Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 862-865

  Kočalka, Petr ^a   Rejman, Dominik ^a   Vaněk, Václav ^a   Rinnová, Markéta ^a   Tomečková, Ivana ^a   Králíková, Šárka ^a   Petrová, Magdalena ^a   Páv, Ondřej ^a   Pohl, Radek ^a   Buděšínský, Miloš ^a   Liboska, Radek ^a   Točík, Zdeněk ^a   Panova, Natalya ^a   Votruba, Ivan ^a   Rosenberg, Ivan ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Nucleotide analogues; Phosphonate; Pyrrolidine; Rat T cell lymphomas; Thymidine phosphorylase

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; NUCLEOTIDE; PHOSPHONIC ACID DERIVATIVE; PROLINOL NUCLEOTIDE; PYRROLIDINE DERIVATIVE; SUGAR; THYMIDINE PHOSPHORYLASE; THYMINE; UNCLASSIFIED DRUG; NUCLEOSIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PURIFICATION; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; T CELL LYMPHOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; ENZYMOLOGY; HUMAN; IC50; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; LYMPHOMA, T-CELL; NUCLEOSIDES; ORGANOPHOSPHONATES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE PHOSPHORYLASE;

EID: 74049150566     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.081     Document Type: Article

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