Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422

Molecular and Cellular Biochemistry

Volumn 357, Issue 1-2, 2011, Pages 199-207

  Grueninger, Fiona ^a   Bohrmann, Bernd ^a   Christensen, Klaus ^a   Graf, Martin ^a   Roth, Doris ^a   Czech, Christian ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Alzheimer's disease; MKK4; Tau phosphorylation

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; OKADAIC ACID; PHOSPHOTRANSFERASE INHIBITOR; SERINE; TAU PROTEIN; THREONINE; MAP2K4 PROTEIN, HUMAN; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; NEUROBLASTOMA; NEUROFIBRILLARY TANGLE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; ALZHEIMER DISEASE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ALZHEIMER DISEASE; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MAP KINASE KINASE 4; MOLECULAR STRUCTURE; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PROTEIN KINASE INHIBITORS; SERINE; TAU PROTEINS;

EID: 84857404010     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0890-6     Document Type: Article

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