Toxicogenomic analysis of a sustained release local anesthetic delivery system

Biomaterials

Volumn 33, Issue 13, 2012, Pages 3586-3593

  Shichor, Iris ^a,b   Shomron, Noam ^c   Lawlor, Michael W ^a   Bae, Seul A ^b   Zoldan, Janet ^b   Langer, Robert ^b   Kohane, Daniel S ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Biocompatibility; Drug delivery; Nerve injury; Neurotoxicity; Prolonged duration local anesthesia; Toxicogenomics

Indexed keywords

AMITRIPTYLINE; BUPIVACAINE; DELIVERY SYSTEMS; DEXAMETHASONES; DORSAL ROOT GANGLIA; DRUG DELIVERY SYSTEM; LOCAL ANESTHETICS; NERVE INJURIES; NEUROTOXICITY; NORMAL FUNCTION; PROLONGED DURATION LOCAL ANESTHESIA; SCIATIC NERVES; SUSTAINED RELEASE; TISSUE INJURY; TOXICOGENOMICS;

ANESTHESIOLOGY; ANESTHETICS; ANIMALS; BIOCOMPATIBILITY; DRUG DELIVERY; TISSUE;

GENE EXPRESSION;

AMITRIPTYLINE; BUPIVACAINE; DEXAMETHASONE; LOCAL ANESTHETIC AGENT; MICROSPHERE; POLYGLACTIN; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG DELIVERY SYSTEM; GENE EXPRESSION; HISTOLOGY; MALE; NERVE BLOCK; NERVE INJURY; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL GANGLION; SUSTAINED DRUG RELEASE; UPREGULATION;

AMITRIPTYLINE; ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; DELAYED-ACTION PREPARATIONS; DEXAMETHASONE; GENE EXPRESSION REGULATION; LACTIC ACID; MALE; MICROSPHERES; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; SCIATIC NERVE; TETRODOTOXIN; TOXICOGENETICS;

ANIMALIA;

EID: 84857441486     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.01.043     Document Type: Article

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