Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Strippoli, Raffaele ^a,b   Benedicto, Ignacio ^c,d   Perez Lozano, Maria Luisa ^c,e   Pellinen, Teijo ^a   Sandoval, Pilar ^c,e   Lopez Cabrera, Manuel ^c,d,e   del Pozo, Miguel Angel ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; CYTOKERATIN; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MOLECULAR MARKER; NERVE CELL ADHESION MOLECULE; PAI 1 PROTEIN; PROTEIN C JUN; PROTEIN ZO1; SMAD1 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE;

ARTICLE; CELL INVASION; CELL JUNCTION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MESOTHELIUM CELL; PERITONEAL DIALYSIS; PERITONEAL FIBROSIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; BIOLOGICAL MODEL; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; MESODERM; METABOLISM; METHODOLOGY; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

GASTROPODA;

DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; MAP KINASE KINASE KINASES; MESODERM; MODELS, BIOLOGICAL; NF-KAPPA B; PERITONEAL DIALYSIS; PERITONEAL FIBROSIS; PHENOTYPE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84857510902     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031492     Document Type: Article

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