Novel roles of the chemorepellent axon guidance molecule RGMa in cell migration and adhesion

Molecular and Cellular Biology

Volumn 32, Issue 5, 2012, Pages 968-980

  Lah, Grace J ^a   Key, Brian ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MEMBRANE PROTEIN; NEOGENIN; REPULSIVE GUIDANCE MOLECULE A; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; GASTRULATION; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; XENOPUS;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CALCIUM; CELL ADHESION; CELL MOVEMENT; EMBRYO, NONMAMMALIAN; GASTRULATION; MEMBRANE PROTEINS; MORPHOGENESIS; NERVE TISSUE PROTEINS; NEURULATION; PROTEIN STRUCTURE, TERTIARY; XENOPUS; XENOPUS PROTEINS;

EID: 84857184898     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.06128-11     Document Type: Article

References (61)

1. Aamar E, Dawid IB. 2008. Protocadherin-18a has a role in cell adhesion, behavior and migration in zebrafish development. Dev. Biol. 318:335- 346.
2. Babitt JL, et al. 2005. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J. Biol. Chem. 280:29820 -29827.
3. Bork P. 1991. Shuffled domains in extracellular proteins. FEBS Lett. 286: 47-54.
4. Brinks H, et al. 2004. The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus. J. Neurosci. 24:3862-3869.
5. Camus LM, Lambert LA. 2007. Molecular evolution of hemojuvelin and the repulsive guidance molecule family. J. Mol. Evol. 65:68-81.
6. Cha JY, et al. 2007. The role of FoxC1 in early Xenopus development. Dev. Dyn. 236:2731-2741.
7. Colombatti A, Bonaldo P. 1991. The superfamily of proteins with von Willebrand-factor type-A-like domains, one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms. Blood 77:2305-2315.
8. Connor RM, Key B. 2002. Expression and role of roundabout-1 in embryonic Xenopus forebrain. Dev. Dyn. 225:22-34.
9. Conrad S, et al. 2010. RGMb controls aggregation and migration of neogenin-positive cells in vitro and in vivo. Mol. Cell. Neurosci. 43:222- 231.
10. Cooke JE, Kemp HA, Moens CB. 2005. EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish. Curr. Biol. 15:536 -542.
11. Cousin H, DeSimone DW, Alfandari D. 2008. PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis. Dev. Biol. 319:86 -99.
12. Feys T, et al. 2007. A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines. Haematologica 92:913-920.
13. Gavert N, et al. 2007. Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res. 67:7703-7712.
14. Gessert S, Maurus D, Kuhl M. 2008. Repulsive guidance molecule A (RGM A) and its receptor neogenin during neural and neural crest cell development of Xenopus laevis. Biol. Cell 100:659-673.
15. Goodeve AC. 2010. The genetic basis of von Willebrand disease. Blood Rev. 24:123-134.
16. Goto T, Hasegawa K, Kinoshita T, Kubota HY. 2001. A novel POZ/zinc finger protein, champignon, interferes with gastrulation movements in Xenopus. Dev. Dyn. 221:14-25.
17. Halbrooks PJ, Ding R, Wozney JM, Bain G. 2007. Role of RGM coreceptors in bone morphogenetic protein signaling. J. Mol. Signal. 2:4.
18. Karaulanov EE, Bottcher RT, Niehrs C. 2006. A role for fibronectinleucine-rich transmembrane cell-surface proteins in homotypic cell adhesion. EMBO Rep. 7:283-290.
19. Kee N, et al. 2008. Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity. J. Neurosci. 28: 12643-12653.
20. Keller R, et al. 2000. Mechanisms of convergence and extension by cell intercalation. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355:897-922.
21. Keller R, Davidson LA, Shook DR. 2003. How we are shaped: the biomechanics of gastrulation. Differentiation 71:171-205.
22. Keller R, Winklbauer R. 1992. Cellular basis of amphibian gastrulation. Curr. Top. Dev. Biol. 27:39-89.
23. Kidd T, Bland KS, Goodman CS. 1999. Slit is the midline repellent for the robo receptor in Drosophila. Cell 96:785-794.
24. Kondo Y, et al. 2008. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat. Genet. 40:741-750.
25. Kwan KM, Kirschner MW. 2003. Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development 130:1961-1972.
26. Lamb TM, et al. 1993. Neural inducion by the secreted polypeptide noggin. Science 262:713-718.
27. Laurent A, et al. 2009. ZFPIP/Zfp462 is maternally required for proper early Xenopus laevis development. Dev. Biol. 327:169 -176.
28. Li J, Ye L, Mansel RE, Jiang WG. 2011. Potential prognostic value of repulsive guidance molecules in breast cancer. Anticancer Res. 31:1703- 1711.
29. Li VSW, et al. 2009. Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. Gastroenterology 137:176-187.
30. Louie SH, et al. 2009. Modulation of the beta-catenin signaling pathway by the Dishevelled-associated protein Hipk1. Plos One 4:e4310.
31. Matsunaga E, et al. 2004. RGM and its receptor neogenin regulate neuronal survival. Nat. Cell Biol. 6:749 -755.
32. Mawdsley DJ, et al. 2004. The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish. Dev. Biol. 269:302- 315.
33. Millard SS, Flanagan JJ, Pappu KS, Wu W, Zipursky SL. 2007. Dscam2 mediates axonal tiling in the Drosophila visual system. Nature 447:720- 724.
34. Mirakaj V, et al. 2011. Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation. Proc. Natl. Acad. Sci. U. S. A. 108:6555-6560.
35. Monnier PP, et al. 2002. RGM is a repulsive guidance molecule for retinal axons. Nature 419:392-395.
36. Muramatsu R, et al. 2011. RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nat. Med. 17:488-494.
37. Niederkofler V, Salie R, Sigrist M, Arber S. 2004. Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J. Neurosci. 24:808-818.
38. Nieuwkoop P, Faber J. 1994. Normal table of Xenopus laevis (Daudin). Garland Publishing Inc., New York, NY.
39. Ogata S, Cho KWY. 2007. Dissection of organizer and animal pole explants from Xenopus laevis embryos and assembly of a cell adhesion assay. J. Vis. Exp. doi:10.3791/187.
40. Okamura Y, Kohmura E, Yamashita T. 2011. TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Neurosci. Res. 71:63-70.
41. Oldekamp J, Kramer N, Alvarez-Bolado G, Skutella T. 2004. Expressionpattern of the repulsive guidance molecules RGM A, B and C during mouse development. Gene Expr. Patterns 4:283-288.
42. Popsueva AE, et al. 2001. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Dev. Biol. 234:483-496.
43. Rajagopalan S, et al. 2004. Neogenin mediates the action of repulsive guidance molecule. Nat. Cell Biol. 6:756-762.
44. Re'em-Kalma Y, Lamb T, Frank D. 1995. Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development. Proc. Natl. Acad. Sci. U. S. A. 92:12141- 12145.
45. Samad TA, et al. 2005. DRAGON, a bone morphogenetic protein coreceptor. J. Biol. Chem. 280:14122-14129.
46. Samad TA, et al. 2004. DRAGON: a member of the repulsive guidance molecule-realted family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive porperties. J. Nuerosci. 24:2027-2036.
47. Schafer MK, Altevogt P. 2010. L1CAM malfunction in the nervous system and human carcinomas. Cell. Mol. Life Sci. 67:2425-2437.
48. Schmidtmer J, Engelkamp D. 2004. Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr. Patterns 4:105-110.
49. Shiau CE, Bronner-Fraser M. 2009. N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons. Development 136:4155-4164.
50. Shin GJ, Wilson NH. 2008. Overexpression of repulsive guidance molecule (RGM) a induces cell death through Neogenin in early vertebrate development. J. Mol. Histol. 39:105-113.
51. Sive HL, Grainger RM, Harland RM. 2007. Dissociation and reaggregation of Xenopus laevis animal caps. CSH Protoc. doi:10.1101/pdb.prot4778.
52. Skoglund P, Rolo A, Chen XJ, Gumbiner BM, Keller R. 2008. Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network. Development 135:2435-2444.
53. Tardif S, et al. 2010. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. J. Biol. Chem. 285:24863- 24870.
54. Tassew NG, Charish J, Chestopalova L, Monnier PP. 2009. Sustained in vivo inhibition of protein domains using single-chain Fv recombinant antibodies and its application to dissect RGMa activity on axonal outgrowth. J. Neurosci. 29:1126 -1131.
55. Tassew NG, et al. 2008. Intraretinal RGMa is involved in retino-tectal mapping. Mol. Cell. Neurosci. 37:761-769.
56. Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ. 1994. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J. Cell Biol. 127:2009-2020.
57. Wilson NH, Key B. 2006. Neogenin interacts with RGMa and Netrin-1 to guide axons within the embryonic vertebrate forebrain. Dev. Biol. 296: 485-498.
58. Wilson NH, Key B. 2007. Neogenin: one receptor, many functions. Int. J. Biochem. Cell Biol. 39:874-878.
59. Wojtowicz WM, Flanagan JJ, Millard SS, Zipursky SL, Clemens JC. 2004. Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell 118:619-633.
60. Xia Y, et al. 2007. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282:18129-18140.
61. Zhou Z, et al. 2010. Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev. Cell 19:90 -102.