Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis

Human Pathology

Volumn 39, Issue 12, 2008, Pages 1751-1755

  Na, Il Kang ^a   Scheibenbogen, Carmen ^a   Adam, Christine ^a   Stroux, Andrea ^a   Ghadjar, Pirus ^a   Thiel, Eckhard ^a   Keilholz, Ulrich ^a   Coupland, Sarah Ellen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

CXCR4; Lymph node metastasis; Non small cell lung cancer

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CUTANEOUS T CELL ATTRACTING CHEMOKINE; STROMAL CELL DERIVED FACTOR 1;

ADULT; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MALE; METASTASIS POTENTIAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS;

CARCINOMA, NON-SMALL-CELL LUNG; CELL NUCLEUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; RECEPTORS, CXCR4; TUMOR MARKERS, BIOLOGICAL;

EID: 56149118023     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2008.04.017     Document Type: Article

References (25)

1. Mountain C.F. The international system for staging lung cancer. Semin Surg Oncol 18 (2000) 106-115
2. Okada M., Tsubota N., Yoshimura M., Miyamoto Y., and Nakai R. Evaluation of TMN classification for lung carcinoma with ipsilateral intrapulmonary metastasis. Ann Thorac Surg 68 (1999) 326-330 [discussion 331]
3. Muller A., Homey B., Soto H., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410 (2001) 50-56
4. Murakami T., Maki W., Cardones A.R., et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res 62 (2002) 7328-7334
5. Cabioglu N., Yazici M.S., Arun B., et al. CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer. Clin Cancer Res 11 (2005) 5686-5693
6. Kato M., Kitayama J., Kazama S., and Nagawa H. Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res 5 (2003) R144-R150
7. Uchida D., Begum N.M., Tomizuka Y., et al. Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma. Lab Invest 84 (2004) 1538-1546
8. Schimanski C.C., Schwald S., Simiantonaki N., et al. Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res 11 (2005) 1743-1750
9. Laverdiere C., Hoang B.H., Yang R., et al. Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. Clin Cancer Res 11 (2005) 2561-2567
10. Schimanski C.C., Bahre R., Gockel I., et al. Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4. Br J Cancer 95 (2006) 210-217
11. Kijima T., Maulik G., Ma P.C., et al. Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res 62 (2002) 6304-6311
12. Phillips R.J., Burdick M.D., Lutz M., Belperio J.A., Keane M.P., and Strieter R.M. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 167 (2003) 1676-1686
13. Cordell J.L., Falini B., Erber W.N., et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32 (1984) 219-229
14. Ghadjar P., Coupland S.E., Na I.K., et al. Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer. J Clin Oncol 24 (2006) 1910-1916
15. Sankoh A.J., Huque M.F., and Dubey S.D. Some comments on frequently used multiple endpoint adjustment methods in clinical trials. Stat Med 16 (1997) 2529-2542
16. Salvucci O., Bouchard A., Baccarelli A., et al. The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res Treat 97 (2006) 275-283
17. Wang N., Wu Q.L., Fang Y., et al. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome. J Transl Med 3 (2005) 26
18. Spano J.P., Andre F., Morat L., et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann Oncol 15 (2004) 613-617
19. Shibuta K., Mori M., Shimoda K., Inoue H., Mitra P., and Barnard G.F. Regional expression of CXCL12/CXCR4 in liver and hepatocellular carcinoma and cell-cycle variation during in vitro differentiation. Jpn J Cancer Res 93 (2002) 789-797
20. Ganju R.K., Brubaker S.A., Meyer J., et al. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem 273 (1998) 23169-23175
21. Vicente-Manzanares M., Rey M., Jones D.R., et al. Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis. J Immunol 163 (1999) 4001-4012
22. Darash-Yahana M., Pikarsky E., Abramovitch R., et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 18 (2004) 1240-1242
23. Smith M.C., Luker K.E., Garbow J.R., et al. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 64 (2004) 8604-8612
24. Su L., Zhang J., Xu H., et al. Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin Cancer Res 11 (2005) 8273-8280
25. Gortz A., Nibbs R.J., McLean P., et al. The chemokine ESkine/CCL27 displays novel modes of intracrine and paracrine function. J Immunol 169 (2002) 1387-1394