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Volumn 8, Issue , 2012, Pages 7-14

Clinical utility of adjunctive retigabine in partial onset seizures in adults

Author keywords

Antiepileptic drugs; Epilepsy; Seizure control

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; BENZODIAZEPINE RECEPTOR; CARBAMAZEPINE; COCAINE; DIAZEPAM; FELBAMATE; LAMOTRIGINE; METHYLPHENIDATE; PHENCYCLIDINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ5; POTASSIUM CHANNEL KV7.2; POTASSIUM CHANNEL KV7.3; RETIGABINE; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84857081441     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S22605     Document Type: Article
Times cited : (4)

References (79)
  • 1
    • 0035009415 scopus 로고    scopus 로고
    • The new generation of GABA enhancers. Potential in the treatment of epilepsy
    • Czuczwar SJ, Patsalos PN. The new generation of GABA enhancers. Potential in the treatment of epilepsy. CNS Drugs. 2001;15(5):339-350.
    • (2001) CNS Drugs , vol.15 , Issue.5 , pp. 339-350
    • Czuczwar, S.J.1    Patsalos, P.N.2
  • 4
    • 43249100266 scopus 로고    scopus 로고
    • Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus
    • Lee CY, Fu WM, Chen CC, Su MJ, Liou HH. Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus. Epilepsia. 2008;49(5):888-897.
    • (2008) Epilepsia , vol.49 , Issue.5 , pp. 888-897
    • Lee, C.Y.1    Fu, W.M.2    Chen, C.C.3    Su, M.J.4    Liou, H.H.5
  • 5
    • 0033957224 scopus 로고    scopus 로고
    • Felbamate block of recombinant N-methyl- D-aspartate receptors: Selectivity for the NR2B subunit
    • Harty TP, Rogawski MA. Felbamate block of recombinant N-methyl- D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000;39(1):47-55.
    • (2000) Epilepsy Res , vol.39 , Issue.1 , pp. 47-55
    • Harty, T.P.1    Rogawski, M.A.2
  • 6
    • 33846487961 scopus 로고    scopus 로고
    • Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings
    • Sitges M, Chiu LM, Guarneros A, Nekrassov V. Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings. Neuropharmacology. 2007;52(2):598-605.
    • (2007) Neuropharmacology , vol.52 , Issue.2 , pp. 598-605
    • Sitges, M.1    Chiu, L.M.2    Guarneros, A.3    Nekrassov, V.4
  • 7
    • 35648948354 scopus 로고    scopus 로고
    • Effects of carbamazepine, phenytoin, valproic acid, oxcarbazepine, topiramate and vinpocetine on the presynaptic Ca2+ channel-mediated release of [3H]glutamate: Comparison with the Na+ channel-mediated release
    • Sitges M, Guarneros A, Nekrassov V. Effects of carbamazepine, phenytoin, valproic acid, oxcarbazepine, topiramate and vinpocetine on the presynaptic Ca2+ channel-mediated release of [3H]glutamate: comparison with the Na+ channel-mediated release. Neuropharmacology. 2007;53(7):854-862.
    • (2007) Neuropharmacology , vol.53 , Issue.7 , pp. 854-862
    • Sitges, M.1    Guarneros, A.2    Nekrassov, V.3
  • 8
    • 36248939227 scopus 로고    scopus 로고
    • Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex
    • Yang J, Wetterstrand C, Jones RS. Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex. Epilepsy Res. 2007;77(2-3):157-164.
    • (2007) Epilepsy Res , vol.77 , Issue.2-3 , pp. 157-164
    • Yang, J.1    Wetterstrand, C.2    Jones, R.S.3
  • 9
    • 85047690079 scopus 로고    scopus 로고
    • An introduction to antiepileptic drugs
    • Perucca E. An introduction to antiepileptic drugs. Epilepsia. 2005; 46(Suppl 4):31-37.
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. 4 , pp. 31-37
    • Perucca, E.1
  • 10
    • 16444378179 scopus 로고    scopus 로고
    • Diagnosis and treatment of mood disorders in persons with epilepsy
    • Gilliam FG. Diagnosis and treatment of mood disorders in persons with epilepsy. Curr Opin Neurol. 2005;18(2):129-133.
    • (2005) Curr Opin Neurol , vol.18 , Issue.2 , pp. 129-133
    • Gilliam, F.G.1
  • 11
    • 40849123949 scopus 로고    scopus 로고
    • The global burden and stigma of epilepsy
    • de Boer HM, Mula M, Sander JW. The global burden and stigma of epilepsy. Epilepsy Behav. 2008;12(4):540-546.
    • (2008) Epilepsy Behav , vol.12 , Issue.4 , pp. 540-546
    • de Boer, H.M.1    Mula, M.2    Sander, J.W.3
  • 13
    • 67650215631 scopus 로고    scopus 로고
    • Third-generation antiepileptic drugs: Mechanisms of action, pharmacokinetics and interactions
    • Luszczki JJ. Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep. 2009;61(2): 197-216.
    • (2009) Pharmacol Rep , vol.61 , Issue.2 , pp. 197-216
    • Luszczki, J.J.1
  • 14
    • 0032906655 scopus 로고    scopus 로고
    • Retigabine N-glucoronidation and its potential role in enterohepatic circulation
    • Hiller A, Nguyen N, Strassburg CP, et al. Retigabine N-glucoronidation and its potential role in enterohepatic circulation. Drug Metab Disp. 1999;27(5):605-612.
    • (1999) Drug Metab Disp , vol.27 , Issue.5 , pp. 605-612
    • Hiller, A.1    Nguyen, N.2    Strassburg, C.P.3
  • 15
    • 0037261396 scopus 로고    scopus 로고
    • Effects of age and sex on the disposition of retigabine
    • Hermann R, Ferron GM, Erb K, et al. Effects of age and sex on the disposition of retigabine. Clin Pharmacol Ther. 2003:73(1):61-70.
    • (2003) Clin Pharmacol Ther , vol.73 , Issue.1 , pp. 61-70
    • Hermann, R.1    Ferron, G.M.2    Erb, K.3
  • 16
    • 0034533728 scopus 로고    scopus 로고
    • Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels
    • Rundfeldt C, Netzer R. Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung. 2000;50(12):1063-1070.
    • (2000) Arzneimittelforschung , vol.50 , Issue.12 , pp. 1063-1070
    • Rundfeldt, C.1    Netzer, R.2
  • 17
    • 0037454126 scopus 로고    scopus 로고
    • Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex
    • Van Rijn CM, Willems-van Bree E. Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex. Eur J Pharmacol. 2003;464(2-3):95-100.
    • (2003) Eur J Pharmacol , vol.464 , Issue.2-3 , pp. 95-100
    • van Rijn, C.M.1    Willems-Van Bree, E.2
  • 18
    • 0028806375 scopus 로고
    • The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro
    • Kapetanovic IM, Yonekawa WD, Kupferberg HJ. The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro. Epilepsy Res. 1995;22(3):167-173.
    • (1995) Epilepsy Res , vol.22 , Issue.3 , pp. 167-173
    • Kapetanovic, I.M.1    Yonekawa, W.D.2    Kupferberg, H.J.3
  • 19
    • 68749110672 scopus 로고    scopus 로고
    • Neural KCNQ (Kv7) channel
    • Brown DA, Passmore GM. Neural KCNQ (Kv7) channels. Br J Pharmacol. 2009;156(8):1185-1195.
    • (2009) Br J Pharmaco , vol.156 , Issue.8 , pp. 1119-1185
    • Brown, D.A.1
  • 20
    • 0030668611 scopus 로고    scopus 로고
    • The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells
    • Rundfeldt C. The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells. Eur J Pharmacol. 1997; 336(2-3):243-249.
    • (1997) Eur J Pharmacol , vol.336 , Issue.2-3 , pp. 243-249
    • Rundfeldt, C.1
  • 21
    • 0033373222 scopus 로고    scopus 로고
    • Retigabine strongly reduces repetitive firing in rat entorhinal cortex
    • Hetka R, Rundfeldt C, Heinemann U, Schmitz D. Retigabine strongly reduces repetitive firing in rat entorhinal cortex. Eur J Pharmacol. 1999;386(2-3):165-171.
    • (1999) Eur J Pharmacol , vol.386 , Issue.2-3 , pp. 165-171
    • Hetka, R.1    Rundfeldt, C.2    Heinemann, U.3    Schmitz, D.4
  • 22
    • 0033862433 scopus 로고    scopus 로고
    • Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels
    • Wickenden AD, Yu W, Zou A, Jegla T, Wagoner PK. Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol. 2000;58(3):591-600.
    • (2000) Mol Pharmacol , vol.58 , Issue.3 , pp. 591-600
    • Wickenden, A.D.1    Yu, W.2    Zou, A.3    Jegla, T.4    Wagoner, P.K.5
  • 23
    • 0032930073 scopus 로고    scopus 로고
    • Metabolism of retigabine (D-23129), a novel anticonvulsant
    • Hempel R, Schupke H, McNeilly PJ, et al. Metabolism of retigabine (D-23129), a novel anticonvulsant. Drug Metab Dispos. 1999;27(5): 613-622.
    • (1999) Drug Metab Dispos , vol.27 , Issue.5 , pp. 613-622
    • Hempel, R.1    Schupke, H.2    McNeilly, P.J.3
  • 25
    • 0036152375 scopus 로고    scopus 로고
    • Multiple dose, linear, doseproportional pharmacokinetics of retigabine in healthy volunteers
    • Ferron GM, Paul J, Fruncillo R, et al. Multiple dose, linear, doseproportional pharmacokinetics of retigabine in healthy volunteers. J Clin Pharmacol. 2002;42(2):175-182.
    • (2002) J Clin Pharmacol , vol.42 , Issue.2 , pp. 175-182
    • Ferron, G.M.1    Paul, J.2    Fruncillo, R.3
  • 26
    • 0037660846 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects
    • Ferron GM, Patat A, Parks V, Rolan P, Troy SM. Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects. Br J Clin Pharmacol. 2003;56(1):39-45.
    • (2003) Br J Clin Pharmacol , vol.56 , Issue.1 , pp. 39-45
    • Ferron, G.M.1    Patat, A.2    Parks, V.3    Rolan, P.4    Troy, S.M.5
  • 29
    • 58149237124 scopus 로고    scopus 로고
    • Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: An ontogenic study
    • Mazarati A, Wu J, Shin D, Kwon YS, Sankar R. Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study. Epilepsia. 2008;49(10):1777-1786.
    • (2008) Epilepsia , vol.49 , Issue.10 , pp. 1777-1786
    • Mazarati, A.1    Wu, J.2    Shin, D.3    Kwon, Y.S.4    Sankar, R.5
  • 30
    • 77954484144 scopus 로고    scopus 로고
    • Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindling
    • Sankar R, Auvin S, Kwon YS, Pineda E, Shin D, Mazarati A. Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindling. Epilepsia. 2010;51(Suppl 3):39-42.
    • (2010) Epilepsia , vol.51 , Issue.SUPPL. 3 , pp. 39-42
    • Sankar, R.1    Auvin, S.2    Kwon, Y.S.3    Pineda, E.4    Shin, D.5    Mazarati, A.6
  • 31
    • 4544384631 scopus 로고    scopus 로고
    • Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel
    • Otto JF, Yang Y, Frankel WM, Wilcox KS, White HS. Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. Epilepsia. 2004; 45(9):1009-1016.
    • (2004) Epilepsia , vol.45 , Issue.9 , pp. 1009-1016
    • Otto, J.F.1    Yang, Y.2    Frankel, W.M.3    Wilcox, K.S.4    White, H.S.5
  • 32
    • 57849141134 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)
    • Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009;83(1):1-43.
    • (2009) Epilepsy Res , vol.83 , Issue.1 , pp. 1-43
    • Bialer, M.1    Johannessen, S.I.2    Levy, R.H.3    Perucca, E.4    Tomson, T.5    White, H.S.6
  • 33
    • 0035111693 scopus 로고    scopus 로고
    • Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
    • De Sarro G, Di Paola ED, Conte G, Pasculli MP, De Sarro A. Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice. Naunyn-Schmiedeb Arch Pharmacol. 2001;363(3):330-336.
    • (2001) Naunyn-Schmiedeb Arch Pharmacol , vol.363 , Issue.3 , pp. 330-336
    • de Sarro, G.1    di Paola, E.D.2    Conte, G.3    Pasculli, M.P.4    de Sarro, A.5
  • 34
    • 64949142097 scopus 로고    scopus 로고
    • Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine and valproate in the mouse maximal electroshock-induced seizure model
    • Luszczki JJ, Wu JZ, Raszewski G, Czuczwar SJ. Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine and valproate in the mouse maximal electroshock-induced seizure model. Naunyn-Schmiedeb Arch Pharmacol. 2009;379(2):163-179.
    • (2009) Naunyn-Schmiedeb Arch Pharmacol , vol.379 , Issue.2 , pp. 163-179
    • Luszczki, J.J.1    Wu, J.Z.2    Raszewski, G.3    Czuczwar, S.J.4
  • 35
    • 34247252905 scopus 로고    scopus 로고
    • Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures
    • 205 Study Group
    • Porter RJ, Partiot A, Sachdeo R, Nohria V, Alves WM; 205 Study Group. Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures. Neurology. 2007;68(15):1197-1204.
    • (2007) Neurology , vol.68 , Issue.15 , pp. 1197-1204
    • Porter, R.J.1    Partiot, A.2    Sachdeo, R.3    Nohria, V.4    Alves, W.M.5
  • 36
    • 79955592696 scopus 로고    scopus 로고
    • Randomized, doubleblind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy
    • French JA, Abou-Khalil BW, Leroy RF, et al. Randomized, doubleblind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy. Neurology. 2011;76(18):1555-1563.
    • (2011) Neurology , vol.76 , Issue.18 , pp. 1555-1563
    • French, J.A.1    Abou-Khalil, B.W.2    Leroy, R.F.3
  • 37
    • 78649984382 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
    • Brodie MJ, Lerche H, Gil-Nagel A, et al. Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy. Neurology. 2010;75(20):1817-1824.
    • (2010) Neurology , vol.75 , Issue.20 , pp. 1817-1824
    • Brodie, M.J.1    Lerche, H.2    Gil-Nagel, A.3
  • 38
    • 0029969951 scopus 로고    scopus 로고
    • D-23129: A new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures
    • Rostock A, Tober C, Rundfeldt C, et al. (1996) D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy Res. 1996;23(3):211-223.
    • (1996) Epilepsy Res , vol.23 , Issue.3 , pp. 211-223
    • Rostock, A.1    Tober, C.2    Rundfeldt, C.3
  • 40
    • 0037462422 scopus 로고    scopus 로고
    • The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain
    • Blackburn-Munro G, Jensen BS. The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. Eur J Pharmacol. 2003;460(2-3):109-116.
    • (2003) Eur J Pharmacol , vol.460 , Issue.2-3 , pp. 109-116
    • Blackburn-Munro, G.1    Jensen, B.S.2
  • 41
    • 34848923432 scopus 로고    scopus 로고
    • Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety
    • Munro G, Erichsen HK, Mirza NR. Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety. Neuropharmacology. 2007;53(5):609-618.
    • (2007) Neuropharmacology , vol.53 , Issue.5 , pp. 609-618
    • Munro, G.1    Erichsen, H.K.2    Mirza, N.R.3
  • 42
    • 37049038680 scopus 로고    scopus 로고
    • Effect of the new antiepileptic drug retigabine in a rodent model of mania
    • Dencker D, Dias R, Pedersen ML, Husum H. Effect of the new antiepileptic drug retigabine in a rodent model of mania. Epilepsy Behav. 2008;12(1):49-53.
    • (2008) Epilepsy Behav , vol.12 , Issue.1 , pp. 49-53
    • Dencker, D.1    Dias, R.2    Pedersen, M.L.3    Husum, H.4
  • 43
    • 34547841517 scopus 로고    scopus 로고
    • The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine
    • Hansen HH, Andreasen JT, Weikop P, Mirza N, Scheel-Krüger J, Mikkelsen JD. The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine. Eur J Pharmacol. 2007;570(1-3):77-88.
    • (2007) Eur J Pharmacol , vol.570 , Issue.1-3 , pp. 77-88
    • Hansen, H.H.1    Andreasen, J.T.2    Weikop, P.3    Mirza, N.4    Scheel-Krüger, J.5    Mikkelsen, J.D.6
  • 44
    • 23044477292 scopus 로고    scopus 로고
    • Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels
    • Korsgaard MP, Hartz BP, Brown WD, Ahring PK, Strobaek D, Mirza NR. Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J Pharmacol Exp Ther. 2005; 314(1):282-292.
    • (2005) J Pharmacol Exp Ther , vol.314 , Issue.1 , pp. 282-292
    • Korsgaard, M.P.1    Hartz, B.P.2    Brown, W.D.3    Ahring, P.K.4    Strobaek, D.5    Mirza, N.R.6
  • 45
    • 33750999596 scopus 로고    scopus 로고
    • Antidystonic effects of Kv7 (KCNQ) channel openers in the dt sz mutant, an animal model of primary paroxysmal dystonia
    • Richter A, Sander SE, Rundfeldt C. Antidystonic effects of Kv7 (KCNQ) channel openers in the dt sz mutant, an animal model of primary paroxysmal dystonia. Br J Pharmacol. 2006;149(6):747-753.
    • (2006) Br J Pharmacol , vol.149 , Issue.6 , pp. 747-753
    • Richter, A.1    Sander, S.E.2    Rundfeldt, C.3
  • 46
    • 21344462822 scopus 로고    scopus 로고
    • A potassium channel, the M-channel, as a therapeutic target
    • Surti TS, Jan LY. A potassium channel, the M-channel, as a therapeutic target. Curr Opin Investig Drugs. 2005;6(7):704-711.
    • (2005) Curr Opin Investig Drugs , vol.6 , Issue.7 , pp. 704-711
    • Surti, T.S.1    Jan, L.Y.2
  • 47
    • 52049097593 scopus 로고    scopus 로고
    • The mechanisms of neurodegenerative processes and current pharmacotherapy of Alzheimer's disease
    • Gongadze N, Antelawa N, Kezeli T, Okudjava M, Pachkoria K. The mechanisms of neurodegenerative processes and current pharmacotherapy of Alzheimer's disease. Georgian Med News. 2008;155:44-48.
    • (2008) Georgian Med News , vol.155 , pp. 44-48
    • Gongadze, N.1    Antelawa, N.2    Kezeli, T.3    Okudjava, M.4    Pachkoria, K.5
  • 49
    • 0036747357 scopus 로고    scopus 로고
    • Seizure freedom with more than one antiepileptic drug
    • Stephen LJ, Brodie MJ. Seizure freedom with more than one antiepileptic drug. Seizure. 2002;11(6):349-351.
    • (2002) Seizure , vol.11 , Issue.6 , pp. 349-351
    • Stephen, L.J.1    Brodie, M.J.2
  • 50
    • 0036333854 scopus 로고    scopus 로고
    • Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat
    • Ebert U, Brandt C, Löscher W. Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat. Epilepsia. 2002;43(Suppl 5):86-95.
    • (2002) Epilepsia , vol.43 , Issue.SUPPL. 5 , pp. 86-95
    • Ebert, U.1    Brandt, C.2    Löscher, W.3
  • 51
    • 33745965631 scopus 로고    scopus 로고
    • Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures
    • Boscia F, Annunziato L, Tagliatella M. Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures. Neuropharmacology. 2006;51(2):283-294.
    • (2006) Neuropharmacology , vol.51 , Issue.2 , pp. 283-294
    • Boscia, F.1    Annunziato, L.2    Tagliatella, M.3
  • 52
    • 77956260084 scopus 로고    scopus 로고
    • Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions
    • Gao Z, Zhang T, Wu M, et al. Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. J Biol Chem. 2010;285(36):28322-28332.
    • (2010) J Biol Chem , vol.285 , Issue.36 , pp. 28322-28332
    • Gao, Z.1    Zhang, T.2    Wu, M.3
  • 54
    • 33745604940 scopus 로고    scopus 로고
    • Retigabine in partial seizures
    • Plosker GL, Scott LJ. Retigabine in partial seizures. CNS Drugs. 2006;20(7):601-608.
    • (2006) CNS Drugs , vol.20 , Issue.7 , pp. 601-608
    • Plosker, G.L.1    Scott, L.J.2
  • 57
    • 79955805815 scopus 로고    scopus 로고
    • Ezogabine: A novel antiepileptic as adjunctive therapy for partial onset seizures
    • Owen RT. Ezogabine: a novel antiepileptic as adjunctive therapy for partial onset seizures. Drugs Today. 2010;46(11):815-822.
    • (2010) Drugs Today , vol.46 , Issue.11 , pp. 815-822
    • Owen, R.T.1
  • 58
    • 80053509410 scopus 로고    scopus 로고
    • Ezogabine: A new angle on potassium gates
    • Faught E. Ezogabine: a new angle on potassium gates. Epilepsy Curr. 2011;11(3):75-78.
    • (2011) Epilepsy Curr , vol.11 , Issue.3 , pp. 75-78
    • Faught, E.1
  • 59
    • 80053645719 scopus 로고    scopus 로고
    • Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizures
    • Weisenberg JL, Wong M. Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizures. Neuropsychiat Dis Treat. 2011;7:409-414.
    • (2011) Neuropsychiat Dis Treat , vol.7 , pp. 409-414
    • Weisenberg, J.L.1    Wong, M.2
  • 61
    • 80053071190 scopus 로고    scopus 로고
    • Retigabine (ezogabine): In partial onset seizures in adults with epilepsy
    • Deeks ED. Retigabine (ezogabine): in partial onset seizures in adults with epilepsy. CNS Drugs. 2011;25(10):887-900.
    • (2011) CNS Drugs , vol.25 , Issue.10 , pp. 887-900
    • Deeks, E.D.1
  • 64
    • 50849132883 scopus 로고    scopus 로고
    • Efficacy of oxcarbazepine treatment in patients diagnosed with cocaine abuse/dependence
    • In Spanish
    • Llopis Llacer JJ, Castillo Aquilella A. Efficacy of oxcarbazepine treatment in patients diagnosed with cocaine abuse/dependence. Adicciones. 2008;20(3):263-270. In Spanish.
    • (2008) Adicciones , vol.20 , Issue.3 , pp. 263-270
    • Llopis Llacer, J.J.1    Castillo, A.A.2
  • 66
    • 79959970402 scopus 로고    scopus 로고
    • Pharmacological treatment for cocaine dependence: Is there something new?
    • Karila L, Reynaud M, Aubin HJ, et al. Pharmacological treatment for cocaine dependence: is there something new? Curr Pharm Des. 2011; 17(14):1359-1368.
    • (2011) Curr Pharm Des , vol.17 , Issue.14 , pp. 1359-1368
    • Karila, L.1    Reynaud, M.2    Aubin, H.J.3
  • 67
    • 33745657854 scopus 로고    scopus 로고
    • Improvement of cervivo-trunco-brachial segmental dystonia with topiramate
    • Papapetropoulos S, Singer C. Improvement of cervivo-trunco-brachial segmental dystonia with topiramate. J Neurol. 2006;253(4):535-536.
    • (2006) J Neurol , vol.253 , Issue.4 , pp. 535-536
    • Papapetropoulos, S.1    Singer, C.2
  • 68
    • 0023205629 scopus 로고
    • Systemic therapy of dystonia
    • Fahn S. Systemic therapy of dystonia. Can J Neurol Sci. 1987; 14(Suppl 3):528-532.
    • (1987) Can J Neurol Sci , vol.14 , Issue.SUPPL. 3 , pp. 528-532
    • Fahn, S.1
  • 69
    • 0020032934 scopus 로고
    • Dystonia associated with carbamazepine toxicity
    • Bradbury AJ, Bentick B, Todd PJ. Dystonia associated with carbamazepine toxicity. Postgrad Med J. 1982;58(682):525-526.
    • (1982) Postgrad Med J , vol.58 , Issue.682 , pp. 525-526
    • Bradbury, A.J.1    Bentick, B.2    Todd, P.J.3
  • 70
    • 0028139124 scopus 로고
    • The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia
    • Richter A, Löschmann PA, Löscher W. The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia. Eur J Pharmacol. 1994;264(3):345-351.
    • (1994) Eur J Pharmacol , vol.264 , Issue.3 , pp. 345-351
    • Richter, A.1    Löschmann, P.A.2    Löscher, W.3
  • 71
    • 0347749546 scopus 로고    scopus 로고
    • Efficacy and tolerance of gabapentin in dystonia and hemifacial spasm: A pilot study
    • In Spanish
    • Linazasoro Cristobal G. Efficacy and tolerance of gabapentin in dystonia and hemifacial spasm: a pilot study. Rev Neurol. 2001;33(5):408-410. In Spanish.
    • (2001) Rev Neurol , vol.33 , Issue.5 , pp. 408-410
    • Linazasoro, C.G.1
  • 72
    • 12844274313 scopus 로고    scopus 로고
    • Dystonia induced by gabapentin
    • Pina MA, Modrego PJ. Dystonia induced by gabapentin. Ann Pharmacother. 2005;39(2):380-382.
    • (2005) Ann Pharmacother , vol.39 , Issue.2 , pp. 380-382
    • Pina, M.A.1    Modrego, P.J.2
  • 73
    • 0031801847 scopus 로고    scopus 로고
    • Antiglutamatergic therapy in Alzheimer's disease - effects of lamotrigine. Short communication
    • Tekin S, Aykut-Binogöl C, Tanridag T, Aktan S. Antiglutamatergic therapy in Alzheimer's disease - effects of lamotrigine. Short communication. J Neural Transm. 1998;105(2-3):295-303.
    • (1998) J Neural Transm , vol.105 , Issue.2-3 , pp. 295-303
    • Tekin, S.1    Aykut-Binogöl, C.2    Tanridag, T.3    Aktan, S.4
  • 74
    • 74549205843 scopus 로고    scopus 로고
    • Comparison of topiramate and risperidone for the treatment of behavioral disturbances of patients with Alzheimer's disease: A double-blind, randomized clinical trial
    • Mowla A, Pani A. Comparison of topiramate and risperidone for the treatment of behavioral disturbances of patients with Alzheimer's disease: a double-blind, randomized clinical trial. J Clin Psychopharmacol. 2010;30(1):40-43.
    • (2010) J Clin Psychopharmacol , vol.30 , Issue.1 , pp. 40-43
    • Mowla, A.1    Pani, A.2
  • 75
    • 70350141271 scopus 로고    scopus 로고
    • Management of agitation and aggression associated with Alzheimer's disease: Controversies and possible solutions
    • Ballard C, Corbett A, Chitramohan R, Aarsland D. Management of agitation and aggression associated with Alzheimer's disease: controversies and possible solutions. Curr Opin Psychoatry. 2009;22(6):532-540.
    • (2009) Curr Opin Psychoatry , vol.22 , Issue.6 , pp. 532-540
    • Ballard, C.1    Corbett, A.2    Chitramohan, R.3    Aarsland, D.4
  • 76
    • 40549084978 scopus 로고    scopus 로고
    • Use of gabapentin in the treatment of behavioural and psychological symptoms in dementia: A review of the evidence
    • Kim Y, Wilkins KM, Tampi RR. Use of gabapentin in the treatment of behavioural and psychological symptoms in dementia: a review of the evidence. Drugs Aging. 2008;25(3):187-196.
    • (2008) Drugs Aging , vol.25 , Issue.3 , pp. 187-196
    • Kim, Y.1    Wilkins, K.M.2    Tampi, R.R.3
  • 78
    • 84992069253 scopus 로고    scopus 로고
    • Familial paroxysmal kinesigenic dyskinesia
    • Pagon RA, Bird TD, Dolan CR, Stephens K, editors, [Updated March 31, 2011]. Seattle, WA: University of Washington
    • Spacey S, Adams P. Familial paroxysmal kinesigenic dyskinesia. In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. Gene Reviews [Internet]. [Updated March 31, 2011]. Seattle, WA: University of Washington; 1993-2005.
    • Gene Reviews [Internet] , pp. 1993-2005
    • Spacey, S.1    Adams, P.2
  • 79
    • 84857075280 scopus 로고    scopus 로고
    • Myoclonus-dystonia
    • Pagon RA, Bird TD, Dolan CR, Stephens K, editors, [Updated December 19, 2005]. Seattle, WA: University of Washington
    • Raymond D, Ozelius L. Myoclonus-dystonia. In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. Gene Reviews [Internet]. [Updated December 19, 2005]. Seattle, WA: University of Washington; 1993-2003.
    • Gene Reviews [Internet] , pp. 1993-2003
    • Raymond, D.1    Ozelius, L.2


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