Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

Nature Genetics

Volumn 37, Issue 1, 2005, Pages 56-65

  Descargues, Pascal ^a   Draison, Céline ^a   Bonnart, Chrystelle ^a   Kreft, Maaike ^b   Kishibe, Mari ^c   Ishida Yamamoto, Akemi ^c   Elias, Peter ^d   Barrandon, Yann ^e   Zambruno, Giovanna ^f   Sonnenberg, Arnoud ^b   Hovnanian, Alain ^a,g  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e EPFL   (Switzerland)

^f LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^g CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOGLEIN 1; LYMPHOEPITHELIAL KAZAL TYPE RELATED INHIBITOR PROTEIN; PROFILAGGRIN; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR KAZAL 5 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL DIVISION; CONTROLLED STUDY; DESMOSOME; DESQUAMATION; EMBRYO; ENZYME ACTIVITY; GENE; GENE CONTROL; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC DISORDER; HAIR DISEASE; KERATINIZATION; KERATINOCYTE; MOUSE; NETHERTON DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SKIN DEFECT; SKIN FUNCTION; SPINK5 GENE; STRATUM CORNEUM;

ANIMALS; CADHERINS; DESMOGLEIN 1; EPIDERMIS; KALLIKREINS; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SERPINS; SKIN DISEASES, GENETIC;

ANIMALIA;

EID: 19944427605     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1493     Document Type: Article

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