N-(4-Substituted-benzoyl)-N′-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 5, 2012, Pages 1801-1816

  Nagy, Veronika ^a,b   Felföldi, Nóra ^a   Kónya, Bálint ^a   Praly, Jean Pierre ^b   Docsa, Tibor ^a   Gergely, Pál ^c   Chrysina, Evangelia D ^d   Tiraidis, Costas ^d   Kosmopoulou, Magda N ^d   Alexacou, Kyra Melinda ^d   Konstantakaki, Maria ^d   Leonidas, Demetres D ^d   Zographos, Spyros E ^d   Oikonomakos, Nikos G ^d   Kozmon, Stanislav ^e   Tvaroška, Igor ^e   Somsák, László ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d INSTITUTE OF BIOLOGY   (Greece)

^e INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Glycogen phosphorylase; Inhibitor; Molecular docking; N Acyl N d glucopyranosyl ureas; X ray crystallography

Indexed keywords

2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL AZIDE; 4 METHYLBENZOYL; ENZYME INHIBITOR; GLUCOSYLAMINE; GLYCOGEN PHOSPHORYLASE INHIBITOR; N (2 NAPHTHOYL) N' (BETA DEXTRO GLUCOPYRANOSYL)UREA; N (2 NAPHTHOYL) N' (BETA DEXTRO GLUCOPYRANOSYL)UREA 2 NAP UREA; N ACETYL N' (BETA DEXTRO GLUCOPYRANOSYL)UREA DERIVATIVE; N ACYL N' (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)UREA DERIVATIVE; N ACYL N' (BETA DEXTRO GLUCOPYRANOSYL)UREA DERIVATIVE; N BENZOYL N' (BETA DEXTRO GLUCOPYRANOSYL)UREA DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEPROTECTION REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME KINETICS; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; RABBIT; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE, MUSCLE FORM; MODELS, MOLECULAR; RABBITS; UREA;

ORYCTOLAGUS CUNICULUS;

EID: 84857362748     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.059     Document Type: Article

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