , vol.40 , Issue.4 , pp. 267-273
    • Rusak, G.1    Gutzeit, H.O.2    Ludwig-Muller, J.3
  • 40
    • 0034729308 scopus 로고    scopus 로고
    • Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells
    • Lee YL, Liao PH, Chen WK, Yang CC: Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells. Cancer Lett 2000;153:51-56.
    • (2000) Cancer Lett , vol.153 , pp. 51-56
    • Lee, Y.L.1    Liao, P.H.2    Chen, W.K.3    Yang, C.C.4
  • 41
    • 64749108144 scopus 로고    scopus 로고
    • Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells
    • Fjaeraa C, Nanberg E: Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells. Biomed Pharmacother 2009;63:254-261.
    • (2009) Biomed Pharmacother , vol.63 , pp. 254-261
    • Fjaeraa, C.1    Nanberg, E.2
  • 42
    • 0344806276 scopus 로고    scopus 로고
    • Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: Description of quantitative structure-activity relationships
    • Sergediené E, Jönsson K, Szymusiak H, Tyrakowska B, Rietjens IMCM, Čenas N: Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships. FEBS Lett 1999;462:392-396.
    • (1999) FEBS Lett , vol.462 , pp. 392-396
    • Sergediené, E.1    Jönsson, K.2    Szymusiak, H.3    Tyrakowska, B.4    Rietjens, I.M.C.M.5    Čenas, N.6
  • 43
    • 0041709308 scopus 로고    scopus 로고
    • Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells
    • Mertens-Talcott SU, Talcott ST, Percival SS: Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 2003;133:2669-2674. (Pubitemid 36935989)
    • (2003) Journal of Nutrition , vol.133 , Issue.8 , pp. 2669-2674
    • Mertens-Talcott, S.U.1    Talcott, S.T.2    Percival, S.S.3
  • 45
    • 0036679876 scopus 로고    scopus 로고
    • Plant phenolic antioxidant and prooxidant activities: Phenolics-induced oxidative damage mediated by metals in plants
    • DOI 10.1016/S0300-483X(02)00196-8, PII S0300483X02001968
    • Sakihama Y, Cohen MF, Grace SC, Yamasaki H: Plant polyphenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicology 2002; 177:67-80. (Pubitemid 34786245)
    • (2002) Toxicology , vol.177 , Issue.1 , pp. 67-80
    • Sakihama, Y.1    Cohen, M.F.2    Grace, S.C.3    Yamasaki, H.4
  • 46
    • 0034515783 scopus 로고    scopus 로고
    • Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds
    • DOI 10.1080/152165400300001471
    • Hadi SM, Asad SF, Singh S, Ahmad A: Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB Life 2000;50:167-171. (Pubitemid 32037930)
    • (2000) IUBMB Life , vol.50 , Issue.3 , pp. 167-171
    • Hadi, S.M.1    Asad, S.F.2    Singh, S.3    Ahmad, A.4
  • 47
    • 3042574709 scopus 로고    scopus 로고
    • Potential toxicity of flavonoids and other dietary phenolics: Significance for their chemopreventive and anticancer properties
    • DOI 10.1016/j.freeradbiomed.2004.04.034, PII S0891584904003806
    • Galati G, O'Brien PJ: Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 2005;37:287-303. (Pubitemid 38833996)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.3 , pp. 287-303
    • Galati, G.1    O'Brien, P.J.2
  • 49
    • 34447096276 scopus 로고    scopus 로고
    • Antioxidative and prooxidative effects of quercetin on A549 cells
    • DOI 10.1016/j.cellbi.2007.04.009, PII S1065699507001436
    • Robaszkiewicz A, Balcerzyk A, Bartosz G: Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biol Int 2007;31:1245-1250. (Pubitemid 47030992)
    • (2007) Cell Biology International , vol.31 , Issue.10 , pp. 1245-1250
    • Robaszkiewicz, A.1    Balcerczyk, A.2    Bartosz, G.3
  • 50
    • 33947595267 scopus 로고    scopus 로고
    • Effect of flavonoids on glutathione level, lipid peroxidation and cytochrome P450 CYP1A1 expression in human laryngeal carcinoma cell lines
    • Durgo K, Vuković L, Rusak G, Osmak M, Franekić Č olić J: Effects of flavonoids on glutathione level, lipid peroxidation and cytochrome P-450 CYP1A1 expression in human laryngeal cell lines. Food Technol Biotechnol 2007;45:69-79. (Pubitemid 46479481)
    • (2007) Food Technology and Biotechnology , vol.45 , Issue.1 , pp. 69-79
    • Durgo, K.1    Vukovic, L.2    Rusak, G.3    Osmak, M.4    Colic, J.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.