Ex vivo analysis of dialysis effluent-derived mesothelial cells as an approach to unveiling the mechanism of peritoneal membrane failure

Peritoneal Dialysis International

Volumn 26, Issue 1, 2006, Pages 26-34

  López Cabrera, Manuel ^a,d   Aguilera, Abelardo ^a,d   Aroeira, Luiz S ^a,d   Ramírez Huesca, Marta ^a,d   Pérez Lozano, M Luisa ^a,d   Jiménez Heffernan, José A ^b,d   Bajo, M Auxiliadora ^c,d   del Peso, Gloria ^c,d   Sánchez Tomero, José A ^a,d   Selgas, Rafael ^c,d  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b HOSPITAL UNIVERSITARIO DE GUADALAJARA   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d Instituto Reina Sofia de Investigacion Nefrologica   (Spain)

Author keywords

Angiogenesis; Epithelial to mesenchymal transition; Fibrosis; Mesothelial cells; Peritoneal membrane failure; Therapeutic intervention; Transforming growth factor; Vascular endothelial growth factor

Indexed keywords

CA 125 ANTIGEN; CALRETININ; CYTOKERATIN; PERITONEAL DIALYSIS FLUID; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; DIALYSIS FLUID;

ANGIOGENESIS; ARTICLE; BIOCOMPATIBILITY; CELL CULTURE; CELL ISOLATION; CELL TRANSPORT; EFFLUENT; EPITHELIUM CELL; EX VIVO STUDY; FIBROSIS; HEMOPERITONEUM; HUMAN; IMMUNOHISTOCHEMISTRY; MESOTHELIUM CELL; MICROVASCULARIZATION; MYOFIBROBLAST; NONHUMAN; OMENTUM; PATHOPHYSIOLOGY; PERITONEAL BIOPSY; PERITONEAL DIALYSIS; PERITONEAL DISEASE; PERITONEAL MEMBRANE FAILURE; PERITONEUM; PERITONITIS; PRIORITY JOURNAL; VASCULAR DISEASE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; REVIEW; TRANSPORT AT THE CELLULAR LEVEL; TREATMENT FAILURE; VASCULARIZATION;

BIOLOGICAL TRANSPORT; CELLS, CULTURED; DIALYSIS SOLUTIONS; EPITHELIAL CELLS; FIBROSIS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PERITONEAL DIALYSIS; PERITONEUM; TREATMENT FAILURE;

EID: 33745501688     PISSN: 08968608     EISSN: None     Source Type: Journal    
DOI: 10.1177/089686080602600103     Document Type: Article

References (41)

1. Selgas R, Bajo MA, del Peso G, Jimenez C. Preserving the peritoneal dialysis membrane in long-term peritoneal dialysis patients. Semin Dial 1995; 8:326-32.
2. Williams JD, Craig KJ, Topley N, Von Ruhland C, Fallon M, Newman GR, et al.; Peritoneal Biopsy Study Group. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol 2002; 13:470-9.
3. Krediet RT, Lindholm B, Rippe B. Pathophysiology of peritoneal membrane failure. Perit Dial Int 2000; 20(Suppl 4): S22-42.
4. Margetts P, Bonniaud P. Basic mechanisms and clinical implications of peritoneal fibrosis. Perit Dial Int 2003; 23:530-41.
5. Rubin J, Herrera GA, Collins D. An autopsy study of peritoneal cavity from patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis 1991; 18:97-102.
6. Brulez HF, Verbrugh HA. First-line defence mechanisms in the peritoneal cavity during peritoneal dialysis. Perit Dial Int 1995; 15(7, Suppl):S24-33.
7. Yáñez-Mo M, Lara-Pezzi E, Selgas R, Ramirez-Huesca M, Dominguez-Jimenez C, Jimenez-Heffernan JA, et al. Peritoneal dialysis induces an epithelial-mesenchymal transition of mesothelia cells. N Engl J Med 2003; 348:403-13.
8. Thiery JP. Epithelial-mesenchymal transition in development and pathologies. Curr Opin Cell Biol 2003; 15:740-6.
9. Barrallo-Gimeno A, Nieto A. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 2005; 132:3151-61.
10. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2:76-83.
11. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, et al. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000; 2:84-9.
12. Jimenez-Heffernan JA, Aguilera A, Aroeira LS, Lara-Pezzi E, Bajo MA, del Peso G, et al. Immunohistochemical characterization of fibroblast subpopulation in normal peritoneal tissue and in peritoneal dialysis-induced fibrosis. Virchows Arch 2004; 444:247-56.
13. Margetts PJ, Kolb M, Galt T, Hoff CM, Shockley TR, Gauldie J. Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function. J Am Soc Nephrol 2001; 12:2029-39.
14. Rosenber ME. Peritoneal dialysis: diabetes of the peritoneal cavity. J Lab Clin Med 1999; 134:103-4.
15. Oldfield MD, Bach LA, Forbes JM, Nikolic-Paterson D, McRobert A, Thallas V, et al. Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J Clin Invest 2001; 108:1853-63.
16. Wang T, Chen YG, Ye RG, Li SL, Li HQ, Chen YX. Effect of glucose on TGF-β1 expression in peritoneal mesothelial cell. Adv Perit Dial 1995; 11:7-10.
17. Lai KN, Lai KB, Lam CW, Chan TM, Li FK, Leung JC. Changes of cytokines profile during peritonitis in patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis 2000; 35:644-52.
18. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9:669-76.
19. Combet S, Miyata T, Moulin P, Pouthier D, Goffin E, Devuyst O. Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis. J Am Soc Nephrol 2000; 11:717-28.
20. Pecoits-Filho R, Araujo MR, Lindholm B, Stenvinkel P, Abensur H, Romao JE, et al. Plasma and dialysate IL-6 and VEGF concentrations are associated with high peritoneal solute transport rate. Nephrol Dial Transplant 2002; 17: 1480-6.
21. Zweers MM, Struijk DG, Smit W, Krediet RT. Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up. J Lab Clin Med 2001; 137:125-32.
22. Aroeira LS, Aguilera A, Selgas R, Ramírez-Huesca M, Pérez-Lozano ML, Cirugeda A, et al. Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor. Am J Kidney Dis 2005; 46: 938-48.
23. Combet S, Ferrier ML, van Landschoot M, Stoenoiu M, Moulin P, Miyata T, et al. Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. J Am Soc Nephrol 2001; 12:2146-57.
24. Betjes MG, Bos HJ, Krediet RT, Arisz L. The mesothelial cells in CAPD effluent and their relation to peritonitis incidence. Perit Dial Int 1991; 11:22-6.
25. Betjes MG, Tuk CW, Struijk DG, Krediet DG, Krediet RT, Arisz L, et al. Adherence of staphylococci to plastic, mesothelial cells and mesothelial extracellular matrix. Adv Perit Dial 1992; 8:215-18.
26. Diaz C, Selgas R, Castro MA, Bajo MA, Fernandez de Castro M, Molina S, et al. Ex vivo proliferation of mesothelial cells directly obtained from peritoneal effluent: its relationship with peritoneal antecedents and functional parameters. Adv Perit Dial 1998; 14:19-24.
27. Leavesley DI, Stanley JM, Faull RJ. Epidermal growth factor modifies the expression and function of extracellular matrix adhesion receptors expressed by peritoneal mesothelial cells from patients on CAPD. Nephrol Dial Transplant 1999; 14:1208-16.
28. Stylianou E, Jenner LA, Davies M, Coles GA, Williams JD. Isolation, culture and characterization of human peritoneal mesothelial cells. Kidney Int 1990; 37:1563-70.
29. Margetts PJ, Bonniaud P, Liu L, Hoff CM, Holmes CJ, West-Mays JA, et al. Transient overexpression of TGF-β1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 2005; 16:425-36.
30. Bajo MA, del Peso G, Castro MA. Pathogenic significance of hypertrophic mesothelial cells in peritoneal effluent and ex vivo culture. Adv Perit Dial 2004; 20:43-6.
31. Yamamoto T, Izumotani T, Otoshi T, Kim M. Morphological studies of mesothelial cells in CAPD effluent and their clinical significance. Am J Kidney Dis 1998; 32:946-52.
32. Izumotani T, Ishimura E, Yamamoto T, Otoshi T, Okuno S, Inaba M, et al. Correlation between peritoneal mesothelial cell cytology and peritoneal histopathology with respect to prognosis in patients on continuous ambulatory peritoneal dialysis. Nephron 2001; 89:43-9.
33. Aguilera A, Yáñez-Mo M, Selgas R, Sánchez-Madrid F, López-Cabrera M. Epithelial to mesenchymal transition as a triggering factor of peritoneal membrane fibrosis and angiogenesis in peritoneal dialysis patients. Curr Opin Investig Drugs 2005; 6:262-8.
34. Yang AH, Chen JY, Lin JK. Myofibroblastic conversion of mesothelial cells. Kidney Int 2003; 63:1530-9.
35. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-84.
36. Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004; 15:1-12.
37. Border WA, Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med 1994; 331:1286-92.
38. Inagi R, Miyata T, Yamamoto T, Suzuki D, Urakami K, Saito A, et al. Glucose degradation product methylglyoxal enhances the production of vascular endothelial growth factor in peritoneal cells: role in the functional and morphological alteration of peritoneal membrane in peritoneal dialysis. FEBS Lett 1999; 463:260-4.
39. Mandl-Weber S, Cohen CD, Haslinger B, Kretzler M, Sitter T. Vascular endothelial growth factor production and regulation in human peritoneal mesothelial cells. Kidney Int 2002; 61:570-8.
40. Szeto CC, Lai KB, Chow KM, Szeto CY, Wong TY, Li PK. Differential effects of transforming growth factor-beta on the synthesis of connective tissue growth factor and vascular endothelial growth factor by peritoneal mesothelial cell. Nephron Exp Nephrol 2005; 99:e95-e104.
41. Selgas R, del Peso G, Bajo MA, Castro MJ, Molina S, Cirugeda A, et al. Vascular endothelial growth factor (VEGF) levels in peritoneal dialysis effluent. J Nephrol 2001; 14:270-4.