Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 16, 2011, Pages 6555-6560

  Mirakaj, Valbona ^a,b   Brown, Sebastian ^a   Laucher, Stefanie ^a   Steinl, Carolin ^c   Klein, Gerd ^c   Köhler, David ^a,b   Skutella, Thomas ^d   Meisel, Christian ^e   Brommer, Benedikt ^e   Rosenberger, Peter ^a,b   Schwab, Jan M ^e  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c Center for Medical Research   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTAXIS ACTIVATOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEUKOCYTE MIGRATION INHIBITION FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NEOGENIN; REPULSIVE GUIDANCE MOLECULE A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; EDEMA; EPITHELIUM; FLOW CYTOMETRY; GENE LOCUS; GENE MUTATION; GRANULOCYTE; HISTOPATHOLOGY; HOMOZYGOTE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY CELL; LEUKOCYTE; LEUKOCYTE MIGRATION INHIBITION; MONOCYTE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANIMALS; CACO-2 CELLS; CHEMOTAXIS; CYTOKINES; EPITHELIUM; GENE EXPRESSION REGULATION; GPI-LINKED PROTEINS; HUMANS; INFLAMMATION; LEUKOCYTES; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; PERITONITIS; ZYMOSAN;

MUS;

EID: 79955586868     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015605108     Document Type: Article

References (33)

1. Ridley AJ, et al. (2003) Cell migration: Integrating signals from front to back. Science 302:1704-1709. (Pubitemid 37505725)
2. Tessier-Lavigne M, Goodman CS (1996) The molecular biology of axon guidance. Science 274:1123-1133. (Pubitemid 26389268)
3. Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76:301-314.
4. Baggiolini M (1998) Chemokines and leukocyte traffic. Nature 392:565-568.
5. Luster AD (1998) Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med 338:436-445.
6. Wu JY, et al. (2001) The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410:948-952. (Pubitemid 32335842)
7. London NR, et al. (2010) Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med 2:23ra19.
8. Rosenberger P, et al. (2009) Hypoxia-inducible factor-dependent induction of netrin- 1 dampens inflammation caused by hypoxia. Nat Immunol 10:195-202.
9. Rao Y, Wong K, Ward M, Jurgensen C, Wu JY (2002) Neuronal migration and molecular conservation with leukocyte chemotaxis. Genes Dev 16:2973-2984. (Pubitemid 35424186)
10. Suzuki K, et al. (2007) Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 446:680-684. (Pubitemid 46606878)
11. Kruger RP, Aurandt J, Guan KL (2005) Semaphorins command cells to move. Nat Rev Mol Cell Biol 6:789-800. (Pubitemid 41726117)
12. Ly NP, et al. (2005) Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci USA 102:14729-14734. (Pubitemid 41457124)
13. Stahl B, Müller B, von Boxberg Y, Cox EC, Bonhoeffer F (1990) Biochemical characterization of a putative axonal guidance molecule of the chick visual system. Neuron 5:735-743.
14. Mueller BK, Yamashita T, Schaffar G, Mueller R (2006) The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system. Philos Trans R Soc Lond B Biol Sci 361:1513-1529. (Pubitemid 44450208)
15. Monnier PP, et al. (2002) RGM is a repulsive guidance molecule for retinal axons. Nature 419:392-395.
16. Rajagopalan S, et al. (2004) Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 6:756-762. (Pubitemid 39144481)
17. Niederkofler V, Salie R, Sigrist M, Arber S (2004) Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J Neurosci 24:808-818. (Pubitemid 38146591)
18. Matsunaga E, et al. (2004) RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol 6:749-755. (Pubitemid 39144480)
19. Matsunaga E, Nakamura H, Chédotal A (2006) Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance. J Neurosci 26: 6082-6088. (Pubitemid 44318373)
20. Matsunaga E, Chédotal A (2004) Repulsive guidance molecule/neogenin: A novel ligand-receptor system playing multiple roles in neural development. Dev Growth Differ 46:481-486. (Pubitemid 40052753)
21. Schwab JM, et al. (2005) Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain. Arch Neurol 62:1561-1568. (Pubitemid 41434561)
22. Hata K, et al. (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J Cell Biol 173:47-58.
23. Chin AC, Parkos CA (2007) Pathobiology of neutrophil transepithelial migration: Implications in mediating epithelial injury. Annu Rev Pathol 2:111-143. (Pubitemid 46448062)
24. Klein G, Müller CA, Tillet E, Chu ML, Timpl R (1995) Collagen type VI in the human bone marrow microenvironment: A strong cytoadhesive component. Blood 86: 1740-1748.
25. Swamy M, Jamora C, Havran W, Hayday A (2010) Epithelial decision makers: In search of the "epimmunome." Nat Immunol 11:656-665.
26. Babitt JL, et al. (2005) Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem 280:29820-29827. (Pubitemid 41177060)
27. Samad TA, et al. (2005) DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem 280:14122-14129. (Pubitemid 40517314)
28. Nohra R, et al. (2010) RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Genes Immun 11:279-293.
29. Lawrence T, Willoughby DA, Gilroy DW (2002) Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2:787-795. (Pubitemid 37328718)
30. Nathan C, Ding A (2010) Nonresolving inflammation. Cell 140:871-882.
31. Hornberger MR, et al. (1999) Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron 22:731-742. (Pubitemid 29203496)
32. Schwab JM, Chiang N, Arita M, Serhan CN (2007) Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447:869-874. (Pubitemid 46920139)
33. Leighton PA, et al. (2001) Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature 410:174-179. (Pubitemid 32216582)