Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes

Journal of Cellular Physiology

Volumn 227, Issue 6, 2012, Pages 2330-2340

  Walsh, Rebecca ^a   Blumenberg, Miroslav ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; EPHRIN B2; KERATIN TYPE I;

ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; KERATINOCYTE; NEWBORN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; EPHRIN-A4; EPIDERMIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; LIGANDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTOR, EPHB2; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 84857496006     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22968     Document Type: Article

References (71)

1. Adams JC, Watt FM. 1989. Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature 340: 307-309.
2. Adams JC, Watt FM. 1990. Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface. Cell 63: 425-435.
3. Arvanitis D, Davy A. 2008. Eph/ephrin signaling: Networks. Genes Dev 22: 416-429.
4. Banno T, Gazel A, Blumenberg M. 2004a. Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling. J Biol Chem 279: 32633-32642.
5. Banno T, Gazel A, Blumenberg M. 2005. Pathway-specific profiling identifies the NF-{kappa}B-dependent tumor necrosis factor {alpha}-regulated genes in epidermal keratinocytes. J Biol Chem 280: 18973-18980. Epub 12005 Feb 18918.
6. Banno T, Gazel A, Blumenberg M, Adachi M, Mukkamala L. 2004b. Effects of tumor necrosis factor-{alpha} (TNF{alpha}) in epidermal keratinocytes revealed using global transcriptional profiling. J Biol Chem 279: 32633-32642. Epub 32004 May 32615.
7. Bardelli A, Parsons DW, Silliman N, Ptak J, Szabo S, Saha S, Markowitz S, Willson JK, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. 2003. Mutational analysis of the tyrosine kinome in colorectal cancers. Science 300: 949.
8. Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H. 2005. EphB receptor activity suppresses colorectal cancer progression. Nature 435: 1126-1130.
9. Bong YS, Lee HS, Carim-Todd L, Mood K, Nishanian TG, Tessarollo L, Daar IO. 2007. ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad Sci USA 104: 17305-17310. Epub 12007 Oct 17322.
10. Boyd AW, Lackmann M. 2001. Signals from Eph and ephrin proteins: A developmental tool kit. Sci STKE 2001: RE20.
11. Brantley-Sieders D, Schmidt S, Parker M, Chen J. 2004. Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr Pharm Des 10: 3431-3442.
12. Brantley-Sieders DM, Chen J. 2004. Eph receptor tyrosine kinases in angiogenesis: From development to disease. Angiogenesis 7: 17-28.
13. Brem H, Stojadinovic O, Diegelmann RF, Entero H, Lee B, Pastar I, Golinko M, Rosenberg H, Tomic-Canic M. 2007. Molecular markers in patients with chronic wounds to guide surgical debridement. Mol Med 13: 30-39.
14. Bruckner K, Klein R. 1998. Signaling by Eph receptors and their ephrin ligands. Curr Opin Neurobiol 8: 375-382.
15. Bruckner K, Pasquale EB, Klein R. 1997. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science 275: 1640-1643.
16. Bush JO, Soriano P. 2009. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev 23: 1586-1599. Epub 2009 Jun 1510.
17. Cahan P, Ahmad AM, Burke H, Fu S, Lai Y, Florea L, Dharker N, Kobrinski T, Kale P, McCaffrey TA. 2005. List of lists-annotated (LOLA): A database for annotation and comparison of published microarray gene lists. Gene 360: 78-82. Epub 2005 Sep 2002.
18. Cooper D, Schermer A, Pruss R, Sun TT. 1984. The use of aIF, AE1, and AE3 monoclonal antibodies for the identification and classification of mammalian epithelial keratins. Differentiation 28: 30-35.
19. Cooper D, Sun TT. 1986. Monoclonal antibody analysis of bovine epithelial keratins. Specific pairs as defined by coexpression. J Biol Chem 261: 4646-4654.
20. Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. 2004. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol 271: 263-271.
21. Davy A, Aubin J, Soriano P. 2004. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18: 572-583.
22. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. 2003. DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol 4: P3. Epub 2003 Apr 2003.
23. Descargues P, Deraison C, Bonnart C, Kreft M, Kishibe M, Ishida-Yamamoto A, Elias P, Barrandon Y, Zambruno G, Sonnenberg A, Hovnanian A. 2005. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Nat Genet 37: 56-65. Epub 2004 Dec 2026.
24. Dickson BJ. 2002. Molecular mechanisms of axon guidance. Science 298: 1959-1964.
25. Dodelet VC, Pasquale EB. 2000. Eph receptors and ephrin ligands: Embryogenesis to tumorigenesis. Oncogene 19: 5614-5619.
26. Eph Nomenclature Committee 1997. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell 90: 403-404.
27. Evans IR, Renne T, Gertler FB, Nobes CD. 2007. Ena/VASP proteins mediate repulsion from ephrin ligands. J Cell Sci 120: 289-298. Epub 2006 Dec 2019.
28. Finelt N, Gazel A, Gorelick S, Blumenberg M. 2005. Transcriptional responses of human epidermal keratinocytes to Oncostatin-M. Cytokine 31: 305-313.
29. Galvin S, Loomis C, Manabe M, Dhouailly D, Sun TT. 1989. The major pathways of keratinocyte differentiation as defined by keratin expression: An overview. [Review]. Adv Dermatol 4: 277-299.
30. Gazel A, Banno T, Walsh R, Blumenberg M. 2006a. Inhibition of JNK promotes differentiation of epidermal keratinocytes. J Biol Chem 28: 28.
31. Gazel A, Rosdy M, Bertino B, Tornier C, Sahuc F, Blumenberg M. 2006b. A characteristic subset of psoriasis-associated genes is induced by oncostatin-M in reconstituted epidermis. J Invest Dermatol 17: 17.
32. Gazel A, Rosdy M, Tornier C, De Fraissinette Ade B, Blumenberg M. 2008. Transcriptional profiling defines the effects of nickel in human epidermal keratinocytes. J Cell Physiol 217: 686-692.
33. Genander M, Holmberg J, Frisen J. 2010. Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells 28: 1196-1205.
34. Guo H, Miao H, Gerber L, Singh J, Denning MF, Gilliam AC, Wang B. 2006. Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res 66: 7050-7058.
35. Hafner C, Becker B, Landthaler M, Vogt T. 2006. Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. Mod Pathol 19: 1369-1377. Epub 2006 Jul 1367.
36. Hafner C, Meyer S, Hagen I, Becker B, Roesch A, Landthaler M, Vogt T. 2005a. Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells. World J Gastroenterol 11: 4511-4518.
37. Hafner C, Meyer S, Langmann T, Schmitz G, Bataille F, Hagen I, Becker B, Roesch A, Rogler G, Landthaler M, Vogt T. 2005b. Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro. World J Gastroenterol 11: 4024-4031.
38. Heroult M, Schaffner F, Augustin HG. 2006. Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression. Exp Cell Res 312: 642-650. Epub 2005 Dec 2005.
39. Ho Sui SJ, Mortimer JR, Arenillas DJ, Brumm J, Walsh CJ, Kennedy BP, Wasserman WW. 2005. oPOSSUM: Identification of over-represented transcription factor binding sites in co-expressed genes. Nucleic Acids Res 33: 3154-3164. Print 2005.
40. Huang da W, Sherman BT, Lempicki RA. 2009. Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13. Epub 2008 Nov 2025.
41. Huusko P, Ponciano-Jackson D, Wolf M, Kiefer JA, Azorsa DO, Tuzmen S, Weaver D, Robbins C, Moses T, Allinen M, Hautaniemi S, Chen Y, Elkahloun A, Basik M, Bova GS, Bubendorf L, Lugli A, Sauter G, Schleutker J, Ozcelik H, Elowe S, Pawson T, Trent JM, Carpten JD, Kallioniemi OP, Mousses S. 2004. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet 36: 979-983. Epub 2004 Aug 2008.
42. Kandouz M, Haidara K, Zhao J, Brisson ML, Batist G. 2010. The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways. Cell Cycle 9: 398-407. Epub 2010 Jan 2012.
43. Klein R. 2004. Eph/ephrin signaling in morphogenesis, neural development and plasticity. Curr Opin Cell Biol 16: 580-589.
44. Lai KO, Chen Y, Po HM, Lok KC, Gong K, Ip NY. 2004. Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: Implications in the regulation of acetylcholinesterase expression. J Biol Chem 279: 13383-13392. Epub 12004 Jan 13315.
45. Lee DD, Stojadinovic O, Krzyzanowska A, Vouthounis C, Blumenberg M, Tomic-Canic M. 2009. Retinoid-responsive transcriptional changes in epidermal keratinocytes. J Cell Physiol 220: 427-439.
46. Lee DD, Zavadil J, Tomic-Canic M, Blumenberg M. 2010. Comprehensive transcriptional profiling of human epidermis, reconstituted epidermal equivalents, and cultured keratinocytes using DNA microarray chips. Methods Mol Biol 585: 193-223.
47. Li D, Turi TG, Schuck A, Freedberg IM, Khitrov G, Blumenberg M. 2001. Rays and arrays: The transcriptional program in the response of human epidermal keratinocytes to UVB illumination. Faseb J 15: 2533-2535.
48. Lin S, Gordon K, Kaplan N, Getsios S. 2010. Ligand targeting of EPHA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. Mol Biol Cell 22: 22.
49. Lindberg K, Rheinwald JG. 1990. Three distinct keratinocyte subtypes identified in human oral epithelium by their patterns of keratin expression in culture and in xenografts. Differentiation 45: 230-241.
50. Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan DW. 2006. EphB3: An endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci 26: 3087-3101.
51. Miao H, Burnett E, Kinch M, Simon E, Wang B. 2000. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol 2: 62-69.
52. Miao H, Strebhardt K, Pasquale EB, Shen TL, Guan JL, Wang B. 2005. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem 280: 923-932. Epub 2004 Nov 2009.
53. Miao H, Wei BR, Peehl DM, Li Q, Alexandrou T, Schelling JR, Rhim JS, Sedor JR, Burnett E, Wang B. 2001. Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway. Nat Cell Biol 3: 527-530.
54. Newman JC, Weiner AM. 2005. L2L: A simple tool for discovering the hidden significance in microarray expression data. Genome Biol 6: R81. Epub 2005 Aug 2031.
55. O'Guin WM, Galvin S, Schermer A, Sun TT. 1987. Patterns of keratin expression define distinct pathways of epithelial development and differentiation. [Review]. Curr Top Dev Biol 22: 97-125.
56. Palmer A, Zimmer M, Erdmann KS, Eulenburg V, Porthin A, Heumann R, Deutsch U, Klein R. 2002. EphrinB phosphorylation and reverse signaling: Regulation by Src kinases and PTP-BL phosphatase. Mol Cell 9: 725-737.
57. Pasquale EB. 2008. Eph-ephrin bidirectional signaling in physiology and disease. Cell 133: 38-52.
58. Pertea G, Huang X, Liang F, Antonescu V, Sultana R, Karamycheva S, Lee Y, White J, Cheung F, Parvizi B, Tsai J, Quackenbush J. 2003. TIGR Gene Indices clustering tools (TGICL): A software system for fast clustering of large EST datasets. Bioinformatics 19: 651-652.
59. Reischl J, Schwenke S, Beekman JM, Mrowietz U, Sturzebecher S, Heubach JF. 2007. Increased expression of Wnt5a in psoriatic plaques. J Invest Dermatol 127: 163-169. Epub 2006 Jul 2020.
60. Robinson NA, Lapic S, Welter JF, Eckert RL. 1997 S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. J Biol Chem 272: 12035-12046.
61. Salaita K, Nair PM, Petit RS, Neve RM, Das D, Gray JW, Groves JT. 2010. Restriction of receptor movement alters cellular response: Physical force sensing by EphA2. Science 327: 1380-1385.
62. Senior PV, Zhang BX, Chan ST. 2010. Loss of cell-surface receptor EphB2 is important for the growth, migration, and invasiveness of a colon cancer cell line. Int J Colorectal Dis 25: 687-694. Epub 2010 Mar 2026.
63. Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME. 2001. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105: 233-244.
64. Stojadinovic O, Lee B, Vouthounis C, Vukelic S, Pastar I, Blumenberg M, Brem H, Tomic-Canic M. 2007. Novel genomic effects of glucocorticoids in epidermal keratinocytes: Inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation. J Biol Chem 282: 4021-4034. Epub 2006 Nov 4029.
65. Tomic-Canic M, Brem H. 2004. Gene array technology and pathogenesis of chronic wounds. Am J Surg 188: 67-72.
66. Vihanto MM, Plock J, Erni D, Frey BM, Frey FJ, Huynh-Do U. 2005. Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin. Faseb J 19: 1689-1691. Epub 2005 Aug 1684.
67. Walsh R, Blumenberg M. 2011. The specific and shared targets of ephrin-a signaling in epidermal keratinocytes. J Biol Chem 286: 9419-9428. Epub 2010 Dec 30.
68. Yang NY, Lopez-Bergami P, Goydos JS, Yip D, Walker AM, Pasquale EB, Ethell IM. 2010. The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand. Pigment Cell Melanoma Res 23: 684-687. Epub 2010 Jul 2023.
69. Yao Y, Richman L, Morehouse C, de los Reyes M, Higgs BW, Boutrin A, White B, Coyle A, Krueger J, Kiener PA, Jallal B. 2008. Type I interferon: Potential therapeutic target for psoriasis? PLoS One 3: e2737.
70. Yokote H, Fujita K, Jing X, Sawada T, Liang S, Yao L, Yan X, Zhang Y, Schlessinger J, Sakaguchi K. 2005. Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains. Proc Natl Acad Sci USA 102: 18866-18871. Epub 12005 Dec 18819.
71. Zhang G, Njauw CN, Park JM, Naruse C, Asano M, Tsao H. 2008. EphA2 is an essential mediator of UV radiation-induced apoptosis. Cancer Res 68: 1691-1696.