Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7368-7380

  Benltifa, Mahmoud ^a,b,c,d   Hayes, Joseph M ^e   Vidal, Sébastien ^a,b,c,d   Gueyrard, David ^a,b,c,d   Goekjian, Peter G ^a,b,c,d   Praly, Jean Pierre ^a,b,c,d   Kizilis, Gregory ^e   Tiraidis, Costas ^e   Alexacou, Kyra Melinda ^e   Chrysina, Evangelia D ^e   Zographos, Spyros E ^e   Leonidas, Demetres D ^e   Archontis, Georgios ^f   Oikonomakos, Nikos G ^e  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ LYON 1   (France)

^c CNRS   (France)

^d CPE LYON   (France)

^e INSTITUTE OF BIOLOGY   (Greece)

^f UNIVERSITY OF CYPRUS   (Cyprus)

Author keywords

1,3 Dipolar cycloaddition; GLIDE docking calculations; Glycogen phosphorylase; Isoxazoline; Quantum polarized ligand docking (QPLD); X ray crystallography

Indexed keywords

ENZYME INHIBITOR; GLUCOSE DERIVATIVE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE INHIBITOR; ISOXAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLOADDITION; DRUG ACTIVITY; DRUG CONFORMATION; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; MOLECULAR DOCKING; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

EID: 71249106036     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.060     Document Type: Article

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