Gene-gene and gene-environmental interactions of childhood asthma: A multifactor dimension reduction approach

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Su, Ming Wei ^a   Tung, Kuan Yen ^a   Liang, Pi Hui ^b   Tsai, Ching Hui ^a   Kuo, Nai Wei ^a   Lee, Yungling Leo ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE P1; GSTP1 PROTEIN, HUMAN; IL4R PROTEIN, HUMAN; INSIG2 PROTEIN, HUMAN; INTERLEUKIN 4 RECEPTOR ALPHA; MEMBRANE PROTEIN; SIGNAL PEPTIDE;

ACCURACY; ADRB2 GENE; ARTICLE; ASTHMA; CASE CONTROL STUDY; CHILD; CHILDHOOD ASTHMA; CONTROLLED STUDY; FEMALE; GENE; GENE INTERACTION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; GSTP1 GENE; HEALTH STATUS; HUMAN; IL13 GENE; INSIG2 GENE; INTERLEUKIN 4 RECEPTOR ALPHA GENE; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PREMATURITY; QUESTIONNAIRE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; STAT6 GENE; TAIWAN; VALIDATION PROCESS; ADOLESCENT; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; MULTIFACTOR DIMENSIONALITY REDUCTION; NEWBORN; POLYMERASE CHAIN REACTION;

ADOLESCENT; ASTHMA; CASE-CONTROL STUDIES; CHILD; DNA; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; INFANT, NEWBORN; INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MULTIFACTOR DIMENSIONALITY REDUCTION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; TAIWAN;

EID: 84857097161     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030694     Document Type: Article

References (60)

1. Spee-van der Wekke J, Meulmeester JF, Radder JJ, Verloove-Vanhorick SP, (1998) School absence and treatment in school children with respiratory symptoms in The Netherlands: data from the Child Health Monitoring System. J Epidemiol Community Health 52: 359-363.
2. Silverstein MD, Mair JE, Katusic SK, Wollan PC, O'Connell EJ, et al. (2001) School attendance and school performance: a population-based study of children with asthma. J Pediatr 139: 278-283.
3. Weiss KB, Sullivan SD, (1994) Socio-economic burden of asthma, allergy, and other atopic illnesses. Pediatr Allergy Immunol 5: 7-12.
4. Rahman I, MacNee W, (2000) Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 16: 534-554.
5. Salam MT, Lin PC, Avol EL, Gauderman WJ, Gilliland FD, (2007) Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma. Thorax 62: 1050-1057.
6. Beuther DA, Sutherland ER, (2007) Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 175: 661-666.
7. Flaherman V, Rutherford GW, (2006) A meta-analysis of the effect of high weight on asthma. Arch Dis Child 91: 334-339.
8. Shore SA, (2008) Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 121: 1087-1093; quiz 1094-1085.
9. Rooyen JM, Pretorius PJ, Britz M, Huisman HW, Schutte AE, et al. (2008) Genetic polymorphisms of beta2- and beta3-adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women. Exp Clin Endocrinol Diabetes 116: 236-240.
10. Busse WW, Lemanske RF Jr, (2001) Asthma. N Engl J Med 344: 350-362.
11. Wills-Karp M, Chiaramonte M, (2003) Interleukin-13 in asthma. Curr Opin Pulm Med 9: 21-27.
12. Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M, (2007) Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370: 1422-1431.
13. Schedel M, Carr D, Klopp N, Woitsch B, Illig T, et al. (2004) A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels. J Allergy Clin Immunol 114: 1100-1105.
14. Trabetti E, Patuzzo C, Malerba G, Galavotti R, Martinati LC, et al. (1999) Association of a lymphotoxin alpha gene polymorphism and atopy in Italian families. J Med Genet 36: 323-325.
15. Shin HD, Park BL, Kim LH, Jung JH, Wang HJ, et al. (2004) Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum Mol Genet 13: 397-403.
16. McLeish S, Turner SW, (2007) Gene-environment interactions in asthma. Arch Dis Child 92: 1032-1035.
17. Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, et al. (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 69: 138-147.
18. Moore JH, Williams SM, (2002) New strategies for identifying gene-gene interactions in hypertension. Ann Med 34: 88-95.
19. Cho YM, Ritchie MD, Moore JH, Park JY, Lee KU, et al. (2004) Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus. Diabetologia 47: 549-554.
20. Tsai CT, Lai LP, Lin JL, Chiang FT, Hwang JJ, et al. (2004) Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation 109: 1640-1646.
21. Bastone L, Reilly M, Rader DJ, Foulkes AS, (2004) MDR and PRP: a comparison of methods for high-order genotype-phenotype associations. Hum Hered 58: 82-92.
22. Soares ML, Coelho T, Sousa A, Batalov S, Conceicao I, et al. (2005) Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Hum Mol Genet 14: 543-553.
23. Balding DJ, (2006) A tutorial on statistical methods for population association studies. Nat Rev Genet 7: 781-791.
24. Shaheen SO, Sterne JA, Montgomery SM, Azima H, (1999) Birth weight, body mass index and asthma in young adults. Thorax 54: 396-402.
25. Hancox RJ, Milne BJ, Poulton R, Taylor DR, Greene JM, et al. (2005) Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med 171: 440-445.
26. von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST, (2001) Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax 56: 835-838.
27. Husemoen LL, Glumer C, Lau C, Pisinger C, Morch LS, et al. (2008) Association of obesity and insulin resistance with asthma and aeroallergen sensitization. Allergy 63: 575-582.
28. Heijink IH, Vellenga E, Borger P, Postma DS, de Monchy JG, et al. (2002) Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and-independent mechanisms in freshly isolated human T cells. Immunology 107: 316-324.
29. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, et al. (2006) A common genetic variant is associated with adult and childhood obesity. Science 312: 279-283.
30. Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, et al. (2005) Schoenheimer effect explained-feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115: 2489-2498.
31. Weiss ST, (2005) Obesity: insight into the origins of asthma. Nat Immunol 6: 537-539.
32. Komakula S, Khatri S, Mermis J, Savill S, Haque S, et al. (2007) Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res 8: 32.
33. Keaney JF, Larson MG, Vasan RS, Wilson PW, Lipinska I, et al. (2003) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol 23: 434-439.
34. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761.
35. Fryer AA, Hume R, Strange RC, (1986) The development of glutathione S-transferase and glutathione peroxidase activities in human lung. Biochim Biophys Acta 883: 448-453.
36. Sutherland TJ, Cowan JO, Young S, Goulding A, Grant AM, et al. (2008) The association between obesity and asthma: interactions between systemic and airway inflammation. Am J Respir Crit Care Med 178: 469-475.
37. Sutherland ER, (2008) Obesity and asthma. Immunol Allergy Clin North Am 28: 589-602, ix.
38. Sin DD, Sutherland ER, (2008) Obesity and the lung: 4. Obesity and asthma. Thorax 63: 1018-1023.
39. Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, et al. (1998) Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 19: 119-120.
40. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA, (1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 337: 1720-1725.
41. Kabesch M, Schedel M, Carr D, Woitsch B, Fritzsch C, et al. (2006) IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol 117: 269-274.
42. White SR, Martin LD, Stern R, Laxman B, Marroquin BA, (2010) Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 299: L681-693.
43. Borish LC, Nelson HS, Lanz MJ, Claussen L, Whitmore JB, et al. (1999) Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am J Respir Crit Care Med 160: 1816-1823.
44. Sandford AJ, Chagani T, Zhu S, Weir TD, Bai TR, et al. (2000) Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity. J Allergy Clin Immunol 106: 135-140.
45. Chan IH, Leung TF, Tang NL, Li CY, Sung YM, et al. (2006) Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children. J Allergy Clin Immunol 117: 127-133.
46. Simoni M, Lombardi E, Berti G, Rusconi F, La Grutta S, et al. (2005) Mould/dampness exposure at home is associated with respiratory disorders in Italian children and adolescents: the SIDRIA-2 Study. Occup Environ Med 62: 616-622.
47. Jaakkola JJ, Hwang BF, Jaakkola N, (2005) Home dampness and molds, parental atopy, and asthma in childhood: a six-year population-based cohort study. Environ Health Perspect 113: 357-361.
48. Hagmolen of Ten Have W, van den Berg NJ, van der Palen J, van Aalderen WM, Bindels PJ, (2007) Residential exposure to mould and dampness is associated with adverse respiratory health. Clin Exp Allergy 37: 1827-1832.
49. Lawson JA, Rennie DC, Senthilselvan A, Cockcroft DW, McDuffie HH, (2005) Regional variations in risk factors for asthma in school children. Can Respir J 12: 321-326.
50. Tsai CH, Tung KY, Chen CH, Lee YL, (2011) Tumour necrosis factor G-308A polymorphism modifies the effect of home dampness on childhood asthma. Occup Environ Med.
51. Motsinger AA, Ritchie MD, (2006) The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction. Genet Epidemiol 30: 546-555.
52. Tsai CH, Huang JH, Hwang BF, Lee YL, (2010) Household environmental tobacco smoke and risks of asthma, wheeze and bronchitic symptoms among children in Taiwan. Respir Res 11: 11.
53. Hwang BF, Lee YL, (2010) Air pollution and prevalence of bronchitic symptoms among children in Taiwan. Chest 138: 956-964.
54. Tung KY, Tsai CH, Lee YL, (2010) Microsomal Epoxide Hydroxylase Genotypes/Diplotypes, Traffic Air Pollution and Childhood Asthma. Chest.
55. Islam T, Gauderman WJ, Berhane K, McConnell R, Avol E, et al. (2007) Relationship between air pollution, lung function and asthma in adolescents. Thorax 62: 957-963.
56. Wang WH, Hwang BF, Chen JM, Wu YF, Lee YL, (in Press) Pulmonary Function, Traffic-related Air Pollution and Incident Bronchitis among Children. (Submitted).
57. Hahn LW, Ritchie MD, Moore JH, (2003) Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 19: 376-382.
58. Ritchie MD, Hahn LW, Moore JH, (2003) Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 24: 150-157.
59. Greene CS, Himmelstein DS, Nelson HH, Kelsey KT, Williams SM, et al. (2010) Enabling personal genomics with an explicit test of epistasis. Pac Symp Biocomput pp. 327-336.
60. Moore JH, (2010) Detecting, characterizing, and interpreting nonlinear gene-gene interactions using multifactor dimensionality reduction. Adv Genet 72: 101-116.