Oral administration of branched chain amino acids improves virus-induced glucose intolerance in mice

European Journal of Pharmacology

Volumn 398, Issue 3, 2000, Pages 409-414

  Utsugi, Toshihiro ^a   Yoshida, Akihiro ^a   Kanda, Tsugiyasu ^a   Kobayashi, Isao ^a   Kurabayashi, Masahiko ^a   Tomono, Shoichi ^a   Kawazu, Shoji ^b   Tajima, Yutaka ^c   Nagai, Ryozo ^d  

^a GUNMA UNIVERSITY   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c SAGA UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Branched chain amino acid; Encephalomyocarditis virus; Glucose intolerance; Insulitis

Indexed keywords

BRANCHED CHAIN AMINO ACID;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENCEPHALOMYOCARDITIS VIRUS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; BLOOD GLUCOSE; CARDIOVIRUS INFECTIONS; ENCEPHALOMYOCARDITIS VIRUS; GLUCOSE INTOLERANCE; MALE; MICE; MICE, INBRED DBA; PANCREAS;

EID: 0034705632     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00221-1     Document Type: Article

References (22)

1. Bae Y.S., Eun H.M., Yoon J.W. Genomic differences between the diabetogenic and nondiabetogenic variants of encephalomyocarditis virus. Virology. 170:1989;282-287.
2. Bae Y.S., Eun H.M., Pon R.T., Giron D., Yoon J.W. Two amino acids, Phe 16 and Ala 776, on the polyprotein are most likely to be responsible for the diabetogenicity of encephalomyocarditis virus. J. Gen. Virol. 71:1990;639-645.
3. Bianchi G.P., Marchesini G., Zoli M., Abbiati R., Ferrario E., Fabbri A., Pisi E. Oral BCAA supplementation in cirrhosis with chronic encephalopathy: effects on prolactin and estradiol levels. Hepatogastroenterology. 39:1992;443-446.
4. Black P.R., Wilmore D.W. Alternations in fuel metabolism in stress. Johnson I.P.A. Advances in Clinical Nutrition. 1983;275-282 MTPP, Lancaster, UK.
5. Clones G., Randall H., Cha C. Amino acid and energy metabolism In septic and traumatized patients. JPEN, J. Parenter Enteral. Nutr. 4:1980;195-205.
6. Cohen S.H., Naviaux R.K., Vanden Brink K.M., Jordan G.W. Comparison of the nucleotide sequences of diabetogenic and nondiabetogenic encephalomyocarditis virus. Virology. 166:1988;603-607.
7. Craighead J.E., McLane M.F. Diabetes mellitus: induction in mice by encephalomyocarditis virus. Science. 22:1968;913-914.
8. Eizirik D.L., Kettelhut I.C., Migliorini R.H. Administration of branched-chain amino acids reduces the diabetogenic effect of streptozotocin in rats. Braz. J. Med. Biol. Res. 20:1987;137-144.
9. Freund H., Hoover H.C. Jr., Atamian S., Fischer J.E. Infusion of the branched chain amino acids in postoperative patients. Anticatabolic properties. Ann. Surg. 190:1979;18-23.
10. Fukuma M., Dan K., Seto Y. Possibility of virus infected animals as models of diverse stage to NIDDM. Shigeta Y. Best Approach to the Ideal Therapy of Diabetes Mellitus. 1987;125-128 Elsevier.
11. Irvine W.J. Immunological aspects of diabetes mellitus: a review (including the silent points of the NDDG report on the classification of diabetes). Irvine W.J. The Immunology of Diabetes. 1980;1-53 Teviot Scientific Publications, Edinburgh, UK.
12. Jun H.S., Yoon S.W., Kang Y., Pak C.Y., Lee M.C., Yoon J.W. Cloning and expression of the VP1 major capsid protein of diabetogenic encephalomyocarditis (EMC) virus and prevention of EMC virus-induced diabetes by immunization with the recombinant VP1 protein. J. Gen. Virol. 76:1995;2557-2566.
13. Jun H.S., Kang Y., Notkins A.L., Yoon J.W. Gain or loss of diabetogenicity resulting from a single point mutation in recombinant encephalomyocarditis virus. J. Virol. 71:1997;9782-9785.
14. Lernmark A. Specificity of leucine stimulation of insulin release. Hormones. 3:1972;47-49.
15. Maddrey W.C. Branched chain amino acid therapy in liver disease. J. Am. Coll. Nutr. 4:1985;639-650.
16. Rudberg S., Dahlqvist G., Aperia A., Lindblad B.S., Efendic S., Skottner A., Persson B. Indications that branched chain amino acids, in addition to glucagon, affect the glomerular filtration rate after a high protein diet in insulin-dependent diabetes. Diabetes Res. 16:1991;101-109.
17. Sener A., Malaisse W.J. The stimulus secretion coupling of amino acid-induced insulin release. Eur. J. Clin. Invest. 11:1981;455-460.
18. Siegel E.G., Trapp V.E., Wollheim C.B., Renold A.E., Schmidt F.H. Beneficial effects of low-carbohydrate-high-protein diets in long-term diabetic rats. Metabolism. 29:1980;421-428.
19. Utsugi T., Kanda T., Tajima Y., Tomono S., Suzuki T., Murata K., Dan K., Seto Y., Kawazu S. A new animal model of non-insulin-dependent diabetes mellitus induced by the NDK25 variant of encephalomyocarditis virus. Diabetes Res. 20:1992;109-119.
20. Yoon J.W. Pathogenic mechanisms of virus-induced type 1 diabetes. Microb. Pathog. 5:1988;77-86.
21. Yoon J.W., McClintock P.R., Onodera T., Notkins A.L. Virus-induced diabetes mellitus: XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus. J. Exp. Med. 152:1980;878-892.
22. Yoshida T., Muto Y., Moriwaki H., Yamato M. Effect of long-term oral supplementation with branched-chain amino acid granules on the prognosis of liver cirrhosis. Gastroenterol. Jpn. 24:1989;692-698.