Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular/connective tissue changes in scarring trachoma

Infection and Immunity

Volumn 80, Issue 1, 2012, Pages 121-130

  Hu, Victor H ^a,b   Weiss, Helen A ^a   Ramadhani, Athumani M ^c   Tolbert, Sonda B ^c   Massae, Patrick ^b   Mabey, David C W ^a   Holland, Martin J ^a   Bailey, Robin L ^a   Burton, Matthew J ^a,b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b Kilimanjaro Centre for Community Ophthalmology   (Tanzania)

^c KILIMANJARO CHRISTIAN MEDICAL CENTRE   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID A1; BACTERIAL DNA; DEFENSIN BETA4A; GELATINASE B; INTERLEUKIN 1BETA; MACROPHAGE ELASTASE; MATRILYSIN; PSORIASIN; RANTES; SECRETED PROTEIN ACIDIC CYSTEIN RICH LIKE 1; STROMELYSIN 2; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; SCLEROPROTEIN;

ARTICLE; BACTERIAL INFECTION; BACTERIUM CULTURE; BACTERIUM DETECTION; CASE CONTROL STUDY; CELLS; CHLAMYDIA TRACHOMATIS; CLINICAL EXAMINATION; CONFOCAL MICROSCOPY; CONNECTIVE TISSUE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; IN VIVO STUDY; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MICROBIOLOGICAL EXAMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRACHOMA; TRACHOMATOUS SCARRING; ADULT; FEMALE; GENE EXPRESSION PROFILING; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; SCAR;

ADULT; CASE-CONTROL STUDIES; CHLAMYDIA TRACHOMATIS; CICATRIX; CONNECTIVE TISSUE; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNITY, INNATE; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; TRACHOMA;

EID: 84857084980     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05965-11     Document Type: Article

References (61)

1. Abrahams C, Ballard RC, Sutter EE. 1979. The pathology of trachoma in a black South African population: light microscopical, histochemical, and electron microscopical findings. S. Afr. Med. J. 55:1115-1118.
2. Abtin A, et al. 2008. Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli. FASEB J. 22:2168 -2176.
3. Abu el-Asrar AM, et al. 1998. Immunopathogenesis of conjunctival scarring in trachoma. Eye 12(Pt 3a):453- 460.
4. al-Rajhi AA, Hidayat A, Nasr A, al-Faran M. 1993. The histopathology and the mechanism of entropion in patients with trachoma. Ophthalmology 100:1293-1296.
5. Bailey RL, Holland MJ, Whittle HC, Mabey DC. 1995. Subjects recovering from human ocular chlamydial infection have enhanced lymphoproliferative responses to chlamydial antigens compared with those of persistently diseased controls. Infect. Immun. 63:389 -392.
6. Bobo L, et al. 1996. Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma. Infect. Immun. 64:3273-3279.
7. Brunham RC, Rey-Ladino J. 2005. Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat. Rev. Immunol. 5:149 -161.
8. Burton MJ, et al. 2007. Bacterial infection and trachoma in the Gambia: a case control study. Invest. Ophthalmol. Vis. Sci. 48:4440-4444.
9. Burton MJ, Bailey RL, Jeffries D, Mabey DC, Holland MJ. 2004. Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic. Infect. Immun. 72:7352-7356.
10. Burton MJ, et al. 2010. Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgery. Invest. Ophthalmol. Vis. Sci. 51:3583-3590.
11. Burton MJ, et al. 2006. The long-term natural history of trachomatous trichiasis in the Gambia. Invest. Ophthalmol. Vis. Sci. 47:847- 852.
12. Burton MJ, et al. 2003. Which members of a community need antibiotics to control trachoma? Conjunctival Chlamydia trachomatis infection load in Gambian villages. Invest. Ophthalmol. Vis. Sci. 44:4215- 4222.
13. Burton MJ, et al. 2005. A randomised controlled trial of azithromycin following surgery for trachomatous trichiasis in the Gambia. Br. J. Ophthalmol. 89:1282-1288.
14. Burton MJ, et al. 2011. Conjunctival transcriptome in scarring trachoma. Infect. Immun. 79:499 -511.
15. Conway DJ, et al. 1997. Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid. Infect. Immun. 65:1003-1006.
16. Darville T, Hiltke TJ. 2010. Pathogenesis of genital tract disease due to Chlamydia trachomatis. J. Infect. Dis. 201(Suppl 2):S114 -S125.
17. Dawson CR, Jones BR, Tarizzo ML. 1981. Guide to trachoma control. World Health Organization, Geneva, Switzerland.
18. Dawson CR, Daghfous MRR, Juster R, Schachter J. 1990. What clinical signs are critical in evaluating the impact of intervention in trachoma?, p. 271-275. In Chlamydia infections. Proc. 7th Int. Symp. Human Chlamydial Infect. Cambridge University Press, London, England.
19. Eckhardt ER, et al. Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and proinflammatory responses in mouse experimental colitis. BMC Gastroenterol. 10:133.
20. El-Asrar AM, et al. 2000. Expression of gelatinase B in trachomatous conjunctivitis. Br. J. Ophthalmol. 84:85-91.
21. Faal N, et al. 2006. Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection? PLoS Med. 3:e266.
22. Faal N, et al. 2005. Temporal cytokine gene expression patterns in subjects with trachoma identify distinct conjunctival responses associated with infection. Clin. Exp. Immunol. 142:347-353.
23. Garreis F, et al. 2011. Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus. Invest. Ophthalmol. Vis. Sci. 52:4914-4922.
24. Glaser R, et al. 2005. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat. Immunol. 6:57- 64.
25. Guzey M, et al. 2000. A survey of trachoma: the histopathology and the mechanism of progressive cicatrization of eyelid tissues. Ophthalmologica 214:277-284.
26. Hazlett L, Wu, M. 2011. Defensins in innate immunity. Cell Tissue Res. 343:175-188.
27. Holland MJ, et al. 1996. T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring. Clin. Exp. Immunol. 105:429-435.
28. Holland MJ, Bailey RL, Hayes LJ, Whittle HC, Mabey DC. 1993. Conjunctival scarring in trachoma is associated with depressed cellmediated immune responses to chlamydial antigens. J. Infect. Dis. 168:1528-1531.
29. Holland MJ, et al. 2010. Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis. Invest. Ophthalmol. Vis. Sci. 51:3893-3902.
30. Hu VH, et al. 2011. Bacterial infection in scarring trachoma. Invest. Ophthalmol. Vis. Sci. 52:2181-2186.
31. Hu VH, et al. 2011. In vivo confocal microscopy of trachoma in relation to normal tarsal conjunctiva. Ophthalmology 118:747-754.
32. Hu VH, et al. 2011. In vivo confocal microscopy in scarring trachoma. Ophthalmology 118:2138 -2146.
33. Jeyaseelan S, et al. 2005. Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium. Am. J. Respir. Cell Mol. Biol. 32:531-539.
34. Jinquan T, et al. 1996. Psoriasin: a novel chemotactic protein. J. Invest. Dermatol. 107:5-10.
35. Kang MH, Oh DJ, Rhee DJ. 2011. Effect of hevin deletion in mice and characterization in trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 52:2187-2193.
36. Lee KC, Eckert RL. 2007. S100A7 (psoriasin): mechanism of antibacterial action in wounds. J. Invest. Dermatol. 127:945-957.
37. -ΔΔCT method. Methods 25:402-408.
38. Madsen P, et al. 1991. Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. J. Invest. Dermatol. 97:701-712.
39. Malle E, Sodin-Semrl S, Kovacevic A. 2009. Serum amyloid A: an acutephase protein involved in tumour pathogenesis. Cell. Mol. Life Sci. 66:9-26.
40. Mariotti SP, Pascolini D, Rose-Nussbaumer J. 2009. Trachoma: global magnitude of a preventable cause of blindness. Br. J. Ophthalmol. 93:563-568.
41. McDermott AM. 2009. The role of antimicrobial peptides at the ocular surface. Ophthalmic Res. 41:60 -75.
42. Mozzato-Chamay N, et al. 2000. Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis-endemic population. J. Infect. Dis. 182:1545-1548.
43. Munoz B, et al. 1999. Incidence of trichiasis in a cohort of women with or without scarring. Int. J. Epidemiol. 28:1167-1171.
44. Natividad A, et al. 2006. A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection. BMC Med. Genet. 7:40.
45. Reference deleted.
46. Natividad A, et al. 2010. Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection. Infect. Immun. 78:4895- 4911.
47. Natividad A, et al. 2007. Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians. Genes Immun. 8:288 -295.
48. Natividad A, et al. 2008. Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cisregulation. Hum. Mol. Genet. 17:323-329.
49. Natividad A, et al. 2005. Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci. Genes Immun. 6:332-340.
50. Parks WC, Wilson CL, Lopez-Boado YS. 2004. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat. Rev. Immunol. 4:617- 629.
51. Reacher MH, Pe'er J, Rapoza PA, Whittum-Hudson JA, Taylor HR. 1991. T cells and trachoma: their role in cicatricial disease. Ophthalmology 98:334 -341.
52. Resnikoff S, et al. 2004. Global data on visual impairment in the year 2002. Bull. World Health Organ. 82:844-851.
53. Stephens RS. 2003. The cellular paradigm of chlamydial pathogenesis. Trends Microbiol. 11:44 -51.
54. Sullivan MM, et al. 2006. Matricellular hevin regulates decorin production and collagen assembly. J. Biol. Chem. 281:27621-27632.
55. West SK, Munoz B, Mkocha H, Hsieh YH, Lynch MC. 2001. Progression of active trachoma to scarring in a cohort of Tanzanian children. Ophthalmic Epidemiol. 8:137-144.
56. Wiesner J, Vilcinskas A. 2010. Antimicrobial peptides: the ancient arm of the human immune system. Virulence 1:440-464.
57. Wolle MA, Munoz BE, Mkocha H, West SK. 2009. Constant ocular infection with Chlamydia trachomatis predicts risk of scarring in children in Tanzania. Ophthalmology 116:243-247.
58. Wynn TA. 2008. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214:199 -210.
59. Wynn TA. 2004. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Immunol. 4:583-594.
60. Wynn TA. 2003. IL-13 effector functions. Annu. Rev. Immunol. 21:425-456.
61. Zheng Y, et al. 2008. Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology 124:357-367.