Chronic hypoxia-induced alterations of key enzymes of glucose oxidative metabolism in developing mouse liver are mTOR dependent

Molecular and Cellular Biochemistry

Volumn 357, Issue 1-2, 2011, Pages 189-197

  Dukhande, Vikas V ^a,b   Sharma, Girish C ^c   Lai, James C K ^a   Farahani, Reza ^c  

^a IDAHO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Energy metabolism; Glycolysis; MTOR signaling; Rapamycin; TCA cycle

Indexed keywords

BETA ACTIN; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE KINASE; RAPAMYCIN; GLUCOSE; TARGET OF RAPAMYCIN KINASE;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; BODY WEIGHT; CONTROLLED STUDY; CYTOPLASM; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GLUCOSE METABOLISM; GLYCOLYSIS; GROWTH RETARDATION; HYPOXIA; IN VIVO STUDY; LIVER DEVELOPMENT; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PERINATAL PERIOD; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS; ANIMAL; ANOXIA; DRUG EFFECT; ENERGY METABOLISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEMATOCRIT; LIVER; METABOLISM; MICROARRAY ANALYSIS; PREGNANCY;

MAMMALIA; MUS;

ANIMALS; ANOXIA; BODY WEIGHT; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE; GLYCOLYSIS; HEMATOCRIT; LIVER; MICE; MICROARRAY ANALYSIS; PREGNANCY; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84857422623     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0889-z     Document Type: Article

References (48)

1. Iadecola C, Salkowski CA, Zhang F, Aber T, Nagayama M, Vogel SN, Ross ME (1999) The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury. J Exp Med 189:719-727 (Pubitemid 29193373)
2. Janssens JP, Pautex S, Hilleret H, Michel JP (2000) Respiratory sleep disorders in the elderly. Rev Med Suisse Romande 120: 869-879
3. Mathur R, Cox IJ, Oatridge A, Shephard DT, Shaw RJ, TaylorRobinson SD (1999) Cerebral bioenergetics in stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160:1994-1999 (Pubitemid 30004709)
4. Kuroiwa S, Katai N, Yoshimura N (1999) A possible role for p16INK4 in neuronal cell death after retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 40:528-533 (Pubitemid 29063853)
5. Henrion J, Schapira M, Luwaert R, Colin L, Delannoy A, Heller FR (2003) Hypoxic hepatitis: clinical and hemodynamic study in 142 consecutive cases. Medicine 82:392-406 (Pubitemid 37448566)
6. Ebert EC (2006) Hypoxic liver injury. Mayo Clin Proc 81: 1232-1236 (Pubitemid 44316289)
7. Kalaria RN, Fiedler C, Hunsaker JC III, Sparks DL (1993) Synaptic neurochemistry of human striatum during development: changes in sudden infant death syndrome. J Neurochem 60:2098-2105 (Pubitemid 23148781)
8. Naeije R (2003) Hepatopulmonary syndrome and portopulmonary hypertension. Swiss Med Wkly 133:163-169 (Pubitemid 36628590)
9. Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, Laderoute K, Johnson RS (2001) Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol 21:3436-3444 (Pubitemid 32381779)
10. Schofield CJ, Ratcliffe PJ (2004) Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5:343-354 (Pubitemid 38579472)
11. Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3:177-185
12. Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3:187-197
13. Guillemin K, Krasnow MA (1997) The hypoxic response: huffing and HIFing. Cell 89:9-12 (Pubitemid 27180579)
14. Chavez JC, Agani F, Pichiule P, LaManna JC (2000) Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia. J Appl Physiol 89:1937-1942
15. Weinberg JM, Venkatachalam MA, Roeser NF, Nissim I (2000) Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates. Proc Natl Acad Sci USA 97:2826-2831 (Pubitemid 30159256)
16. Semenza GL (2001) Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. Pediatr Res 49: 614-617 (Pubitemid 32390848)
17. Holness MJ, Sugden MC (2003) Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 31:1143-1151 (Pubitemid 38030927)
18. Roche TE, Baker JC, Yan X, Hiromasa Y, Gong X, Peng T, Dong J, Turkan A, Kasten SA (2001) Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Prog Nucleic Acid Res Mol Biol 70:33-75
19. Heacock CS, Sutherland RM (1990) Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br J Cancer 62:217-225 (Pubitemid 20242439)
20. Farahani R, Kanaan A, Gavrialov O, Brunnert S, Douglas RM, Morcillo P, Haddad GG (2008) Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development. Pediatr Pulmonol 43:20-28
21. Fan LW, Lin S, Pang Y, Lei M, Zhang F, Rhodes PG, Cai Z (2005) Hypoxia-ischemia induced neurological dysfunction and brain injury in the neonatal rat. Behav Brain Res 165:80-90 (Pubitemid 41476207)
22. Kanaan A, Farahani R, Douglas RM, Lamanna JC, Haddad GG (2006) Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination. Am J Physiol Regul Integr Comp Physiol 290:R1105-R1114
23. Bilali F, Kumar P, Feerick J, Berezin S, Farahani R (2008) Hypoxia-induced hypomyelination in the developing brain is mammalian target of rapamycin-4E-binding protein-1 signaling dependent. Neuroreport 19:635-639 (Pubitemid 351489359)
24. Pettersen EO, Juul NO, Ronning OW (1986) Regulation of protein metabolism of human cells during and after acute hypoxia. Cancer Res 46:4346-4351 (Pubitemid 16046852)
25. D'Angio CT, Finkelstein JN (2000) Oxygen regulation of gene expression: a study in opposites. Mol Genet Metab 71:371-380
26. Prabhakar NR (2001) Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol 90:1986-1994
27. Webster KA (2003) Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia. J Exp Biol 206:2911-2922 (Pubitemid 37073828)
28. Arsham AM, Howell JJ, Simon MC (2003) A novel hypoxiainducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 278:29655-29660 (Pubitemid 36962350)
29. Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926-1945 (Pubitemid 39071573)
30. Lawrence JC Jr, Abraham RT (1997) PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci 22:345-349
31. Sipula IJ, Brown NF, Perdomo G (2006) Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation. Metabolism 55:1637-1644 (Pubitemid 44827130)
32. Ramanathan A, Schreiber SL (2009) Direct control of mitochondrial function by mTOR. Proc Natl Acad Sci USA 106:22229-22232
33. Scafidi S, Douglas RM, Farahani R, Banasiak KJ, Haddad GG (2007) Prostaglandin transporter expression in mouse brain during development and in response to hypoxia. Neuroscience 146:1150-1157 (Pubitemid 46694143)
34. Wu TL (2006) Two-dimensional difference gel electrophoresis. Methods Mol Biol 328:71-95
35. Clark JB, Lai JCK (1989) Glycolytic, tricarboxylic acid cycle and related enzymes in brain. In: Boulton AA, Baker BG, Butterworth RF (eds) Neuro Methods. Humana, Clifton, pp 233-281
36. Dukhande VV, Isaac AO, Chatterji T, Lai JC (2009) Reduced glutathione regenerating enzymes undergo developmental decline and sexual dimorphism in the rat cerebral cortex. Brain Res 1286:19-24
37. Gwak GY, Yoon JH, Kim KM, Lee HS, Chung JW, Gores GJ (2005) Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression. J Hepatol 42:358-364 (Pubitemid 40254250)
38. Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271:32529-32537
39. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12:149-162 (Pubitemid 28060446)
40. Ebert BL, Firth JD, Ratcliffe PJ (1995) Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 270:29083-29089
41. Vannucci SJ, Reinhart R, Maher F, Bondy CA, Lee WH, Vannucci RC, Simpson IA (1998) Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxiaischemia in the immature rat brain. Brain Res Dev Brain Res 107:255-264 (Pubitemid 28257157)
42. Yecies JL, Manning BD (2011) mTOR links oncogenic signaling to tumor cell metabolism. J Mol Med 89:221-228
43. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484 (Pubitemid 43199434)
44. Coutant A, Rescan C, Gilot D, Loyer P, Guguen-Guillouzo C, Baffet G (2002) PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Hepatology 36:1079-1088 (Pubitemid 35253423)
45. Lai JC, White BK, Buerstatte CR, Haddad GG, Novotny EJ Jr, Behar KL (2003) Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions. Neurochem Res 28:933-940 (Pubitemid 36438412)
46. Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr (2004) Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18:2893-2904 (Pubitemid 39602308)
47. Reiter AK, Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2005) Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab 288:E980-E988 (Pubitemid 40547893)
48. Tinton SA, Buc-Calderon PM (1999) Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes. FEBS Lett 446:55-59 (Pubitemid 29127249)