Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca 2+ ions in pancreatic β-cells

Diabetes

Volumn 61, Issue 3, 2012, Pages 574-585

  Noordeen, Nafeesa A ^a   Meur, Gargi ^a   Rutter, Guy A ^a   Leclerc, Isabelle ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CALCIUM BINDING PROTEIN; CALCIUM ION; CARBOHYDRATE BINDING PROTEIN; CARBOHYDRATE RESPONSIVE ELEMENT BINDING PROTEIN; DIAZOXIDE; EGTAZIC ACID; GLUCOSE; NIFEDIPINE; PROTEIN; PYRUVATE KINASE; SORCIN; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHELATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MOBILIZATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA INTERFERENCE;

BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CALCIUM; CALCIUM-BINDING PROTEINS; CELL NUCLEUS; CELLS, CULTURED; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; OXIDATIVE STRESS;

EID: 84857438937     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1329     Document Type: Article

References (48)

1. Uyeda K, Repa JJ. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 2006;4:107-110 (Pubitemid 44138720)
2. Stoeckman AK, Ma L, Towle HC. Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem 2004;279:15662-15669 (Pubitemid 38618968)
3. Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 2004;101:7281-7286 (Pubitemid 38638024)
4. Dentin R, Benhamed F, Hainault I, et al. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes 2006;55:2159-2170 (Pubitemid 44743612)
5. Noordeen NA, Khera TK, Sun G, et al. Carbohydrate-responsive elementbinding protein (ChREBP) is a negative regulator of ARNT/HIF-1β gene expression in pancreatic islet b-cells. Diabetes 2010;59:153-160
6. da Silva Xavier G, Rutter GA, Diraison F, Andreolas C, Leclerc I. ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res 2006;47:2482-2491 (Pubitemid 44936110)
7. Wang H, Wollheim CB. ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells. J Biol Chem 2002;277:32746-32752 (Pubitemid 34984782)
8. Chen J, Hui ST, Couto FM, et al. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J 2008;22:3581-3594
9. Cha-Molstad H, Saxena G, Chen J, Shalev A. Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells. J Biol Chem 2009;284:16898-16905
10. da Silva Xavier G, Sun G, Qian Q, Rutter GA, Leclerc I. ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells. Biochem Biophys Res Commun 2010;402:252-257
11. Ishii S, Iizuka K, Miller BC, Uyeda K. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci USA 2004;101:15597-15602 (Pubitemid 39473533)
12. Li MV, Chang B, Imamura M, Poungvarin N, Chan L. Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes 2006;55:1179-1189 (Pubitemid 44195353)
13. Davies MN, O'Callaghan BL, Towle HC. Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity. J Biol Chem 2008;283:24029-24038
14. Postic C, Dentin R, Denechaud PD, Girard J. ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr 2007;27:179-192 (Pubitemid 351373354)
15. 2+ levels in the heart by sorcin and FKBP12, two accessory proteins of ryanodine receptors. Trends Pharmacol Sci 1998;19:479-482
16. 2+-dependent processes in the full-length protein. J Mol Biol 2002;317:447-458
17. Maki M, Kitaura Y, Satoh H, Ohkouchi S, Shibata H. Structures, functions and molecular evolution of the penta-EF-hand Ca2+-binding proteins. Biochim Biophys Acta 2002;1600:51-60 (Pubitemid 38224398)
18. Appelblom H, Nurmi J, Soukka T, et al. Homogeneous TR-FRET highthroughput screening assay for calcium-dependent multimerization of sorcin. J Biomol Screen 2007;12:842-848 (Pubitemid 47340701)
19. Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI. Association of sorcin with the cardiac ryanodine receptor. J Biol Chem 1995;270:26411-26418
20. Meyers MB, Puri TS, Chien AJ, et al. Sorcin associates with the poreforming subunit of voltage-dependent L-type Ca2+ channels. J Biol Chem 1998;273:18930-18935 (Pubitemid 28366281)
21. Lokuta AJ, Meyers MB, Sander PR, Fishman GI, Valdivia HH. Modulation of cardiac ryanodine receptors by sorcin. J Biol Chem 1997;272:25333-25338 (Pubitemid 27415725)
22. Fabiato A. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol 1983;245:C1-C14 (Pubitemid 14225289)
23. Farrell EF, Antaramian A, Rueda A, Gómez AM, Valdivia HH. Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart. J Biol Chem 2003;278:34660-34666 (Pubitemid 37553315)
24. Stern MD, Cheng H. Putting out the fire: what terminates calcium-induced calcium release in cardiac muscle? Cell Calcium 2004;35:591-601 (Pubitemid 38618571)
25. Rafiq I, Kennedy HJ, Rutter GA. Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells. J Biol Chem 1998;273:23241-23247 (Pubitemid 28417509)
26. Kennedy HJ, Viollet B, Rafiq I, Kahn A, Rutter GA. Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet beta-cells. J Biol Chem 1997; 272:20636-20640 (Pubitemid 27355623)
27. Rani S, Mehta JP, Barron N, et al. Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion. Cell Physiol Biochem 2010;25: 667-674
28. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 1998;95:2509-2514 (Pubitemid 28145972)
29. Noordeen NA, Carafoli F, Hohenester E, Horton MA, Leitinger B. A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1. J Biol Chem 2006;281:22744-22751
30. Merla G, Howald C, Antonarakis SE, Reymond A. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. Hum Mol Genet 2004;13:1505-1514 (Pubitemid 39023058)
31. Sakiyama H, Wynn RM, Lee WR, et al. Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. J Biol Chem 2008;283:24899-24908
32. Lee PS, Squires PE, Buchan AM, Yuen BH, Leung PC. P2-purinoreceptor evoked changes in intracellular calcium oscillations in single isolated human granulosa-lutein cells. Endocrinology 1996;137:3756-3761 (Pubitemid 26284643)
33. Meur G, Qian Q, da Silva Xavier G, et al. Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol Chem 2011;286:13647-13656
34. Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Proc Natl Acad Sci USA 2003;100:5107-5112 (Pubitemid 36542666)
35. Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/ dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci USA 2001;98:13710-13715 (Pubitemid 33115963)
36. Kawaguchi T, Osatomi K, Yamashita H, Kabashima T, Uyeda K. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMPactivated protein kinase. J Biol Chem 2002;277:3829-3835 (Pubitemid 34968632)
37. Palanivel R, Veluthakal R, Kowluru A. Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting INS-1 cells. Am J Physiol Endocrinol Metab 2004; 286:E1032-E1041 (Pubitemid 38668828)
38. Parameswara VK, Sule AJ, Esser V. Have we overlooked the importance of serine/threonine protein phosphatases in pancreatic beta-cells? Role played by protein phosphatase 2A in insulin secretion. JOP 2005;6:303-315 (Pubitemid 41581750)
39. Rabinovitch A, Grill V, Renold AE, Cerasi E. Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats. J Clin Invest 1976;58:1209-1216
40. Tian G, Sandler S, Gylfe E, Tengholm A. Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets. Diabetes 2011;60: 1535-1543
41. Leclerc I, Rutter GA. AMP-activated protein kinase: a new β-cell glucose sensor? Regulation by amino acids and calcium ions. Diabetes 2004;53 (Suppl. 3):S67-S74 (Pubitemid 39564525)
42. Dolmetsch RE, Xu K, Lewis RS. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 1998;392:933-936 (Pubitemid 28232066)
43. Dror V, Kalynyak TB, Bychkivska Y, et al. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. J Biol Chem 2008;283:9909-9916
44. Chen J, Fontes G, Saxena G, Poitout V, Shalev A. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated β-cell death. Diabetes 2010;59:440-447
45. 2+ microdomains and the control of insulin secretion. Cell Calcium 2006;40:539-551
46. Rutter GA. Visualising insulin secretion. The Minkowski Lecture 2004. Diabetologia 2004;47:1861-1872 (Pubitemid 40110192)
47. Suarez J, Belke DD, Gloss B, et al. In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol 2004;286:H68-H75 (Pubitemid 38049464)
48. Frank KF, Bölck B, Ding Z, et al. Overexpression of sorcin enhances cardiac contractility in vivo and in vitro. J Mol Cell Cardiol 2005;38:607-615 (Pubitemid 40461824)