-
1
-
-
76549180307
-
Leucine-induced hypoglycemia
-
Fajans SS. Leucine-induced hypoglycemia. N Engl J Med. 1965;272:1224-1227.
-
(1965)
N Engl J Med
, vol.272
, pp. 1224-1227
-
-
Fajans, S.S.1
-
2
-
-
4043171462
-
Upstream and downstream of mTOR
-
DOI 10.1101/gad.1212704
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926-1945. (Pubitemid 39071573)
-
(2004)
Genes and Development
, vol.18
, Issue.16
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
3
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
DOI 10.1126/science.1124147
-
Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, et al. Hypothalamic mTOR signaling regulates food intake. Science. 2006;312:927-930. (Pubitemid 43727328)
-
(2006)
Science
, vol.312
, Issue.5775
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Blake, S.K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
4
-
-
34548251464
-
Disruption of BCATm in Mice Leads to Increased Energy Expenditure Associated with the Activation of a Futile Protein Turnover Cycle
-
DOI 10.1016/j.cmet.2007.08.003, PII S1550413107002252
-
She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, et al. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007;6:181-194. (Pubitemid 47324140)
-
(2007)
Cell Metabolism
, vol.6
, Issue.3
, pp. 181-194
-
-
She, P.1
Reid, T.M.2
Bronson, S.K.3
Vary, T.C.4
Hajnal, A.5
Lynch, C.J.6
Hutson, S.M.7
-
5
-
-
0347627142
-
Regulation of protein synthesis by branched-chain amino acids in vivo
-
DOI 10.1016/j.bbrc.2003.07.013
-
Yoshizawa F. Regulation of protein synthesis by branched-chain amino acids in vivo. Biochem Biophys Res Commun. 2004;313:417-422. (Pubitemid 37543602)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.313
, Issue.2
, pp. 417-422
-
-
Yoshizawa, F.1
-
6
-
-
0033808169
-
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway
-
Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr. 2000;130:2413-2419.
-
(2000)
J Nutr
, vol.130
, pp. 2413-2419
-
-
Anthony, J.C.1
Yoshizawa, F.2
Anthony, T.G.3
Vary, T.C.4
Jefferson, L.S.5
Kimball, S.R.6
-
7
-
-
0036710413
-
Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue
-
Lynch CJ, Patson BJ, Anthony J, Vaval A, Jefferson LS, Vary TC. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. Am J Physiol Endocrinol Metab. 2002;283:E503-E513. (Pubitemid 35230488)
-
(2002)
American Journal of Physiology - Endocrinology and Metabolism
, vol.283
, Issue.3
-
-
Lynch, C.J.1
Patson, B.J.2
Anthony, J.3
Vaval, A.4
Jefferson, L.S.5
Vary, T.C.6
-
8
-
-
0035069433
-
Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats
-
Anthony TG, Anthony JC, Yoshizawa F, Kimball SR, Jefferson LS. Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats. J Nutr. 2001;131:1171-1176. (Pubitemid 32275095)
-
(2001)
Journal of Nutrition
, vol.131
, Issue.4
, pp. 1171-1176
-
-
Anthony, T.G.1
Anthony, J.C.2
Yoshizawa, F.3
Kimball, S.R.4
Jefferson, L.S.5
-
9
-
-
24744457955
-
Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein activity
-
Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F. Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr. 2005;135:2103-2108. (Pubitemid 41298372)
-
(2005)
Journal of Nutrition
, vol.135
, Issue.9
, pp. 2103-2108
-
-
Doi, M.1
Yamaoka, I.2
Nakayama, M.3
Mochizuki, S.4
Sugahara, K.5
Yoshizawa, F.6
-
10
-
-
34447574828
-
Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis
-
DOI 10.1152/ajpendo.00609.2006
-
Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. Am J Physiol Endocrinol Metab. 2007; 292:E1683-E1693. (Pubitemid 47084704)
-
(2007)
American Journal of Physiology - Endocrinology and Metabolism
, vol.292
, Issue.6
-
-
Doi, M.1
Yamaoka, I.2
Nakayama, M.3
Sugahara, K.4
Yoshizawa, F.5
-
11
-
-
0017886564
-
Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting
-
Chang TW, Goldberg AL. Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting. J Biol Chem. 1978;253:3696-3701. (Pubitemid 8346566)
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.10
, pp. 3696-3701
-
-
Chang, T.W.1
Goldberg, A.L.2
-
12
-
-
0026519615
-
Short-term regulation of insulin-mediated glucose utilization in fourday fasted human volunteers: Role of amino acid availability
-
Flakoll PJ, Wentzel LS, Rice DE, Hill JO, Abumrad NN. Short-term regulation of insulin-mediated glucose utilization in fourday fasted human volunteers: role of amino acid availability. Diabetologia. 1992;35:357-366.
-
(1992)
Diabetologia
, vol.35
, pp. 357-366
-
-
Flakoll, P.J.1
Wentzel, L.S.2
Rice, D.E.3
Hill, J.O.4
Abumrad, N.N.5
-
13
-
-
0022384175
-
Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man
-
DOI 10.1007/BF00291080
-
Tessari P, Inchiostro S, Biolo G, Duner E, Nosadini R, Tiengo A, et al. Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man. Diabetologia. 1985;28:870-872. (Pubitemid 16176059)
-
(1985)
Diabetologia
, vol.28
, Issue.11
, pp. 870-872
-
-
Tessari, P.1
Inchiostro, S.2
Biolo, G.3
-
14
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem. 2001;276:38052-38060.
-
(2001)
J Biol Chem
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
15
-
-
0001437616
-
Bidirectional modulation of insulin action by amino acids
-
Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR. Bidirectional modulation of insulin action by amino acids. J Clin Invest. 1998;101:1519-1529. (Pubitemid 28166850)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.7
, pp. 1519-1529
-
-
Patti, M.-E.1
Brambilla, E.2
Luzi, L.3
Landaker, E.J.4
Kahn, C.R.5
-
16
-
-
0034947869
-
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
-
DOI 10.1128/MCB.21.15.5050-5062.2001
-
Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, et al. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol. 2001;21:5050-5062. (Pubitemid 32656402)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.15
, pp. 5050-5062
-
-
Takano, A.1
Usui, I.2
Haruta, T.3
Kawahara, J.4
Uno, T.5
Iwata, M.6
Kobayashi, M.7
-
17
-
-
0036926381
-
Leucine promotes glucose uptake in skeletal muscles of rats
-
DOI 10.1016/S0006-291X(02)02717-1, PII S0006291X02027171
-
Nishitani S, Matsumura T, Fujitani S, Sonaka I, Miura Y, Yagasaki K. Leucine promotes glucose uptake in skeletal muscles of rats. Biochem Biophys Res Commun. 2002;299:693-696. (Pubitemid 36034542)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.299
, Issue.5
, pp. 693-696
-
-
Nishitani, S.1
Matsumura, T.2
Fujitani, S.3
Sonaka, I.4
Miura, Y.5
Yagasaki, K.6
-
18
-
-
0034283186
-
L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: Evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport
-
Peyrollier K, Hajduch E, Blair AS, Hyde R, Hundal HS. L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport. Biochem J. 2000;350: 361-368.
-
(2000)
Biochem J
, vol.350
, pp. 361-368
-
-
Peyrollier, K.1
Hajduch, E.2
Blair, A.S.3
Hyde, R.4
Hundal, H.S.5
-
19
-
-
0019814363
-
The stimulus-secretion coupling of amino acid-induced insulin release: insulinotropic action of branched-chain amino acids at physiological concentrations of glucose and glutamine
-
Sener A, Malaisse WJ. The stimulus-secretion coupling of amino acid-induced insulin release: insulinotropic action of branched-chain amino acids at physiological concentrations of glucose and glutamine. Eur J Clin Invest. 1981;11:455-460. (Pubitemid 12200822)
-
(1981)
European Journal of Clinical Investigation
, vol.11
, Issue.6
, pp. 455-460
-
-
Sener, A.1
Malaisse, W.L.2
-
20
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
-
DOI 10.1210/en.2004-0921
-
Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity- linked insulin resistance. Endocrinology. 2005;146:1473-1481. (Pubitemid 40289337)
-
(2005)
Endocrinology
, vol.146
, Issue.3
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
21
-
-
11144342783
-
Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle
-
DOI 10.1152/ajpendo.00272.2004
-
Baum JI, O'Connor JC, Seyler JE, Anthony TG, Freund GG, Layman DK. Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2005;288:E86-E91. (Pubitemid 40023794)
-
(2005)
American Journal of Physiology - Endocrinology and Metabolism
, vol.288
, Issue.1
-
-
Baum, J.I.1
O'Connor, J.C.2
Seyler, J.E.3
Anthony, T.G.4
Freund, G.G.5
Layman, D.K.6
-
22
-
-
0028265564
-
Effects of glucose and amino acid infusion on glucose turnover in insulin- resistant obese and type II diabetic patients
-
DOI 10.1016/0026-0495(94)90071-X
-
Tappy L, Acheson K, Normand S, Pachiaudi C, Jéquier E, Riou JP. Effects of glucose and amino acid infusion on glucose turnover in insulin-resistant obese and type II diabetic patients. Metabolism. 1994;43:428-434. (Pubitemid 24113161)
-
(1994)
Metabolism: Clinical and Experimental
, vol.43
, Issue.4
, pp. 428-434
-
-
Tappy, L.1
Acheson, K.2
Normand, S.3
Pachiaudi, C.4
Jequier, E.5
Riou, J.-P.6
-
23
-
-
0026635421
-
Effects of infused amino acids on glucose production and utilization in healthy human subjects
-
Tappy L, Acheson K, Normand S, Schneeberger D, Thélin A, Pachiaudi C, et al. Effects of infused amino acids on glucose production and utilization in healthy human subjects. Am J Physiol. 1992;262:E826-E833.
-
(1992)
Am J Physiol
, vol.262
-
-
Tappy, L.1
Acheson, K.2
Normand, S.3
Schneeberger, D.4
Thélin, A.5
Pachiaudi, C.6
-
24
-
-
0003170174
-
The experimental induction in man of sensitivity of leucine hypoglycemia
-
Fajans SS, Knopf RF, Floyd JC, Power L, Conn JW. The experimental induction in man of sensitivity of leucine hypoglycemia. J Clin Invest. 1963;42:216-229.
-
(1963)
J Clin Invest
, vol.42
, pp. 216-229
-
-
Fajans, S.S.1
Knopf, R.F.2
Floyd, J.C.3
Power, L.4
Conn, J.W.5
-
25
-
-
0014818609
-
The stimulation of insulin release by essential amino acids from rabbit pancreas in vitro
-
Milner RD. The stimulation of insulin release by essential amino acids from rabbit pancreas in vitro. J Endocrinol. 1970;47:347-356.
-
(1970)
J Endocrinol
, vol.47
, pp. 347-356
-
-
Milner, R.D.1
-
26
-
-
0027030204
-
A new animal model of non-insulin-dependent diabetes mellitus induced by the NDK25 variant of encephalomyocarditis virus
-
Utsugi T, Kanda T, Tajima Y, Tomono S, Suzuki T, Murata K, et al. A new animal model of non-insulin-dependent diabetes mellitus induced by the NDK25 variant of encephalomyocarditis virus. Diabetes Res. 1992;20:109-119. (Pubitemid 24070698)
-
(1992)
Diabetes Research
, vol.20
, Issue.4
, pp. 109-119
-
-
Utsugi, T.1
Kanda, T.2
Tajima, Y.3
Tomono, S.4
Suzuki, T.5
Murata, K.6
Dan, K.7
Seto, Y.8
Kawazu, S.9
-
27
-
-
0034705632
-
Oral administration of branched chain amino acids improves virus-induced glucose intolerance in mice
-
DOI 10.1016/S0014-2999(00)00221-1, PII S0014299900002211
-
Utsugi T, Yoshida A, Kanda T, Kobayashi I, Kurabayashi M, Tomono S, et al. Oral administration of branched chain amino acids improves virus-induced glucose intolerance in mice. Eur J Pharmacol. 2000;398:409-414. (Pubitemid 30349106)
-
(2000)
European Journal of Pharmacology
, vol.398
, Issue.3
, pp. 409-414
-
-
Utsugi, T.1
Yoshida, A.2
Kanda, T.3
Kobayashi, I.4
Kurabayashi, M.5
Tomono, S.6
Kawazu, S.7
Tajima, Y.8
Nagai, R.9
-
28
-
-
0023477319
-
Administration of branched-chain amino acids reduces the diabetogenic effect of streptozotocin in rats
-
Eizirik DL, Kettelhut IC, Migliorini RH. Administration of branched-chain amino acids reduces the diabetogenic effect of streptozotocin in rats. Braz J Med Biol Res. 1987;20:137-144.
-
(1987)
Braz J Med Biol Res
, vol.20
, pp. 137-144
-
-
Eizirik, D.L.1
Kettelhut, I.C.2
Migliorini, R.H.3
-
29
-
-
0344064140
-
12 myotubes
-
DOI 10.1016/j.bbrc.2003.11.039
-
Doi M, Yamaoka I, Fukunaga T, Nakayama M. Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes. Biochem Biophys Res Commun. 2003;312:1111-1117. (Pubitemid 37490930)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.312
, Issue.4
, pp. 1111-1117
-
-
Doi, M.1
Yamaoka, I.2
Fukunaga, T.3
Nakayama, M.4
-
30
-
-
47949127883
-
Effect of orally administered isoleucine with and without glucose on insulin, glucagon and glucose concentrations in non-diabetic subjects
-
Nuttall FQ, Schweim K, Gannon MC. Effect of orally administered isoleucine with and without glucose on insulin, glucagon and glucose concentrations in non-diabetic subjects. E Spen Eur E J Clin Nutr Metab. 2008;3:e152-e158.
-
(2008)
E Spen Eur e J Clin Nutr Metab
, vol.3
-
-
Nuttall, F.Q.1
Schweim, K.2
Gannon, M.C.3
-
31
-
-
13344285343
-
Mammalian AMP-activated protein kinase subfamily
-
DOI 10.1074/jbc.271.2.611
-
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, et al. Mammalian AMP-activated protein kinase subfamily. J Biol Chem. 1996;271:611-614. (Pubitemid 26034902)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.2
, pp. 611-614
-
-
Stapleton, D.1
Mitchelhill, K.I.2
Gao, G.3
Widmer, J.4
Michell, B.J.5
Teh, T.6
House, C.M.7
Fernandez, C.S.8
Cox, T.9
Witters, L.A.10
Kemp, B.E.11
-
32
-
-
0017886564
-
Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting
-
Chang TW, Goldberg AL. Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting. J Biol Chem. 1978;253:3696-3701. (Pubitemid 8346566)
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.10
, pp. 3696-3701
-
-
Chang, T.W.1
Goldberg, A.L.2
-
33
-
-
0017306730
-
The formation of alanine from amino acids in diaphragm muscle of the rat
-
Goldstein L, Newsholme EA. The formation of alanine from amino acids in diaphragm muscle of the rat. Biochem J. 1976;154:555-558.
-
(1976)
Biochem J
, vol.154
, pp. 555-558
-
-
Goldstein, L.1
Newsholme, E.A.2
-
34
-
-
0026519615
-
Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: Role of amino acid availability
-
Flakoll PJ, Wentzel LS, Rice DE, Hill JO, Abumrad NN. Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability. Diabetologia. 1992;35:357-366.
-
(1992)
Diabetologia
, vol.35
, pp. 357-366
-
-
Flakoll, P.J.1
Wentzel, L.S.2
Rice, D.E.3
Hill, J.O.4
Abumrad, N.N.5
-
35
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem. 2001;276:38052-38060.
-
(2001)
J Biol Chem
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
37
-
-
0030017082
-
Contributions of gluconeogenesis to glucose production in the fasted state
-
Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC. Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest. 1996;98:378-385. (Pubitemid 26255737)
-
(1996)
Journal of Clinical Investigation
, vol.98
, Issue.2
, pp. 378-385
-
-
Landau, B.R.1
Wahren, J.2
Chandramouli, V.3
Schumann, W.C.4
Ekberg, K.5
Kalhan, S.C.6
-
38
-
-
0017365525
-
Increase in level of functional messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) during induction by cyclic adenosine 3':5' monophosphate
-
Iynedjian PB, Hanson RW. Increase in level of functional messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) during induction by cyclic adenosine 3′:5′-monophosphate. J Biol Chem. 1977;252:655-662. (Pubitemid 8028890)
-
(1977)
Journal of Biological Chemistry
, vol.252
, Issue.2
, pp. 655-662
-
-
Iynedjian, P.B.1
Hanson, R.W.2
-
39
-
-
27744597336
-
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells
-
DOI 10.1074/jbc.M508027200
-
Xu H, Yang Q, Shen M, Huang X, Dembski M, Gimeno R, et al. Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells. J Biol Chem. 2005;280:36013-36018. (Pubitemid 41633871)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.43
, pp. 36013-36018
-
-
Xu, H.1
Yang, Q.2
Shen, M.3
Huang, X.4
Dembski, M.5
Gimeno, R.6
Tartaglia, L.A.7
Kapeuer, R.8
Wu, Z.9
-
40
-
-
2642564455
-
0, a neutral amino acid transporter related to Hartnup disorder
-
0, a neutral amino acid transporter related to Hartnup disorder. J Biol Chem. 2004;279:24467-24476.
-
(2004)
J Biol Chem
, vol.279
, pp. 24467-24476
-
-
Bröer, A.1
Klingel, K.2
Kowalczuk, S.3
Rasko, J.E.4
Cavanaugh, J.5
Bröer, S.6
-
42
-
-
33746920715
-
The effect of valine on lipid metabolic homeostasis in regenerating remnant liver after hepatectomy
-
Chida A, Doi H, Komatsu H, Sato K, Ueda O, Hayashi M, et al. The effect of valine on lipid metabolic homeostasis in regenerating remnant liver after hepatectomy. J Surg Met Nutr. 2003;37:179-188.
-
(2003)
J Surg Met Nutr
, vol.37
, pp. 179-188
-
-
Chida, A.1
Doi, H.2
Komatsu, H.3
Sato, K.4
Ueda, O.5
Hayashi, M.6
|