Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic

Infection and Immunity

Volumn 72, Issue 12, 2004, Pages 7352-7356

  Burton, Matthew J ^a,b   Bailey, Robin L ^a,b   Jeffries, David ^b   Mabey, David C W ^a   Holland, Martin J ^a,b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GELATINASE B; GENE PRODUCT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; BLINDNESS; CHILD; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONJUNCTIVITIS; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENDEMIC DISEASE; FEMALE; FIBROGENESIS; GAMBIA; GENE EXPRESSION REGULATION; HUMAN; IMMUNOPATHOLOGY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR FORMATION; T LYMPHOCYTE ACTIVATION; TRACHOMA;

CHILD; COLLAGEN TYPE I; CONJUNCTIVA; CYTOKINES; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 9; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; TRACHOMA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2;

EID: 9244263031     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.12.7352-7356.2004     Document Type: Article

References (47)

1. Abu el-Asrar, A. M., K. Geboes, S. A. Al Kharashi, A. A. Al Mosallam, K. F. Tabbara, A. A. al Rajhi, and L. Missotten. 1998. An immunohistochemical study of collagens in trachoma and vernal keratoconjunctivitis. Eye 12:1001-1006.
2. Abu el-Asrar, A. M., K. Geboes, S. A. Al Kharashi, K. F. Tabbara, and L. Missotten. 1998. Collagen content and types in trachomatous conjunctivitis. Eye 12:735-739.
3. Abu el-Asrar, A. M., K. Geboes, K. F. Tabbara, S. A. Al Kharashi, L. Missotten, and V. Desmet. 1998. Immunopathogenesis of conjunctival scarring in trachoma. Eye 12:453-460.
4. al Rajhi, A. A., A. Hidayat, A. Nasr, and M. al Faran. 1993. The histopathology and the mechanism of entropion in patients with trachoma. Ophthalmology 100:1293-1296.
5. Annes, J. P., J. S. Munger, and D. B. Rifkin. 2003. Making sense of latent TGFbeta activation. J. Cell Sci. 116:217-224.
6. Ault, K. A., K. A. Kelly, P. K. Ruther, A. A. Izzo, L. S. Izzo, I. M. Sigar, and K. H. Ramsey. 2002. Chlamydia trachomatis enhances the expression of matrix metalloproteinases in an in vitro model of the human fallopian tube infection. Am. J. Obstet. Gynecol. 187:1377-1383.
7. Blobe, G. C., W. P. Schiemann, and H. F. Lodish. 2000. Role of transforming growth factor beta in human disease. N. Engl. J. Med. 342:1350-1358.
8. Bobo, L., N. Novak, H. Mkocha, S. Vitale, S. West, and T. C. Quinn. 1996. Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma. Infect. Immun. 64:3273-3279.
9. Cassatella, M. A., L. Meda, S. Gasperini, A. D'Andrea, X. Ma, and G. Trinchieri. 1995. Interleukin-12 production by human polymorphonuclear leukocytes. Eur. J. Immunol. 25:1-5.
10. Conway, D. J., M. J. Holland, R. L. Bailey, A. E. Campbell, O. S. M. Mahdi, R. Jennings, E. Mbena, and D. C. W. Mabey. 1997. Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-α) gene promoter and with elevated TNF-α levels in tear fluid. Infect. Immun. 65:1003-1006.
11. Cordeiro, M. F., M. B. Reichel, J. A. Gay, F. D'Esposita, R. A. Alexander, and P. T. Khaw. 1999. Transforming growth factor-beta1, -beta2, and -beta3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring. Investig. Ophthalmol. Vis. Sci. 40:1975-1982.
12. Cotter, T. W., K. H. Ramsey, G. S. Miranpuri, C. E. Poulsen, and G. I. Byrne. 1997. Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect. Immun. 65:2145-2152.
13. Dawson, C. R., B. R. Jones, and M. L. Tarizzo. 1981. Guide to trachoma control. World Health Organization, Geneva, Switzerland.
14. Dawson, C. R., R. Marx, T. Daghfous, R. Juster, and J. Schachter. 1990. What clinical signs are critical in evaluating the intervention in trachoma?, p. 271-278. In W. R. Bowie (ed.), Chlamydial infections. Cambridge University Press, Cambridge, United Kingdom.
15. El Asrar, A. M., K. Geboes, S. A. Al Kharashi, A. A. Al Mosallam, L. Missotten, L. Paemen, and G. Opdenakker. 2000. Expression of gelatinase B in trachomatous conjunctivitis. Br. J. Ophthalmol. 84:85-91.
16. Holland, M. J., R. L. Bailey, D. J. Conway, F. Culley, G. Miranpuri, G. I. Byrne, H. C. Whittle, and D. C. Mabey. 1996. T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring. Clin. Exp. Immunol. 105:429-435.
17. Holland, M. J., R. L. Bailey, L. J. Hayes, H. C. Whittle, and D. C. Mabey. 1993. Conjunctival scarring in trachoma is associated with depressed cell-mediated immune responses to chlamydial antigens. J. Infect. Dis. 168:1528-1531.
18. Holland, M. J., D. J. Conway, T. J. Blanchard, O. M. Mahdi, R. L. Bailey, H. C. Whittle, and D. C. Mabey. 1997. Synthetic peptides based on Chlamydia trachomatis antigens identify cytotoxic T lymphocyte responses in subjects from a trachoma-endemic population. Clin. Exp. Immunol. 107:44-49.
19. Ito, J. I., and J. M. Lyons. 1999. Role of gamma interferon in controlling murine chlamydial genital tract infection. Infect. Immun. 67:5518-5521.
20. Kolb, M., P. J. Margetts, D. C. Anthony, F. Pitossi, and J. Gauldie. 2001. Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J. Clin. Investig. 107:1529-1536.
21. Mabey, D. C., R. L. Bailey, and Y. J. Hutin. 1992. The epidemiology and pathogenesis of trachoma. Rev. Med. Microbiol. 3:112-119.
22. Mathews, S. A., K. M. Volp, and P. Timms. 1999. Development of a quantitative gene expression assay for Chlamydia trachomatis identified temporal expression of sigma factors. FEBS Lett. 458:354-358.
23. Meller, D., D. Q. Li, and S. C. Tseng. 2000. Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1beta and tumor necrosis factor-alpha. Investig. Ophthalmol. Vis. Sci. 41:2922-2929.
24. Morrison, S. G., and R. P. Morrison. 2000. In situ analysis of the evolution of the primary immune response in murine Chlamydia trachomatis genital tract infection. Infect. Immun. 68:2870-2879.
25. + T cells. Infect. Immun. 68:6979-6987.
26. Mozzato-Chamay, N., O. S. Mahdi, O. Jallow, D. C. Mabey, R. L. Bailey, and D. J. Conway. 2000. Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis-endemic population. J. Infect. Dis. 182:1545-1548.
27. Opal, S. M., and V. A. DePalo. 2000. Anti-inflammatory cytokines. Chest 117:1162-1172.
28. Pasquale, L. R., M. E. Dorman-Pease, G. A. Lutty, H. A. Quigley, and H. D. Jampel. 1993. Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye. Investig. Ophthalmol. Vis. Sci. 34:23-30.
29. Perry, L. L., K. Feilzer, and H. D. Caldwell. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. J. Immunol. 158:3344-3352.
30. Perry, L. L., K. Feilzer, S. Hughes, and H. D. Caldwell. 1999. Clearance of Chlamydia trachomatis from the murine genital mucosa does not require perforin-mediated cytolysis or Fas-mediated apoptosis. Infect. Immun. 67:1379-1385.
31. Ramsey, K. H., I. M. Sigar, L. S. Izzo, K. Cohoon, N. Shaba, and A. A. Izzo. 2002. Expression of matrix metalloproteases subsequent to Chlamydia trachomatis (mouse pneumonitis agent) genital tract infection in susceptible and resistant strains of female mice, p. 249-252. In J. S. Schachter (ed.), Chlamydial infections. Proceedings of the Tenth International Symposium on Human Chlamydial Infections. International Chlamydia Symposium, San Francisco, Calif.
32. Rank, R. G., K. H. Ramsey, E. A. Pack, and D. M. Williams. 1992. Effect of gamma interferon on resolution of murine chlamydial genital infection. Infect. Immun. 60:4427-4429.
33. Rodel, J., E. Straube, W. Lungershausen, M. Hartmann, and A. Groh. 1998. Secretion of cytokines by human synoviocytes during in vitro infection with Chlamydia trachomatis. J. Rheumatol. 25:2161-2168.
34. Rottenberg, M. E., A. Gigliotti-Rothfuchs, and H. Wigzell. 2002. The role of IFN-gamma in the outcome of chlamydial infection. Curr. Opin. Immunol. 14:444-451.
35. Sakaguchi, S. 2003. Regulatory T cells: mediating compromises between host and parasite. Nat. Immunol. 4:10-11.
36. Saren, P., H. G. Welgus, and P. T. Kovanen. 1996. TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J. Immunol. 157:4159-4165.
37. Schonbeck, U., F. Mach, and P. Libby. 1998. Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. J. Immunol. 161:3340-3346.
38. Siwik, D. A., D. L. Chang, and W. S. Colucci. 2000. Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circ. Res. 86:1259-1265.
39. Thylefors, B., A. D. Negrel, R. Pararajasegaram, and K. Y. Dadzie. 1995. Global data on blindness. Bull. W. H. O. 73:115-121.
40. West, S. K., B. Munoz, H. Mkocha, Y. H. Hsieh, and M. C. Lynch. 2001. Progression of active trachoma to scarring in a cohort of Tanzanian children. Ophthalmic Epidemiol. 8:137-144.
41. Wick, W., M. Platten, and M. Weller. 2001. Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. J. Neurooncol. 53:177-185.
42. Williams, D. M., B. G. Grubbs, E. Pack, K. Kelly, and R. G. Rank. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect. Immun. 65:2876-2882.
43. Williams, D. M., B. G. Grubbs, S. Park-Snyder, R. G. Rank, and L. F. Bonewald. 1996. Activation of latent transforming growth factor beta during Chlamydia trachomatis-induced murine pneumonia. Res. Microbiol. 147:251-262.
44. Wong, T. T., A. L. Mead, and P. T. Khaw. 2003. Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery. Investig. Ophthalmol. Vis. Sci. 44:1097-1103.
45. Wong, T. T., C. Sethi, J. T. Daniels, G. A. Limb, G. Murphy, and P. T. Khaw. 2002. Matrix metalloproteinases in disease and repair processes in the anterior segment. Surv. Ophthalmol. 47:239-256.
46. Xue, M. L., D. Wakefield, M. D. Willcox, A. R. Lloyd, N. Di Girolamo, N. Cole, and A. Thakur. 2003. Regulation of MMPs and TIMPs by IL-1beta during corneal ulceration and infection. Investig. Ophthalmol. Vis. Sci. 44:2020-2025.
47. Yang, X., J. Gartner, L. Zhu, S. Wang, and R. C. Brunham. 1999. IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection. J. Immunol. 162:1010-1017.