Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2275-2284

  Hikishima, Sadao ^a   Hashimoto, Mariko ^a   Magnowska, Lucyna ^b   Bzowska, Agnieszka ^b   Yokomatsu, Tsutomu ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

9 Deazaguanines; Multi substrate analogues inhibitors; Phosphate mimic; Purine nucleoside phosphorylase

Indexed keywords

9 (5',5' DIFLUORO 5' PHOSPHONOPENTYL) 9 DEAZAGUANINE; 9 (5',5' DIFLUORO 5' PHOSPHONOPENTYL)GUANINE; 9 DEAZAGUANINE DERIVATIVE; GUANINE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CALF (BOVINE); DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; IC 50; NONHUMAN; PKA; SPLEEN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATTLE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; ERYTHROCYTES; GUANINE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS; PURINE-NUCLEOSIDE PHOSPHORYLASE; SPLEEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

MAMMALIA;

EID: 77649231394     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.062     Document Type: Article

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