Semaphorin signaling meets rap

Science Signaling

Volumn 5, Issue 212, 2012, Pages

  Bos, Johannes L ^a   Pannekoek, Willem Jan ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAP PROTEIN; RAP1 PROTEIN; SEMAPHORIN; CELL ADHESION MOLECULE; NERVE GROWTH FACTOR; NERVE PROTEIN; PLEXIN;

ANIMAL CELL; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; MOUSE; NERVE FIBER GROWTH; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; ANIMAL; ARTICLE; BIOLOGICAL MODEL; GENETICS; METABOLISM; NERVE FIBER; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CELL ADHESION MOLECULES; MODELS, BIOLOGICAL; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; RAP1 GTP-BINDING PROTEINS; SEMAPHORINS; SIGNAL TRANSDUCTION;

EID: 84857483804     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002913     Document Type: Review

References (23)

1. J. L. Bos, H. Rehmann, A. Wittinghofer, GEFs and GAPs: Critical elements in the control of small G proteins. Cell 129, 865-877 (2007).
2. D. E. Martin, M. N. Hall, The expanding TOR signaling network. Curr. Opin. Cell Biol. 17, 158-166 (2005).
3. S. Y. Moon, Y. Zheng, Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 13, 13-22 (2003).
4. M. Gloerich, J. L. Bos, Regulating Rap small G-proteins in time and space. Trends Cell Biol. 21, 615-623 (2011).
5. A. W. Püschel, GTPases in semaphorin signaling. Adv. Exp. Med. Biol. 600, 12-23 (2007).
6. Y. Wang, H. He, N. Srivastava, S. Vikarunnessa, Y.-b. Chen, J. Jiang, C. W. Cowan, X. Zhang, Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization. Sci. Signal. 5, ra6 (2012).
7. A. Scrima, C. Thomas, D. Deaconescu, A. Wittinghofer, The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J. 27, 1145-1153 (2008).
8. B. Sot, C. Kötting, D. Deaconescu, Y. Suveyzdis, K. Gerwert, A. Wittinghofer, Unravelling the mechanism of dual-specifi city GAPs. EMBO J. 29, 1205-1214 (2010).
9. H. O. Park, J. Chant, I. Herskowitz, BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Nature 365, 269-274 (1993).
10. T. Clackson, W. Yang, L. W. Rozamus, M. Hatada, J. F. Amara, C. T. Rollins, L. F. Stevenson, S. R. Magari, S. A. Wood, N. L. Courage, X. Lu, F. Cerasoli Jr., M. Gilman, D. A. Holt, Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specifi city. Proc. Natl. Acad. Sci. U.S.A. 95, 10437-10442 (1998).
11. M. Negishi, I. Oinuma, H. Katoh, Plexins: Axon guidance and signal transduction. Cell. Mol. Life Sci. 62, 1363-1371 (2005).
12. A. E. Christensen, F. Selheim, J. de Rooij, S. Dremier, F. Schwede, K. K. Dao, A. Martinez, C. Maenhaut, J. L. Bos, H. G. Genieser, S. O. Døskeland, cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J. Biol. Chem. 278, 35394-35402 (2003).
13. S. Hisata, T. Sakisaka, T. Baba, T. Yamada, K. Aoki, M. Matsuda, Y. Takai, Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. J. Cell Biol. 178, 843-860 (2007).
14. C. Y. Jeon, H. J. Kim, J. Y. Lee, J. B. Kim, S. C. Kim, J. B. Park, p190RhoGAP and Rap-dependent RhoGAP (ARAP3) inactivate RhoA in response to nerve growth factor leading to neurite outgrowth from PC12 cells. Exp. Mol. Med. 42, 335-344 (2010).
15. J. D. Jordan, J. C. He, N. J. Eungdamrong, I. Gomes, W. Ali, T. Nguyen, T. G. Bivona, M. R. Philips, L. A. Devi, R. Iyengar, Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J. Biol. Chem. 280, 11413-11421 (2005).
16. S. E. Bilasy, T. Satoh, T. Terashima, T. Kataoka, RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures. Neurosci. Res. 71, 200-209 (2011).
17. C. Chang, C. E. Adler, M. Krause, S. G. Clark, F. B. Gertler, M. Tessier-Lavigne, C. I. Bargmann, MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr. Biol. 16, 854-862 (2006).
18. C. C. Quinn, D. S. Pfeil, E. Chen, E. L. Stovall, M. V. Harden, M. K. Gavin, W. C. Forrester, E. F. Ryder, M. C. Soto, W. G. Wadsworth, UNC-6/netrin and SLT-1/slit guidance cues orient axon out-growth mediated by MIG-10/RIAM/lamellipodin. Curr. Biol. 16, 845-853 (2006).
19. A. A. Derijck, S. Van Erp, R. J. Pasterkamp, Semaphorin signaling: Molecular switches at the midline. Trends Cell Biol. 20, 568-576 (2010).
20. J. R. Terman, A. L. Kolodkin, Nervy links protein kinase a to plexin-mediated semaphorin repulsion. Science 303, 1204-1207 (2004).
21. K. Aoki, T. Nakamura, M. Matsuda, Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells. J. Biol. Chem. 279, 713-719 (2004).
22. C. Micucci, S. Orciari, A. Catalano, Semaphorins and their receptors in stem and cancer cells. Curr. Med. Chem. 17, 3462-3475 (2010).
23. R. J. Pasterkamp, R. J. Giger, Semaphorin function in neural plasticity and disease. Curr. Opin. Neurobiol. 19, 263-274 (2009).