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Volumn 29, Issue 2, 2012, Pages 101-110

CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer

Author keywords

Angiogenesis; CD133; Chemokine; Colorectal metastases; Hepatectomy

Indexed keywords

CD133 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; STROMAL CELL DERIVED FACTOR 1;

EID: 84857148325     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-011-9433-5     Document Type: Article
Times cited : (40)

References (47)
  • 2
    • 0029881854 scopus 로고    scopus 로고
    • Surgical resection of colorectal carcinoma metastases to the liver: A prognostic scoring system to improve case selection, based on 1568 patients
    • DOI 10.1002/(SICI)1097-0142(19960401)77:7<1254::AID-CNCR5>3.0.CO;2- I
    • B Nordlinger M Guiguet JC Vaillant, et al. 1996 Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie Cancer 77 1254 1262 8608500 10.1002/(SICI)1097-0142(19960401)77: 7<1254::AID-CNCR5>3.0.CO;2-I 1:STN:280:DyaK287pslCiuw%3D%3D (Pubitemid 26102322)
    • (1996) Cancer , vol.77 , Issue.7 , pp. 1254-1262
    • Nordlinger, B.1    Guiguet, M.2    Vaillant, J.-C.3    Balladur, P.4    Boudjema, K.5    Bachellier, P.6    Jaeck, D.7
  • 4
    • 50549121134 scopus 로고
    • The distribution of secondary growth in cancer
    • 10.1016/S0140-6736(00)49915-0
    • S Paget 1889 The distribution of secondary growth in cancer Lancet 1 571 573 10.1016/S0140-6736(00)49915-0
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 5
    • 33746051169 scopus 로고    scopus 로고
    • Chemokines, chemokine receptors, and cancer metastasis
    • DOI 10.1189/jlb.1105633
    • T Kakinuma ST Hwang 2006 Chemokines, chemokine receptors, and cancer metastasis J Leukoc Biol 79 639 651 16478915 10.1189/jlb.1105633 1:CAS:528:DC%2BD28XjsFCmur4%3D (Pubitemid 44835596)
    • (2006) Journal of Leukocyte Biology , vol.79 , Issue.4 , pp. 639-651
    • Kakinuma, T.1    Hwang, S.T.2
  • 6
    • 0025735630 scopus 로고
    • Properties of the novel proinflammatory supergene "intercrine" cytokine family
    • 1910690 10.1146/annurev.iy.09.040191.003153 1:CAS:528:DyaK3MXmsFegurc%3D
    • JJ Oppenheim CO Zachariae N Mukaida, et al. 1991 Properties of the novel proinflammatory supergene "intercrine" cytokine family Annu Rev Immunol 9 617 648 1910690 10.1146/annurev.iy.09.040191.003153 1:CAS:528:DyaK3MXmsFegurc%3D
    • (1991) Annu Rev Immunol , vol.9 , pp. 617-648
    • Oppenheim, J.J.1    Zachariae, C.O.2    Mukaida, N.3
  • 7
    • 0035856010 scopus 로고    scopus 로고
    • Chemokines and the molecular basis of cancer metastasis
    • 11556308 10.1056/NEJM200109133451113 1:CAS:528:DC%2BD3MXntFCnsbk%3D
    • PM Murphy 2001 Chemokines and the molecular basis of cancer metastasis N Engl J Med 345 833 835 11556308 10.1056/NEJM200109133451113 1:CAS:528: DC%2BD3MXntFCnsbk%3D
    • (2001) N Engl J Med , vol.345 , pp. 833-835
    • Murphy, P.M.1
  • 8
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • DOI 10.1182/blood-2005-08-3182
    • JA Burger TJ Kipps 2006 CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment Blood 107 1761 1767 16269611 10.1182/blood-2005-08-3182 1:CAS:528:DC%2BD28XitFChsLo%3D (Pubitemid 43289351)
    • (2006) Blood , vol.107 , Issue.5 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 9
    • 33646472556 scopus 로고    scopus 로고
    • Cancer CXC chemokine networks and tumour angiogenesis
    • 16510280 10.1016/j.ejca.2006.01.006 1:CAS:528:DC%2BD28Xjs1GrtL0%3D
    • RM Strieter MD Burdick J Mestas, et al. 2006 Cancer CXC chemokine networks and tumour angiogenesis Eur J Cancer 42 768 778 16510280 10.1016/j.ejca.2006.01.006 1:CAS:528:DC%2BD28Xjs1GrtL0%3D
    • (2006) Eur J Cancer , vol.42 , pp. 768-778
    • Strieter, R.M.1    Burdick, M.D.2    Mestas, J.3
  • 10
    • 33748873913 scopus 로고    scopus 로고
    • Chemokines and cancer
    • DOI 10.1002/ijc.22024
    • A Zlotnik 2006 Chemokines and cancer Int J Cancer 119 2026 2029 16671092 10.1002/ijc.22024 1:CAS:528:DC%2BD28XhtVSks7bE (Pubitemid 44423657)
    • (2006) International Journal of Cancer , vol.119 , Issue.9 , pp. 2026-2029
    • Zlotnik, A.1
  • 11
    • 0033818476 scopus 로고    scopus 로고
    • Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: A possible role for tumor progression
    • 10999740 1:CAS:528:DC%2BD3cXntFCis7c%3D
    • T Koshiba R Hosotani Y Miyamoto, et al. 2000 Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression Clin Cancer Res 6 3530 3535 10999740 1:CAS:528:DC%2BD3cXntFCis7c%3D
    • (2000) Clin Cancer Res , vol.6 , pp. 3530-3535
    • Koshiba, T.1    Hosotani, R.2    Miyamoto, Y.3
  • 12
    • 33747499900 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome
    • DOI 10.1097/01.sla.0000217690.65909.9c, PII 0000065820060700000016
    • J Kim T Mori SL Chen, et al. 2006 Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome Ann Surg 244 113 120 16794396 10.1097/01.sla.0000217690.65909.9c (Pubitemid 44297455)
    • (2006) Annals of Surgery , vol.244 , Issue.1 , pp. 113-120
    • Kim, J.1    Mori, T.2    Chen, S.L.3    Amersi, F.F.4    Martinez, S.R.5    Kuo, C.6    Turner, R.R.7    Ye, X.8    Bilchik, A.J.9    Morton, D.L.10    Hoon, D.S.B.11
  • 15
    • 67649438676 scopus 로고    scopus 로고
    • Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases
    • 19287949 10.3892/ijo-00000218 1:CAS:528:DC%2BD1MXkt1ejtb4%3D
    • H Yoshidome H Kohno T Shida, et al. 2009 Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases Int J Oncol 34 923 930 19287949 10.3892/ijo-00000218 1:CAS:528:DC%2BD1MXkt1ejtb4%3D
    • (2009) Int J Oncol , vol.34 , pp. 923-930
    • Yoshidome, H.1    Kohno, H.2    Shida, T.3
  • 16
    • 35448930176 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis
    • DOI 10.1593/neo.07559
    • O Kollmar K Rupertus C Scheuer, et al. 2007 Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis Neoplasia 9 862 870 17971906 10.1593/neo.07559 1:CAS:528:DC%2BD2sXhtl2rtr3P (Pubitemid 47623426)
    • (2007) Neoplasia , vol.9 , Issue.10 , pp. 862-870
    • Kollmar, O.1    Rupertus, K.2    Scheuery, C.3    Junker, B.4    Tilton, B.5    Schilling, M.K.6    Mengery, M.D.7
  • 17
    • 18444401114 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival
    • DOI 10.1200/JCO.2005.07.078
    • J Kim H Takeuchi ST Lam, et al. 2005 Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival J Clin Oncol 23 2744 2753 15837989 10.1200/JCO.2005.07.078 1:CAS:528:DC%2BD2MXktleqtrg%3D (Pubitemid 46179464)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.12 , pp. 2744-2753
    • Kim, J.1    Takeuchi, H.2    Lam, S.T.3    Turner, R.R.4    Wang, H.-J.5    Kuo, C.6    Foshag, L.7    Bilchik, A.J.8    Hoon, D.S.B.9
  • 18
    • 34248140257 scopus 로고    scopus 로고
    • Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    • DOI 10.1158/0008-5472.CAN-06-4429
    • J Miki B Furusato H Li, et al. 2007 Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens Cancer Res 67 3153 3161 17409422 10.1158/0008-5472.CAN-06-4429 1:CAS:528:DC%2BD2sXksVGlu70%3D (Pubitemid 46724852)
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3153-3161
    • Miki, J.1    Furusato, B.2    Li, H.3    Gu, Y.4    Takahashi, H.5    Egawa, S.6    Sesterhenn, I.A.7    McLeod, D.G.8    Srivastava, S.9    Rhim, J.S.10
  • 19
    • 34547106802 scopus 로고    scopus 로고
    • Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence
    • DOI 10.1002/cncr.22774
    • EH Lin M Hassan Y Li, et al. 2007 Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence Cancer 110 534 542 17594720 10.1002/cncr.22774 1:CAS:528:DC%2BD2sXpt1yqu7w%3D (Pubitemid 47106141)
    • (2007) Cancer , vol.110 , Issue.3 , pp. 534-542
    • Lin, E.H.1    Hassan, M.2    Li, Y.3    Zhao, H.4    Nooka, A.5    Sorenson, E.6    Xie, K.7    Champlin, R.8    Wu, X.9    Li, D.10
  • 22
    • 33846821757 scopus 로고    scopus 로고
    • Tissue microenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma
    • DOI 10.1593/neo.06670
    • L Zhang H Yeger B Das, et al. 2007 Tissue microenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma Neoplasia 9 36 46 17325742 10.1593/neo.06670 1:CAS:528:DC%2BD2sXhvFCht7c%3D (Pubitemid 46203933)
    • (2007) Neoplasia , vol.9 , Issue.1 , pp. 36-46
    • Zhang, L.1    Yeger, H.2    Das, B.3    Irwinz, M.S.4    Baruchel, S.5
  • 23
    • 0034111038 scopus 로고    scopus 로고
    • Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: Long-term results
    • DOI 10.1097/00000658-200004000-00006
    • M Minagawa M Makuuchi G Torzilli, et al. 2000 Extension of the frontiers of surgical indications in the treatment of liver metastasis from colorectal cancer: long-term results Ann Surg 231 487 499 10749608 10.1097/00000658- 200004000-00006 1:STN:280:DC%2BD3c3htlaisA%3D%3D (Pubitemid 30185854)
    • (2000) Annals of Surgery , vol.231 , Issue.4 , pp. 487-499
    • Minagawa, M.1    Makuuchi, M.2    Torzilli, G.3    Takayama, T.4    Kawasaki, S.5    Kosuge, T.6    Yamamoto, J.7    Imamura, H.8
  • 25
    • 0033504042 scopus 로고    scopus 로고
    • Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: Analysis of 1001 consecutive cases
    • DOI 10.1097/00000658-199909000-00004
    • Y Fong J Fortner RL Sun, et al. 1999 Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases Ann Surg 230 309 318 10493478 10.1097/00000658- 199909000-00004 1:STN:280:DyaK1MvitFahsw%3D%3D (Pubitemid 30191861)
    • (1999) Annals of Surgery , vol.230 , Issue.3 , pp. 309-321
    • Fong, Y.1    Fortner, J.2    Sun, R.L.3    Brennan, M.F.4    Blumgart, L.H.5
  • 27
    • 34447272058 scopus 로고    scopus 로고
    • Mechanisms of metastasis: Epithelial-to-mesenchymal transition and contribution of tumor microenvironment
    • DOI 10.1002/jcb.21215
    • JC Tse R Kalluri 2007 Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment J Cell Biochem 101 816 829 17243120 10.1002/jcb.21215 1:CAS:528:DC%2BD2sXnvVSqu70%3D (Pubitemid 47040864)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.4 , pp. 816-829
    • Tse, J.C.1    Kalluri, R.2
  • 28
    • 32144454172 scopus 로고    scopus 로고
    • Mechanisms of disease: The many roles of chemokines and chemokine receptors in inflammation
    • DOI 10.1056/NEJMra052723
    • IF Charo RM Ransohoff 2006 The many roles of chemokines and chemokine receptors in inflammation N Engl J Med 354 610 621 16467548 10.1056/NEJMra052723 1:CAS:528:DC%2BD28XhtlKisro%3D (Pubitemid 43209108)
    • (2006) New England Journal of Medicine , vol.354 , Issue.6 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 29
    • 78449300594 scopus 로고    scopus 로고
    • CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression
    • Erratum 2011;30:269-270
    • Sun X, Cheng G, Hao M et al (2010) CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev 29:709-722. Erratum 2011;30:269-270
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 709-722
    • Sun, X.1    Cheng, G.2    Hao, M.3
  • 32
    • 0038079014 scopus 로고    scopus 로고
    • The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases
    • IS Zeelenberg L Ruuls-Van Stalle E Roos 2003 The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases Cancer Res 63 3833 3839 12839981 1:CAS:528:DC%2BD3sXltVGqs7k%3D (Pubitemid 36793074)
    • (2003) Cancer Research , vol.63 , Issue.13 , pp. 3833-3839
    • Zeelenberg, I.S.1    Ruuls-Van Stalle, L.2    Roos, E.3
  • 33
    • 34347330516 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells
    • 17016644 1:CAS:528:DC%2BD28Xht1Wjs7vM
    • T Onoue D Uchida NM Begum, et al. 2006 Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells Int J Oncol 29 1133 1138 17016644 1:CAS:528:DC%2BD28Xht1Wjs7vM
    • (2006) Int J Oncol , vol.29 , pp. 1133-1138
    • Onoue, T.1    Uchida, D.2    Begum, N.M.3
  • 34
    • 43849086665 scopus 로고    scopus 로고
    • Up-regulation of stromal cell-derived factor-1α and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma
    • M Taki K Higashikawa S Yoneda, et al. 2008 Up-regulation of stromal cell-derived factor-1alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma Oncol Rep 19 993 998 18357387 1:CAS:528:DC%2BD1cXksl2rsrg%3D (Pubitemid 351802671)
    • (2008) Oncology Reports , vol.19 , Issue.4 , pp. 993-998
    • Taki, M.1    Higashikawa, K.2    Yoneda, S.3    Ono, S.4    Shigeishi, H.5    Nagayama, M.6    Kamata, N.7
  • 35
    • 34548093249 scopus 로고    scopus 로고
    • Association between expression of vascular endothelial growth factor C, chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer
    • 17641542 10.1159/000106070 1:CAS:528:DC%2BD2sXpsVejsbk%3D
    • S Fukunaga K Maeda E Noda, et al. 2006 Association between expression of vascular endothelial growth factor C, chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer Oncology 71 204 211 17641542 10.1159/000106070 1:CAS:528:DC%2BD2sXpsVejsbk%3D
    • (2006) Oncology , vol.71 , pp. 204-211
    • Fukunaga, S.1    Maeda, K.2    Noda, E.3
  • 36
    • 38049100467 scopus 로고    scopus 로고
    • A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer
    • 17763975 10.1245/s10434-007-9595-1
    • SU Woo JW Bae CH Kim, et al. 2008 A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer Ann Surg Oncol 15 281 285 17763975 10.1245/s10434-007- 9595-1
    • (2008) Ann Surg Oncol , vol.15 , pp. 281-285
    • Woo, S.U.1    Bae, J.W.2    Kim, C.H.3
  • 37
    • 28544440733 scopus 로고    scopus 로고
    • Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells
    • DOI 10.1158/1078-0432.CCR-05-0537
    • L Su J Zhang H Xu, et al. 2005 Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells Clin Cancer Res 11 8273 8280 16322285 10.1158/1078-0432.CCR-05-0537 1:CAS:528:DC%2BD2MXht1KjsrjP (Pubitemid 41746937)
    • (2005) Clinical Cancer Research , vol.11 , Issue.23 , pp. 8273-8280
    • Su, L.1    Zhang, J.2    Xu, H.3    Wang, Y.4    Chu, Y.5    Liu, R.6    Xiong, S.7
  • 38
    • 73449099315 scopus 로고    scopus 로고
    • Nuclear localization of CXCR4 determines prognosis for colorectal cancer patients
    • 19308676 10.1007/s12307-008-0016-1 1:CAS:528:DC%2BD1MXhsFKrs7fI
    • FM Speetjens GJ Liefers CJ Korbee, et al. 2009 Nuclear localization of CXCR4 determines prognosis for colorectal cancer patients Cancer Microenviron 2 1 7 19308676 10.1007/s12307-008-0016-1 1:CAS:528:DC%2BD1MXhsFKrs7fI
    • (2009) Cancer Microenviron , vol.2 , pp. 1-7
    • Speetjens, F.M.1    Liefers, G.J.2    Korbee, C.J.3
  • 39
    • 56149118023 scopus 로고    scopus 로고
    • Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis
    • 18701133 10.1016/j.humpath.2008.04.017 1:CAS:528:DC%2BD1cXhtlyltb%2FK
    • IK Na C Scheibenbogen C Adam, et al. 2008 Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis Hum Pathol 39 1751 1755 18701133 10.1016/j.humpath.2008.04.017 1:CAS:528:DC%2BD1cXhtlyltb%2FK
    • (2008) Hum Pathol , vol.39 , pp. 1751-1755
    • Na, I.K.1    Scheibenbogen, C.2    Adam, C.3
  • 40
    • 0034855942 scopus 로고    scopus 로고
    • Nuclear localization of EGF receptor and its potential new role as a transcription factor
    • DOI 10.1038/ncb0901-802
    • SY Lin K Makino W Xia, et al. 2001 Nuclear localization of EGF receptor and its potential new role as a transcription factor Nat Cell Biol 3 802 808 11533659 10.1038/ncb0901-802 1:CAS:528:DC%2BD3MXmvF2ls74%3D (Pubitemid 32842685)
    • (2001) Nature Cell Biology , vol.3 , Issue.9 , pp. 802-808
    • Lin, S.-Y.1    Makino, K.2    Xia, W.3    Matin, A.4    Wen, Y.5    Kwong, K.Y.6    Bourguignon, L.7    Hung, M.-C.8
  • 41
    • 36049020021 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-κB-dependent pathway in human lung cancer cells
    • DOI 10.1016/j.bcp.2007.08.025, PII S0006295207005862
    • YC Huang YC Hsiao YJ Chen, et al. 2007 Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-kappaB-dependent pathway in human lung cancer cells Biochem Pharmacol 74 1702 1712 17904532 10.1016/j.bcp.2007.08.025 1:CAS:528:DC%2BD2sXhtlWrt7vF (Pubitemid 350088681)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.12 , pp. 1702-1712
    • Huang, Y.-C.1    Hsiao, Y.-C.2    Chen, Y.-J.3    Wei, Y.-Y.4    Lai, T.-H.5    Tang, C.-H.6
  • 42
    • 0345687920 scopus 로고    scopus 로고
    • Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells
    • DOI 10.1038/sj.onc.1207097
    • M Burger A Glodek T Hartmann, et al. 2003 Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells Oncogene 22 8093 8101 14603250 10.1038/sj.onc.1207097 1:CAS:528:DC%2BD3sXoslSisLc%3D (Pubitemid 37487300)
    • (2003) Oncogene , vol.22 , Issue.50 , pp. 8093-8101
    • Burger, M.1    Glodek, A.2    Hartmann, T.3    Schmitt-Graff, A.4    Silberstein, L.E.5    Fujii, N.6    Kipps, T.J.7    Burger, J.A.8
  • 44
    • 33744994778 scopus 로고    scopus 로고
    • Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: Potential regulation by ligand-dependent degradation and HIF-1α
    • DOI 10.1016/j.bbrc.2006.05.110, PII S0006291X06011703
    • H Shim SK Lau S Devi, et al. 2006 Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: potential regulation by ligand-dependent degradation and HIF-1alpha Biochem Biophys Res Commun 346 252 258 16756955 10.1016/j.bbrc.2006.05.110 1:CAS:528:DC%2BD28Xls1Gmtrc%3D (Pubitemid 43865990)
    • (2006) Biochemical and Biophysical Research Communications , vol.346 , Issue.1 , pp. 252-258
    • Shim, H.1    Lau, S.K.2    Devi, S.3    Yoon, Y.4    Cho, H.T.5    Liang, Z.6
  • 45
    • 42449111736 scopus 로고    scopus 로고
    • Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
    • 18071913 10.1007/s10585-007-9133-3 1:CAS:528:DC%2BD1cXnt1ensL0%3D
    • SY Kim CH Lee BV Midura, et al. 2008 Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases Clin Exp Metastasis 25 201 211 18071913 10.1007/s10585-007-9133-3 1:CAS:528:DC%2BD1cXnt1ensL0%3D
    • (2008) Clin Exp Metastasis , vol.25 , pp. 201-211
    • Kim, S.Y.1    Lee, C.H.2    Midura, B.V.3
  • 46
    • 53849134099 scopus 로고    scopus 로고
    • CD133 expression is an independent prognostic marker for low survival in colorectal cancer
    • 18781171 10.1038/sj.bjc.6604664 1:CAS:528:DC%2BD1cXht1Cmtr%2FP
    • D Horst L Kriegl J Engel, et al. 2008 CD133 expression is an independent prognostic marker for low survival in colorectal cancer Br J Cancer 99 1285 1289 18781171 10.1038/sj.bjc.6604664 1:CAS:528:DC%2BD1cXht1Cmtr%2FP
    • (2008) Br J Cancer , vol.99 , pp. 1285-1289
    • Horst, D.1    Kriegl, L.2    Engel, J.3
  • 47
    • 68949122522 scopus 로고    scopus 로고
    • Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor-1alpha-mediated stellate cell activation
    • 19434726 10.1002/hep.22890 1:CAS:528:DC%2BD1MXotVCmuro%3D
    • F Hong A Tuyama TF Lee, et al. 2009 Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation Hepatology 49 2055 2067 19434726 10.1002/hep.22890 1:CAS:528:DC%2BD1MXotVCmuro%3D
    • (2009) Hepatology , vol.49 , pp. 2055-2067
    • Hong, F.1    Tuyama, A.2    Lee, T.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.