A possible role for p16(INK4) in neuronal cell death after retinal ischemia-reperfusion injury

Investigative Ophthalmology and Visual Science

Volumn 40, Issue 2, 1999, Pages 528-533

  Kuroiwa, Sachiko ^a   Katai, Naomichi ^a   Yoshimura, Nagahisa ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALBINDIN; PROTEIN P16; SYNTAXIN; MEMBRANE PROTEIN; PROTEIN P16INK4A;

ANIMAL MODEL; ARTICLE; CELL CYCLE; CELL DEATH; CELL TYPE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; RETINA AMACRINE CELL; RETINA BIPOLAR GANGLION CELL; RETINA HORIZONTAL NERVE CELL; RETINA ISCHEMIA; ANIMAL; APOPTOSIS; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NECROSIS; NERVE CELL; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; REPERFUSION INJURY; RETINA BLOOD VESSEL; RETINA DISEASE; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IN SITU NICK-END LABELING; MALE; MEMBRANE PROTEINS; NECROSIS; NEURONS; QA-SNARE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RETINAL DISEASES; RETINAL VESSELS;

EID: 0032587383     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Büchi ER. Cell death in rat retina after a pressure-induced ischemia-reperfusion insult: an electron microscopic study. I. Ganglion cell layer and inner nuclear layer. Exp Eye Res. 1992;55:605-613.
2. Kuroiwa S, Katai N, Shibuki H, et al.. Expression of cell cycle-related genes in dying cells in retinal ischemic injury. Invest Ophthalmol Vis Sci. 1998;39:610-617.
3. Kranenburg O, van der Eb AJ, Zantema A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 1996;15:46-54.
4. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704-707.
5. Quelle DE, Zindy F, Shmun RF, Sherr CJ. Alternative reading frames of the INK4a tumor suppresser gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 1995; 83:993-1000.
6. Kamijo T, Zindy F, Roussel MF, et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 1997;91:649-659.
7. Stefánsson E, Wilson CA, Schoen T, Kuwabara T. Experimental ischemia induces cell mitosis in the adult rat retina. Invest Ophthalmol Vis Sci. 1988;29:1050-1055.
8. Inoue A, Obata K, Akagawa K. Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1. J Biol Chem. 1992;267:10613-10619.
9. Chu Y, Humphrey MF, Constable IJ. Horizontal cells of the normal and dystrophic rat retina: a wholemount study using immunolabelling for the 28-kDa calcium-binding protein. Exp Eye Res. 1993; 57:141-148.
10. INK4a. Cell. 1997;88:593-602.
11. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
12. Buchou T, Kranenburg O, van Dam H, et al. Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines. Oncogene. 1993;8:1765-1773.
13. Barres BA, Hart IK, Coles HSR, et al. Cell death and control of cell survival in the oligodendrocyte lineage. Cell. 1992;70:31-46.
14. Portera-Cailliau C, Price DL, Martin LJ. Non-NMDA and NMDA receptor-mediated cxcitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis. J Comp Neurol. 1997;378:88-104.
15. Sgonc R, Wick G. Methods for the detection of apoptosis. Int Arch Allergy Immunol. 1994;105:327-332.
16. Massey SC. Cell types using glutamate as a neurotransmitter in the vertebrate retina. Prog Retina Res. 1990;9:399-425.
17. Hamasaki-Britto DE, Hermans-Borgmeyer I, Heinemann S, Hughes TE. Expression of glutamate receptor genes in the mammalian retina: the localization of GluR1 through GluR7 mRNAs. J Neurosci. 1993;13:1888-1898.
18. Brandstätter JH, Hartveit E, Sassoè-Pognetto M, Wässle H. Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina. Eur J Neurosci. 1994;6:1100-1112.
19. Freeman RS, Estus S, Johnson EM Jr. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron. 1994;12:343-355.
20. Wang J, Walsh K. Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science. 1996;273: 359-361.
21. Park DS, Morris EJ, Stefanis L, et al. Multiple pathways of neuron death induced by DNA-damaging agents. NGF deprivation, and oxidative stress. J Neurosci. 1998;18:830-840.